Motif ID: Emx1_Emx2

Z-value: 0.557

Transcription factors associated with Emx1_Emx2:

Gene SymbolEntrez IDGene Name
Emx1 ENSMUSG00000033726.8 Emx1
Emx2 ENSMUSG00000043969.4 Emx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Emx1mm10_v2_chr6_+_85187438_851875100.271.6e-02Click!
Emx2mm10_v2_chr19_+_59458372_594584500.075.6e-01Click!


Activity profile for motif Emx1_Emx2.

activity profile for motif Emx1_Emx2


Sorted Z-values histogram for motif Emx1_Emx2

Sorted Z-values for motif Emx1_Emx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Emx1_Emx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 168 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_118961578 5.564 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr3_+_127633134 5.027 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr7_-_103827922 4.890 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr4_-_82505274 4.324 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr4_-_82505749 4.156 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505707 3.551 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr17_-_36032682 3.229 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr2_-_160619971 2.945 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chrX_+_106920618 2.238 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr8_-_21906412 2.055 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr13_-_97747373 2.026 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr17_-_48432723 2.023 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr3_-_49757257 1.969 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr18_+_57142782 1.964 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr13_-_97747399 1.960 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr12_-_98577940 1.827 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr14_+_26259109 1.817 ENSMUST00000174494.1
 Duxbl3
double homeobox B-like 3
chr6_+_42245907 1.792 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr7_+_126781483 1.766 ENSMUST00000172352.1
ENSMUST00000094037.4
 Tbx6

T-box 6

chr3_+_90541146 1.658 ENSMUST00000107333.1
ENSMUST00000107331.1
ENSMUST00000098910.2
 S100a16


S100 calcium binding protein A16



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 12.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 5.8 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 5.0 GO:0021954 central nervous system neuron development(GO:0021954)
0.6 4.7 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
1.1 3.2 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.4 3.2 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.1 2.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 2.2 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.0 2.1 GO:0042742 defense response to bacterium(GO:0042742)
0.7 2.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.5 1.8 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.2 1.8 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.2 1.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.7 GO:0051592 response to calcium ion(GO:0051592)
0.5 1.5 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.1 1.5 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.4 1.2 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.4 1.2 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.2 4.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 3.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 3.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 2.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.1 GO:0000786 nucleosome(GO:0000786)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.2 0.9 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 0.8 GO:0008623 CHRAC(GO:0008623)
0.1 0.8 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.6 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.5 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.9 5.6 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 5.0 GO:0070888 E-box binding(GO:0070888)
1.2 4.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.4 3.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 2.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 2.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.5 2.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.3 2.0 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.5 1.5 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.4 1.2 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.4 1.2 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.2 1.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 1.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.0 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 2.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.0 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 1.8 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.3 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.0 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.8 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.1 0.6 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions