Motif ID: Egr4

Z-value: 0.795


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 10.457 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr11_-_19018956 9.155 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr18_+_35829798 8.501 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr11_-_86993682 7.674 ENSMUST00000018571.4
 Ypel2
yippee-like 2 (Drosophila)
chr11_-_19018714 7.165 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chr4_+_86748526 6.517 ENSMUST00000082026.7
ENSMUST00000045512.8
 Dennd4c

DENN/MADD domain containing 4C

chr2_+_124610278 6.318 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr4_+_128883549 5.684 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr2_-_102186322 5.610 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr2_+_124610573 5.345 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chrX_-_145505175 4.930 ENSMUST00000143610.1
 Amot
angiomotin
chr10_-_81350389 4.469 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
 Hmg20b



high mobility group 20B



chr14_-_54926784 4.411 ENSMUST00000022813.6
 Efs
embryonal Fyn-associated substrate
chr10_-_81350191 4.246 ENSMUST00000122993.1
 Hmg20b
high mobility group 20B
chr2_+_32535315 4.089 ENSMUST00000133512.1
ENSMUST00000048375.5
 Fam102a

family with sequence similarity 102, member A

chr12_+_17690793 4.088 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr6_+_4747306 4.047 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr14_+_84443553 4.034 ENSMUST00000071370.5
 Pcdh17
protocadherin 17
chr7_+_35119285 3.988 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr10_-_81350305 3.966 ENSMUST00000167481.1
 Hmg20b
high mobility group 20B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 16.3 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.7 14.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.7 12.7 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.4 11.7 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 8.5 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.3 5.7 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 5.5 GO:0032869 cellular response to insulin stimulus(GO:0032869)
1.0 5.1 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
1.2 4.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.5 4.0 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.3 4.0 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.1 4.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 3.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 3.7 GO:0051607 defense response to virus(GO:0051607)
0.9 3.5 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.2 3.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 3.4 GO:0001967 suckling behavior(GO:0001967)
0.1 3.4 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 3.4 GO:0007601 visual perception(GO:0007601)
0.8 3.2 GO:0002572 pro-T cell differentiation(GO:0002572)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.6 GO:0005667 transcription factor complex(GO:0005667)
3.2 12.7 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 8.1 GO:0016607 nuclear speck(GO:0016607)
0.0 7.8 GO:0001726 ruffle(GO:0001726)
0.4 6.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 6.2 GO:0008180 COP9 signalosome(GO:0008180)
0.1 4.8 GO:0016235 aggresome(GO:0016235)
1.3 4.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 3.4 GO:1990391 DNA repair complex(GO:1990391)
0.0 3.2 GO:0031965 nuclear membrane(GO:0031965)
0.1 3.0 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 2.2 GO:0031011 Ino80 complex(GO:0031011)
0.2 1.9 GO:0045298 tubulin complex(GO:0045298)
0.2 1.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 1.7 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.3 GO:0010369 chromocenter(GO:0010369)
0.1 1.0 GO:0016461 unconventional myosin complex(GO:0016461)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.6 14.5 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 12.4 GO:0008134 transcription factor binding(GO:0008134)
0.0 12.0 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.6 11.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 10.5 GO:0070410 co-SMAD binding(GO:0070410)
0.1 6.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 5.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 5.6 GO:0042393 histone binding(GO:0042393)
0.2 5.1 GO:0032183 SUMO binding(GO:0032183)
1.0 4.9 GO:0043532 angiostatin binding(GO:0043532)
0.0 4.4 GO:0017124 SH3 domain binding(GO:0017124)
0.2 4.0 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 3.7 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 3.5 GO:0005109 frizzled binding(GO:0005109)
1.1 3.4 GO:0005118 sevenless binding(GO:0005118)
0.1 3.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 3.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 3.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.3 2.7 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 11.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 5.9 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 5.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 4.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 3.7 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 3.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 2.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 2.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 1.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.9 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.3 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 12.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 11.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 8.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.3 3.7 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 1.7 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.7 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 1.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 0.8 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling