Motif ID: Elf3

Z-value: 1.038


Transcription factors associated with Elf3:

Gene SymbolEntrez IDGene Name
Elf3 ENSMUSG00000003051.7 Elf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf3mm10_v2_chr1_-_135258449_1352584720.281.2e-02Click!


Activity profile for motif Elf3.

activity profile for motif Elf3


Sorted Z-values histogram for motif Elf3

Sorted Z-values for motif Elf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_53159885 11.528 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr17_+_35049966 11.454 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr5_+_17574268 9.596 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr10_-_83648713 9.209 ENSMUST00000020500.7
 Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr19_+_5740885 8.624 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr3_-_52104891 8.222 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr1_+_138963709 8.122 ENSMUST00000168527.1
 Dennd1b
DENN/MADD domain containing 1B
chr12_-_65172560 7.910 ENSMUST00000052201.8
 Mis18bp1
MIS18 binding protein 1
chr13_-_103920508 7.079 ENSMUST00000053927.5
ENSMUST00000091269.4
ENSMUST00000022222.5
 Erbb2ip


Erbb2 interacting protein


chrX_+_169685191 6.970 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr14_-_70207637 6.968 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr15_+_55557399 6.334 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr7_-_102250086 5.881 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr13_-_103920295 5.758 ENSMUST00000169083.1
 Erbb2ip
Erbb2 interacting protein
chr1_-_128592284 5.696 ENSMUST00000052172.6
ENSMUST00000142893.1
 Cxcr4

chemokine (C-X-C motif) receptor 4

chr4_-_63403330 5.351 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr9_-_66919646 5.343 ENSMUST00000041139.7
 Rab8b
RAB8B, member RAS oncogene family
chr1_+_136467958 5.199 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr10_-_83648631 4.868 ENSMUST00000146876.2
ENSMUST00000176294.1
 Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr4_-_118489755 4.830 ENSMUST00000184261.1
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 14.8 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.3 14.0 GO:1902476 chloride transmembrane transport(GO:1902476)
2.2 11.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
1.6 9.6 GO:0003350 pulmonary myocardium development(GO:0003350)
1.2 9.4 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743)
2.9 8.6 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.7 8.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 7.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.8 7.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 6.5 GO:0016601 Rac protein signal transduction(GO:0016601)
1.4 5.7 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
1.8 5.3 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.8 5.3 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
1.3 5.2 GO:0021698 cerebellar cortex structural organization(GO:0021698)
1.7 5.1 GO:0060913 stem cell fate specification(GO:0048866) cardiac cell fate determination(GO:0060913) regulation of cardiac cell fate specification(GO:2000043)
0.2 5.0 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.4 4.9 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.2 4.8 GO:0045026 plasma membrane fusion(GO:0045026)
0.7 4.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.4 4.2 GO:0042939 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.4 GO:0016607 nuclear speck(GO:0016607)
0.6 14.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 14.0 GO:0034707 chloride channel complex(GO:0034707)
0.6 11.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 9.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 9.6 GO:0000776 kinetochore(GO:0000776)
0.1 8.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 8.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.6 7.9 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.8 6.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 6.1 GO:0031965 nuclear membrane(GO:0031965)
0.1 5.6 GO:0072562 blood microparticle(GO:0072562)
0.3 5.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 5.3 GO:0051286 cell tip(GO:0051286)
0.2 5.2 GO:0051233 spindle midzone(GO:0051233)
0.6 4.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 4.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 4.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.4 4.2 GO:0032426 stereocilium tip(GO:0032426)
1.4 4.1 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 21.2 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
3.8 11.5 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 10.3 GO:0005525 GTP binding(GO:0005525)
0.4 9.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.7 9.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 8.9 GO:0030165 PDZ domain binding(GO:0030165)
0.1 8.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 7.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 7.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 7.0 GO:0051219 phosphoprotein binding(GO:0051219)
1.9 5.7 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 5.5 GO:0045296 cadherin binding(GO:0045296)
0.7 5.3 GO:0030911 TPR domain binding(GO:0030911)
0.4 5.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 5.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 5.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 5.0 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.3 4.9 GO:0017166 vinculin binding(GO:0017166)
0.1 4.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 4.2 GO:0017081 chloride channel regulator activity(GO:0017081)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 13.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 12.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 9.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 6.4 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.2 5.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 4.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 3.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 3.1 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 2.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 2.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.3 2.7 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 2.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 2.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 1.9 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.9 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 1.7 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 14.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.5 8.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 7.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 7.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 5.7 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.3 5.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 4.9 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.2 4.1 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.8 4.0 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 3.8 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 3.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 3.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 2.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.9 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.3 2.7 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.2 2.7 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 2.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 1.9 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 1.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation