Motif ID: Ep300

Z-value: 0.781


Transcription factors associated with Ep300:

Gene SymbolEntrez IDGene Name
Ep300 ENSMUSG00000055024.6 Ep300

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ep300mm10_v2_chr15_+_81586206_81586250-0.537.3e-07Click!


Activity profile for motif Ep300.

activity profile for motif Ep300


Sorted Z-values histogram for motif Ep300

Sorted Z-values for motif Ep300



Network of associatons between targets according to the STRING database.



First level regulatory network of Ep300

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_98348404 14.036 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr4_+_125490688 10.465 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr9_-_29411736 10.106 ENSMUST00000115236.1
 Ntm
neurotrimin
chr6_+_65671590 9.977 ENSMUST00000054351.4
 Ndnf
neuron-derived neurotrophic factor
chr1_-_21961581 8.290 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
 Kcnq5


potassium voltage-gated channel, subfamily Q, member 5


chr5_+_130448801 7.478 ENSMUST00000111288.2
 Caln1
calneuron 1
chr18_+_51117754 7.373 ENSMUST00000116639.2
 Prr16
proline rich 16
chr1_-_21961942 7.187 ENSMUST00000115300.1
 Kcnq5
potassium voltage-gated channel, subfamily Q, member 5
chr17_+_55445550 6.630 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr6_-_136173492 6.557 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr6_+_99692679 6.279 ENSMUST00000101122.1
 Gpr27
G protein-coupled receptor 27
chr4_+_103313806 6.097 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr9_-_29412204 5.529 ENSMUST00000115237.1
 Ntm
neurotrimin
chr1_-_87573825 5.386 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr11_+_97415527 5.242 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr8_-_84800344 5.181 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr19_+_23758819 5.097 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr4_+_123183456 4.446 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr3_-_88950401 4.276 ENSMUST00000090938.4
 Dap3
death associated protein 3
chr16_-_52452465 4.243 ENSMUST00000170035.1
ENSMUST00000164728.1
 Alcam

activated leukocyte cell adhesion molecule


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.0 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.1 14.4 GO:0071805 potassium ion transmembrane transport(GO:0071805)
4.7 14.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
1.0 10.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.1 10.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) vascular wound healing(GO:0061042)
0.4 8.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.9 7.4 GO:0005513 detection of calcium ion(GO:0005513)
0.4 7.3 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 7.0 GO:0008045 motor neuron axon guidance(GO:0008045)
1.6 6.6 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.4 6.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.4 6.5 GO:0051639 actin filament network formation(GO:0051639)
2.1 6.3 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
1.2 6.1 GO:0010637 diet induced thermogenesis(GO:0002024) negative regulation of mitochondrial fusion(GO:0010637)
0.1 5.8 GO:0008637 apoptotic mitochondrial changes(GO:0008637)
0.5 5.4 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.3 5.2 GO:0015693 magnesium ion transport(GO:0015693)
0.3 5.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 5.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.7 4.0 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 22.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 19.8 GO:0005739 mitochondrion(GO:0005739)
0.1 16.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 15.4 GO:0043025 neuronal cell body(GO:0043025)
0.3 10.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 10.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 9.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 8.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.5 7.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 7.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 7.0 GO:0042101 T cell receptor complex(GO:0042101)
0.0 6.8 GO:0000139 Golgi membrane(GO:0000139)
1.6 6.5 GO:0032127 dense core granule membrane(GO:0032127)
0.3 5.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.4 5.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
1.3 4.0 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.6 3.8 GO:0097443 sorting endosome(GO:0097443)
0.0 3.6 GO:0008021 synaptic vesicle(GO:0008021)
0.9 3.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 3.3 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 19.2 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
4.7 14.0 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
2.1 10.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 10.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 10.0 GO:0008201 heparin binding(GO:0008201)
0.5 7.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.6 7.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
1.3 6.6 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.8 6.6 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.4 6.5 GO:0017166 vinculin binding(GO:0017166)
0.0 6.3 GO:0017124 SH3 domain binding(GO:0017124)
0.1 6.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 5.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.4 5.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 4.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 4.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.5 GO:0008013 beta-catenin binding(GO:0008013)
0.4 4.0 GO:0034711 inhibin binding(GO:0034711)
0.2 4.0 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 4.0 GO:0001540 beta-amyloid binding(GO:0001540)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 11.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 9.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 8.1 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 7.7 PID_CDC42_PATHWAY CDC42 signaling events
0.1 7.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.2 6.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 4.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 3.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.3 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 3.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.2 2.7 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 2.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 2.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 1.9 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.8 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.4 1.5 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.1 1.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.4 15.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 13.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.6 10.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.4 7.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 7.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 7.0 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 6.6 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.2 6.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 5.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
1.0 4.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 3.7 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.2 3.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 3.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.2 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.2 2.8 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 2.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 2.7 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.2 2.7 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation