Motif ID: E2f3

Z-value: 1.612


Transcription factors associated with E2f3:

Gene SymbolEntrez IDGene Name
E2f3 ENSMUSG00000016477.11 E2f3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f3mm10_v2_chr13_-_29984219_299843530.535.6e-07Click!


Activity profile for motif E2f3.

activity profile for motif E2f3


Sorted Z-values histogram for motif E2f3

Sorted Z-values for motif E2f3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_137314394 25.970 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr11_-_101551837 20.600 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr2_-_127133909 16.165 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr19_+_41482632 15.476 ENSMUST00000067795.5
 Lcor
ligand dependent nuclear receptor corepressor
chr2_+_109280738 14.946 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr4_+_46450892 13.501 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr3_+_69004969 13.230 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4

chr18_+_11657349 13.061 ENSMUST00000047322.6
 Rbbp8
retinoblastoma binding protein 8
chr19_+_21778325 12.107 ENSMUST00000096194.2
ENSMUST00000025663.6
 Tmem2

transmembrane protein 2

chr12_+_24708241 12.005 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr1_-_134079114 11.998 ENSMUST00000020692.6
 Btg2
B cell translocation gene 2, anti-proliferative
chr3_+_69004711 11.981 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr15_+_102296256 11.897 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr3_+_41742615 11.816 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr4_+_115000156 11.493 ENSMUST00000030490.6
 Stil
Scl/Tal1 interrupting locus
chr5_+_114568016 11.442 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr11_-_100759942 10.918 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr19_+_40894692 10.649 ENSMUST00000050092.6
 Zfp518a
zinc finger protein 518A
chr2_-_180225812 10.488 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr10_+_20347788 10.329 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 25.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
6.9 20.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
2.0 18.4 GO:0033504 floor plate development(GO:0033504)
5.4 16.2 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
1.0 15.9 GO:0033327 Leydig cell differentiation(GO:0033327)
1.1 14.9 GO:0072520 seminiferous tubule development(GO:0072520)
0.6 13.5 GO:0043486 histone exchange(GO:0043486)
2.6 13.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
1.9 13.0 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
2.0 12.1 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.7 12.0 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.7 12.0 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.0 11.9 GO:0051307 meiotic chromosome separation(GO:0051307)
0.7 11.7 GO:0006312 mitotic recombination(GO:0006312)
0.2 10.5 GO:0001755 neural crest cell migration(GO:0001755)
0.2 10.3 GO:0000266 mitochondrial fission(GO:0000266)
2.5 10.0 GO:0035624 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) response to high density lipoprotein particle(GO:0055099)
3.2 9.6 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
1.3 9.4 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.3 9.2 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 25.2 GO:0000796 condensin complex(GO:0000796)
0.2 21.2 GO:0005814 centriole(GO:0005814)
3.4 20.6 GO:0070531 BRCA1-A complex(GO:0070531)
5.4 16.2 GO:0000799 nuclear condensin complex(GO:0000799)
0.4 16.1 GO:0016592 mediator complex(GO:0016592)
2.1 14.9 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 13.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 13.1 GO:0017053 transcriptional repressor complex(GO:0017053)
2.4 12.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 10.8 GO:0072686 mitotic spindle(GO:0072686)
2.6 10.5 GO:0043259 laminin-10 complex(GO:0043259)
0.7 9.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 9.4 GO:0030673 axolemma(GO:0030673)
0.1 9.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 9.4 GO:0005802 trans-Golgi network(GO:0005802)
0.1 8.4 GO:0036064 ciliary basal body(GO:0036064)
0.7 8.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
2.0 7.9 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 7.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 6.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 59.9 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 27.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 20.5 GO:0003684 damaged DNA binding(GO:0003684)
0.2 19.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 18.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 16.3 GO:0042393 histone binding(GO:0042393)
2.7 16.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.3 16.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
1.2 15.9 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 15.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.9 14.9 GO:0051010 microtubule plus-end binding(GO:0051010)
1.2 14.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
3.0 12.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
2.4 12.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.2 10.0 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.5 9.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
1.6 9.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.5 9.2 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.4 8.9 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
2.9 8.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 41.6 PID_ATM_PATHWAY ATM pathway
0.9 41.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.8 24.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.8 16.9 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.3 11.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 11.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
1.3 10.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 10.4 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 10.0 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 9.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 9.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 8.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 6.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 5.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 5.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.3 5.1 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.2 3.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.8 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 2.8 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 28.9 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4 18.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 18.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.4 15.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 14.1 REACTOME_KINESINS Genes involved in Kinesins
0.7 13.8 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.7 10.0 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 9.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 8.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.6 8.6 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 8.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 7.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 7.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.3 6.7 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.6 6.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 6.2 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 6.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 5.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.4 5.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.5 5.0 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER