Motif ID: Ep300
Z-value: 0.781
Transcription factors associated with Ep300:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Ep300 | ENSMUSG00000055024.6 | Ep300 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ep300 | mm10_v2_chr15_+_81586206_81586250 | -0.53 | 7.3e-07 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 14.0 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 2.1 | 6.3 | GO:1900738 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
| 1.6 | 6.6 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 1.2 | 6.1 | GO:0010637 | diet induced thermogenesis(GO:0002024) negative regulation of mitochondrial fusion(GO:0010637) |
| 1.1 | 10.0 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) vascular wound healing(GO:0061042) |
| 1.0 | 10.5 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.9 | 7.4 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.8 | 3.3 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.8 | 3.8 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.7 | 3.7 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.7 | 2.9 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
| 0.7 | 1.4 | GO:0097112 | gamma-aminobutyric acid receptor clustering(GO:0097112) |
| 0.7 | 4.0 | GO:0046880 | regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) |
| 0.7 | 2.0 | GO:0046122 | purine deoxyribonucleoside metabolic process(GO:0046122) |
| 0.6 | 1.9 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) |
| 0.6 | 3.5 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 0.6 | 1.7 | GO:0031554 | regulation of DNA-templated transcription, termination(GO:0031554) |
| 0.5 | 5.4 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.5 | 1.6 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.5 | 2.6 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 0.5 | 2.5 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.5 | 1.5 | GO:0035963 | response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) |
| 0.5 | 2.4 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.4 | 6.5 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.4 | 1.7 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.4 | 1.6 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
| 0.4 | 2.4 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.4 | 7.3 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
| 0.4 | 2.3 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.4 | 1.5 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
| 0.4 | 6.6 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.4 | 1.4 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.4 | 1.4 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.4 | 2.5 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.4 | 8.1 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.3 | 1.3 | GO:0032289 | central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912) |
| 0.3 | 1.2 | GO:1900110 | negative regulation of histone H3-K9 dimethylation(GO:1900110) |
| 0.3 | 2.1 | GO:0002829 | negative regulation of type 2 immune response(GO:0002829) |
| 0.3 | 5.2 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.3 | 5.2 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.3 | 2.3 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.3 | 1.4 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) |
| 0.3 | 2.8 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.2 | 0.9 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.2 | 0.9 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.2 | 1.2 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.2 | 2.6 | GO:0035635 | entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535) |
| 0.2 | 2.1 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
| 0.2 | 1.1 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
| 0.2 | 1.8 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.2 | 7.0 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.2 | 0.5 | GO:1904154 | trimming of terminal mannose on B branch(GO:0036509) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 0.2 | 0.5 | GO:0006550 | isoleucine catabolic process(GO:0006550) |
| 0.2 | 1.4 | GO:0006183 | GTP biosynthetic process(GO:0006183) |
| 0.2 | 1.5 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 0.1 | 0.7 | GO:0015960 | diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966) |
| 0.1 | 0.9 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 2.1 | GO:1903963 | arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
| 0.1 | 0.6 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.1 | 1.4 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.1 | 3.3 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.1 | 1.9 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
| 0.1 | 1.5 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 0.4 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.1 | 5.1 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.1 | 2.2 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 0.7 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.1 | 3.7 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 0.3 | GO:0002946 | tRNA C5-cytosine methylation(GO:0002946) |
| 0.1 | 0.9 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.9 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.1 | 14.4 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.1 | 0.6 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.1 | 0.7 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.1 | 0.5 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 0.1 | 2.7 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 16.0 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.1 | 2.1 | GO:0006813 | potassium ion transport(GO:0006813) |
| 0.1 | 2.6 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.1 | 2.7 | GO:0051926 | dopamine receptor signaling pathway(GO:0007212) negative regulation of calcium ion transport(GO:0051926) |
| 0.1 | 2.2 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.1 | 1.7 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.1 | 1.8 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.1 | 0.8 | GO:0060510 | Type II pneumocyte differentiation(GO:0060510) |
| 0.1 | 0.5 | GO:0032261 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) |
| 0.1 | 4.0 | GO:0001676 | long-chain fatty acid metabolic process(GO:0001676) |
| 0.1 | 0.8 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.1 | 2.5 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.1 | 0.9 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.1 | 5.8 | GO:0008637 | apoptotic mitochondrial changes(GO:0008637) |
| 0.0 | 0.7 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 1.1 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 1.9 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.1 | GO:0039533 | regulation of MDA-5 signaling pathway(GO:0039533) |
| 0.0 | 0.9 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.4 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 2.2 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 0.8 | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway(GO:2000052) |
| 0.0 | 0.7 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.9 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.7 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.1 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.0 | 2.5 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.2 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
| 0.0 | 1.9 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 0.2 | GO:0048680 | positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572) |
| 0.0 | 0.3 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.0 | 0.6 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.1 | GO:0021506 | anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995) |
| 0.0 | 0.3 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 2.6 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 1.0 | GO:0001558 | regulation of cell growth(GO:0001558) |
| 0.0 | 0.6 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.5 | GO:0019319 | hexose biosynthetic process(GO:0019319) |
| 0.0 | 0.2 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 0.5 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.5 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 1.3 | 4.0 | GO:0043512 | inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512) |
| 0.9 | 3.5 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.6 | 3.8 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.5 | 2.4 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.5 | 7.8 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.4 | 7.0 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.4 | 5.1 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.4 | 2.1 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.3 | 5.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.3 | 2.3 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.3 | 10.9 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.3 | 22.9 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.2 | 0.7 | GO:0070985 | TFIIK complex(GO:0070985) |
| 0.2 | 10.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 8.1 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.2 | 2.6 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.2 | 1.1 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.2 | 7.3 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 2.8 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 2.2 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.2 | 0.9 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.2 | 1.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.2 | 1.7 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.2 | 2.3 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.2 | 1.7 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 1.4 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 0.4 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.1 | 0.7 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.1 | 0.7 | GO:0097361 | CIA complex(GO:0097361) |
| 0.1 | 16.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 0.4 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.1 | 3.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 3.3 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 0.9 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.1 | 2.9 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.1 | 1.9 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 0.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 1.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 2.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.4 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 9.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 3.6 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 0.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.1 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 2.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 1.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.8 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.7 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 6.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 15.4 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 1.9 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 3.1 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 2.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 1.8 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 19.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 0.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 14.0 | GO:0031752 | D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752) |
| 2.1 | 10.5 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
| 1.3 | 6.6 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.8 | 6.6 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.8 | 2.4 | GO:0016901 | glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901) |
| 0.6 | 2.5 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.6 | 2.4 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.6 | 1.8 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.6 | 7.2 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.5 | 2.0 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
| 0.5 | 7.4 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.5 | 1.8 | GO:0008061 | chitin binding(GO:0008061) |
| 0.4 | 2.7 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.4 | 4.0 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.4 | 2.6 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.4 | 5.2 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.4 | 6.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.4 | 2.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.4 | 1.4 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.4 | 1.4 | GO:0043546 | molybdopterin cofactor binding(GO:0043546) |
| 0.3 | 2.1 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.3 | 3.5 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.3 | 19.2 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.2 | 4.0 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.2 | 1.7 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.2 | 1.7 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.2 | 1.4 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.2 | 2.1 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.2 | 2.5 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.2 | 0.5 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.2 | 3.1 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.2 | 1.2 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.2 | 1.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 1.8 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 0.6 | GO:0035473 | lipase binding(GO:0035473) |
| 0.1 | 0.9 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.1 | 3.7 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.1 | 1.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 4.9 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 1.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 1.7 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 3.3 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 1.6 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 5.4 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 3.3 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.6 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 1.4 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.1 | 1.5 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 0.1 | 0.9 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.1 | 1.2 | GO:0001163 | RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.1 | 4.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 0.5 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.1 | 10.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 6.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 0.5 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 3.2 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.1 | 0.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 10.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 0.5 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 1.0 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 1.0 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 0.8 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.3 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.0 | 1.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 6.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 2.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 4.5 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.3 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 0.0 | 0.5 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 1.1 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.4 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.1 | GO:0051022 | Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 0.0 | 0.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.5 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 3.3 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 1.8 | GO:0008173 | RNA methyltransferase activity(GO:0008173) |
| 0.0 | 1.1 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.1 | GO:0005118 | sevenless binding(GO:0005118) |
| 0.0 | 0.9 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 3.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.6 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 4.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.5 | GO:0016891 | endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) |
| 0.0 | 1.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.2 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.1 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.0 | 0.1 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.5 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.3 | 4.5 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.3 | 2.3 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.2 | 2.7 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.2 | 11.5 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.2 | 8.1 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.2 | 6.6 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 9.3 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.1 | 3.2 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.1 | 1.3 | PID_S1P_S1P3_PATHWAY | S1P3 pathway |
| 0.1 | 3.7 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 7.7 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.1 | 7.0 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 1.7 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 1.2 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 3.3 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.1 | 1.9 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 11.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.6 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.1 | 0.8 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 1.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 1.4 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.8 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 1.8 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.8 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.7 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 2.6 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.4 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.0 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.6 | 10.5 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.4 | 15.5 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.4 | 7.8 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.4 | 15.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 13.5 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.3 | 7.4 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.3 | 2.4 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.2 | 6.5 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 2.7 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.2 | 3.5 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 2.5 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 2.1 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.2 | 2.7 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.2 | 2.8 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 2.2 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.1 | 3.2 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 2.4 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 1.7 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 3.7 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 1.7 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 6.6 | REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.1 | 1.9 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 0.6 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 2.8 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.6 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 5.5 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.2 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 7.0 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 1.4 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 1.4 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 1.7 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 0.7 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 3.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.7 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 1.5 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.7 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 2.2 | REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.0 | 0.8 | REACTOME_CIRCADIAN_CLOCK | Genes involved in Circadian Clock |
| 0.0 | 0.9 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.7 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.5 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.8 | REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
