ISMARA results: Ebf3

Motif ID: Ebf3

Z-value: 1.463

Transcription factors associated with Ebf3:

Gene Symbol	Entrez ID	Gene Name
Ebf3	ENSMUSG00000010476.7	Ebf3

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Ebf3	mm10_v2_chr7_-_137314394_137314445	-0.57	6.7e-08	Click!

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Showing 1 to 20 of 200 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr15_-_66812593	40.155	ENSMUST00000100572.3	Sla	src-like adaptor
chr7_+_123982799	20.556	ENSMUST00000106437.1	Hs3st4	heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr1_-_56969827	19.125	ENSMUST00000176759.1	Satb2	special AT-rich sequence binding protein 2
chr1_-_56969864	18.537	ENSMUST00000177424.1	Satb2	special AT-rich sequence binding protein 2
chr8_+_70493156	16.208	ENSMUST00000008032.7	Crlf1	cytokine receptor-like factor 1
chr5_+_117781017	13.274	ENSMUST00000138579.2	Nos1	nitric oxide synthase 1, neuronal
chr15_-_98677451	12.884	ENSMUST00000120997.1 ENSMUST00000109149.2 ENSMUST00000003451.4	Rnd1	Rho family GTPase 1
chr1_-_193370260	12.186	ENSMUST00000016323.4	Camk1g	calcium/calmodulin-dependent protein kinase I gamma
chr1_+_75400070	11.838	ENSMUST00000113589.1	Speg	SPEG complex locus
chr1_-_193370225	11.816	ENSMUST00000169907.1	Camk1g	calcium/calmodulin-dependent protein kinase I gamma
chr11_+_104231465	11.634	ENSMUST00000145227.1	Mapt	microtubule-associated protein tau
chr11_+_104231573	11.437	ENSMUST00000132977.1 ENSMUST00000132245.1 ENSMUST00000100347.4	Mapt	microtubule-associated protein tau
chr11_+_104231515	11.314	ENSMUST00000106993.3	Mapt	microtubule-associated protein tau
chr15_-_45114926	11.171	ENSMUST00000022967.5	Kcnv1	potassium channel, subfamily V, member 1
chr11_+_104231390	11.032	ENSMUST00000106992.3	Mapt	microtubule-associated protein tau
chr9_-_110743653	11.023	ENSMUST00000166716.1	Pth1r	parathyroid hormone 1 receptor
chr2_-_118703963	10.945	ENSMUST00000104937.1	Ankrd63	ankyrin repeat domain 63
chr2_+_170731807	10.678	ENSMUST00000029075.4	Dok5	docking protein 5
chr3_+_26331150	10.297	ENSMUST00000099182.2	A830092H15Rik	RIKEN cDNA A830092H15 gene
chr5_-_139129662	10.260	ENSMUST00000026973.7	Prkar1b	protein kinase, cAMP dependent regulatory, type I beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 154 entries

Log-likelihood per target	Total log-likelihood	Term	Description
5.0	45.4	GO:1900034	regulation of cellular response to heat(GO:1900034)
2.4	37.7	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4	25.0	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2	24.0	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
1.6	19.8	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
2.7	16.2	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
4.4	13.3	GO:0030827	negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
4.4	13.3	GO:0099548	drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.5	12.5	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894)
2.0	12.2	GO:0097646	calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2	11.8	GO:0055013	cardiac muscle cell development(GO:0055013)
0.9	11.0	GO:0060732	positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.7	10.7	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
1.4	9.7	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
1.3	9.4	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
1.9	9.3	GO:0090273	regulation of somatostatin secretion(GO:0090273)
1.8	9.2	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.4	9.2	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.3	8.9	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.7	8.7	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 85 entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.5	45.4	GO:0045298	tubulin complex(GO:0045298)
0.3	39.9	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	30.3	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	22.8	GO:0005794	Golgi apparatus(GO:0005794)
1.5	19.8	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	19.8	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	19.3	GO:0043025	neuronal cell body(GO:0043025)
5.4	16.2	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
1.2	13.3	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.0	13.3	GO:0044327	dendritic spine head(GO:0044327)
0.3	12.9	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.3	12.6	GO:0031941	filamentous actin(GO:0031941)
2.4	12.2	GO:1903440	calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0	10.9	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.4	9.7	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.2	9.5	GO:0031526	brush border membrane(GO:0031526)
3.1	9.2	GO:0045160	myosin I complex(GO:0045160)
2.2	8.9	GO:1990769	proximal neuron projection(GO:1990769)
0.2	8.3	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.3	7.3	GO:0016327	apicolateral plasma membrane(GO:0016327)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 109 entries

Log-likelihood per target	Total log-likelihood	Term	Description
6.5	45.4	GO:0099609	microtubule lateral binding(GO:0099609)
1.0	40.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.6	23.7	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	22.4	GO:0003682	chromatin binding(GO:0003682)
1.8	19.8	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
2.4	16.9	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
4.4	13.3	GO:0004517	nitric-oxide synthase activity(GO:0004517)
2.4	12.2	GO:0097643	amylin receptor activity(GO:0097643)
1.3	11.6	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.2	11.3	GO:0070888	E-box binding(GO:0070888)
0.4	10.6	GO:0017046	peptide hormone binding(GO:0017046)
0.7	10.4	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
1.2	9.7	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
3.1	9.4	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
1.9	9.4	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	9.3	GO:0044325	ion channel binding(GO:0044325)
1.8	9.2	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.2	8.9	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.8	8.7	GO:0050815	phosphoserine binding(GO:0050815)
0.2	8.3	GO:0005158	insulin receptor binding(GO:0005158)

Gene overrepresentation in C2:CP category:

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Showing 1 to 20 of 31 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	57.1	PID_PDGFRB_PATHWAY	PDGFR-beta signaling pathway
2.4	45.4	PID_P38_GAMMA_DELTA_PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	21.0	PID_P53_DOWNSTREAM_PATHWAY	Direct p53 effectors
0.4	19.1	ST_ADRENERGIC	Adrenergic Pathway
0.7	13.0	PID_RET_PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	11.3	NABA_SECRETED_FACTORS	Genes encoding secreted soluble factors
0.3	7.8	PID_RAS_PATHWAY	Regulation of Ras family activation
0.2	7.2	PID_INTEGRIN_A4B1_PATHWAY	Alpha4 beta1 integrin signaling events
0.3	6.9	PID_PTP1B_PATHWAY	Signaling events mediated by PTP1B
0.2	6.2	PID_NETRIN_PATHWAY	Netrin-mediated signaling events
0.1	5.5	PID_ARF6_TRAFFICKING_PATHWAY	Arf6 trafficking events
0.4	5.3	PID_IGF1_PATHWAY	IGF1 pathway
0.5	4.4	PID_TCR_JNK_PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	4.4	PID_TAP63_PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	3.8	PID_P53_REGULATION_PATHWAY	p53 pathway
0.1	3.7	PID_LIS1_PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.4	3.2	PID_S1P_S1P1_PATHWAY	S1P1 pathway
0.1	3.1	PID_BMP_PATHWAY	BMP receptor signaling
0.1	3.0	PID_DELTA_NP63_PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	2.3	PID_ARF6_PATHWAY	Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 20 of 51 entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	31.1	REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.2	24.6	REACTOME_CRMPS_IN_SEMA3A_SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.3	23.2	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.5	20.6	REACTOME_HS_GAG_BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.9	19.8	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.4	13.0	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
1.8	12.9	REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3	12.7	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	Genes involved in Voltage gated Potassium channels
0.4	12.2	REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.9	9.4	REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2	8.9	REACTOME_REGULATION_OF_INSULIN_SECRETION	Genes involved in Regulation of Insulin Secretion
0.3	8.7	REACTOME_SIGNALING_BY_HIPPO	Genes involved in Signaling by Hippo
0.3	7.8	REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.3	6.8	REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING	Genes involved in Insulin Synthesis and Processing
0.5	6.2	REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.2	6.2	REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2	6.0	REACTOME_RAP1_SIGNALLING	Genes involved in Rap1 signalling
0.4	5.8	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2	5.3	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.5	5.1	REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand