Motif ID: Dmc1

Z-value: 1.138


Transcription factors associated with Dmc1:

Gene SymbolEntrez IDGene Name
Dmc1 ENSMUSG00000022429.10 Dmc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmc1mm10_v2_chr15_-_79605084_796051140.224.9e-02Click!


Activity profile for motif Dmc1.

activity profile for motif Dmc1


Sorted Z-values histogram for motif Dmc1

Sorted Z-values for motif Dmc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dmc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_14229390 11.372 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr16_-_43979050 9.237 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr18_+_61105561 7.754 ENSMUST00000025523.6
 Csf1r
colony stimulating factor 1 receptor
chr8_+_66386292 7.164 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr14_+_75955003 7.078 ENSMUST00000050120.2
 Kctd4
potassium channel tetramerisation domain containing 4
chr4_+_128058962 6.421 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr7_-_45103747 6.134 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr2_-_104257400 5.476 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr3_+_95526777 5.178 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr10_-_117282262 4.846 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr18_+_37484955 4.327 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr1_-_173942445 4.257 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr4_+_126609818 4.180 ENSMUST00000097886.3
ENSMUST00000164362.1
 5730409E04Rik

RIKEN cDNA 5730409E04Rik gene

chr17_+_55445375 4.161 ENSMUST00000133899.1
ENSMUST00000086878.3
 St6gal2

beta galactoside alpha 2,6 sialyltransferase 2

chr5_+_112255813 4.153 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
 Crybb1


crystallin, beta B1


chr4_+_118961578 4.092 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr9_+_21032038 4.000 ENSMUST00000019616.4
 Icam5
intercellular adhesion molecule 5, telencephalin
chr8_+_104340594 3.951 ENSMUST00000034343.4
 Cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr7_-_14562171 3.828 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr18_-_82406777 3.799 ENSMUST00000065224.6
 Galr1
galanin receptor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.7 GO:0007416 synapse assembly(GO:0007416)
0.3 11.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
2.5 9.9 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.3 9.9 GO:0018345 protein palmitoylation(GO:0018345)
0.4 7.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.4 5.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.3 5.2 GO:0030574 collagen catabolic process(GO:0030574)
1.6 4.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.2 4.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 4.2 GO:0007601 visual perception(GO:0007601)
0.7 4.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 4.0 GO:0030032 lamellipodium assembly(GO:0030032)
1.0 3.9 GO:0006710 androgen catabolic process(GO:0006710)
1.3 3.8 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.7 3.7 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.4 3.5 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3 3.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 3.5 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 3.4 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.5 3.3 GO:0001867 complement activation, lectin pathway(GO:0001867)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 30.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 11.2 GO:0010008 endosome membrane(GO:0010008)
3.3 9.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 9.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 6.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.5 4.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 4.9 GO:0005811 lipid particle(GO:0005811)
1.0 4.8 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 4.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 3.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 3.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.3 3.1 GO:0044294 dendritic growth cone(GO:0044294)
0.9 2.8 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.9 2.8 GO:0044299 C-fiber(GO:0044299)
0.2 2.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 2.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 2.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 2.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.2 2.1 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 12.8 GO:0005537 mannose binding(GO:0005537)
0.3 9.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 9.9 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 9.0 GO:0005509 calcium ion binding(GO:0005509)
0.6 7.2 GO:0001846 opsonin binding(GO:0001846)
0.3 7.2 GO:0042287 MHC protein binding(GO:0042287)
1.3 6.4 GO:0019770 IgG receptor activity(GO:0019770)
0.2 6.1 GO:0001968 fibronectin binding(GO:0001968)
0.1 5.5 GO:0005125 cytokine activity(GO:0005125)
0.4 5.3 GO:0031005 filamin binding(GO:0031005)
1.6 4.8 GO:0003796 lysozyme activity(GO:0003796)
0.8 4.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.5 4.2 GO:0005212 structural constituent of eye lens(GO:0005212)
1.4 4.1 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.6 3.9 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.9 3.8 GO:0004966 galanin receptor activity(GO:0004966)
0.1 3.6 GO:0051018 protein kinase A binding(GO:0051018)
0.1 3.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.8 3.4 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 3.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.6 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 7.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 6.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 5.1 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 5.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.5 ST_ADRENERGIC Adrenergic Pathway
0.1 3.5 PID_ATM_PATHWAY ATM pathway
0.1 2.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.2 2.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 2.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.2 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.9 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 0.8 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
2.6 7.7 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 5.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 4.9 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 4.5 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 4.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 4.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 3.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 3.2 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.7 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 2.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.5 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 1.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.4 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides