Motif ID: E2f7

Z-value: 1.243


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.243.3e-02Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 32.856 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3037111 31.962 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3025417 28.364 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3015654 24.685 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 24.603 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr10_-_69352886 12.390 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr12_+_24708984 8.718 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr15_+_102296256 8.489 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr12_+_24708241 7.577 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr11_+_102248842 7.281 ENSMUST00000100392.4
 BC030867
cDNA sequence BC030867
chr3_+_108383829 6.054 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
 Psrc1


proline/serine-rich coiled-coil 1


chr7_+_110122299 5.766 ENSMUST00000033326.8
 Wee1
WEE 1 homolog 1 (S. pombe)
chr4_+_126556994 5.268 ENSMUST00000147675.1
 Clspn
claspin
chr2_+_72476225 5.238 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr4_+_126556935 5.173 ENSMUST00000048391.8
 Clspn
claspin
chr6_-_88898664 5.130 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr17_-_35516780 5.072 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
 Tcf19


transcription factor 19


chr4_+_136172367 5.027 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr11_-_101466222 4.929 ENSMUST00000040430.7
 Vat1
vesicle amine transport protein 1 homolog (T californica)
chr6_-_67037399 4.860 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 16.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.2 10.6 GO:0090166 Golgi disassembly(GO:0090166)
1.0 10.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.6 8.5 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 7.8 GO:0006342 chromatin silencing(GO:0006342)
0.2 7.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7 7.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 6.3 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.0 5.6 GO:0030010 establishment of cell polarity(GO:0030010)
0.3 5.4 GO:0051382 kinetochore assembly(GO:0051382)
0.2 5.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.7 5.0 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.0 4.9 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.4 4.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.4 4.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.7 4.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 3.9 GO:0006270 DNA replication initiation(GO:0006270)
0.6 3.2 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.1 3.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 3.1 GO:0021924 cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.3 GO:0005876 spindle microtubule(GO:0005876)
3.3 16.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 8.8 GO:0072686 mitotic spindle(GO:0072686)
0.3 8.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 8.1 GO:0000786 nucleosome(GO:0000786)
0.0 7.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.9 7.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 4.9 GO:0042555 MCM complex(GO:0042555)
0.0 4.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 4.8 GO:0000776 kinetochore(GO:0000776)
0.4 4.0 GO:0005915 zonula adherens(GO:0005915)
0.9 2.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.2 2.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.7 2.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 1.7 GO:0032993 protein-DNA complex(GO:0032993)
0.2 1.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.2 1.2 GO:0005638 lamin filament(GO:0005638)
0.1 1.1 GO:0042382 paraspeckles(GO:0042382)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 1.0 GO:0032021 NELF complex(GO:0032021)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 16.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.8 12.2 GO:0035173 histone kinase activity(GO:0035173)
1.7 10.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.6 9.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 7.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 6.7 GO:0001047 core promoter binding(GO:0001047)
0.1 5.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 5.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 5.0 GO:0070097 delta-catenin binding(GO:0070097)
0.9 4.6 GO:0043515 kinetochore binding(GO:0043515)
0.0 4.3 GO:0031072 heat shock protein binding(GO:0031072)
0.1 3.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 3.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 2.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.4 2.6 GO:0070883 pre-miRNA binding(GO:0070883)
0.2 2.1 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 2.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 1.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 22.3 PID_E2F_PATHWAY E2F transcription factor network
0.4 18.7 PID_ATR_PATHWAY ATR signaling pathway
2.0 18.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 8.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 7.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.4 5.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 4.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.9 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.3 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 18.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.8 18.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 15.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.8 11.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.7 5.0 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.5 4.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 3.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 3.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 3.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.6 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 2.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 2.0 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.9 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.8 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor