Motif ID: Egr3

Z-value: 0.863


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_700774450.395.3e-04Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 96 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_119184374 8.763 ENSMUST00000084650.4
Gpr139
G protein-coupled receptor 139
chr12_-_67221221 7.507 ENSMUST00000178814.1
ENSMUST00000179345.2
Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr6_-_144209558 7.072 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr17_-_87282771 6.902 ENSMUST00000161759.1
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr6_-_49214954 6.813 ENSMUST00000031838.7
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr17_+_87282880 6.697 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr17_-_87282793 6.654 ENSMUST00000146560.2
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr4_+_123183456 6.147 ENSMUST00000126995.1
Hpcal4
hippocalcin-like 4
chr4_+_123183722 5.986 ENSMUST00000152194.1
Hpcal4
hippocalcin-like 4
chrX_+_143664365 5.005 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr8_+_62951361 4.765 ENSMUST00000119068.1
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr11_+_98937669 4.677 ENSMUST00000107475.2
ENSMUST00000068133.3
Rara

retinoic acid receptor, alpha

chrX_+_143664290 4.473 ENSMUST00000112868.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr7_-_144939823 4.397 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr5_+_77265454 4.359 ENSMUST00000080359.5
Rest
RE1-silencing transcription factor
chr10_+_40883819 4.157 ENSMUST00000105509.1
Wasf1
WAS protein family, member 1
chr17_-_83631892 4.145 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr4_-_41695935 3.564 ENSMUST00000145379.1
Cntfr
ciliary neurotrophic factor receptor
chr10_-_29144194 3.430 ENSMUST00000070359.2
Gm9996
predicted gene 9996
chr11_-_109722214 3.210 ENSMUST00000020938.7
Fam20a
family with sequence similarity 20, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.5 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.8 9.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 8.8 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 7.7 GO:0051028 mRNA transport(GO:0051028)
1.0 7.2 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.9 7.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 6.7 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.5 4.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.6 4.7 GO:0060010 Sertoli cell fate commitment(GO:0060010)
1.1 4.4 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.6 4.4 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.9 3.6 GO:0003360 brainstem development(GO:0003360)
0.0 3.3 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.5 3.2 GO:0070166 enamel mineralization(GO:0070166)
0.6 3.1 GO:0007403 glial cell fate determination(GO:0007403)
0.6 3.0 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.5 2.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 2.6 GO:0045773 positive regulation of axon extension(GO:0045773)
0.3 2.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.4 2.1 GO:0046684 response to pyrethroid(GO:0046684)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 8.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 8.2 GO:0031225 anchored component of membrane(GO:0031225)
0.6 7.2 GO:0031209 SCAR complex(GO:0031209)
0.0 6.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 5.4 GO:0000790 nuclear chromatin(GO:0000790)
1.2 3.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.4 3.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 2.4 GO:0031430 M band(GO:0031430)
0.0 2.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 2.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.3 GO:0097228 sperm principal piece(GO:0097228)
0.1 1.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.6 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.4 11.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 11.4 GO:0030507 spectrin binding(GO:0030507)
0.5 9.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.4 8.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 7.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.4 4.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 4.4 GO:0070064 proline-rich region binding(GO:0070064)
0.2 4.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.6 3.6 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 3.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 3.1 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1 2.8 GO:0008146 sulfotransferase activity(GO:0008146)
0.7 2.7 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.3 2.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 2.1 GO:0031402 sodium ion binding(GO:0031402)
0.4 1.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 1.7 GO:0005522 profilin binding(GO:0005522)
0.2 1.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 4.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 4.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 3.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.6 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 6.8 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.1 5.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 4.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 3.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.7 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 1.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.4 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)