Motif ID: Erg
Z-value: 1.288
Transcription factors associated with Erg:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Erg | ENSMUSG00000040732.12 | Erg |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Erg | mm10_v2_chr16_-_95459245_95459384 | 0.75 | 3.7e-15 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 14.1 | GO:1905072 | detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072) |
| 3.5 | 38.9 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 2.6 | 10.4 | GO:0050904 | diapedesis(GO:0050904) |
| 2.3 | 11.4 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
| 2.0 | 6.1 | GO:0060913 | stem cell fate specification(GO:0048866) cardiac cell fate determination(GO:0060913) regulation of cardiac cell fate specification(GO:2000043) |
| 1.9 | 5.7 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 1.8 | 5.4 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 1.8 | 7.0 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 1.7 | 8.5 | GO:0061438 | renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) |
| 1.5 | 24.3 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 1.5 | 4.4 | GO:0042939 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 1.4 | 4.2 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 1.3 | 14.8 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 1.3 | 9.1 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 1.2 | 3.5 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 1.1 | 3.4 | GO:0035696 | monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437) |
| 1.1 | 3.3 | GO:0090187 | zymogen granule exocytosis(GO:0070625) positive regulation of pancreatic juice secretion(GO:0090187) |
| 1.0 | 7.3 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 1.0 | 12.4 | GO:0002281 | macrophage activation involved in immune response(GO:0002281) |
| 1.0 | 2.0 | GO:0061010 | gall bladder development(GO:0061010) |
| 1.0 | 6.0 | GO:0048597 | post-embryonic camera-type eye morphogenesis(GO:0048597) |
| 1.0 | 6.7 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.9 | 5.7 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.9 | 4.5 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
| 0.9 | 2.7 | GO:0071544 | diphosphoinositol polyphosphate catabolic process(GO:0071544) |
| 0.9 | 5.4 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.9 | 2.6 | GO:0002432 | granuloma formation(GO:0002432) |
| 0.8 | 8.4 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.8 | 2.5 | GO:1900141 | regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) |
| 0.7 | 2.2 | GO:0099548 | trans-synaptic signaling by nitric oxide(GO:0099548) |
| 0.7 | 2.2 | GO:0035604 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529) |
| 0.6 | 1.2 | GO:0033278 | cell proliferation in midbrain(GO:0033278) |
| 0.6 | 2.5 | GO:2000318 | positive regulation of T-helper 17 type immune response(GO:2000318) |
| 0.6 | 1.8 | GO:2000097 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.6 | 1.1 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.6 | 2.3 | GO:0002681 | somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) |
| 0.5 | 0.5 | GO:1901492 | positive regulation of lymphangiogenesis(GO:1901492) |
| 0.5 | 2.6 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.5 | 3.0 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310) |
| 0.5 | 4.5 | GO:0002693 | positive regulation of cellular extravasation(GO:0002693) |
| 0.5 | 1.5 | GO:0070488 | neutrophil aggregation(GO:0070488) |
| 0.5 | 7.8 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.5 | 4.4 | GO:0060613 | fat pad development(GO:0060613) |
| 0.5 | 2.4 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.5 | 4.6 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.5 | 2.7 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.5 | 1.4 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.4 | 4.0 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.4 | 12.6 | GO:0045026 | plasma membrane fusion(GO:0045026) |
| 0.4 | 1.6 | GO:1902262 | apoptotic process involved in patterning of blood vessels(GO:1902262) |
| 0.4 | 6.0 | GO:0050765 | negative regulation of phagocytosis(GO:0050765) |
| 0.4 | 1.6 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.4 | 14.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.4 | 1.9 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.4 | 2.6 | GO:0045651 | positive regulation of macrophage differentiation(GO:0045651) |
| 0.4 | 2.6 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.4 | 0.7 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
| 0.4 | 1.1 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.4 | 5.0 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.4 | 2.1 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.4 | 1.1 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 0.3 | 0.7 | GO:0060437 | lung growth(GO:0060437) |
| 0.3 | 3.8 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.3 | 4.8 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 0.3 | 1.7 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 0.3 | 1.0 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.3 | 1.0 | GO:2000619 | negative regulation of histone H4-K16 acetylation(GO:2000619) |
| 0.3 | 1.2 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.3 | 1.8 | GO:0046880 | regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) |
| 0.3 | 16.8 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway(GO:2001238) |
| 0.3 | 22.6 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
| 0.3 | 1.1 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.3 | 1.9 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.3 | 0.8 | GO:0048294 | negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.3 | 5.4 | GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947) |
| 0.3 | 3.3 | GO:0048680 | positive regulation of axon regeneration(GO:0048680) |
| 0.3 | 3.8 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.3 | 0.8 | GO:0002946 | tRNA C5-cytosine methylation(GO:0002946) |
| 0.2 | 1.0 | GO:1904995 | regulation of leukocyte tethering or rolling(GO:1903236) negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995) |
| 0.2 | 1.4 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.2 | 0.7 | GO:0008612 | peptidyl-lysine modification to peptidyl-hypusine(GO:0008612) |
| 0.2 | 1.9 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.2 | 0.7 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 0.2 | 0.9 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.2 | 0.9 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.2 | 1.4 | GO:0002002 | regulation of angiotensin levels in blood(GO:0002002) |
| 0.2 | 3.2 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.2 | 0.6 | GO:2001180 | regulation of interleukin-18 production(GO:0032661) negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180) |
| 0.2 | 0.6 | GO:1903061 | regulation of protein lipidation(GO:1903059) positive regulation of protein lipidation(GO:1903061) positive regulation of neuronal action potential(GO:1904457) |
| 0.2 | 6.7 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.2 | 4.6 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.2 | 0.8 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.2 | 2.6 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.2 | 2.1 | GO:0032695 | negative regulation of interleukin-12 production(GO:0032695) |
| 0.2 | 2.9 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.2 | 1.1 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) regulation of peroxisome size(GO:0044375) |
| 0.2 | 0.5 | GO:0098501 | polynucleotide dephosphorylation(GO:0098501) |
| 0.2 | 2.1 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.2 | 1.2 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.2 | 1.2 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.2 | 1.9 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.2 | 1.0 | GO:0071361 | cellular response to ethanol(GO:0071361) |
| 0.2 | 0.5 | GO:0001803 | antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805) |
| 0.2 | 1.6 | GO:0006817 | phosphate ion transport(GO:0006817) |
| 0.2 | 0.9 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.1 | 0.9 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.1 | 3.3 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.1 | 1.0 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.1 | 1.2 | GO:0097369 | sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.1 | 3.4 | GO:0002042 | cell migration involved in sprouting angiogenesis(GO:0002042) |
| 0.1 | 0.7 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 0.1 | 0.4 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
| 0.1 | 0.7 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.1 | 0.8 | GO:0016559 | peroxisome fission(GO:0016559) |
| 0.1 | 4.1 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.1 | 0.8 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.1 | 1.6 | GO:0015809 | arginine transport(GO:0015809) |
| 0.1 | 2.8 | GO:0001921 | positive regulation of receptor recycling(GO:0001921) |
| 0.1 | 0.4 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
| 0.1 | 0.5 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.1 | 1.6 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 0.3 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 0.1 | 0.3 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.1 | 0.2 | GO:0021649 | vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835) |
| 0.1 | 0.6 | GO:1903003 | positive regulation of protein deubiquitination(GO:1903003) |
| 0.1 | 0.8 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.1 | 4.4 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.1 | 0.7 | GO:0031087 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.1 | 1.5 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.1 | 4.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 0.3 | GO:1903215 | regulation of mRNA modification(GO:0090365) negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.1 | 2.7 | GO:0051567 | histone H3-K9 methylation(GO:0051567) |
| 0.1 | 1.7 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.1 | 0.5 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.1 | 0.2 | GO:1904975 | response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976) |
| 0.1 | 1.3 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.1 | 3.2 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 3.9 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 0.3 | GO:0023035 | CD40 signaling pathway(GO:0023035) protein linear polyubiquitination(GO:0097039) |
| 0.1 | 0.3 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.1 | 0.3 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.1 | 1.0 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.1 | 0.6 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.1 | 1.6 | GO:0010996 | response to auditory stimulus(GO:0010996) |
| 0.0 | 0.8 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.0 | 0.3 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.0 | 1.0 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.0 | 0.6 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 1.5 | GO:0030517 | negative regulation of axon extension(GO:0030517) |
| 0.0 | 0.2 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.0 | 0.2 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.0 | 0.6 | GO:0000479 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) |
| 0.0 | 0.6 | GO:0001946 | lymphangiogenesis(GO:0001946) |
| 0.0 | 1.1 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 0.2 | GO:0035826 | rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476) |
| 0.0 | 0.3 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.0 | 0.7 | GO:0033622 | integrin activation(GO:0033622) |
| 0.0 | 0.6 | GO:0060004 | reflex(GO:0060004) |
| 0.0 | 0.7 | GO:2000401 | regulation of lymphocyte migration(GO:2000401) |
| 0.0 | 0.3 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.5 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.3 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.0 | 0.7 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.2 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.0 | 0.1 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
| 0.0 | 0.2 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.0 | 0.4 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.0 | 1.1 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 0.1 | GO:0010873 | positive regulation of cholesterol esterification(GO:0010873) |
| 0.0 | 1.0 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.0 | 0.3 | GO:0045907 | positive regulation of vasoconstriction(GO:0045907) |
| 0.0 | 0.9 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.0 | 0.1 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
| 0.0 | 1.3 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.8 | GO:0007032 | endosome organization(GO:0007032) |
| 0.0 | 0.5 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 3.1 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 0.8 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 0.5 | GO:0030593 | neutrophil chemotaxis(GO:0030593) |
| 0.0 | 0.2 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
| 0.0 | 2.4 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
| 0.0 | 0.5 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.0 | 0.5 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
| 0.0 | 0.1 | GO:0010649 | regulation of cell communication by electrical coupling(GO:0010649) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) |
| 0.0 | 0.8 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.0 | 1.3 | GO:0098656 | anion transmembrane transport(GO:0098656) |
| 0.0 | 1.2 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 0.1 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.5 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.0 | 0.3 | GO:1900046 | regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046) |
| 0.0 | 0.1 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.2 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 2.1 | 10.4 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 2.1 | 6.2 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 1.4 | 5.7 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.9 | 2.6 | GO:0030690 | Noc1p-Noc2p complex(GO:0030690) |
| 0.8 | 8.4 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.8 | 2.4 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.7 | 4.4 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.7 | 4.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.6 | 1.9 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.6 | 3.0 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.6 | 1.8 | GO:0043512 | inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512) |
| 0.4 | 1.8 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.4 | 3.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.4 | 1.6 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.4 | 1.8 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.4 | 8.6 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.3 | 27.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.3 | 1.5 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.3 | 3.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 2.9 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.2 | 4.4 | GO:0031528 | microvillus membrane(GO:0031528) sperm midpiece(GO:0097225) |
| 0.2 | 6.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 3.3 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.2 | 4.7 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.2 | 0.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.2 | 18.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 2.8 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.2 | 8.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 1.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.2 | 1.2 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.2 | 2.8 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 2.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 0.2 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 0.1 | 1.2 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 2.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 4.2 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 0.6 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 19.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 0.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.1 | 0.3 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.1 | 1.0 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 0.7 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 1.0 | GO:0016589 | NURF complex(GO:0016589) |
| 0.1 | 0.7 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 0.5 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.1 | 33.8 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 1.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 0.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 1.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 4.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 2.2 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 2.3 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.1 | 0.3 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 3.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 1.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 2.4 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 0.4 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.0 | 0.8 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 7.8 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.4 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 7.7 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 1.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 1.0 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.4 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.0 | 0.6 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 2.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 4.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.1 | GO:0016012 | dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012) |
| 0.0 | 0.7 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 2.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 1.0 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 11.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.4 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.0 | 96.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 0.3 | GO:0031414 | N-terminal protein acetyltransferase complex(GO:0031414) |
| 0.0 | 0.2 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 4.0 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 0.3 | GO:0098797 | plasma membrane protein complex(GO:0098797) |
| 0.0 | 0.6 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 1.1 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.7 | GO:0005776 | autophagosome(GO:0005776) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 38.9 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 2.8 | 14.1 | GO:0005534 | galactose binding(GO:0005534) |
| 2.1 | 14.6 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 1.9 | 5.7 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 1.4 | 4.2 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 1.3 | 5.4 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 1.2 | 4.7 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 1.1 | 7.8 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 1.0 | 4.2 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.9 | 2.7 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.9 | 6.2 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.8 | 5.9 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.8 | 3.3 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
| 0.8 | 4.9 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.8 | 4.5 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.7 | 2.2 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
| 0.7 | 2.6 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.6 | 10.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.6 | 7.7 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.6 | 12.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.5 | 2.1 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.5 | 1.5 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 0.5 | 1.4 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.5 | 3.8 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.5 | 5.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.5 | 1.4 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.4 | 2.7 | GO:0000298 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) |
| 0.4 | 1.2 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) |
| 0.4 | 1.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.4 | 1.5 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.4 | 7.9 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.3 | 1.0 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.3 | 11.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 2.2 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.3 | 4.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.2 | 1.5 | GO:0050786 | arachidonic acid binding(GO:0050544) RAGE receptor binding(GO:0050786) |
| 0.2 | 8.0 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.2 | 2.2 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.2 | 1.0 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.2 | 2.6 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.2 | 1.1 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.2 | 3.4 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.2 | 0.8 | GO:0004441 | inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) |
| 0.2 | 4.6 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.2 | 11.5 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.2 | 0.6 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.2 | 1.8 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.2 | 4.1 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) |
| 0.2 | 2.2 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.2 | 1.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.2 | 2.0 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) DNA binding, bending(GO:0008301) |
| 0.2 | 2.7 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.2 | 0.7 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.2 | 3.2 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.2 | 1.2 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.2 | 1.2 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.1 | 15.8 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 1.0 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795) |
| 0.1 | 2.6 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 0.6 | GO:0034511 | U3 snoRNA binding(GO:0034511) |
| 0.1 | 0.7 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.1 | 5.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 1.9 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 1.0 | GO:0070290 | phospholipase D activity(GO:0004630) N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 5.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 0.6 | GO:0019961 | interferon binding(GO:0019961) |
| 0.1 | 0.5 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.1 | 2.8 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 1.0 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.1 | 2.5 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.1 | 1.3 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 0.5 | GO:0046403 | polynucleotide 3'-phosphatase activity(GO:0046403) |
| 0.1 | 2.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 1.1 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 1.3 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 8.5 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 8.4 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.1 | 0.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.1 | 0.3 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 1.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 0.8 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 0.1 | 4.7 | GO:0030551 | cyclic nucleotide binding(GO:0030551) |
| 0.1 | 0.6 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 0.9 | GO:0004467 | long-chain fatty acid-CoA ligase activity(GO:0004467) decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 0.7 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 1.0 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 0.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 0.3 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 1.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 3.2 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 0.3 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.1 | 2.3 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 5.2 | GO:0004872 | receptor activity(GO:0004872) molecular transducer activity(GO:0060089) |
| 0.1 | 0.2 | GO:0070012 | oligopeptidase activity(GO:0070012) |
| 0.1 | 7.3 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.1 | 2.4 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.1 | 1.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.7 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 0.8 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 0.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 8.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 0.8 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.0 | 8.7 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.4 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.0 | 0.4 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 1.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.0 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 0.5 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.0 | 0.6 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 1.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.3 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.0 | 1.5 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.0 | 1.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 3.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.6 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.0 | 1.5 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 1.8 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 16.8 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.2 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.3 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 0.5 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 0.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 0.2 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.8 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 5.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.3 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 1.3 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 5.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.7 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 1.0 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.0 | 0.1 | GO:0001163 | RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.0 | 1.8 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 0.3 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 2.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.2 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 0.1 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.0 | 0.7 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.0 | 0.3 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.2 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.6 | 39.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.4 | 14.0 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.3 | 5.4 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.3 | 9.7 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.3 | 4.7 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.3 | 8.8 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.3 | 5.7 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.2 | 5.6 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 4.0 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.2 | 4.5 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.2 | 5.9 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 7.7 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.2 | 21.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 18.2 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 22.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.4 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 4.1 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 1.5 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.1 | 4.8 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 5.2 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.1 | 7.5 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 7.0 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.1 | 2.9 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.1 | 1.4 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.1 | 4.6 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 1.9 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.0 | ST_GAQ_PATHWAY | G alpha q Pathway |
| 0.1 | 2.4 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 0.9 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 0.7 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.1 | 7.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.1 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 1.5 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.2 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.2 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 3.7 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.4 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 0.5 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.2 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.4 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 4.1 | NABA_MATRISOME_ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 0.6 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.7 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.0 | 0.8 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.7 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.2 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.6 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.9 | 5.4 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.7 | 8.2 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.6 | 10.8 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.5 | 12.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.5 | 10.5 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.4 | 1.8 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.4 | 4.2 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.3 | 9.3 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.3 | 2.6 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.3 | 10.5 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 17.6 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 2.4 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 7.0 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.2 | 7.3 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 4.7 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 2.2 | REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.2 | 4.5 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 2.8 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 1.3 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.4 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 2.0 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 4.1 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 19.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.9 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 13.1 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
| 0.1 | 0.7 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.1 | 3.1 | REACTOME_SIGNALING_BY_SCF_KIT | Genes involved in Signaling by SCF-KIT |
| 0.1 | 0.3 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.1 | 2.2 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 1.9 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 1.0 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.1 | 1.0 | REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING | Genes involved in Activation of Kainate Receptors upon glutamate binding |
| 0.1 | 4.2 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 0.4 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 0.8 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.1 | 0.7 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.9 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 1.8 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 1.3 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 1.4 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 2.7 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 3.0 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 2.6 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 1.5 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.5 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 1.0 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.5 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 0.7 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.6 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.7 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.2 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.3 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.6 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.8 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.2 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.6 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.5 | REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS | Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
| 0.0 | 1.2 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
