Motif ID: Esr1
Z-value: 1.012
Transcription factors associated with Esr1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Esr1 | ENSMUSG00000019768.10 | Esr1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Esr1 | mm10_v2_chr10_+_4611971_4612021 | 0.39 | 3.8e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.7 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 1.8 | 5.5 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 1.4 | 4.2 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632) |
| 1.4 | 6.9 | GO:0002024 | diet induced thermogenesis(GO:0002024) |
| 1.4 | 4.1 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
| 1.4 | 4.1 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) |
| 1.3 | 2.5 | GO:0034759 | regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759) |
| 1.2 | 5.0 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 1.2 | 3.5 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 1.2 | 3.5 | GO:0051542 | elastin biosynthetic process(GO:0051542) |
| 1.2 | 3.5 | GO:0044413 | regulation of lung blood pressure(GO:0014916) evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 1.2 | 4.6 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 1.1 | 4.5 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 1.1 | 3.2 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
| 1.0 | 3.1 | GO:0002765 | immune response-inhibiting signal transduction(GO:0002765) |
| 1.0 | 3.0 | GO:1900149 | positive regulation of Schwann cell migration(GO:1900149) |
| 1.0 | 3.0 | GO:0006566 | threonine metabolic process(GO:0006566) |
| 0.9 | 3.4 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.8 | 2.5 | GO:0002035 | brain renin-angiotensin system(GO:0002035) |
| 0.8 | 2.4 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
| 0.8 | 3.1 | GO:0061526 | acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526) |
| 0.8 | 3.1 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.7 | 2.9 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.7 | 3.5 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.7 | 3.5 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.7 | 2.7 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.7 | 1.4 | GO:0002578 | negative regulation of antigen processing and presentation(GO:0002578) |
| 0.7 | 2.1 | GO:0043181 | vacuolar sequestering(GO:0043181) |
| 0.7 | 2.0 | GO:0010360 | desmosome assembly(GO:0002159) negative regulation of anion channel activity(GO:0010360) |
| 0.7 | 2.0 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.6 | 3.2 | GO:0070305 | response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321) |
| 0.6 | 2.6 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.6 | 3.7 | GO:0032439 | endosome localization(GO:0032439) |
| 0.6 | 0.6 | GO:0036482 | neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) |
| 0.6 | 2.8 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.5 | 1.6 | GO:0060785 | regulation of apoptosis involved in tissue homeostasis(GO:0060785) |
| 0.5 | 1.5 | GO:0072720 | cellular response to UV-A(GO:0071492) response to dithiothreitol(GO:0072720) |
| 0.5 | 5.1 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.5 | 1.5 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.5 | 1.5 | GO:0030300 | regulation of intestinal cholesterol absorption(GO:0030300) |
| 0.5 | 1.4 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 0.5 | 2.4 | GO:0032423 | regulation of mismatch repair(GO:0032423) |
| 0.5 | 3.3 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.5 | 1.4 | GO:2000850 | negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 0.4 | 4.6 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.4 | 4.6 | GO:0060347 | heart trabecula formation(GO:0060347) |
| 0.4 | 1.2 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 0.4 | 1.6 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.4 | 2.0 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.4 | 1.2 | GO:0015886 | heme transport(GO:0015886) |
| 0.4 | 1.1 | GO:0002940 | tRNA N2-guanine methylation(GO:0002940) |
| 0.4 | 1.1 | GO:0061744 | motor behavior(GO:0061744) |
| 0.4 | 2.5 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
| 0.4 | 1.1 | GO:0051030 | snRNA transport(GO:0051030) |
| 0.4 | 3.5 | GO:0046959 | habituation(GO:0046959) |
| 0.3 | 2.1 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.3 | 0.9 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.3 | 0.9 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.3 | 1.8 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.3 | 3.8 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.3 | 1.7 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.3 | 0.8 | GO:0060672 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.3 | 0.8 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.3 | 2.2 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.3 | 0.8 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.3 | 4.0 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.3 | 0.8 | GO:0016132 | brassinosteroid metabolic process(GO:0016131) brassinosteroid biosynthetic process(GO:0016132) |
| 0.2 | 1.0 | GO:0009597 | detection of virus(GO:0009597) |
| 0.2 | 0.7 | GO:0048611 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
| 0.2 | 2.6 | GO:0051126 | negative regulation of actin nucleation(GO:0051126) |
| 0.2 | 0.9 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.2 | 1.8 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.2 | 2.4 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.2 | 0.6 | GO:0006532 | aspartate biosynthetic process(GO:0006532) |
| 0.2 | 3.1 | GO:0015809 | arginine transport(GO:0015809) |
| 0.2 | 0.6 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.2 | 1.8 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.2 | 0.4 | GO:0036166 | phenotypic switching(GO:0036166) |
| 0.2 | 1.4 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.2 | 2.2 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.2 | 2.0 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) |
| 0.2 | 1.4 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.2 | 0.8 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
| 0.2 | 7.8 | GO:0033014 | tetrapyrrole biosynthetic process(GO:0033014) |
| 0.2 | 2.4 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.2 | 2.6 | GO:2000009 | negative regulation of protein localization to cell surface(GO:2000009) |
| 0.2 | 0.5 | GO:1903048 | regulation of acetylcholine-gated cation channel activity(GO:1903048) |
| 0.2 | 2.1 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
| 0.2 | 0.3 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
| 0.2 | 0.7 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
| 0.2 | 1.0 | GO:0098707 | ferrous iron import(GO:0070627) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.2 | 0.5 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.2 | 1.0 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.2 | 1.3 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.2 | 0.7 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.2 | 1.3 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.2 | 1.6 | GO:0019321 | pentose metabolic process(GO:0019321) |
| 0.2 | 0.5 | GO:0090204 | protein localization to nuclear pore(GO:0090204) positive regulation of calcium-transporting ATPase activity(GO:1901896) |
| 0.2 | 1.3 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) positive regulation by host of viral genome replication(GO:0044829) |
| 0.2 | 3.0 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.2 | 0.6 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.2 | 4.3 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.2 | 0.5 | GO:1901165 | regulation of MDA-5 signaling pathway(GO:0039533) positive regulation of trophoblast cell migration(GO:1901165) positive regulation of dendritic cell chemotaxis(GO:2000510) |
| 0.1 | 2.3 | GO:2001046 | positive regulation of integrin-mediated signaling pathway(GO:2001046) |
| 0.1 | 1.3 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.1 | 1.5 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.6 | GO:0033563 | dorsal/ventral axon guidance(GO:0033563) |
| 0.1 | 0.5 | GO:0015786 | UDP-glucose transport(GO:0015786) |
| 0.1 | 1.6 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.1 | 2.0 | GO:0018195 | peptidyl-arginine modification(GO:0018195) |
| 0.1 | 0.9 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.1 | 1.2 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.1 | 0.6 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 0.1 | 0.6 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.1 | 0.3 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.1 | 1.1 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.1 | 1.0 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 0.6 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.1 | 1.0 | GO:0006071 | glycerol metabolic process(GO:0006071) |
| 0.1 | 1.6 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.1 | 1.5 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.1 | 0.8 | GO:0035729 | cellular response to hepatocyte growth factor stimulus(GO:0035729) |
| 0.1 | 0.5 | GO:0006680 | glucosylceramide catabolic process(GO:0006680) |
| 0.1 | 1.4 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 1.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 0.8 | GO:2000767 | positive regulation of cytoplasmic translation(GO:2000767) |
| 0.1 | 0.4 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 1.4 | GO:0006857 | oligopeptide transport(GO:0006857) |
| 0.1 | 0.9 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 1.3 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.1 | 0.9 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.1 | 0.4 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.1 | 0.7 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.1 | 0.6 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.1 | 1.5 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 0.4 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 1.0 | GO:0002031 | G-protein coupled receptor internalization(GO:0002031) |
| 0.1 | 0.6 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) |
| 0.1 | 1.5 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.1 | 0.9 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
| 0.1 | 7.6 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.1 | 2.2 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.1 | 0.3 | GO:2000338 | interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338) |
| 0.1 | 0.5 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 0.4 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 0.4 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.1 | 0.2 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.1 | 0.2 | GO:0042795 | snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.1 | 0.6 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.1 | 0.3 | GO:1900020 | prolactin secretion(GO:0070459) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
| 0.1 | 0.3 | GO:0000965 | mitochondrial RNA 3'-end processing(GO:0000965) |
| 0.1 | 0.9 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 2.1 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.1 | 0.4 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 0.1 | 4.2 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 2.0 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.1 | 1.5 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 0.6 | GO:0035814 | negative regulation of renal sodium excretion(GO:0035814) |
| 0.1 | 0.6 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.1 | 1.2 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 1.6 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.1 | 1.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 1.0 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.1 | 0.6 | GO:1905146 | lysosomal lumen acidification(GO:0007042) lysosomal protein catabolic process(GO:1905146) |
| 0.1 | 0.2 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.1 | 0.6 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 0.6 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.1 | 0.5 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.1 | 0.5 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.1 | 1.5 | GO:0030431 | sleep(GO:0030431) |
| 0.1 | 1.5 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.1 | 0.3 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 1.2 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.1 | 0.7 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
| 0.1 | 1.2 | GO:0021819 | layer formation in cerebral cortex(GO:0021819) |
| 0.1 | 1.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 2.8 | GO:0048713 | regulation of oligodendrocyte differentiation(GO:0048713) |
| 0.1 | 1.1 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.1 | 0.5 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 1.9 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 1.3 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 0.2 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.0 | 0.3 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.0 | 0.4 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 0.0 | 1.0 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 1.2 | GO:0009648 | photoperiodism(GO:0009648) |
| 0.0 | 0.1 | GO:0070093 | regulation of epinephrine secretion(GO:0014060) negative regulation of glucagon secretion(GO:0070093) |
| 0.0 | 1.6 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.2 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.0 | 1.6 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 0.0 | 0.1 | GO:0019858 | cytosine metabolic process(GO:0019858) |
| 0.0 | 2.1 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.0 | 0.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.0 | 0.1 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 0.0 | 0.2 | GO:0018002 | N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920) |
| 0.0 | 2.6 | GO:0050810 | regulation of steroid biosynthetic process(GO:0050810) |
| 0.0 | 0.3 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.3 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.0 | 1.3 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 0.4 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 0.0 | 0.6 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.0 | 0.5 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.0 | 1.0 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 1.0 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.0 | 1.2 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.7 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.0 | 1.4 | GO:0030317 | sperm motility(GO:0030317) |
| 0.0 | 1.2 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 0.5 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 0.4 | GO:0071549 | response to dexamethasone(GO:0071548) cellular response to dexamethasone stimulus(GO:0071549) |
| 0.0 | 0.5 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 0.7 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.5 | GO:0008089 | anterograde axonal transport(GO:0008089) axonal transport(GO:0098930) |
| 0.0 | 1.1 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.0 | 0.5 | GO:0051447 | negative regulation of meiotic cell cycle(GO:0051447) |
| 0.0 | 0.8 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.0 | 0.4 | GO:0001890 | placenta development(GO:0001890) |
| 0.0 | 0.8 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 0.2 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 0.0 | 0.4 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
| 0.0 | 0.2 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 0.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 1.9 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.3 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.0 | 0.2 | GO:0031274 | pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 0.5 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 0.0 | 1.0 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.0 | 1.0 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 0.2 | GO:0006744 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 0.3 | GO:1904294 | positive regulation of ERAD pathway(GO:1904294) |
| 0.0 | 0.5 | GO:0097009 | energy homeostasis(GO:0097009) |
| 0.0 | 0.6 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.3 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.0 | 1.1 | GO:0050775 | positive regulation of dendrite morphogenesis(GO:0050775) |
| 0.0 | 0.5 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 0.7 | GO:0045471 | response to ethanol(GO:0045471) |
| 0.0 | 0.2 | GO:0044065 | regulation of respiratory system process(GO:0044065) |
| 0.0 | 0.1 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.0 | 0.5 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
| 0.0 | 0.4 | GO:0002548 | monocyte chemotaxis(GO:0002548) |
| 0.0 | 0.1 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) |
| 0.0 | 2.6 | GO:0060828 | regulation of canonical Wnt signaling pathway(GO:0060828) |
| 0.0 | 0.0 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.3 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.2 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.0 | 0.8 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 0.0 | GO:0021631 | optic nerve morphogenesis(GO:0021631) |
| 0.0 | 0.7 | GO:0046324 | regulation of glucose import(GO:0046324) |
| 0.0 | 0.6 | GO:0042274 | ribosomal small subunit biogenesis(GO:0042274) |
| 0.0 | 1.1 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 0.2 | GO:0009303 | rRNA transcription(GO:0009303) positive regulation of Wnt signaling pathway(GO:0030177) |
| 0.0 | 1.3 | GO:0071229 | cellular response to acid chemical(GO:0071229) |
| 0.0 | 0.7 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.3 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.2 | GO:0098855 | HCN channel complex(GO:0098855) |
| 1.0 | 3.0 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.9 | 3.5 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.9 | 4.3 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.7 | 3.5 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.7 | 2.0 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.6 | 3.7 | GO:0045179 | apical cortex(GO:0045179) |
| 0.6 | 2.9 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.5 | 4.9 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.5 | 1.6 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.5 | 1.5 | GO:0005584 | collagen type I trimer(GO:0005584) |
| 0.5 | 1.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.5 | 1.8 | GO:1903349 | omegasome membrane(GO:1903349) |
| 0.4 | 4.6 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.4 | 1.2 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.4 | 10.3 | GO:0031430 | M band(GO:0031430) |
| 0.4 | 5.7 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.4 | 3.5 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.4 | 1.8 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.3 | 5.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.3 | 2.0 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.3 | 1.3 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.2 | 1.0 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.2 | 0.9 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.2 | 3.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.2 | 1.8 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.2 | 0.8 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.2 | 3.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 2.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 0.6 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.2 | 0.5 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.2 | 1.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.2 | 0.6 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.1 | 2.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 2.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.7 | GO:1990745 | EARP complex(GO:1990745) |
| 0.1 | 1.5 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 0.7 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 1.9 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 1.4 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 1.5 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 1.0 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 0.5 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.1 | 0.7 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 0.7 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.1 | 1.3 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.1 | 0.5 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.1 | 0.6 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.1 | 11.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 0.5 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 0.7 | GO:0071203 | WASH complex(GO:0071203) |
| 0.1 | 1.0 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 0.6 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 0.8 | GO:0089701 | U2AF(GO:0089701) |
| 0.1 | 2.1 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 0.4 | GO:0043293 | apoptosome(GO:0043293) |
| 0.1 | 0.6 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 1.7 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 1.5 | GO:0042611 | MHC protein complex(GO:0042611) |
| 0.1 | 2.9 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 1.5 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 2.6 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 0.5 | GO:0033061 | DNA recombinase mediator complex(GO:0033061) |
| 0.1 | 0.5 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.1 | 0.5 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 0.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 6.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 1.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.6 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 0.9 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.1 | 0.2 | GO:0031417 | NatC complex(GO:0031417) |
| 0.1 | 0.4 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.3 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.1 | 0.8 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 2.8 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 1.1 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 3.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 0.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 0.8 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.8 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 1.3 | GO:0098827 | endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827) |
| 0.0 | 0.7 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.5 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 2.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 0.1 | GO:0071920 | cleavage body(GO:0071920) |
| 0.0 | 1.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 1.1 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.3 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.0 | 1.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 1.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.2 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.2 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.6 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 0.0 | 0.6 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.6 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.5 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.3 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 1.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.3 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.0 | 3.3 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.0 | 0.4 | GO:0044754 | autolysosome(GO:0044754) |
| 0.0 | 3.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.3 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 1.0 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 0.3 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.0 | 1.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 5.2 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.2 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 1.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.6 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.0 | 0.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.3 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 0.5 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.7 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 5.8 | GO:0005924 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055) |
| 0.0 | 0.7 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 3.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 1.8 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 2.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.9 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.0 | 0.8 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 3.1 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.0 | 1.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 0.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.1 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 0.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 1.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.2 | GO:0070069 | cytochrome complex(GO:0070069) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 6.9 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 1.5 | 4.4 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 1.2 | 5.0 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.1 | 4.5 | GO:0047237 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238) |
| 1.0 | 3.1 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
| 1.0 | 3.0 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.9 | 3.5 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.9 | 3.5 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.9 | 3.4 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.8 | 3.2 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.7 | 3.5 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.7 | 2.1 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.7 | 2.0 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.6 | 7.7 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.6 | 3.8 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.6 | 3.1 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.6 | 4.9 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.6 | 4.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.6 | 1.8 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.5 | 1.6 | GO:0072541 | peroxynitrite reductase activity(GO:0072541) |
| 0.5 | 1.5 | GO:0036470 | tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) |
| 0.5 | 1.4 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.5 | 1.4 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.4 | 2.6 | GO:0023029 | MHC class Ib protein binding(GO:0023029) |
| 0.4 | 3.0 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.4 | 1.2 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
| 0.4 | 1.2 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.4 | 1.2 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.4 | 1.5 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.4 | 2.9 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.4 | 2.5 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.4 | 1.8 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.3 | 2.4 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.3 | 4.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.3 | 2.9 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.3 | 4.1 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.3 | 2.2 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.3 | 3.0 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.3 | 0.9 | GO:0004155 | 6,7-dihydropteridine reductase activity(GO:0004155) |
| 0.3 | 2.9 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.3 | 0.8 | GO:0009918 | sterol delta7 reductase activity(GO:0009918) 7-dehydrocholesterol reductase activity(GO:0047598) |
| 0.3 | 1.0 | GO:0019962 | interferon receptor activity(GO:0004904) type I interferon receptor activity(GO:0004905) type I interferon binding(GO:0019962) |
| 0.3 | 1.0 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.2 | 1.5 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
| 0.2 | 0.6 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 0.2 | 2.4 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.2 | 2.1 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.2 | 2.5 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.2 | 1.9 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.2 | 6.8 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.2 | 0.6 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
| 0.2 | 0.8 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.2 | 0.6 | GO:0031779 | melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782) |
| 0.2 | 1.5 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.2 | 1.7 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.2 | 3.1 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.2 | 1.9 | GO:0010857 | calcium-dependent protein kinase activity(GO:0010857) |
| 0.2 | 0.6 | GO:0042134 | snoRNP binding(GO:0030519) rRNA primary transcript binding(GO:0042134) |
| 0.2 | 0.7 | GO:0070976 | TIR domain binding(GO:0070976) |
| 0.2 | 3.8 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.2 | 0.9 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.2 | 1.0 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.2 | 0.7 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.2 | 3.0 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.2 | 4.6 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.2 | 0.8 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.2 | 1.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.2 | 0.6 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.2 | 2.0 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.2 | 0.6 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.2 | 1.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 0.6 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.1 | 1.0 | GO:0015091 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
| 0.1 | 0.4 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
| 0.1 | 1.3 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 3.2 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 0.7 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.1 | 0.9 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.1 | 1.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 4.6 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 6.0 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 0.8 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 1.2 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.1 | 3.5 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 0.7 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
| 0.1 | 0.5 | GO:0030984 | kininogen binding(GO:0030984) |
| 0.1 | 1.2 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.1 | 1.3 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 0.3 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 0.4 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.1 | 3.0 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 1.0 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.1 | 1.0 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 5.1 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.1 | 5.3 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 0.4 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 1.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 2.9 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 6.0 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.1 | 5.1 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 0.7 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 1.3 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 1.0 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 1.3 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 0.4 | GO:0043199 | sulfate binding(GO:0043199) |
| 0.1 | 0.5 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.1 | 0.3 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 3.8 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 1.1 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 0.6 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.1 | 0.6 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 0.2 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.1 | 0.6 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.1 | 0.3 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.1 | 0.7 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 0.4 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 1.1 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 3.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 3.5 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.1 | 0.6 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.1 | 0.5 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 0.7 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.1 | 2.0 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.1 | 2.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 4.8 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 1.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 1.4 | GO:0071617 | lysophospholipid acyltransferase activity(GO:0071617) |
| 0.1 | 4.5 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 0.5 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 2.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 0.5 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 0.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 1.6 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 0.8 | GO:0005536 | glucose binding(GO:0005536) |
| 0.1 | 1.0 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 1.0 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 0.3 | GO:0005290 | L-histidine transmembrane transporter activity(GO:0005290) |
| 0.1 | 0.9 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 1.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 1.6 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.1 | 1.9 | GO:0005496 | steroid binding(GO:0005496) |
| 0.1 | 0.2 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 0.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 0.6 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 1.3 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.0 | 1.0 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 0.3 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 0.3 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.0 | 0.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 1.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 2.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.4 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 1.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 1.0 | GO:0005261 | cation channel activity(GO:0005261) |
| 0.0 | 1.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 0.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.1 | GO:0046997 | sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 0.0 | 0.2 | GO:1990190 | peptide-glutamate-N-acetyltransferase activity(GO:1990190) |
| 0.0 | 5.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.3 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.4 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.2 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.0 | 0.2 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.0 | 1.3 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.8 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.2 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.0 | 1.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 2.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 2.5 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 0.7 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 4.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.4 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.3 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 1.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 1.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 3.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 0.3 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.8 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.0 | 0.2 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.0 | 0.3 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.0 | 0.2 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 0.1 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.3 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 0.1 | GO:0032564 | dATP binding(GO:0032564) |
