Motif ID: Elf3
Z-value: 1.038
Transcription factors associated with Elf3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Elf3 | ENSMUSG00000003051.7 | Elf3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Elf3 | mm10_v2_chr1_-_135258449_135258472 | 0.28 | 1.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 14.8 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 2.9 | 8.6 | GO:1902460 | transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
| 2.2 | 11.0 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 1.8 | 5.3 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) |
| 1.7 | 5.1 | GO:0060913 | stem cell fate specification(GO:0048866) cardiac cell fate determination(GO:0060913) regulation of cardiac cell fate specification(GO:2000043) |
| 1.6 | 9.6 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 1.4 | 5.7 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 1.4 | 4.2 | GO:0042939 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 1.3 | 5.2 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
| 1.2 | 9.4 | GO:0035743 | CD4-positive, alpha-beta T cell cytokine production(GO:0035743) |
| 1.1 | 3.3 | GO:0046544 | regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544) |
| 1.0 | 2.0 | GO:2001187 | positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 0.9 | 3.4 | GO:0097211 | response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) |
| 0.8 | 2.3 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.8 | 7.0 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.8 | 2.3 | GO:0045004 | DNA replication proofreading(GO:0045004) |
| 0.8 | 5.3 | GO:0051461 | regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.7 | 8.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.7 | 4.4 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.7 | 2.2 | GO:0021649 | vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835) |
| 0.7 | 4.1 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.6 | 1.8 | GO:2000256 | positive regulation of male germ cell proliferation(GO:2000256) |
| 0.6 | 2.9 | GO:1903181 | regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) |
| 0.6 | 2.9 | GO:0046208 | spermine catabolic process(GO:0046208) |
| 0.5 | 2.1 | GO:0006547 | histidine metabolic process(GO:0006547) |
| 0.5 | 2.6 | GO:0002121 | inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236) |
| 0.5 | 1.5 | GO:0046370 | fructose biosynthetic process(GO:0046370) |
| 0.5 | 1.4 | GO:0035696 | monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437) |
| 0.4 | 4.0 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.4 | 1.3 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
| 0.4 | 1.7 | GO:0010046 | arginine biosynthetic process(GO:0006526) response to mycotoxin(GO:0010046) |
| 0.4 | 1.7 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.4 | 1.5 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.4 | 1.9 | GO:1990839 | response to endothelin(GO:1990839) |
| 0.4 | 1.4 | GO:0097694 | establishment of RNA localization to telomere(GO:0097694) |
| 0.4 | 4.9 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.3 | 0.3 | GO:0031123 | RNA 3'-end processing(GO:0031123) |
| 0.3 | 2.7 | GO:0036462 | TRAIL-activated apoptotic signaling pathway(GO:0036462) |
| 0.3 | 1.9 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.3 | 1.6 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.3 | 14.0 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.3 | 2.5 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.3 | 1.8 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.3 | 1.2 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 0.3 | 3.9 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.3 | 2.1 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.3 | 0.8 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 0.3 | 1.7 | GO:0071361 | cellular response to ethanol(GO:0071361) |
| 0.3 | 0.8 | GO:2000338 | positive regulation of interleukin-23 production(GO:0032747) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338) |
| 0.3 | 1.6 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.3 | 3.6 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.2 | 0.7 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.2 | 1.9 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.2 | 1.7 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.2 | 0.9 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.2 | 1.2 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.2 | 5.0 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.2 | 2.9 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.2 | 1.6 | GO:0032494 | response to peptidoglycan(GO:0032494) |
| 0.2 | 0.8 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.2 | 3.7 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.2 | 6.5 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.2 | 1.0 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.2 | 4.8 | GO:0045026 | plasma membrane fusion(GO:0045026) |
| 0.2 | 1.9 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
| 0.1 | 1.6 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.1 | 0.4 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144) |
| 0.1 | 1.8 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 2.4 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.1 | 0.7 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 0.1 | 1.9 | GO:0002467 | germinal center formation(GO:0002467) |
| 0.1 | 7.8 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
| 0.1 | 3.5 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 1.3 | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) |
| 0.1 | 0.7 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.1 | 0.8 | GO:0030242 | pexophagy(GO:0030242) |
| 0.1 | 1.0 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.1 | 2.4 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.1 | 0.7 | GO:0034770 | histone H4-K20 methylation(GO:0034770) |
| 0.1 | 2.0 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 0.1 | 0.8 | GO:0048304 | positive regulation of isotype switching to IgG isotypes(GO:0048304) |
| 0.1 | 2.4 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 0.7 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.1 | 1.2 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.1 | 0.5 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.1 | 1.8 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 0.5 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.1 | 3.0 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.1 | 1.6 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 0.2 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
| 0.1 | 0.2 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.1 | 0.7 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.1 | 0.5 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.1 | 0.6 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 1.8 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 1.6 | GO:0010996 | response to auditory stimulus(GO:0010996) |
| 0.1 | 4.1 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.1 | 2.3 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.0 | 0.3 | GO:0031642 | negative regulation of myelination(GO:0031642) negative regulation of receptor catabolic process(GO:2000645) |
| 0.0 | 0.3 | GO:0048793 | pronephros development(GO:0048793) |
| 0.0 | 2.5 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.0 | 1.0 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 3.0 | GO:0045580 | regulation of T cell differentiation(GO:0045580) |
| 0.0 | 0.4 | GO:0001553 | luteinization(GO:0001553) |
| 0.0 | 3.3 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.0 | 1.1 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.0 | 1.0 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.0 | 0.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.4 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 1.3 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 0.1 | GO:0006788 | heme oxidation(GO:0006788) |
| 0.0 | 1.3 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.0 | 0.3 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.5 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 0.2 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.0 | 0.6 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 1.3 | GO:0051168 | nuclear export(GO:0051168) |
| 0.0 | 1.0 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.0 | 0.4 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 1.2 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 4.2 | GO:0051604 | protein maturation(GO:0051604) |
| 0.0 | 0.2 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.0 | 2.1 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 0.1 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.0 | 1.1 | GO:0007411 | axon guidance(GO:0007411) |
| 0.0 | 0.4 | GO:0008089 | anterograde axonal transport(GO:0008089) |
| 0.0 | 0.0 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.0 | 0.1 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.0 | 0.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 1.3 | GO:0051028 | mRNA transport(GO:0051028) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.1 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 1.4 | 4.1 | GO:0036125 | mitochondrial fatty acid beta-oxidation multienzyme complex(GO:0016507) fatty acid beta-oxidation multienzyme complex(GO:0036125) |
| 0.9 | 2.7 | GO:0030690 | Noc1p-Noc2p complex(GO:0030690) |
| 0.8 | 6.8 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.6 | 11.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.6 | 4.9 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.6 | 2.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.6 | 14.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.6 | 7.9 | GO:0000778 | condensed nuclear chromosome kinetochore(GO:0000778) |
| 0.5 | 2.3 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.4 | 2.8 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.4 | 4.2 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.3 | 14.0 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.3 | 5.3 | GO:0051286 | cell tip(GO:0051286) |
| 0.3 | 1.7 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.3 | 0.8 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.3 | 5.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.3 | 1.9 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.2 | 2.9 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.2 | 1.4 | GO:0070187 | telosome(GO:0070187) |
| 0.2 | 1.3 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.2 | 0.7 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.2 | 1.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 1.7 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.2 | 5.2 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 4.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 3.2 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.1 | 8.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 2.0 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 1.8 | GO:0031105 | septin complex(GO:0031105) |
| 0.1 | 3.4 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 0.4 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.1 | 1.8 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 1.6 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 1.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 0.8 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.9 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 27.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 9.6 | GO:0000776 | kinetochore(GO:0000776) |
| 0.1 | 0.4 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 0.4 | GO:0089701 | U2AF(GO:0089701) |
| 0.1 | 5.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 2.6 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 1.1 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 3.2 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 3.3 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 0.6 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 0.8 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 1.0 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 0.5 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 1.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 8.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.7 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 9.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 2.1 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.4 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 1.1 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.2 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.0 | 6.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 4.4 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 3.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.2 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.0 | 0.0 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 1.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.2 | GO:0022627 | small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.1 | GO:0097225 | sperm midpiece(GO:0097225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 11.5 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 1.9 | 5.7 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 1.1 | 3.3 | GO:0034437 | glycoprotein transporter activity(GO:0034437) |
| 1.0 | 4.1 | GO:0016508 | long-chain-enoyl-CoA hydratase activity(GO:0016508) long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 1.0 | 2.9 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
| 0.8 | 2.5 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
| 0.8 | 2.3 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.7 | 9.6 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.7 | 2.1 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
| 0.7 | 2.7 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.7 | 5.3 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.6 | 2.3 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.6 | 1.7 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.5 | 2.3 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.5 | 1.9 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.4 | 1.8 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.4 | 2.7 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.4 | 1.7 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.4 | 9.9 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.4 | 5.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.4 | 1.8 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.3 | 4.2 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.3 | 0.9 | GO:0016501 | prostacyclin receptor activity(GO:0016501) |
| 0.3 | 1.5 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.3 | 1.5 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.3 | 4.9 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.3 | 2.0 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.3 | 0.5 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.3 | 1.0 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.2 | 2.6 | GO:0019992 | diacylglycerol binding(GO:0019992) inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.2 | 1.4 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.2 | 2.9 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.2 | 7.1 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.2 | 0.8 | GO:0070976 | TIR domain binding(GO:0070976) |
| 0.2 | 1.0 | GO:0019961 | interferon binding(GO:0019961) |
| 0.2 | 0.8 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.2 | 2.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 0.8 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.2 | 2.4 | GO:0005522 | profilin binding(GO:0005522) |
| 0.2 | 5.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 2.1 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.2 | 7.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 0.5 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.1 | 0.7 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.1 | 1.0 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.1 | 1.7 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 2.1 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 1.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 3.3 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.3 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.1 | 3.0 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 2.9 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.1 | 3.9 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 0.3 | GO:0032450 | alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450) |
| 0.1 | 2.5 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.1 | 1.4 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 2.0 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.1 | 1.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 1.7 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 0.9 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.1 | 0.8 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 0.9 | GO:0001163 | RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.1 | 0.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 4.0 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.1 | 0.3 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.1 | 0.3 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 1.2 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.3 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 8.9 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 2.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.7 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 1.0 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.1 | 5.1 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 8.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 4.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 0.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 7.0 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.1 | 1.0 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 0.3 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 1.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.4 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 1.8 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.0 | 21.2 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.0 | 0.4 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.0 | 0.5 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.8 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.4 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.0 | 1.1 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 2.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.6 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 10.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 1.6 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.6 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.5 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 2.2 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 5.0 | GO:0001012 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 0.0 | 0.1 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.0 | 0.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 1.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 5.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 1.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 2.6 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 0.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.2 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.5 | GO:0004527 | exonuclease activity(GO:0004527) |
| 0.0 | 0.0 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.1 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.7 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.3 | 12.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 2.2 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.2 | 2.8 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 5.5 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 6.4 | PID_S1P_S1P3_PATHWAY | S1P3 pathway |
| 0.2 | 3.1 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.1 | 1.9 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.1 | 1.2 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 13.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 0.8 | PID_CD40_PATHWAY | CD40/CD40L signaling |
| 0.1 | 13.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 0.8 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.1 | 2.9 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 9.3 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 2.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.3 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.1 | 1.3 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 1.4 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 1.9 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 1.4 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 1.7 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 3.7 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 3.3 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.9 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.0 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.7 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.3 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.4 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.7 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.8 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.0 | 0.6 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.3 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 14.8 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.8 | 4.0 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.5 | 8.2 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.4 | 1.5 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 3.3 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.3 | 5.7 | REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.3 | 1.4 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.3 | 5.3 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.3 | 1.7 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.3 | 2.7 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.2 | 4.1 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 7.0 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 2.7 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.2 | 2.2 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.2 | 2.9 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 3.5 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 1.9 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 4.9 | REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.1 | 2.9 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 1.2 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 7.9 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 0.8 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 1.8 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 3.8 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 1.9 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 1.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.3 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 1.3 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.7 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 1.7 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.8 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.7 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.3 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 0.6 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.4 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.3 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 1.7 | REACTOME_SIGNALING_BY_SCF_KIT | Genes involved in Signaling by SCF-KIT |
| 0.0 | 0.2 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 1.4 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 0.8 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.9 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.8 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.2 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
