Motif ID: E2f6

Z-value: 0.702


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.673.6e-11Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 7.310 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_+_139543889 5.968 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr10_-_127534540 5.966 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr2_-_64097994 5.135 ENSMUST00000131615.2
 Fign
fidgetin
chr6_-_23248264 4.651 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_-_98004634 4.254 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chrX_-_141725181 4.235 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr15_-_98004695 4.123 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr9_+_65890237 4.114 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr14_-_67715585 3.920 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr4_+_126556935 3.841 ENSMUST00000048391.8
 Clspn
claspin
chr2_-_117342709 3.767 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr13_+_112987802 3.737 ENSMUST00000038404.4
 Ccno
cyclin O
chr11_+_82388900 3.528 ENSMUST00000054245.4
ENSMUST00000092852.2
 Tmem132e

transmembrane protein 132E

chr4_+_8691303 3.486 ENSMUST00000051558.3
 Chd7
chromodomain helicase DNA binding protein 7
chr7_-_70360593 3.419 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr4_-_91372028 3.419 ENSMUST00000107110.1
ENSMUST00000008633.8
ENSMUST00000107118.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr9_+_119402444 3.338 ENSMUST00000035093.8
ENSMUST00000165044.1
 Acvr2b

activin receptor IIB

chr4_+_8690399 3.247 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr12_-_46818749 3.198 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 383 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.0 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.5 8.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.4 7.6 GO:0051383 kinetochore organization(GO:0051383)
0.3 7.0 GO:0007530 sex determination(GO:0007530)
0.7 6.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
2.2 6.7 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.2 6.3 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.4 5.7 GO:0010216 maintenance of DNA methylation(GO:0010216)
1.3 5.3 GO:0003360 brainstem development(GO:0003360)
0.4 5.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.9 4.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 4.7 GO:0043249 erythrocyte maturation(GO:0043249)
1.5 4.6 GO:0030421 defecation(GO:0030421)
0.6 4.5 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.5 4.5 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.9 4.4 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.4 4.0 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.1 3.9 GO:0007129 synapsis(GO:0007129)
0.1 3.9 GO:0001947 heart looping(GO:0001947)
0.9 3.7 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.8 GO:0000791 euchromatin(GO:0000791)
0.1 8.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.7 8.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 8.0 GO:0016363 nuclear matrix(GO:0016363)
1.5 7.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 6.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.3 GO:0005844 polysome(GO:0005844)
0.1 5.1 GO:0060077 inhibitory synapse(GO:0060077)
1.6 4.9 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 4.7 GO:0000776 kinetochore(GO:0000776)
0.1 4.6 GO:0016592 mediator complex(GO:0016592)
0.0 4.4 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.9 GO:0005813 centrosome(GO:0005813)
0.2 3.5 GO:0097470 ribbon synapse(GO:0097470)
0.0 3.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.3 GO:0005874 microtubule(GO:0005874)
0.4 3.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 3.0 GO:0032426 stereocilium tip(GO:0032426)
0.2 2.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 2.9 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.5 GO:0003723 RNA binding(GO:0003723)
0.3 10.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.7 8.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 7.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.5 7.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 7.3 GO:0042393 histone binding(GO:0042393)
1.2 7.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 6.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 6.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2 5.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 5.0 GO:0008013 beta-catenin binding(GO:0008013)
0.8 4.9 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 4.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 4.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 4.5 GO:0005178 integrin binding(GO:0005178)
0.5 4.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 4.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 4.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 4.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 3.9 GO:0019992 diacylglycerol binding(GO:0019992)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 11.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 11.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 9.5 PID_PLK1_PATHWAY PLK1 signaling events
0.2 8.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 7.9 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 5.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 5.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 5.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 3.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 3.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 3.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 3.1 ST_STAT3_PATHWAY STAT3 Pathway
0.2 2.8 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 2.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.5 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 2.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 8.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 7.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 6.3 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.4 5.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 4.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 4.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 3.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 3.7 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.2 3.7 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.2 3.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 3.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 3.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 3.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 3.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 2.9 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 2.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse