Motif ID: E2f3
Z-value: 1.612
Transcription factors associated with E2f3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2f3 | ENSMUSG00000016477.11 | E2f3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f3 | mm10_v2_chr13_-_29984219_29984353 | 0.53 | 5.6e-07 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 20.6 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 5.4 | 16.2 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 3.6 | 25.2 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 3.2 | 9.6 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 2.6 | 13.1 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 2.5 | 10.0 | GO:0035624 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) response to high density lipoprotein particle(GO:0055099) |
| 2.5 | 7.4 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 2.2 | 6.7 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 2.0 | 18.4 | GO:0033504 | floor plate development(GO:0033504) |
| 2.0 | 12.1 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 2.0 | 7.9 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
| 1.9 | 7.6 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
| 1.9 | 13.0 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 1.8 | 5.5 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) |
| 1.8 | 5.4 | GO:0019085 | early viral transcription(GO:0019085) |
| 1.3 | 5.4 | GO:0061428 | embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 1.3 | 9.4 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 1.3 | 9.2 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 1.2 | 8.5 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) axis elongation involved in somitogenesis(GO:0090245) |
| 1.2 | 8.3 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 1.1 | 14.9 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 1.1 | 6.3 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 1.0 | 3.1 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 1.0 | 15.9 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 1.0 | 11.9 | GO:0051307 | meiotic chromosome separation(GO:0051307) |
| 0.9 | 8.4 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.9 | 3.6 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.8 | 5.0 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.8 | 4.1 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.8 | 3.2 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.8 | 6.2 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.7 | 12.0 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.7 | 8.9 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.7 | 5.2 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.7 | 11.7 | GO:0006312 | mitotic recombination(GO:0006312) |
| 0.7 | 12.0 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.7 | 3.3 | GO:0061511 | centriole elongation(GO:0061511) |
| 0.6 | 7.0 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.6 | 13.5 | GO:0043486 | histone exchange(GO:0043486) |
| 0.6 | 1.8 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 0.6 | 1.8 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.6 | 8.6 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.6 | 3.4 | GO:0036337 | Fas signaling pathway(GO:0036337) |
| 0.6 | 3.9 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.5 | 1.6 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
| 0.5 | 4.3 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.4 | 3.8 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.4 | 1.7 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.4 | 3.3 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.4 | 1.2 | GO:0035672 | transepithelial chloride transport(GO:0030321) oligopeptide transmembrane transport(GO:0035672) |
| 0.4 | 2.5 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.4 | 2.0 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.4 | 6.3 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.4 | 6.8 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.4 | 1.1 | GO:0090204 | protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046) |
| 0.4 | 1.8 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
| 0.4 | 6.8 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.4 | 3.6 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.4 | 1.4 | GO:1905245 | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) negative regulation of metalloendopeptidase activity(GO:1904684) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247) |
| 0.4 | 3.5 | GO:1904152 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) regulation of retrograde protein transport, ER to cytosol(GO:1904152) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.3 | 1.4 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
| 0.3 | 1.7 | GO:0006680 | glucosylceramide catabolic process(GO:0006680) |
| 0.3 | 5.0 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.3 | 2.4 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.3 | 3.2 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.3 | 7.3 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.3 | 2.0 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.3 | 2.8 | GO:2000773 | negative regulation of cellular senescence(GO:2000773) |
| 0.3 | 2.4 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.2 | 10.5 | GO:0001755 | neural crest cell migration(GO:0001755) |
| 0.2 | 1.1 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.2 | 5.4 | GO:0031290 | retinal ganglion cell axon guidance(GO:0031290) |
| 0.2 | 1.0 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.2 | 0.8 | GO:0031622 | fever generation(GO:0001660) regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622) negative regulation of action potential(GO:0045759) trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553) |
| 0.2 | 1.6 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.2 | 6.6 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.2 | 1.8 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216) |
| 0.2 | 10.3 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.2 | 1.3 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.2 | 5.0 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.2 | 8.4 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.2 | 1.5 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.1 | 0.9 | GO:0051096 | regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096) |
| 0.1 | 2.7 | GO:0048635 | negative regulation of muscle organ development(GO:0048635) |
| 0.1 | 1.0 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.1 | 1.3 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.1 | 2.8 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.1 | 3.7 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058) |
| 0.1 | 4.6 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.1 | 5.5 | GO:0050879 | multicellular organismal movement(GO:0050879) musculoskeletal movement(GO:0050881) |
| 0.1 | 1.0 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 3.3 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.1 | 4.9 | GO:0033120 | positive regulation of RNA splicing(GO:0033120) |
| 0.1 | 1.8 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 1.5 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.1 | 9.0 | GO:0072164 | ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164) |
| 0.1 | 0.4 | GO:0060406 | positive regulation of penile erection(GO:0060406) |
| 0.1 | 1.9 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.1 | 1.2 | GO:0021854 | hypothalamus development(GO:0021854) |
| 0.1 | 6.4 | GO:0097194 | execution phase of apoptosis(GO:0097194) |
| 0.1 | 0.9 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.1 | 0.9 | GO:0060033 | anatomical structure regression(GO:0060033) |
| 0.1 | 0.3 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) mitochondrial RNA 3'-end processing(GO:0000965) |
| 0.1 | 1.8 | GO:0007020 | microtubule nucleation(GO:0007020) |
| 0.1 | 1.9 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.1 | 3.2 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.1 | 1.2 | GO:1902751 | positive regulation of cell cycle G2/M phase transition(GO:1902751) |
| 0.1 | 3.4 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 5.0 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.1 | 1.2 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.1 | 1.2 | GO:0034243 | regulation of transcription elongation from RNA polymerase II promoter(GO:0034243) |
| 0.0 | 2.5 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 0.0 | 1.7 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 0.7 | GO:0060008 | Sertoli cell differentiation(GO:0060008) |
| 0.0 | 0.1 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.0 | 6.0 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 0.0 | 3.8 | GO:0048511 | rhythmic process(GO:0048511) |
| 0.0 | 2.1 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.0 | 1.2 | GO:0006360 | transcription from RNA polymerase I promoter(GO:0006360) |
| 0.0 | 3.0 | GO:0008033 | tRNA processing(GO:0008033) |
| 0.0 | 6.9 | GO:0042391 | regulation of membrane potential(GO:0042391) |
| 0.0 | 0.2 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.0 | 2.5 | GO:0032886 | regulation of microtubule-based process(GO:0032886) |
| 0.0 | 0.1 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.0 | 1.9 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 3.0 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.0 | 0.2 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.0 | 0.1 | GO:0046490 | isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490) |
| 0.0 | 0.2 | GO:0010718 | positive regulation of epithelial to mesenchymal transition(GO:0010718) |
| 0.0 | 1.7 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 1.7 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 0.0 | GO:0033262 | regulation of nuclear cell cycle DNA replication(GO:0033262) |
| 0.0 | 0.3 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 16.2 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 3.6 | 25.2 | GO:0000796 | condensin complex(GO:0000796) |
| 3.4 | 20.6 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 2.6 | 10.5 | GO:0043259 | laminin-10 complex(GO:0043259) |
| 2.4 | 12.0 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 2.1 | 14.9 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 2.0 | 7.9 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 1.7 | 5.1 | GO:0034679 | integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679) |
| 1.7 | 6.6 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 1.5 | 6.2 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 1.2 | 3.6 | GO:0034657 | GID complex(GO:0034657) |
| 1.0 | 5.0 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 1.0 | 2.9 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.9 | 5.5 | GO:0000938 | GARP complex(GO:0000938) |
| 0.7 | 8.3 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.7 | 9.9 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.6 | 6.3 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.6 | 1.8 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.6 | 3.9 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.5 | 2.5 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.5 | 5.4 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.5 | 1.4 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.4 | 1.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.4 | 5.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.4 | 5.7 | GO:0005675 | holo TFIIH complex(GO:0005675) |
| 0.4 | 16.1 | GO:0016592 | mediator complex(GO:0016592) |
| 0.4 | 1.5 | GO:0032021 | NELF complex(GO:0032021) |
| 0.3 | 1.0 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.3 | 3.2 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.3 | 6.4 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.3 | 6.8 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.3 | 3.7 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.3 | 5.0 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.3 | 1.8 | GO:0001740 | Barr body(GO:0001740) |
| 0.2 | 9.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.2 | 1.2 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.2 | 6.6 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.2 | 21.2 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 2.4 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.2 | 2.0 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 1.5 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 10.8 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 1.1 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.1 | 13.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 13.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 8.4 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 2.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 1.8 | GO:0045120 | pronucleus(GO:0045120) |
| 0.1 | 0.9 | GO:0032300 | mismatch repair complex(GO:0032300) |
| 0.1 | 1.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 4.7 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.1 | 9.4 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.1 | 4.3 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 2.0 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.4 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 0.1 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.0 | 9.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 5.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 7.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 4.1 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 1.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 1.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.6 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 1.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 5.9 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 5.7 | GO:0030424 | axon(GO:0030424) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 12.1 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 2.9 | 8.8 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 2.7 | 16.2 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 2.4 | 12.0 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 1.9 | 7.6 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 1.8 | 5.4 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 1.6 | 9.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.5 | 6.2 | GO:0036033 | mediator complex binding(GO:0036033) |
| 1.5 | 9.2 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 1.4 | 8.3 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 1.3 | 5.1 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 1.2 | 10.0 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 1.2 | 7.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 1.2 | 15.9 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 1.2 | 14.0 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 1.1 | 5.7 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 1.1 | 7.9 | GO:0070087 | DNA translocase activity(GO:0015616) chromo shadow domain binding(GO:0070087) |
| 1.1 | 3.2 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
| 0.9 | 3.6 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.9 | 14.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.8 | 2.4 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.8 | 4.1 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.7 | 4.3 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.7 | 4.2 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.7 | 5.4 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.7 | 4.7 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.6 | 1.7 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.5 | 3.8 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.5 | 8.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.5 | 1.6 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.5 | 5.4 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.5 | 3.4 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.5 | 9.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.4 | 1.7 | GO:0070976 | calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976) |
| 0.4 | 8.9 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.4 | 5.2 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.3 | 20.5 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.3 | 2.4 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.3 | 1.0 | GO:0015173 | hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.3 | 7.0 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.3 | 1.2 | GO:0015563 | uptake transmembrane transporter activity(GO:0015563) |
| 0.3 | 16.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.3 | 1.4 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.3 | 1.8 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.2 | 5.0 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.2 | 1.9 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) |
| 0.2 | 18.6 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.2 | 19.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.2 | 1.8 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) mRNA CDS binding(GO:1990715) |
| 0.2 | 15.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.2 | 4.4 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.2 | 1.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 1.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.2 | 0.9 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.1 | 4.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 7.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 6.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 2.1 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 0.4 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
| 0.1 | 1.0 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 3.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 1.6 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 1.7 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 1.4 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 3.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 3.1 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 1.2 | GO:0001163 | RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.1 | 1.3 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.1 | 16.3 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 27.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 0.8 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 0.1 | 3.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 1.8 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 5.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 3.2 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 59.9 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 5.0 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.1 | 2.0 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 1.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 1.7 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 3.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.8 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 0.5 | GO:0015299 | solute:proton antiporter activity(GO:0015299) |
| 0.0 | 1.0 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 7.9 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 3.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.9 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 1.5 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 6.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 8.8 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 0.6 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 0.3 | GO:0031489 | myosin V binding(GO:0031489) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 10.5 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 1.0 | 41.6 | PID_ATM_PATHWAY | ATM pathway |
| 0.9 | 41.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.8 | 16.9 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.8 | 24.4 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.3 | 5.1 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.3 | 11.3 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.2 | 8.6 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.2 | 3.4 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.2 | 10.0 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.2 | 5.4 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.2 | 2.4 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.1 | 2.8 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 1.5 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 9.8 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 11.3 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 10.4 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 5.4 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 1.7 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 6.4 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 3.3 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.1 | 2.8 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 9.3 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.5 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 1.8 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.8 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 0.5 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.2 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.8 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 28.9 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.7 | 10.0 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.7 | 13.8 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.6 | 6.6 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.6 | 8.6 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.5 | 14.1 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.5 | 5.0 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.4 | 18.6 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 5.1 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.4 | 5.0 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.4 | 15.9 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.3 | 6.7 | REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER | Genes involved in Formation of incision complex in GG-NER |
| 0.3 | 7.4 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.3 | 18.0 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.3 | 1.8 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.2 | 2.4 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 7.6 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 3.6 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.2 | 6.2 | REACTOME_MEIOSIS | Genes involved in Meiosis |
| 0.1 | 2.4 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 5.4 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 4.1 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 8.4 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 9.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 8.8 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 1.7 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 1.9 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 1.6 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.7 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 1.1 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 6.2 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.0 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 1.8 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.2 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 1.7 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 3.3 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.4 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 3.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.4 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.0 | 4.8 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.0 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.4 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 2.5 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
