ISMARA results: E2f8

Motif ID: E2f8

Z-value: 0.974

Transcription factors associated with E2f8:

Gene Symbol	Entrez ID	Gene Name
E2f8	ENSMUSG00000046179.11	E2f8

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
E2f8	mm10_v2_chr7_-_48881596_48881619	0.85	4.2e-22	Click!

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Showing 1 to 20 of 84 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr5_+_123749696	13.669	ENSMUST00000031366.7	Kntc1	kinetochore associated 1
chr7_-_115824699	12.170	ENSMUST00000169129.1	Sox6	SRY-box containing gene 6
chr17_+_56303321	11.683	ENSMUST00000001258.8	Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1
chr17_+_56303396	10.814	ENSMUST00000113038.1	Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1
chr7_+_110122299	10.279	ENSMUST00000033326.8	Wee1	WEE 1 homolog 1 (S. pombe)
chr12_+_24708984	9.328	ENSMUST00000154588.1	Rrm2	ribonucleotide reductase M2
chr8_+_40926220	8.852	ENSMUST00000034004.9	Pdgfrl	platelet-derived growth factor receptor-like
chr6_-_88898664	8.829	ENSMUST00000058011.6	Mcm2	minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr2_+_145785980	8.821	ENSMUST00000110005.1 ENSMUST00000094480.4	Rin2	Ras and Rab interactor 2
chr7_-_48881032	8.676	ENSMUST00000058745.8	E2f8	E2F transcription factor 8
chr11_+_98907801	8.613	ENSMUST00000092706.6	Cdc6	cell division cycle 6
chr9_-_36726374	8.309	ENSMUST00000172702.2 ENSMUST00000172742.1 ENSMUST00000034625.5	Chek1	checkpoint kinase 1
chr16_-_18811615	8.056	ENSMUST00000096990.3	Cdc45	cell division cycle 45
chr12_+_24708241	7.614	ENSMUST00000020980.5	Rrm2	ribonucleotide reductase M2
chr7_-_48881596	7.566	ENSMUST00000119223.1	E2f8	E2F transcription factor 8
chr2_+_163054682	7.467	ENSMUST00000018005.3	Mybl2	myeloblastosis oncogene-like 2
chr1_-_128359610	6.901	ENSMUST00000027601.4	Mcm6	minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr17_+_56040350	6.190	ENSMUST00000002914.8	Chaf1a	chromatin assembly factor 1, subunit A (p150)
chr15_+_55557399	6.155	ENSMUST00000022998.7	Mtbp	Mdm2, transformed 3T3 cell double minute p53 binding protein
chr19_+_38931008	5.717	ENSMUST00000145051.1	Hells	helicase, lymphoid specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 44 entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.2	33.4	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.9	16.9	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
5.4	16.2	GO:0032877	positive regulation of DNA endoreduplication(GO:0032877)
0.1	16.0	GO:0007093	mitotic cell cycle checkpoint(GO:0007093)
1.6	15.9	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.6	15.2	GO:0006270	DNA replication initiation(GO:0006270)
1.1	12.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
2.2	10.9	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.8	10.0	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.9	9.3	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	8.8	GO:0006897	endocytosis(GO:0006897)
0.0	8.2	GO:0030010	establishment of cell polarity(GO:0030010)
2.7	8.1	GO:0036388	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
2.6	7.9	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.1	7.5	GO:0090307	mitotic spindle assembly(GO:0090307)
0.2	6.2	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7	5.1	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.1	4.4	GO:0043550	regulation of lipid kinase activity(GO:0043550)
1.2	3.6	GO:0015910	peroxisomal long-chain fatty acid import(GO:0015910)
0.7	3.6	GO:0002121	inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 27 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	36.6	GO:0005657	replication fork(GO:0005657)
0.1	27.3	GO:0005667	transcription factor complex(GO:0005667)
1.4	20.7	GO:0042555	MCM complex(GO:0042555)
3.4	16.9	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
4.6	13.7	GO:1990423	RZZ complex(GO:1990423)
0.6	13.4	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.4	10.9	GO:0005721	pericentric heterochromatin(GO:0005721)
2.7	8.1	GO:0036387	nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.2	8.1	GO:0051233	spindle midzone(GO:0051233)
1.6	7.9	GO:0035189	Rb-E2F complex(GO:0035189)
0.1	7.7	GO:0000776	kinetochore(GO:0000776)
1.5	7.5	GO:0031523	Myb complex(GO:0031523)
2.1	6.2	GO:0033186	CAF-1 complex(GO:0033186)
0.1	3.6	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.1	3.6	GO:0032590	dendrite membrane(GO:0032590)
1.1	3.4	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.4	3.0	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.8	2.4	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.1	1.5	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	1.2	GO:0071013	catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 35 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	28.4	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
5.6	22.5	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
1.6	22.5	GO:0003688	DNA replication origin binding(GO:0003688)
3.4	16.9	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2	11.3	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.4	11.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1	10.9	GO:0004386	helicase activity(GO:0004386)
2.8	8.3	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
0.0	7.5	GO:0005096	GTPase activator activity(GO:0005096)
0.2	7.1	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.1	6.4	GO:0032452	histone demethylase activity(GO:0032452)
0.8	6.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.2	4.4	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.7	3.6	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.3	3.6	GO:0019992	diacylglycerol binding(GO:0019992)
0.1	3.5	GO:0017025	TBP-class protein binding(GO:0017025)
0.4	3.4	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1	3.4	GO:0035064	methylated histone binding(GO:0035064)
0.1	3.2	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
1.0	3.0	GO:0071207	histone pre-mRNA stem-loop binding(GO:0071207)

Gene overrepresentation in C2:CP category:

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Showing 1 to 13 of 13 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	20.8	PID_ATR_PATHWAY	ATR signaling pathway
2.1	18.6	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	18.3	PID_E2F_PATHWAY	E2F transcription factor network
0.2	10.9	PID_DELTA_NP63_PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	8.8	PID_AJDISS_2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.6	7.9	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	3.6	PID_HES_HEY_PATHWAY	Notch-mediated HES/HEY network
0.1	2.4	PID_RANBP2_PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	2.2	PID_ERBB4_PATHWAY	ErbB4 signaling events
0.1	1.5	PID_TOLL_ENDOGENOUS_PATHWAY	Endogenous TLR signaling
0.0	1.0	PID_DNA_PK_PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.9	PID_FAS_PATHWAY	FAS (CD95) signaling pathway
0.0	0.5	PID_RAS_PATHWAY	Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 15 of 15 entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.1	41.5	REACTOME_G1_S_SPECIFIC_TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
1.5	21.6	REACTOME_UNWINDING_OF_DNA	Genes involved in Unwinding of DNA
2.1	18.6	REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.6	10.3	REACTOME_G0_AND_EARLY_G1	Genes involved in G0 and Early G1
0.1	6.0	REACTOME_MITOTIC_PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.6	5.8	REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.3	3.6	REACTOME_AMINE_DERIVED_HORMONES	Genes involved in Amine-derived hormones
0.2	3.6	REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	3.6	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.3	3.0	REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1	2.4	REACTOME_MICRORNA_MIRNA_BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	2.2	REACTOME_SIGNALING_BY_EGFR_IN_CANCER	Genes involved in Signaling by EGFR in Cancer
0.4	1.6	REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND	Genes involved in Processive synthesis on the lagging strand
0.1	1.0	REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	1.0	REACTOME_DOUBLE_STRAND_BREAK_REPAIR	Genes involved in Double-Strand Break Repair