Motif ID: Erg

Z-value: 1.288


Transcription factors associated with Erg:

Gene SymbolEntrez IDGene Name
Erg ENSMUSG00000040732.12 Erg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ergmm10_v2_chr16_-_95459245_954593840.753.7e-15Click!


Activity profile for motif Erg.

activity profile for motif Erg


Sorted Z-values histogram for motif Erg

Sorted Z-values for motif Erg



Network of associatons between targets according to the STRING database.



First level regulatory network of Erg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 15.886 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr12_+_75308308 14.764 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr2_+_32646586 14.084 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr4_+_144893077 12.198 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr11_-_55419898 11.158 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr4_+_144893127 10.819 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr11_-_106715251 10.420 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr16_-_95459245 9.828 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
 Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr6_+_4003926 9.330 ENSMUST00000031670.8
 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr16_-_38713235 8.696 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr3_-_10208569 8.399 ENSMUST00000029041.4
 Fabp4
fatty acid binding protein 4, adipocyte
chr1_-_56969864 8.352 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56972437 7.979 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 7.937 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr2_-_148443543 7.837 ENSMUST00000099269.3
 Cd93
CD93 antigen
chr11_-_101785252 7.680 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr16_+_43363855 7.554 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr8_+_104101625 7.255 ENSMUST00000034339.8
 Cdh5
cadherin 5
chr13_-_41487306 7.200 ENSMUST00000021794.6
 Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr17_+_43389436 7.076 ENSMUST00000113599.1
 Gpr116
G protein-coupled receptor 116

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 191 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 38.9 GO:0042572 retinol metabolic process(GO:0042572)
1.5 24.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 22.6 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.3 16.8 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
1.3 14.8 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
4.7 14.1 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.4 14.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 12.6 GO:0045026 plasma membrane fusion(GO:0045026)
1.0 12.4 GO:0002281 macrophage activation involved in immune response(GO:0002281)
2.3 11.4 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
2.6 10.4 GO:0050904 diapedesis(GO:0050904)
1.3 9.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.7 8.5 GO:0061438 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439)
0.8 8.4 GO:0071285 cellular response to lithium ion(GO:0071285)
0.5 7.8 GO:0030574 collagen catabolic process(GO:0030574)
1.0 7.3 GO:0001955 blood vessel maturation(GO:0001955)
1.8 7.0 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.0 6.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 6.7 GO:0035162 embryonic hemopoiesis(GO:0035162)
2.0 6.1 GO:0060913 stem cell fate specification(GO:0048866) cardiac cell fate determination(GO:0060913) regulation of cardiac cell fate specification(GO:2000043)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 96.1 GO:0016021 integral component of membrane(GO:0016021)
0.1 33.8 GO:0009986 cell surface(GO:0009986)
0.3 27.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 19.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 18.3 GO:0072562 blood microparticle(GO:0072562)
0.0 11.5 GO:0005667 transcription factor complex(GO:0005667)
2.8 11.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
2.1 10.4 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.4 8.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 8.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.8 8.4 GO:0031091 platelet alpha granule(GO:0031091)
0.0 7.8 GO:0043235 receptor complex(GO:0043235)
0.0 7.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
2.1 6.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 6.0 GO:0001891 phagocytic cup(GO:0001891)
1.4 5.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.2 4.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.7 4.4 GO:0097443 sorting endosome(GO:0097443)
0.2 4.4 GO:0031528 microvillus membrane(GO:0031528) sperm midpiece(GO:0097225)
0.7 4.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 38.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 16.8 GO:0003682 chromatin binding(GO:0003682)
0.1 15.8 GO:0008013 beta-catenin binding(GO:0008013)
2.1 14.6 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
2.8 14.1 GO:0005534 galactose binding(GO:0005534)
0.6 12.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 11.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.3 11.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.6 10.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 8.7 GO:0005516 calmodulin binding(GO:0005516)
0.1 8.5 GO:0008201 heparin binding(GO:0008201)
0.1 8.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 8.4 GO:0008083 growth factor activity(GO:0008083)
0.2 8.0 GO:0005504 fatty acid binding(GO:0005504)
0.4 7.9 GO:0001968 fibronectin binding(GO:0001968)
1.1 7.8 GO:0001849 complement component C1q binding(GO:0001849)
0.6 7.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 7.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.9 6.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.8 5.9 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 39.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 22.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 21.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 18.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.4 14.0 PID_ALK1_PATHWAY ALK1 signaling events
0.3 9.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.3 8.8 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.7 8.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 7.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 7.5 PID_LKB1_PATHWAY LKB1 signaling events
0.1 7.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 5.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 5.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.2 5.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 5.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 5.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 4.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.3 4.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 4.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 17.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 13.1 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.5 12.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.6 10.8 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.5 10.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 10.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 9.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.7 8.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 7.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 7.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
2.2 6.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.9 5.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.2 4.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 4.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.4 4.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 4.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 4.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 3.1 REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT
0.0 3.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription