Motif ID: E2f4

Z-value: 2.514


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.735.4e-14Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 169 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_34751502 49.741 ENSMUST00000060710.7
 Cdc25c
cell division cycle 25C
chr8_-_53638945 46.940 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)
chr19_+_6084983 46.181 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr11_-_101551837 45.432 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr14_-_47418407 42.074 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr1_-_189688074 38.810 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr6_+_124830217 37.781 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr1_-_169531343 36.734 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_+_134510999 33.825 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr9_+_72438534 32.405 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr1_-_169531447 31.802 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_+_72438519 30.565 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr2_+_163054682 26.689 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr4_-_116123618 26.235 ENSMUST00000102704.3
ENSMUST00000102705.3
 Rad54l

RAD54 like (S. cerevisiae)

chr18_+_34751803 25.635 ENSMUST00000181453.1
ENSMUST00000181641.1
 2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr15_+_57912199 25.440 ENSMUST00000022992.6
 Tbc1d31
TBC1 domain family, member 31
chr4_-_133967296 25.258 ENSMUST00000105893.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr4_-_133967235 24.941 ENSMUST00000123234.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr2_-_26503814 24.923 ENSMUST00000028288.4
 Notch1
notch 1
chr10_+_79997463 24.226 ENSMUST00000171637.1
ENSMUST00000043866.7
 Abca7

ATP-binding cassette, sub-family A (ABC1), member 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 79.7 GO:0040034 regulation of development, heterochronic(GO:0040034)
5.4 75.4 GO:0070986 left/right axis specification(GO:0070986)
1.9 68.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.7 52.6 GO:0051225 spindle assembly(GO:0051225)
1.7 49.7 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
1.0 46.9 GO:0006284 base-excision repair(GO:0006284)
15.4 46.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
15.1 45.4 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.7 45.3 GO:0008340 determination of adult lifespan(GO:0008340)
1.0 38.8 GO:0051310 metaphase plate congression(GO:0051310)
0.1 37.7 GO:0051301 cell division(GO:0051301)
2.7 35.0 GO:0035881 amacrine cell differentiation(GO:0035881)
3.6 32.7 GO:0055059 asymmetric neuroblast division(GO:0055059)
1.9 28.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
6.6 26.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
8.3 24.9 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
4.8 24.2 GO:1902995 apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427)
0.4 24.0 GO:0007051 spindle organization(GO:0007051)
7.0 21.1 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.0 21.0 GO:0007049 cell cycle(GO:0007049)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 77.3 GO:0005634 nucleus(GO:0005634)
11.4 68.5 GO:0031262 Ndc80 complex(GO:0031262)
1.0 62.9 GO:0005882 intermediate filament(GO:0005882)
0.0 56.6 GO:0005654 nucleoplasm(GO:0005654)
6.6 46.2 GO:0008278 cohesin complex(GO:0008278)
7.6 45.4 GO:0070531 BRCA1-A complex(GO:0070531)
2.1 42.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 39.9 GO:0043198 dendritic shaft(GO:0043198)
3.2 38.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.4 33.8 GO:0000922 spindle pole(GO:0000922)
0.1 33.2 GO:0016607 nuclear speck(GO:0016607)
0.4 31.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.4 29.4 GO:0000786 nucleosome(GO:0000786)
0.3 29.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 29.0 GO:0005667 transcription factor complex(GO:0005667)
5.3 26.7 GO:0031523 Myb complex(GO:0031523)
5.0 24.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
1.0 24.2 GO:0001891 phagocytic cup(GO:0001891)
2.1 19.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 19.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 49.7 GO:0050699 WW domain binding(GO:0050699)
0.3 47.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
9.4 46.9 GO:0000405 bubble DNA binding(GO:0000405)
0.7 42.1 GO:0003684 damaged DNA binding(GO:0003684)
1.1 38.8 GO:0070840 dynein complex binding(GO:0070840)
0.2 38.3 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 38.1 GO:0003682 chromatin binding(GO:0003682)
0.7 29.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
3.3 26.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
3.8 26.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
2.6 26.2 GO:0036310 annealing helicase activity(GO:0036310)
4.3 25.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.9 25.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.7 24.9 GO:0005112 Notch binding(GO:0005112)
8.1 24.2 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
3.1 22.0 GO:0015616 DNA translocase activity(GO:0015616)
0.9 22.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
1.7 19.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
3.4 17.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 16.4 GO:0008134 transcription factor binding(GO:0008134)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 111.6 PID_ATM_PATHWAY ATM pathway
1.2 56.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
1.2 42.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 36.0 PID_E2F_PATHWAY E2F transcription factor network
0.3 30.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 26.3 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.6 22.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 21.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.5 17.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.5 14.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 12.5 NABA_COLLAGENS Genes encoding collagen proteins
1.1 12.2 PID_ALK2_PATHWAY ALK2 signaling events
0.4 11.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.4 10.2 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 8.8 PID_FGF_PATHWAY FGF signaling pathway
0.2 8.0 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 6.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 6.8 PID_LKB1_PATHWAY LKB1 signaling events
0.2 6.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 5.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 80.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
3.2 67.0 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
2.2 54.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
5.0 49.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.1 32.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6 28.9 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 26.9 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.2 26.3 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
1.2 24.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 18.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 17.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.7 14.8 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.3 13.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
1.1 12.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 11.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.5 9.0 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
1.0 8.8 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.5 8.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.5 7.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
2.3 6.8 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway