Motif ID: Dlx5_Dlx4

Z-value: 1.473

Transcription factors associated with Dlx5_Dlx4:

Gene SymbolEntrez IDGene Name
Dlx4 ENSMUSG00000020871.7 Dlx4
Dlx5 ENSMUSG00000029755.9 Dlx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx5mm10_v2_chr6_-_6882068_6882092-0.582.3e-08Click!


Activity profile for motif Dlx5_Dlx4.

activity profile for motif Dlx5_Dlx4


Sorted Z-values histogram for motif Dlx5_Dlx4

Sorted Z-values for motif Dlx5_Dlx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx5_Dlx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 33.623 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr8_-_4779513 22.527 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chrM_+_9870 18.211 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr1_-_24612700 17.346 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr12_-_55014329 15.679 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chrM_+_10167 15.066 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr1_+_6487231 14.725 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr9_-_66514567 13.281 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr3_+_55782500 12.458 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr15_+_25773985 12.446 ENSMUST00000125667.1
 Myo10
myosin X
chr9_-_16378231 12.231 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr9_+_65890237 11.581 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr1_+_139454747 11.574 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr2_-_121235689 11.046 ENSMUST00000142400.1
 Trp53bp1
transformation related protein 53 binding protein 1
chr9_-_36726374 10.961 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr17_-_59013264 10.657 ENSMUST00000174122.1
ENSMUST00000025065.5
 Nudt12

nudix (nucleoside diphosphate linked moiety X)-type motif 12

chr16_+_52031549 10.312 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr3_+_146121655 10.288 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr2_+_118814237 10.242 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr13_-_89742244 9.795 ENSMUST00000109543.2
ENSMUST00000159337.1
ENSMUST00000159910.1
ENSMUST00000109544.2
 Vcan



versican




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 237 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 36.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.8 31.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.6 26.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6 25.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.4 24.2 GO:0008347 glial cell migration(GO:0008347)
0.3 20.1 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
1.1 18.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.3 17.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 15.3 GO:0006338 chromatin remodeling(GO:0006338)
1.2 14.7 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 14.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
1.4 13.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 13.0 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.4 12.2 GO:0010842 retina layer formation(GO:0010842)
1.6 11.0 GO:0030035 microspike assembly(GO:0030035)
1.6 11.0 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.7 11.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.2 11.0 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
2.1 10.7 GO:0051661 maintenance of centrosome location(GO:0051661)
0.8 10.7 GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 52.6 GO:0070469 respiratory chain(GO:0070469)
0.9 31.6 GO:1990752 microtubule end(GO:1990752)
0.0 28.9 GO:0005654 nucleoplasm(GO:0005654)
0.0 21.9 GO:0005694 chromosome(GO:0005694)
0.2 20.6 GO:0005814 centriole(GO:0005814)
4.6 18.3 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.3 17.4 GO:0016459 myosin complex(GO:0016459)
0.1 15.8 GO:0000776 kinetochore(GO:0000776)
3.9 15.7 GO:0008623 CHRAC(GO:0008623)
0.1 15.6 GO:0032993 protein-DNA complex(GO:0032993)
0.2 14.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
2.3 11.6 GO:0036449 microtubule minus-end(GO:0036449)
0.2 11.2 GO:0005657 replication fork(GO:0005657)
0.3 11.0 GO:0035861 site of double-strand break(GO:0035861)
1.6 9.8 GO:0044305 calyx of Held(GO:0044305)
0.3 9.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 9.7 GO:0001741 XY body(GO:0001741)
0.0 9.6 GO:0016604 nuclear body(GO:0016604)
0.1 8.4 GO:0030175 filopodium(GO:0030175)
0.3 7.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 49.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.6 46.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 22.5 GO:0042169 SH2 domain binding(GO:0042169)
0.9 19.0 GO:0000400 four-way junction DNA binding(GO:0000400)
1.0 17.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 16.7 GO:0030507 spectrin binding(GO:0030507)
0.1 16.2 GO:0001047 core promoter binding(GO:0001047)
0.2 14.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 13.9 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
2.3 13.8 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.3 11.8 GO:0001784 phosphotyrosine binding(GO:0001784)
3.7 11.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.8 11.0 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 11.0 GO:0042393 histone binding(GO:0042393)
2.7 10.7 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.3 10.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 10.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
3.3 9.8 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
1.6 9.7 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 9.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 19.4 PID_PLK1_PATHWAY PLK1 signaling events
2.0 18.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 16.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.6 16.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.5 9.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 9.4 PID_CD40_PATHWAY CD40/CD40L signaling
0.3 8.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 8.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 6.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 6.2 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 6.0 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.2 5.4 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.1 4.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.4 4.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 4.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 3.5 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 3.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 20.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 20.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 20.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 18.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
1.2 16.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 12.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 11.3 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.3 10.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 8.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.4 6.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 6.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 6.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 6.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 5.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 4.8 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.3 4.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 4.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 3.8 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 3.7 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.3 3.5 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions