Motif ID: E2f7
Z-value: 1.243
Transcription factors associated with E2f7:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2f7 | ENSMUSG00000020185.10 | E2f7 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f7 | mm10_v2_chr10_+_110745433_110745572 | 0.24 | 3.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 10.6 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 1.0 | 10.4 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 1.0 | 4.9 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
| 0.9 | 16.3 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.7 | 5.0 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 0.7 | 7.1 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.7 | 2.1 | GO:0045004 | DNA replication proofreading(GO:0045004) |
| 0.7 | 4.0 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.6 | 3.2 | GO:0048631 | regulation of skeletal muscle tissue growth(GO:0048631) |
| 0.6 | 8.5 | GO:0000212 | meiotic spindle organization(GO:0000212) |
| 0.6 | 1.7 | GO:1904760 | myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760) |
| 0.5 | 2.2 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 0.4 | 1.2 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) |
| 0.4 | 1.1 | GO:1904959 | regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959) |
| 0.4 | 4.9 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.4 | 1.5 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.4 | 4.2 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.3 | 5.4 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.3 | 1.0 | GO:2000569 | T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570) |
| 0.3 | 2.6 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.3 | 0.9 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.3 | 2.0 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.3 | 1.2 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
| 0.2 | 2.1 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.2 | 7.2 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.2 | 0.8 | GO:0051026 | chiasma assembly(GO:0051026) |
| 0.2 | 6.3 | GO:0090224 | regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224) |
| 0.2 | 5.1 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.1 | 3.1 | GO:0021924 | cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930) |
| 0.1 | 0.7 | GO:0000076 | DNA replication checkpoint(GO:0000076) |
| 0.1 | 3.9 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 2.4 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.1 | 1.0 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.1 | 0.3 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.1 | 0.4 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 0.1 | 0.8 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 0.5 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 3.2 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 0.1 | 7.8 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.1 | 0.2 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.1 | 0.5 | GO:0034379 | very-low-density lipoprotein particle assembly(GO:0034379) |
| 0.1 | 0.4 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.1 | 1.5 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.1 | 2.4 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.1 | 1.1 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 0.1 | 0.2 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.0 | 1.4 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.8 | GO:0090031 | positive regulation of steroid hormone biosynthetic process(GO:0090031) |
| 0.0 | 5.6 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.0 | 0.2 | GO:0009146 | purine nucleoside triphosphate catabolic process(GO:0009146) |
| 0.0 | 1.1 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.0 | 1.4 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.0 | 0.5 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.4 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 0.0 | 0.2 | GO:0043486 | histone exchange(GO:0043486) |
| 0.0 | 0.3 | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation(GO:1904707) |
| 0.0 | 1.2 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 0.2 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.0 | 0.2 | GO:0048484 | enteric nervous system development(GO:0048484) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 16.3 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.9 | 7.3 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.9 | 2.6 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
| 0.7 | 2.1 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.4 | 4.0 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.3 | 4.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.3 | 18.3 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.3 | 8.7 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.3 | 1.0 | GO:0032021 | NELF complex(GO:0032021) |
| 0.2 | 1.2 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476) |
| 0.2 | 8.1 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 0.9 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.2 | 1.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 2.4 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.2 | 0.6 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
| 0.1 | 1.1 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 0.7 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.1 | 0.4 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.1 | 8.8 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 0.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 0.3 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.0 | 7.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 4.8 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 0.2 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.0 | 1.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 4.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 0.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 1.0 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 1.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.9 | GO:0000922 | spindle pole(GO:0000922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 16.3 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 1.7 | 10.4 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.9 | 4.6 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.8 | 12.2 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.6 | 9.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.4 | 2.6 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.4 | 5.0 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.4 | 3.3 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.3 | 1.7 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.3 | 0.8 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.2 | 2.1 | GO:0008296 | 3'-5'-exodeoxyribonuclease activity(GO:0008296) |
| 0.2 | 0.9 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.2 | 0.9 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 1.1 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.1 | 1.1 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 5.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 1.5 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 5.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 3.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 7.4 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 0.3 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.1 | 0.4 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.1 | 1.0 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 2.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 0.2 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.1 | 1.2 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 0.4 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 2.0 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 0.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 6.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 4.3 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.0 | 0.2 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 1.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.3 | GO:0048038 | quinone binding(GO:0048038) |
| 0.0 | 0.6 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.5 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 2.9 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.8 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 18.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.4 | 5.0 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.4 | 18.7 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.3 | 22.3 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.2 | 7.4 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.1 | 2.9 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.1 | 1.7 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 8.4 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 4.0 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.9 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 0.5 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.0 | 1.0 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.2 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.0 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 0.3 | PID_HIV_NEF_PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 1.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.2 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 18.2 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 1.0 | 18.5 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.8 | 11.0 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.7 | 5.0 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.5 | 4.5 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.3 | 15.4 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.2 | 3.8 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.1 | 3.5 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 2.0 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 2.6 | REACTOME_MICRORNA_MIRNA_BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 2.0 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.1 | 0.9 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 3.2 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.7 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 2.2 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.8 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 1.1 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 1.1 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.3 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
