Motif ID: E2f2_E2f5
Z-value: 3.768
Transcription factors associated with E2f2_E2f5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2f2 | ENSMUSG00000018983.9 | E2f2 |
| E2f5 | ENSMUSG00000027552.8 | E2f5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f2 | mm10_v2_chr4_+_136172367_136172395 | 0.93 | 2.1e-33 | Click! |
| E2f5 | mm10_v2_chr3_+_14578609_14578687 | 0.79 | 1.8e-17 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 167 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.5 | 154.9 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 19.6 | 137.2 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 5.4 | 130.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 2.2 | 117.9 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 13.8 | 110.5 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 5.8 | 98.7 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 6.8 | 94.8 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 10.3 | 92.8 | GO:0033504 | floor plate development(GO:0033504) |
| 9.2 | 83.0 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 1.8 | 78.1 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 25.1 | 75.2 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 10.8 | 64.9 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 6.1 | 54.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 2.4 | 41.3 | GO:0006312 | mitotic recombination(GO:0006312) |
| 9.8 | 39.3 | GO:0006272 | leading strand elongation(GO:0006272) |
| 3.9 | 38.9 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 9.4 | 37.8 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 7.5 | 37.6 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 3.1 | 36.8 | GO:0019985 | translesion synthesis(GO:0019985) |
| 2.3 | 34.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 83 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 237.4 | GO:0005694 | chromosome(GO:0005694) |
| 0.0 | 219.2 | GO:0005634 | nucleus(GO:0005634) |
| 0.9 | 136.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.5 | 136.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 8.3 | 125.0 | GO:0042555 | MCM complex(GO:0042555) |
| 2.2 | 121.0 | GO:0005657 | replication fork(GO:0005657) |
| 1.0 | 100.8 | GO:0005814 | centriole(GO:0005814) |
| 19.7 | 98.7 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 1.8 | 96.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 1.1 | 74.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.9 | 55.7 | GO:0044815 | DNA packaging complex(GO:0044815) |
| 10.4 | 51.9 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 7.0 | 49.3 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 4.2 | 37.6 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.4 | 34.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.3 | 33.5 | GO:0005819 | spindle(GO:0005819) |
| 2.5 | 32.5 | GO:0000800 | lateral element(GO:0000800) |
| 5.9 | 29.4 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 1.1 | 26.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 2.4 | 23.6 | GO:0000796 | condensin complex(GO:0000796) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 116 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 202.5 | GO:0001047 | core promoter binding(GO:0001047) |
| 24.8 | 148.9 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.5 | 132.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 25.5 | 101.8 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 19.7 | 98.7 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 6.5 | 97.8 | GO:0035173 | histone kinase activity(GO:0035173) |
| 6.9 | 96.0 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 1.0 | 80.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.2 | 79.1 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 1.2 | 77.3 | GO:0000975 | regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212) |
| 0.9 | 74.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 2.3 | 72.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.5 | 68.7 | GO:0004386 | helicase activity(GO:0004386) |
| 0.2 | 55.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.5 | 54.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 48.5 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.3 | 47.7 | GO:0042393 | histone binding(GO:0042393) |
| 1.9 | 46.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 6.3 | 44.4 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.9 | 43.9 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 35 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 298.2 | PID_E2F_PATHWAY | E2F transcription factor network |
| 6.2 | 271.7 | PID_ATR_PATHWAY | ATR signaling pathway |
| 11.2 | 156.2 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 17.1 | 154.1 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 2.9 | 92.8 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 1.4 | 72.9 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.5 | 47.9 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.9 | 43.6 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 1.4 | 36.9 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.6 | 21.8 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.4 | 17.7 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.4 | 17.6 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.4 | 15.5 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.7 | 14.0 | PID_CD40_PATHWAY | CD40/CD40L signaling |
| 0.4 | 11.1 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.6 | 10.9 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.4 | 9.5 | PID_ATM_PATHWAY | ATM pathway |
| 0.7 | 9.2 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.2 | 9.1 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 8.1 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 51 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.4 | 368.3 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 17.7 | 195.0 | REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 9.8 | 137.7 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.7 | 124.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 5.2 | 88.3 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 7.8 | 70.6 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 2.4 | 64.4 | REACTOME_KINESINS | Genes involved in Kinesins |
| 1.0 | 56.3 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 3.9 | 54.5 | REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 3.0 | 36.5 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 4.3 | 30.2 | REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.8 | 27.3 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 26.5 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.9 | 24.8 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.6 | 19.7 | REACTOME_RNA_POL_I_TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 4.7 | 18.8 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.8 | 16.9 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.7 | 15.5 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.2 | 14.5 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 2.2 | 13.5 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
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