| 0.0 | 0.3 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.1 | GO:0004177 | aminopeptidase activity(GO:0004177) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.3 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 3.8 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.2 | 7.2 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.2 | 6.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 5.1 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.2 | 2.8 | PID_LYMPH_ANGIOGENESIS_PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 5.0 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 3.6 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 4.5 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 3.3 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 2.4 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 1.4 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 1.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.7 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 0.5 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 1.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 1.8 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 1.1 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 3.1 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.7 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 3.3 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.3 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 2.7 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 1.3 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.1 | 0.5 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 1.2 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 3.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 1.0 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.6 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.4 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.9 | PID_EPO_PATHWAY | EPO signaling pathway |
| 0.0 | 0.8 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 6.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 5.3 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.8 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.3 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.4 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.3 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.8 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 1.3 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 1.6 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.6 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.5 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.3 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 1.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.5 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.7 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.5 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
| 0.6 | 5.0 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.4 | 5.6 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.3 | 8.2 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.3 | 3.8 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.3 | 2.4 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.3 | 5.9 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.3 | 2.4 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.3 | 5.1 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.2 | 2.0 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.2 | 4.5 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 5.4 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 5.7 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 2.0 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.2 | 2.5 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.2 | 3.0 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 1.4 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
| 0.2 | 6.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 4.3 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 4.7 | REACTOME_CA_DEPENDENT_EVENTS | Genes involved in Ca-dependent events |
| 0.1 | 1.9 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.9 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.0 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 2.1 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 1.0 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 0.5 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 1.4 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 4.7 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 0.5 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 0.9 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 2.9 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.0 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 0.8 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.0 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 1.4 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 3.5 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 0.5 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 5.0 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 6.3 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 1.5 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 1.0 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 0.9 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 2.7 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 0.8 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 1.3 | REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.1 | 0.8 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.3 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.8 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 2.6 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 1.7 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.3 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 3.2 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 1.2 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.9 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 1.0 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.8 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.5 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.8 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 3.0 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.6 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.3 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 2.9 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.7 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.2 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 1.3 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.4 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.6 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.4 | REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 0.3 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 0.1 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.1 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.3 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.4 | REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS | Genes involved in Host Interactions of HIV factors |
| 0.0 | 0.7 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
