Motif ID: En1

Z-value: 0.598


Transcription factors associated with En1:

Gene SymbolEntrez IDGene Name
En1 ENSMUSG00000058665.7 En1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1mm10_v2_chr1_+_120602405_120602418-0.122.9e-01Click!


Activity profile for motif En1.

activity profile for motif En1


Sorted Z-values histogram for motif En1

Sorted Z-values for motif En1



Network of associatons between targets according to the STRING database.



First level regulatory network of En1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.888 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr14_+_67234620 6.882 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr1_+_6487231 5.228 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr16_-_26989974 4.853 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr12_+_109453455 3.934 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr9_+_65587187 3.218 ENSMUST00000047099.5
ENSMUST00000131483.1
ENSMUST00000141046.1
 Pif1


PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)


chr16_-_59555752 3.108 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr9_+_65587149 3.096 ENSMUST00000134538.1
ENSMUST00000136205.1
 Pif1

PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)

chr6_+_4755327 2.983 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr15_-_56694525 2.691 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr16_-_45953565 2.683 ENSMUST00000134802.1
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr12_+_109452833 2.563 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr10_+_127514939 2.519 ENSMUST00000035735.9
 Ndufa4l2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr3_+_141465564 2.495 ENSMUST00000106236.2
ENSMUST00000075282.3
 Unc5c

unc-5 homolog C (C. elegans)

chr19_+_47014672 2.455 ENSMUST00000037636.3
 Ina
internexin neuronal intermediate filament protein, alpha
chr11_-_77725281 2.431 ENSMUST00000078623.4
 Cryba1
crystallin, beta A1
chr16_-_45844303 2.400 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr1_+_72824482 2.379 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr11_-_99024179 2.379 ENSMUST00000068031.7
 Top2a
topoisomerase (DNA) II alpha
chr11_-_28583995 2.049 ENSMUST00000146385.2
 Ccdc85a
coiled-coil domain containing 85A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 7.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 6.9 GO:0035563 positive regulation of chromatin binding(GO:0035563)
1.0 6.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.9 6.3 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.4 5.2 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 4.9 GO:0006270 DNA replication initiation(GO:0006270)
0.6 4.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 4.2 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 3.1 GO:0002377 immunoglobulin production(GO:0002377)
0.0 2.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 2.8 GO:0008340 determination of adult lifespan(GO:0008340)
0.7 2.7 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.6 2.4 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.4 2.4 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 2.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.3 2.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 2.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 2.0 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 2.0 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 1.9 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.7 GO:0045180 basal cortex(GO:0045180)
0.1 6.3 GO:0005657 replication fork(GO:0005657)
0.0 5.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 4.0 GO:0005814 centriole(GO:0005814)
0.2 2.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 2.5 GO:0005883 neurofilament(GO:0005883)
0.1 2.1 GO:0000242 pericentriolar material(GO:0000242)
0.3 2.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 1.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 1.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.3 1.5 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.3 GO:0042581 specific granule(GO:0042581)
0.0 1.3 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.2 GO:0000145 exocyst(GO:0000145)
0.2 1.1 GO:1990357 terminal web(GO:1990357)
0.2 1.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 7.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.1 6.3 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.0 5.2 GO:0001047 core promoter binding(GO:0001047)
0.0 5.1 GO:0005509 calcium ion binding(GO:0005509)
0.7 4.5 GO:0005042 netrin receptor activity(GO:0005042)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.9 2.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 2.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.6 GO:0030246 carbohydrate binding(GO:0030246)
0.6 2.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.3 2.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 2.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 2.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 2.0 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.3 1.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.7 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.7 GO:0070410 co-SMAD binding(GO:0070410)
0.4 1.6 GO:0008422 beta-glucosidase activity(GO:0008422)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 6.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 1.8 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.3 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 1.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.1 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 0.9 PID_ATM_PATHWAY ATM pathway
0.0 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.8 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 4.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 4.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 2.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.3 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 1.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.8 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.2 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.4 1.1 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.1 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 0.9 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.9 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.3 0.8 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway