Motif ID: En2

Z-value: 0.640


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.272.0e-02Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

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Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 10.473 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr5_-_53707532 9.462 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr14_-_67715585 7.468 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr4_+_109978004 5.833 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr6_+_8948608 5.223 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chrX_-_60893430 5.169 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr2_+_25372315 5.112 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr5_+_33658123 5.049 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr3_-_27153861 4.784 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr9_+_65890237 4.589 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr3_-_27153844 4.517 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr6_+_146888481 4.436 ENSMUST00000016631.7
ENSMUST00000111623.2
 Ppfibp1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

chr6_+_4755327 4.219 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr13_-_114458720 4.056 ENSMUST00000022287.5
 Fst
follistatin
chr8_+_83955507 4.000 ENSMUST00000005607.8
 Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr5_+_33658567 3.940 ENSMUST00000114426.3
 Tacc3
transforming, acidic coiled-coil containing protein 3
chr4_+_62583568 3.688 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr10_+_73821857 3.483 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
 Pcdh15



















protocadherin 15



















chr2_-_72986716 3.391 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr18_+_34625009 3.121 ENSMUST00000166044.1
 Kif20a
kinesin family member 20A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 12.1 GO:0030953 astral microtubule organization(GO:0030953)
1.3 10.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
3.2 9.5 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.5 9.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3 7.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 7.5 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
0.1 6.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.4 5.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 5.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.3 5.5 GO:0007530 sex determination(GO:0007530)
0.4 4.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 4.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.5 4.1 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.4 3.5 GO:0050957 equilibrioception(GO:0050957)
0.1 3.0 GO:0009409 response to cold(GO:0009409)
0.1 2.9 GO:0034508 centromere complex assembly(GO:0034508)
0.0 2.9 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.6 2.8 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.9 2.6 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 2.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.1 GO:0070469 respiratory chain(GO:0070469)
1.9 9.3 GO:0097149 centralspindlin complex(GO:0097149)
0.1 8.8 GO:0043195 terminal bouton(GO:0043195)
0.0 7.8 GO:0005813 centrosome(GO:0005813)
0.0 6.7 GO:0000785 chromatin(GO:0000785)
0.1 5.8 GO:0005871 kinesin complex(GO:0005871)
0.0 5.1 GO:0043292 contractile fiber(GO:0043292)
0.1 3.5 GO:0032420 stereocilium(GO:0032420)
0.0 3.0 GO:0000776 kinetochore(GO:0000776)
0.1 2.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 2.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 2.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 2.1 GO:0005774 vacuolar membrane(GO:0005774)
0.1 2.0 GO:0001772 immunological synapse(GO:0001772)
0.1 1.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 1.3 GO:0000786 nucleosome(GO:0000786)
0.1 1.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 7.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 6.9 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 6.9 GO:0045296 cadherin binding(GO:0045296)
0.0 6.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 5.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 5.8 GO:0003777 microtubule motor activity(GO:0003777)
0.1 5.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 5.0 GO:0097602 cullin family protein binding(GO:0097602)
0.1 4.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 4.1 GO:0048185 activin binding(GO:0048185)
0.0 4.0 GO:0042393 histone binding(GO:0042393)
0.0 3.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 2.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 2.5 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 2.4 GO:0047485 protein N-terminus binding(GO:0047485)
0.3 2.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 2.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 1.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.8 PID_PLK1_PATHWAY PLK1 signaling events
0.2 8.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 4.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 4.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 5.8 REACTOME_KINESINS Genes involved in Kinesins
0.0 3.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 3.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.0 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.1 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.0 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.8 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.7 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.3 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.2 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway