Motif ID: Ebf1

Z-value: 1.358


Transcription factors associated with Ebf1:

Gene SymbolEntrez IDGene Name
Ebf1 ENSMUSG00000078561.3 Ebf1
Ebf1 ENSMUSG00000057098.8 Ebf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ebf1mm10_v2_chr11_+_44617310_446173360.307.4e-03Click!


Activity profile for motif Ebf1.

activity profile for motif Ebf1


Sorted Z-values histogram for motif Ebf1

Sorted Z-values for motif Ebf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ebf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_58313189 13.731 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr2_+_172550991 12.202 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr2_-_180225812 11.335 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr19_+_7268296 11.029 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr17_-_35702040 10.706 ENSMUST00000166980.2
ENSMUST00000145900.1
 Ddr1

discoidin domain receptor family, member 1

chr1_+_135729147 9.684 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr17_-_6782775 9.184 ENSMUST00000064234.6
 Ezr
ezrin
chr5_-_124095749 9.158 ENSMUST00000031354.4
 Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr2_+_172550761 8.501 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr17_-_35701937 7.715 ENSMUST00000155628.1
 Ddr1
discoidin domain receptor family, member 1
chr11_-_114795888 7.673 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17
chr2_+_130295148 7.659 ENSMUST00000110288.2
 Ebf4
early B cell factor 4
chr17_-_35702297 7.466 ENSMUST00000135078.1
 Ddr1
discoidin domain receptor family, member 1
chr19_+_5740885 7.269 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr2_+_79255500 7.144 ENSMUST00000099972.4
 Itga4
integrin alpha 4
chr15_+_79028212 7.116 ENSMUST00000180086.1
 H1f0
H1 histone family, member 0
chr11_-_98053415 7.089 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr17_-_34000257 6.927 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
 H2-K1




histocompatibility 2, K1, K region




chr2_-_181459364 6.680 ENSMUST00000155535.1
ENSMUST00000029106.6
ENSMUST00000087409.3
 Zbtb46


zinc finger and BTB domain containing 46


chr12_+_112620030 6.674 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 786 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 33.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
6.9 20.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
2.7 18.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
2.9 14.5 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.4 13.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.4 11.8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
2.3 11.5 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.4 11.4 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.9 11.2 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.3 10.6 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
2.3 9.3 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
3.0 9.0 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
3.0 9.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.4 8.5 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
1.0 8.3 GO:0071493 cellular response to UV-B(GO:0071493)
2.0 8.0 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.7 7.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.8 7.4 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
2.4 7.3 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.8 7.2 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 248 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 45.2 GO:1903561 extracellular vesicle(GO:1903561)
0.1 42.1 GO:0005667 transcription factor complex(GO:0005667)
0.3 18.6 GO:0005604 basement membrane(GO:0005604)
1.5 17.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 16.4 GO:0005925 focal adhesion(GO:0005925)
0.1 16.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 15.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 15.1 GO:0000791 euchromatin(GO:0000791)
0.1 13.4 GO:0016323 basolateral plasma membrane(GO:0016323)
2.8 11.3 GO:0043259 laminin-10 complex(GO:0043259)
0.1 11.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 10.4 GO:0017053 transcriptional repressor complex(GO:0017053)
3.1 9.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
1.4 8.5 GO:0031262 Ndc80 complex(GO:0031262)
0.1 8.1 GO:0032993 protein-DNA complex(GO:0032993)
0.1 8.1 GO:0031012 extracellular matrix(GO:0031012)
0.1 8.0 GO:0005814 centriole(GO:0005814)
1.6 7.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.4 7.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
1.9 7.7 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 444 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 36.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
3.7 33.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 26.0 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
1.5 19.7 GO:0030881 beta-2-microglobulin binding(GO:0030881)
1.2 18.6 GO:0003680 AT DNA binding(GO:0003680)
1.3 17.6 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.2 16.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
1.0 15.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 15.1 GO:0005080 protein kinase C binding(GO:0005080)
0.6 12.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.4 12.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 11.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.9 11.6 GO:0044548 S100 protein binding(GO:0044548)
0.5 11.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.1 10.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.8 10.9 GO:0042605 peptide antigen binding(GO:0042605)
0.1 10.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.0 9.8 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.1 9.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 9.2 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 30.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 22.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 19.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 17.5 NABA_COLLAGENS Genes encoding collagen proteins
0.3 17.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
1.9 15.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
1.3 11.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 10.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.6 10.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.2 9.3 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 9.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.4 9.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 9.1 PID_CDC42_PATHWAY CDC42 signaling events
0.2 8.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 7.8 PID_BARD1_PATHWAY BARD1 signaling events
0.1 7.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 7.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 7.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 7.1 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.5 7.0 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 31.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 27.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.8 11.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 10.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 9.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 9.7 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 9.3 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.6 9.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
1.1 8.9 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.5 8.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.6 8.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.5 8.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 7.8 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.3 7.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.4 7.1 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 6.6 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 6.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 6.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.4 6.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 5.9 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation