Motif ID: Elf1_Elf2_Etv2_Elf4

Z-value: 3.010

Transcription factors associated with Elf1_Elf2_Etv2_Elf4:

Gene SymbolEntrez IDGene Name
Elf1 ENSMUSG00000036461.9 Elf1
Elf2 ENSMUSG00000037174.12 Elf2
Elf4 ENSMUSG00000031103.6 Elf4
Etv2 ENSMUSG00000006311.8 Etv2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf1mm10_v2_chr14_+_79515618_795156940.402.8e-04Click!
Elf2mm10_v2_chr3_-_51277470_512775140.315.5e-03Click!
Elf4mm10_v2_chrX_-_48454152_48454193-0.262.3e-02Click!


Activity profile for motif Elf1_Elf2_Etv2_Elf4.

activity profile for motif Elf1_Elf2_Etv2_Elf4


Sorted Z-values histogram for motif Elf1_Elf2_Etv2_Elf4

Sorted Z-values for motif Elf1_Elf2_Etv2_Elf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf1_Elf2_Etv2_Elf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_63403330 35.973 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr7_-_127042420 32.188 ENSMUST00000032915.6
 Kif22
kinesin family member 22
chr11_+_61485431 29.267 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr19_+_6084983 29.048 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr10_-_83648713 25.600 ENSMUST00000020500.7
 Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr2_+_156840077 25.250 ENSMUST00000081335.6
ENSMUST00000073352.3
 Tgif2

TGFB-induced factor homeobox 2

chrX_+_100625737 24.551 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr2_+_5845243 24.392 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr2_+_105682463 24.315 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr16_+_48994185 24.303 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr6_-_23248264 24.018 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_+_111733924 23.413 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr7_+_51879041 22.127 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr4_-_118437331 21.589 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr13_-_103920508 20.758 ENSMUST00000053927.5
ENSMUST00000091269.4
ENSMUST00000022222.5
 Erbb2ip


Erbb2 interacting protein


chr16_-_18811972 20.605 ENSMUST00000000028.7
ENSMUST00000115585.1
 Cdc45

cell division cycle 45

chr10_-_83648631 20.596 ENSMUST00000146876.2
ENSMUST00000176294.1
 Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr7_+_51878967 20.047 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr11_-_12037391 19.984 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr7_-_132813528 19.588 ENSMUST00000097999.2
 Fam53b
family with sequence similarity 53, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,077 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 124.8 GO:0008380 RNA splicing(GO:0008380)
2.7 80.2 GO:0007080 mitotic metaphase plate congression(GO:0007080)
3.6 60.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
5.6 56.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.7 50.0 GO:0006270 DNA replication initiation(GO:0006270)
12.1 48.2 GO:0019323 pentose catabolic process(GO:0019323)
1.1 48.2 GO:0035411 catenin import into nucleus(GO:0035411)
1.2 46.1 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
3.1 43.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
4.7 42.3 GO:0048251 elastic fiber assembly(GO:0048251)
10.1 40.4 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
1.8 40.1 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
1.5 38.1 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
1.0 38.1 GO:0006284 base-excision repair(GO:0006284)
1.8 37.5 GO:0002183 cytoplasmic translational initiation(GO:0002183)
6.1 36.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
5.2 36.3 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.5 35.6 GO:0034508 centromere complex assembly(GO:0034508)
0.7 35.1 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
3.5 34.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 362 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 415.2 GO:0005634 nucleus(GO:0005634)
0.2 340.1 GO:0005654 nucleoplasm(GO:0005654)
2.1 121.0 GO:0005871 kinesin complex(GO:0005871)
0.3 90.3 GO:0005813 centrosome(GO:0005813)
0.3 80.5 GO:0016607 nuclear speck(GO:0016607)
0.6 80.1 GO:0015934 large ribosomal subunit(GO:0015934)
0.7 66.9 GO:0032587 ruffle membrane(GO:0032587)
1.2 64.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
2.6 61.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.7 60.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
3.1 52.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.5 49.5 GO:0005681 spliceosomal complex(GO:0005681)
0.6 44.8 GO:0005814 centriole(GO:0005814)
0.7 44.0 GO:0016459 myosin complex(GO:0016459)
5.0 40.0 GO:0005818 aster(GO:0005818)
1.5 38.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.8 33.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.6 31.7 GO:0000922 spindle pole(GO:0000922)
0.5 31.2 GO:0016328 lateral plasma membrane(GO:0016328)
6.1 30.7 GO:0032133 chromosome passenger complex(GO:0032133)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 612 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 211.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.8 129.2 GO:0003735 structural constituent of ribosome(GO:0003735)
1.3 91.9 GO:0003777 microtubule motor activity(GO:0003777)
0.8 75.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
4.2 58.6 GO:0003688 DNA replication origin binding(GO:0003688)
1.3 57.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 57.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
7.5 44.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.0 42.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 41.4 GO:0042393 histone binding(GO:0042393)
3.7 40.4 GO:0070990 snRNP binding(GO:0070990)
0.3 39.3 GO:0003682 chromatin binding(GO:0003682)
12.3 37.0 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.6 36.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.8 36.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.5 36.3 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
4.4 35.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
1.3 34.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.9 34.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
3.1 33.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 181.5 PID_PLK1_PATHWAY PLK1 signaling events
2.1 82.8 PID_AURORA_B_PATHWAY Aurora B signaling
1.2 77.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
1.7 66.2 PID_ATR_PATHWAY ATR signaling pathway
1.9 57.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.9 49.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
1.0 47.7 PID_IGF1_PATHWAY IGF1 pathway
1.5 45.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
1.4 40.7 PID_MYC_PATHWAY C-MYC pathway
0.7 36.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.6 33.9 PID_E2F_PATHWAY E2F transcription factor network
0.7 28.2 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.4 26.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.7 24.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.5 23.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
1.0 22.8 PID_IL23_PATHWAY IL23-mediated signaling events
0.6 21.0 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.8 20.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.3 20.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.8 19.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 113.4 REACTOME_KINESINS Genes involved in Kinesins
0.5 83.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.5 80.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.4 79.3 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
1.3 70.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.8 64.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 63.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
2.7 62.5 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.9 60.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
3.1 49.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.5 49.1 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
2.3 48.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
2.5 47.2 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
1.9 44.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.4 42.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
1.3 40.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
1.4 37.1 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
1.8 33.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.4 33.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
2.2 31.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)