Motif ID: En1
Z-value: 0.598
Transcription factors associated with En1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
En1 | ENSMUSG00000058665.7 | En1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
En1 | mm10_v2_chr1_+_120602405_120602418 | -0.12 | 2.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 7.9 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
1.0 | 6.7 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
0.9 | 6.3 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
0.7 | 2.7 | GO:1900623 | positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
0.6 | 1.2 | GO:0070487 | monocyte aggregation(GO:0070487) |
0.6 | 2.4 | GO:0045091 | regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091) |
0.6 | 4.5 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
0.5 | 1.6 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
0.5 | 1.5 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
0.4 | 5.2 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
0.4 | 1.7 | GO:0070829 | heterochromatin maintenance(GO:0070829) |
0.4 | 6.9 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
0.4 | 2.4 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
0.4 | 1.1 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
0.4 | 1.1 | GO:0048162 | preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162) |
0.3 | 1.0 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
0.3 | 1.2 | GO:0030091 | protein repair(GO:0030091) |
0.3 | 2.3 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.3 | 0.8 | GO:0016332 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) |
0.3 | 1.1 | GO:0033087 | negative regulation of immature T cell proliferation(GO:0033087) |
0.3 | 0.5 | GO:0072076 | nephrogenic mesenchyme development(GO:0072076) |
0.2 | 0.7 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
0.2 | 0.7 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
0.2 | 1.0 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
0.2 | 0.2 | GO:0039692 | single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) |
0.2 | 0.7 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
0.2 | 0.5 | GO:0036363 | transforming growth factor beta activation(GO:0036363) |
0.2 | 1.1 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
0.2 | 0.6 | GO:0030862 | neuroblast division in subventricular zone(GO:0021849) positive regulation of polarized epithelial cell differentiation(GO:0030862) |
0.2 | 0.2 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) |
0.2 | 0.8 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
0.2 | 1.8 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
0.2 | 0.9 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
0.2 | 1.1 | GO:0044351 | macropinocytosis(GO:0044351) |
0.2 | 4.2 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
0.2 | 0.5 | GO:0072554 | arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) |
0.2 | 0.7 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
0.2 | 0.9 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) |
0.2 | 1.9 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
0.2 | 0.5 | GO:0097029 | mature conventional dendritic cell differentiation(GO:0097029) |
0.2 | 2.0 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.2 | 2.0 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
0.2 | 0.7 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
0.1 | 0.4 | GO:1990859 | cellular response to endothelin(GO:1990859) |
0.1 | 1.2 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
0.1 | 2.0 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
0.1 | 0.8 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
0.1 | 0.4 | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response(GO:1903896) |
0.1 | 0.4 | GO:0019659 | fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
0.1 | 2.4 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
0.1 | 0.8 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
0.1 | 4.9 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.1 | 0.4 | GO:2000812 | unidimensional cell growth(GO:0009826) establishment or maintenance of cell polarity regulating cell shape(GO:0071963) regulation of barbed-end actin filament capping(GO:2000812) |
0.1 | 0.7 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
0.1 | 0.5 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
0.1 | 2.8 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.1 | 0.6 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
0.1 | 0.5 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
0.1 | 1.7 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.1 | 0.8 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
0.1 | 1.2 | GO:0050849 | negative regulation of calcium-mediated signaling(GO:0050849) |
0.1 | 0.4 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
0.1 | 0.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.1 | 1.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
0.1 | 0.2 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
0.1 | 0.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.1 | 0.8 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
0.1 | 0.2 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
0.1 | 0.2 | GO:1902277 | negative regulation of pancreatic amylase secretion(GO:1902277) |
0.1 | 0.6 | GO:1900194 | negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194) |
0.1 | 0.4 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
0.1 | 0.4 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
0.1 | 1.1 | GO:0046040 | IMP metabolic process(GO:0046040) |
0.1 | 1.0 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
0.1 | 0.7 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
0.1 | 0.3 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
0.1 | 0.5 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
0.1 | 0.2 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.1 | 0.7 | GO:0016926 | protein desumoylation(GO:0016926) |
0.1 | 0.2 | GO:0042713 | operant conditioning(GO:0035106) sperm ejaculation(GO:0042713) |
0.1 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
0.1 | 0.6 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
0.1 | 1.0 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
0.1 | 0.5 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
0.1 | 0.6 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
0.1 | 0.3 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
