Motif ID: E2f1

Z-value: 2.598


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569720_1545697990.869.0e-24Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_34372004 37.812 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chrX_-_60893430 37.130 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_+_45669907 31.365 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr4_+_126556935 30.261 ENSMUST00000048391.8
 Clspn
claspin
chr17_+_56303396 27.439 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr4_-_59549314 26.185 ENSMUST00000148331.2
ENSMUST00000030076.5
 Ptbp3

polypyrimidine tract binding protein 3

chr5_-_106458440 24.108 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr15_+_55557399 23.449 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr15_-_78773452 23.428 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_+_56303321 23.425 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr4_-_59549243 23.221 ENSMUST00000173699.1
ENSMUST00000173884.1
ENSMUST00000102883.4
ENSMUST00000174586.1
 Ptbp3



polypyrimidine tract binding protein 3



chr9_+_65890237 22.495 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr14_-_52020698 21.422 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr10_-_128704978 21.162 ENSMUST00000026416.7
ENSMUST00000026415.7
 Cdk2

cyclin-dependent kinase 2

chr9_-_61946768 21.037 ENSMUST00000034815.7
 Kif23
kinesin family member 23
chr2_+_163054682 20.482 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr4_+_115000156 20.480 ENSMUST00000030490.6
 Stil
Scl/Tal1 interrupting locus
chr4_+_126556994 20.323 ENSMUST00000147675.1
 Clspn
claspin
chr5_+_123749696 19.495 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr14_-_47276790 19.425 ENSMUST00000111792.1
ENSMUST00000111791.1
ENSMUST00000111790.1
 Wdhd1


WD repeat and HMG-box DNA binding protein 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 419 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 72.5 GO:0010216 maintenance of DNA methylation(GO:0010216)
4.1 61.0 GO:0043249 erythrocyte maturation(GO:0043249)
3.8 56.7 GO:0007076 mitotic chromosome condensation(GO:0007076)
10.7 53.3 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
2.9 52.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
5.1 50.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
9.3 46.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
2.2 44.8 GO:0030903 notochord development(GO:0030903)
2.0 44.7 GO:0040034 regulation of development, heterochronic(GO:0040034)
1.6 43.4 GO:0006270 DNA replication initiation(GO:0006270)
5.9 41.2 GO:0098535 de novo centriole assembly(GO:0098535)
3.7 40.8 GO:0002315 marginal zone B cell differentiation(GO:0002315)
2.4 38.8 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
2.1 38.1 GO:0007530 sex determination(GO:0007530)
4.1 37.2 GO:0033504 floor plate development(GO:0033504)
1.4 36.7 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
2.5 32.0 GO:2000381 negative regulation of mesoderm development(GO:2000381)
1.7 31.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.5 30.9 GO:0031297 replication fork processing(GO:0031297)
1.6 29.6 GO:0030261 chromosome condensation(GO:0030261)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 122.7 GO:0005657 replication fork(GO:0005657)
0.6 90.3 GO:0000775 chromosome, centromeric region(GO:0000775)
0.2 82.9 GO:0000228 nuclear chromosome(GO:0000228)
0.0 82.9 GO:0005654 nucleoplasm(GO:0005654)
6.1 61.3 GO:0000796 condensin complex(GO:0000796)
0.6 57.9 GO:0005814 centriole(GO:0005814)
0.0 55.3 GO:0005634 nucleus(GO:0005634)
9.4 46.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 46.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 45.6 GO:0005694 chromosome(GO:0005694)
1.3 42.1 GO:0000788 nuclear nucleosome(GO:0000788)
6.1 36.7 GO:0098536 deuterosome(GO:0098536)
10.1 30.4 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
2.2 25.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
6.1 24.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
8.0 24.1 GO:1990423 RZZ complex(GO:1990423)
1.3 22.2 GO:0044453 nuclear membrane part(GO:0044453)
4.4 21.8 GO:0031523 Myb complex(GO:0031523)
2.1 21.1 GO:0001739 sex chromatin(GO:0001739)
4.2 21.0 GO:0097149 centralspindlin complex(GO:0097149)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 269 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 106.2 GO:0042393 histone binding(GO:0042393)
0.1 74.8 GO:0003677 DNA binding(GO:0003677)
0.3 60.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.5 59.6 GO:0004386 helicase activity(GO:0004386)
14.4 57.7 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.4 56.3 GO:0003714 transcription corepressor activity(GO:0003714)
8.2 49.0 GO:0010997 anaphase-promoting complex binding(GO:0010997)
9.4 46.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9 42.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.0 41.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
1.0 37.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.1 28.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
2.3 27.1 GO:0035173 histone kinase activity(GO:0035173)
3.7 26.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.6 25.5 GO:0003680 AT DNA binding(GO:0003680)
0.2 25.2 GO:0017048 Rho GTPase binding(GO:0017048)
7.8 23.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.6 23.3 GO:0001671 ATPase activator activity(GO:0001671)
4.6 23.0 GO:0043515 kinetochore binding(GO:0043515)
0.8 23.0 GO:0070182 DNA polymerase binding(GO:0070182)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 167.5 PID_E2F_PATHWAY E2F transcription factor network
2.3 112.6 PID_AURORA_B_PATHWAY Aurora B signaling
1.6 69.0 PID_ATR_PATHWAY ATR signaling pathway
3.1 42.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.2 37.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.4 28.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.5 23.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
2.5 22.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.6 20.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.7 19.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.4 17.8 NABA_COLLAGENS Genes encoding collagen proteins
0.1 17.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5 15.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 14.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 13.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.3 12.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.5 12.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.3 10.7 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.5 9.0 PID_MYC_PATHWAY C-MYC pathway
0.4 9.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 73.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.3 69.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
4.0 67.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.7 57.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 37.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
2.1 33.9 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.8 30.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
1.1 30.2 REACTOME_KINESINS Genes involved in Kinesins
1.5 30.1 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 29.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6 27.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
2.2 24.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
1.0 22.9 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.8 22.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
1.2 20.7 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
2.9 20.0 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
2.1 19.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 18.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.7 17.8 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.5 15.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression