Motif ID: Egr1

Z-value: 2.903


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_34861215-0.028.9e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 64.239 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_-_67922136 51.735 ENSMUST00000021288.3
ENSMUST00000108677.1
Usp43

ubiquitin specific peptidase 43

chr4_+_125490688 49.339 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr4_+_127169131 39.170 ENSMUST00000046659.7
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr11_+_119942763 38.729 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr3_+_54156039 34.289 ENSMUST00000029311.6
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr11_+_98348404 32.806 ENSMUST00000078694.6
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr9_-_102354685 28.812 ENSMUST00000035129.7
ENSMUST00000085169.5
Ephb1

Eph receptor B1

chr7_+_73740277 27.252 ENSMUST00000107456.2
Fam174b
family with sequence similarity 174, member B
chr12_+_108334341 27.161 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr5_-_139129662 25.849 ENSMUST00000026973.7
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr14_-_102982630 25.629 ENSMUST00000184744.1
KCTD12
mmu-mir-5130
chr5_+_32136458 25.340 ENSMUST00000031017.9
Fosl2
fos-like antigen 2
chr15_-_45114926 24.976 ENSMUST00000022967.5
Kcnv1
potassium channel, subfamily V, member 1
chr9_-_37552904 24.477 ENSMUST00000065668.5
Nrgn
neurogranin
chr8_+_104170513 24.259 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
Bean1



brain expressed, associated with Nedd4, 1



chr2_-_167188787 24.009 ENSMUST00000059826.8
Kcnb1
potassium voltage gated channel, Shab-related subfamily, member 1
chr5_-_139130159 23.923 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_+_137288273 23.549 ENSMUST00000024099.4
ENSMUST00000085934.3
Ache

acetylcholinesterase

chr7_-_27396542 23.141 ENSMUST00000108363.1
Sptbn4
spectrin beta, non-erythrocytic 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 240 entries
Log-likelihood per target Total log-likelihoodTermDescription
28.7 86.0 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
4.2 50.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
4.5 49.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
2.3 49.0 GO:0006491 N-glycan processing(GO:0006491)
8.9 44.4 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
2.3 41.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 38.8 GO:0016579 protein deubiquitination(GO:0016579)
2.8 37.0 GO:0016191 synaptic vesicle uncoating(GO:0016191)
2.0 36.9 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
2.3 36.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.0 36.4 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.7 36.0 GO:0034605 cellular response to heat(GO:0034605)
1.4 34.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
10.9 32.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
5.3 32.0 GO:0032796 uropod organization(GO:0032796)
5.8 28.8 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
5.5 27.7 GO:0034436 glycoprotein transport(GO:0034436)
0.2 27.6 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 27.5 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
2.7 27.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 87.8 GO:0051233 spindle midzone(GO:0051233)
0.2 71.1 GO:0043025 neuronal cell body(GO:0043025)
1.9 66.1 GO:0032839 dendrite cytoplasm(GO:0032839)
1.0 66.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
4.5 57.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 56.0 GO:0005769 early endosome(GO:0005769)
1.0 53.4 GO:0034704 calcium channel complex(GO:0034704)
1.4 41.1 GO:0032590 dendrite membrane(GO:0032590)
0.5 40.0 GO:0043198 dendritic shaft(GO:0043198)
2.6 39.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.4 39.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 39.2 GO:0031526 brush border membrane(GO:0031526)
0.6 38.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
5.9 35.5 GO:0008091 spectrin(GO:0008091)
0.2 34.6 GO:0045211 postsynaptic membrane(GO:0045211)
3.2 32.0 GO:0032426 stereocilium tip(GO:0032426)
1.9 28.8 GO:0032433 filopodium tip(GO:0032433)
2.3 27.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
1.4 27.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
2.2 26.4 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 94.0 GO:0043274 phospholipase binding(GO:0043274)
3.2 58.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
4.5 49.8 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
9.9 49.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.3 47.0 GO:0005516 calmodulin binding(GO:0005516)
0.5 45.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
4.5 40.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
4.8 38.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
10.9 32.8 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
3.0 32.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.6 32.7 GO:0001540 beta-amyloid binding(GO:0001540)
2.9 32.0 GO:0032036 myosin heavy chain binding(GO:0032036)
2.3 31.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.1 30.7 GO:0032183 SUMO binding(GO:0032183)
1.2 30.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
2.5 29.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
9.2 27.7 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
1.2 27.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
2.3 27.1 GO:0004016 adenylate cyclase activity(GO:0004016)
1.7 26.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 87.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.3 58.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.6 56.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
1.4 56.6 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
1.7 51.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.9 49.3 PID_RAC1_PATHWAY RAC1 signaling pathway
2.6 44.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.7 35.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.7 31.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.0 30.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 28.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
1.2 27.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4 23.2 PID_LKB1_PATHWAY LKB1 signaling events
0.5 20.8 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.2 19.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 19.6 PID_BMP_PATHWAY BMP receptor signaling
0.7 18.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.5 17.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.6 13.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.3 8.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 108.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
3.9 85.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
1.7 70.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
2.2 60.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
3.5 49.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.2 40.6 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.5 40.1 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
1.3 38.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
2.4 35.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
4.7 32.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
2.9 32.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
1.4 29.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
1.1 27.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
3.9 27.2 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
1.0 23.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.3 21.6 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.8 20.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.4 17.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.6 17.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.3 15.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels