Motif ID: Egr3
Z-value: 0.863
Transcription factors associated with Egr3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Egr3 | ENSMUSG00000033730.3 | Egr3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Egr3 | mm10_v2_chr14_+_70077375_70077445 | 0.39 | 5.3e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.7 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 1.1 | 4.4 | GO:2000705 | regulation of dense core granule biogenesis(GO:2000705) |
| 1.0 | 7.2 | GO:1990416 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.9 | 3.6 | GO:0003360 | brainstem development(GO:0003360) |
| 0.9 | 7.1 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.8 | 9.0 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.6 | 4.4 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.6 | 3.1 | GO:0007403 | glial cell fate determination(GO:0007403) |
| 0.6 | 3.0 | GO:0032485 | regulation of Ral protein signal transduction(GO:0032485) |
| 0.5 | 3.2 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.5 | 4.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.5 | 2.7 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.4 | 2.1 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.4 | 1.2 | GO:0060084 | synaptic transmission involved in micturition(GO:0060084) |
| 0.4 | 0.7 | GO:0010871 | negative regulation of receptor biosynthetic process(GO:0010871) |
| 0.4 | 1.1 | GO:0035482 | gastric motility(GO:0035482) gastric emptying(GO:0035483) negative regulation of gastric acid secretion(GO:0060455) |
| 0.4 | 9.5 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.3 | 1.7 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.3 | 2.4 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.2 | 0.8 | GO:0070858 | negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252) |
| 0.2 | 0.6 | GO:2000812 | response to rapamycin(GO:1901355) regulation of barbed-end actin filament capping(GO:2000812) |
| 0.2 | 0.8 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 0.2 | 0.5 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 0.1 | 6.7 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
| 0.1 | 8.8 | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200) |
| 0.1 | 0.4 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
| 0.1 | 1.8 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.1 | 0.5 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) axis elongation involved in somitogenesis(GO:0090245) |
| 0.1 | 0.4 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.1 | 7.7 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.1 | 0.3 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.1 | 0.2 | GO:0061763 | multivesicular body-lysosome fusion(GO:0061763) |
| 0.0 | 1.4 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.0 | 0.6 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.0 | 3.3 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 0.3 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.0 | 1.4 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.0 | 2.6 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.0 | 0.3 | GO:1902510 | regulation of apoptotic DNA fragmentation(GO:1902510) |
| 0.0 | 0.5 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) negative regulation of autophagosome assembly(GO:1902902) |
| 0.0 | 2.1 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.0 | 0.1 | GO:0000189 | MAPK import into nucleus(GO:0000189) |
| 0.0 | 1.3 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
| 0.0 | 0.7 | GO:0071364 | response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364) |
| 0.0 | 0.6 | GO:0072348 | sulfur compound transport(GO:0072348) |
| 0.0 | 0.7 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.0 | 0.5 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 0.2 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.0 | 0.7 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.6 | 7.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.5 | 9.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.4 | 3.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 2.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 1.2 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 2.4 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 1.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 0.6 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.1 | 8.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 0.2 | GO:0031417 | NatC complex(GO:0031417) |
| 0.1 | 8.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.3 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 0.4 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 0.9 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.5 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 6.9 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 2.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.5 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 2.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.1 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 5.4 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 0.5 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.3 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.7 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.6 | 3.6 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 0.5 | 9.6 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.4 | 1.8 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.4 | 8.8 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.4 | 4.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.4 | 11.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.3 | 12.1 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.3 | 2.5 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.2 | 4.1 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.2 | 0.9 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.2 | 3.1 | GO:0001163 | RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.2 | 1.4 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.2 | 11.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.2 | 4.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 0.5 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.1 | 1.7 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.4 | GO:0019153 | protein-disulfide reductase (glutathione) activity(GO:0019153) |
| 0.1 | 3.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 1.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 2.1 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 7.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 0.3 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 0.4 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.1 | 2.8 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 0.3 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.0 | 0.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.6 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.6 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.0 | 0.7 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 1.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.7 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.8 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 1.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.6 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.5 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.6 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 4.4 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 3.1 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 4.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.7 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.4 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.7 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.9 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 0.5 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.6 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.3 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 2.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.3 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.6 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.2 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 4.4 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 3.5 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.7 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 1.4 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 5.3 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 1.4 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 0.6 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 3.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.3 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 6.8 | REACTOME_DIABETES_PATHWAYS | Genes involved in Diabetes pathways |
| 0.0 | 0.4 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.6 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 1.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.6 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.3 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