0.0 | 1.1 | GO:0007263 | nitric oxide mediated signal transduction(GO:0007263) |
0.0 | 0.3 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
0.0 | 0.5 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
0.0 | 0.3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
0.0 | 0.1 | GO:0031622 | positive regulation of fever generation(GO:0031622) |
0.0 | 0.8 | GO:0008209 | androgen metabolic process(GO:0008209) |
0.0 | 2.9 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
0.0 | 0.2 | GO:0072592 | oxygen metabolic process(GO:0072592) |
0.0 | 0.3 | GO:0032782 | bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
0.0 | 0.6 | GO:0018195 | peptidyl-arginine modification(GO:0018195) |
0.0 | 0.2 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
0.0 | 0.2 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
0.0 | 3.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
0.0 | 0.1 | GO:0060558 | regulation of calcidiol 1-monooxygenase activity(GO:0060558) |
0.0 | 0.5 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
0.0 | 0.3 | GO:0006953 | acute-phase response(GO:0006953) |
0.0 | 1.1 | GO:0003016 | respiratory system process(GO:0003016) |
0.0 | 0.2 | GO:0043615 | astrocyte cell migration(GO:0043615) |
0.0 | 0.1 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
0.0 | 1.9 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
0.0 | 0.4 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
0.0 | 0.2 | GO:0048023 | positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
0.0 | 0.2 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
0.0 | 0.2 | GO:0019348 | dolichol metabolic process(GO:0019348) |
0.0 | 1.7 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
0.0 | 0.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
0.0 | 1.2 | GO:0045724 | positive regulation of cilium assembly(GO:0045724) |
0.0 | 0.3 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.0 | 1.1 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.0 | 1.5 | GO:0030901 | midbrain development(GO:0030901) |
0.0 | 0.5 | GO:0006828 | manganese ion transport(GO:0006828) |
0.0 | 0.4 | GO:0006825 | copper ion transport(GO:0006825) |
0.0 | 0.6 | GO:0033622 | integrin activation(GO:0033622) |
0.0 | 0.3 | GO:0019985 | translesion synthesis(GO:0019985) |
0.0 | 1.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.0 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
0.0 | 0.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
0.0 | 0.9 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
0.0 | 0.6 | GO:0097120 | receptor localization to synapse(GO:0097120) |
0.0 | 0.4 | GO:0050832 | defense response to fungus(GO:0050832) |
0.0 | 1.1 | GO:0030071 | regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099) |
0.0 | 0.1 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
0.0 | 0.8 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
0.0 | 0.8 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
0.0 | 0.1 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
0.0 | 1.1 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
0.0 | 0.2 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
0.0 | 0.2 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
0.0 | 0.9 | GO:0016574 | histone ubiquitination(GO:0016574) |
0.0 | 1.3 | GO:0060349 | bone morphogenesis(GO:0060349) |
0.0 | 0.0 | GO:1904978 | regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980) |
0.0 | 0.4 | GO:0070207 | protein homotrimerization(GO:0070207) |
0.0 | 0.5 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
0.0 | 0.1 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
0.0 | 0.2 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.0 | 0.3 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
0.0 | 0.0 | GO:1990046 | positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046) |
0.0 | 0.5 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
0.0 | 0.7 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
0.0 | 0.1 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
0.0 | 0.1 | GO:0048368 | lateral mesoderm development(GO:0048368) |
0.0 | 0.8 | GO:0046847 | filopodium assembly(GO:0046847) |
0.0 | 0.3 | GO:0009409 | response to cold(GO:0009409) |
0.0 | 0.1 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 6.7 | GO:0045180 | basal cortex(GO:0045180) |
0.3 | 1.9 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
0.3 | 2.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.3 | 2.5 | GO:0005883 | neurofilament(GO:0005883) |
0.3 | 1.5 | GO:0061689 | tricellular tight junction(GO:0061689) |
0.2 | 1.1 | GO:1990357 | terminal web(GO:1990357) |
0.2 | 0.9 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
0.2 | 2.7 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
0.2 | 1.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
0.2 | 0.5 | GO:1990047 | spindle matrix(GO:1990047) |
0.2 | 1.1 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
0.2 | 0.6 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
0.1 | 1.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.1 | 0.5 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
0.1 | 0.4 | GO:0032021 | NELF complex(GO:0032021) |
0.1 | 0.5 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
0.1 | 1.3 | GO:0042581 | specific granule(GO:0042581) |
0.1 | 2.1 | GO:0000242 | pericentriolar material(GO:0000242) |
0.1 | 6.3 | GO:0005657 | replication fork(GO:0005657) |
0.1 | 1.8 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.1 | 0.2 | GO:0070939 | Dsl1p complex(GO:0070939) |
0.1 | 1.2 | GO:0000145 | exocyst(GO:0000145) |
0.1 | 0.6 | GO:0070545 | PeBoW complex(GO:0070545) |
0.1 | 0.5 | GO:0097165 | nuclear stress granule(GO:0097165) |
0.1 | 0.3 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
0.1 | 0.2 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
0.1 | 0.9 | GO:0035102 | PRC1 complex(GO:0035102) |
0.0 | 0.2 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
0.0 | 0.2 | GO:0032585 | multivesicular body membrane(GO:0032585) |
0.0 | 0.8 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.0 | 0.2 | GO:1990131 | Iml1 complex(GO:1990130) Gtr1-Gtr2 GTPase complex(GO:1990131) |
0.0 | 0.3 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
0.0 | 0.2 | GO:1990769 | proximal neuron projection(GO:1990769) |
0.0 | 0.3 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
0.0 | 0.6 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.0 | 0.2 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
0.0 | 4.0 | GO:0005814 | centriole(GO:0005814) |
0.0 | 0.7 | GO:0044224 | juxtaparanode region of axon(GO:0044224) cerebellar mossy fiber(GO:0044300) |
0.0 | 0.6 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
0.0 | 0.4 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
0.0 | 0.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.0 | 0.1 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
0.0 | 5.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.0 | 0.2 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
0.0 | 0.2 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
0.0 | 0.3 | GO:0030056 | hemidesmosome(GO:0030056) |
0.0 | 0.4 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.0 | 0.3 | GO:0036038 | MKS complex(GO:0036038) |
0.0 | 1.1 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.4 | GO:0097225 | sperm midpiece(GO:0097225) |
0.0 | 0.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
0.0 | 0.5 | GO:0005605 | basal lamina(GO:0005605) |
0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 0.2 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
0.0 | 1.6 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 1.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 0.4 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 0.9 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.4 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.0 | 0.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.0 | 0.1 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
0.0 | 0.3 | GO:0005686 | U2 snRNP(GO:0005686) |
0.0 | 0.7 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 0.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 0.1 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 0.1 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.0 | 0.2 | GO:0001741 | XY body(GO:0001741) |
0.0 | 1.3 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
0.0 | 0.1 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
0.0 | 0.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.0 | 0.0 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
0.0 | 0.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.0 | 1.3 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
0.0 | 0.1 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.1 | 6.3 | GO:0033680 | ATP-dependent DNA/RNA helicase activity(GO:0033680) |
0.9 | 2.7 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.7 | 4.5 | GO:0005042 | netrin receptor activity(GO:0005042) |
0.6 | 2.4 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
0.4 | 1.6 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
0.3 | 2.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.3 | 1.0 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
0.3 | 1.9 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
0.3 | 2.4 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.3 | 0.9 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
0.3 | 2.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.2 | 0.8 | GO:1902379 | chemoattractant activity involved in axon guidance(GO:1902379) |
0.2 | 1.2 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
0.2 | 0.9 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.2 | 0.5 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
0.1 | 1.7 | GO:0036310 | annealing helicase activity(GO:0036310) |
0.1 | 1.1 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.1 | 2.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.1 | 0.6 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
0.1 | 1.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
0.1 | 0.5 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
0.1 | 0.7 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
0.1 | 1.5 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
0.1 | 2.0 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
0.1 | 0.4 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
0.1 | 1.2 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
0.1 | 0.7 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
0.1 | 0.5 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
0.1 | 0.4 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.1 | 1.5 | GO:0030228 | lipoprotein particle receptor activity(GO:0030228) |
0.1 | 0.4 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
0.1 | 0.1 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.1 | 0.3 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
0.1 | 0.3 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153) |
0.1 | 0.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.1 | 1.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.1 | 0.4 | GO:0030620 | U2 snRNA binding(GO:0030620) |
0.1 | 1.7 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.1 | 0.5 | GO:0002135 | CTP binding(GO:0002135) |
0.1 | 0.2 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
0.1 | 0.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.1 | 0.8 | GO:0008301 | DNA binding, bending(GO:0008301) |
0.1 | 0.3 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
0.1 | 1.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.1 | 1.0 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.1 | 1.6 | GO:0042605 | peptide antigen binding(GO:0042605) |
0.1 | 1.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.1 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.1 | 1.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.1 | 0.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.1 | 0.3 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.1 | 0.2 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
0.0 | 1.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.5 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.0 | 0.2 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
0.0 | 0.6 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.0 | 0.4 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.0 | 1.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
0.0 | 7.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.8 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.0 | 5.2 | GO:0001047 | core promoter binding(GO:0001047) |
0.0 | 3.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.4 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.0 | 0.4 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
0.0 | 0.2 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
0.0 | 0.3 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
0.0 | 0.7 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
0.0 | 0.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.1 | GO:0016508 | long-chain-enoyl-CoA hydratase activity(GO:0016508) |
0.0 | 8.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.0 | 0.6 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.0 | 0.2 | GO:0004630 | phospholipase D activity(GO:0004630) |
0.0 | 0.1 | GO:0050347 | trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347) |
0.0 | 1.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.0 | 0.2 | GO:0008312 | 7S RNA binding(GO:0008312) |
0.0 | 0.1 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
0.0 | 0.8 | GO:0035591 | signaling adaptor activity(GO:0035591) |
0.0 | 0.3 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
0.0 | 0.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.0 | 0.0 | GO:0008252 | nucleotidase activity(GO:0008252) |
0.0 | 0.9 | GO:0070063 | RNA polymerase binding(GO:0070063) |
0.0 | 0.1 | GO:0008308 | voltage-gated anion channel activity(GO:0008308) |
0.0 | 1.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
0.0 | 0.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
0.0 | 0.2 | GO:0070097 | delta-catenin binding(GO:0070097) |
0.0 | 0.6 | GO:0051059 | NF-kappaB binding(GO:0051059) |
0.0 | 0.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
0.0 | 1.5 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
0.0 | 0.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
0.0 | 2.6 | GO:0030246 | carbohydrate binding(GO:0030246) |
0.0 | 0.8 | GO:0002039 | p53 binding(GO:0002039) |
0.0 | 0.1 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.0 | 0.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.0 | 5.1 | GO:0005509 | calcium ion binding(GO:0005509) |
0.0 | 0.0 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
0.0 | 0.4 | GO:0030332 | cyclin binding(GO:0030332) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.8 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
0.1 | 6.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 1.2 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.1 | 4.5 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.1 | 7.0 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
0.1 | 1.1 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
0.1 | 2.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.1 | 1.3 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.0 | 1.3 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
0.0 | 0.4 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.0 | 3.9 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 0.8 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
0.0 | 0.9 | PID_ATM_PATHWAY | ATM pathway |
0.0 | 0.8 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.0 | 0.6 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.0 | 1.7 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.0 | 1.1 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.0 | 0.8 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
0.0 | 0.2 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.0 | 1.2 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.0 | 0.2 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
0.0 | 0.2 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
0.0 | 0.4 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 1.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 1.1 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.1 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
0.3 | 0.8 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
0.3 | 4.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.2 | 7.1 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.2 | 2.7 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
0.1 | 0.9 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.1 | 0.5 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.1 | 1.1 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
0.1 | 1.9 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.1 | 0.5 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.1 | 4.5 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
0.1 | 1.1 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.1 | 2.3 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
0.1 | 0.5 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
0.1 | 1.8 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
0.1 | 2.2 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
0.1 | 0.4 | REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
0.1 | 0.9 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
0.0 | 1.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 0.4 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
0.0 | 0.6 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
0.0 | 0.5 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.0 | 1.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 1.2 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
0.0 | 0.2 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.0 | 0.4 | REACTOME_IRON_UPTAKE_AND_TRANSPORT | Genes involved in Iron uptake and transport |
0.0 | 0.9 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
0.0 | 0.7 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
0.0 | 0.4 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
0.0 | 1.4 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.0 | 0.2 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
0.0 | 0.4 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
0.0 | 1.1 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.0 | 0.5 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
0.0 | 0.2 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 0.3 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
0.0 | 0.4 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.0 | 0.7 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.0 | 0.2 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
0.0 | 0.1 | REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM | Genes involved in Bile acid and bile salt metabolism |
0.0 | 0.7 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
0.0 | 0.3 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
0.0 | 0.8 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |