Motif ID: Esr1

Z-value: 1.012


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4611971_46120210.393.8e-04Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_66860458 6.917 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr1_+_34579693 5.952 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr3_+_117575268 5.629 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr19_-_57182293 5.529 ENSMUST00000133369.1
 Ablim1
actin-binding LIM protein 1
chr4_+_152199805 5.500 ENSMUST00000105652.2
 Acot7
acyl-CoA thioesterase 7
chr16_-_76373827 5.463 ENSMUST00000121927.1
 Nrip1
nuclear receptor interacting protein 1
chr4_-_141598206 5.440 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr1_-_87573825 5.118 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr18_-_38211957 5.026 ENSMUST00000159405.1
ENSMUST00000160721.1
 Pcdh1

protocadherin 1

chr10_-_125308809 4.989 ENSMUST00000105257.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr1_-_43163891 4.596 ENSMUST00000008280.7
 Fhl2
four and a half LIM domains 2
chr8_-_68735058 4.515 ENSMUST00000136060.1
ENSMUST00000130214.1
ENSMUST00000078350.6
 Csgalnact1


chondroitin sulfate N-acetylgalactosaminyltransferase 1


chr5_-_143909782 4.165 ENSMUST00000031613.4
ENSMUST00000100483.2
 Aimp2

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

chr7_+_45699843 4.150 ENSMUST00000003360.7
 Car11
carbonic anhydrase 11
chrX_-_104857228 4.150 ENSMUST00000033575.5
 Magee2
melanoma antigen, family E, 2
chr15_-_93595877 4.129 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr13_+_31806627 4.075 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr11_+_32286946 3.993 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chr14_+_57999305 3.839 ENSMUST00000180534.1
 3110083C13Rik
RIKEN cDNA 3110083C13 gene
chr5_-_77408034 3.818 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 254 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 GO:0033014 tetrapyrrole biosynthetic process(GO:0033014)
1.9 7.7 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 7.6 GO:0030032 lamellipodium assembly(GO:0030032)
1.4 6.9 GO:0002024 diet induced thermogenesis(GO:0002024)
1.8 5.5 GO:0001543 ovarian follicle rupture(GO:0001543)
0.5 5.1 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
1.2 5.0 GO:1901475 pyruvate transmembrane transport(GO:1901475)
1.2 4.6 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.4 4.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.4 4.6 GO:0060347 heart trabecula formation(GO:0060347)
1.1 4.5 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.2 4.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.4 4.2 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
0.1 4.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
1.4 4.1 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
1.4 4.1 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.3 4.0 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.3 3.8 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.6 3.7 GO:0032439 endosome localization(GO:0032439)
1.2 3.5 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.4 10.3 GO:0031430 M band(GO:0031430)
0.1 6.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.8 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.4 5.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 5.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 5.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.5 4.9 GO:0061574 ASAP complex(GO:0061574)
0.4 4.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.9 4.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 3.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 3.7 GO:0045179 apical cortex(GO:0045179)
0.9 3.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.7 3.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.4 3.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 3.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 3.3 GO:0005911 cell-cell junction(GO:0005911)
0.0 3.3 GO:0043204 perikaryon(GO:0043204)
0.0 3.3 GO:0000139 Golgi membrane(GO:0000139)
1.1 3.2 GO:0098855 HCN channel complex(GO:0098855)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 196 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
2.3 6.9 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 6.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 6.0 GO:0015485 cholesterol binding(GO:0015485)
0.1 6.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 5.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 5.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 5.1 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 5.1 GO:0046875 ephrin receptor binding(GO:0046875)
1.2 5.0 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.6 4.9 GO:0048495 Roundabout binding(GO:0048495)
0.6 4.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 4.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 4.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 4.6 GO:0050699 WW domain binding(GO:0050699)
0.0 4.6 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 4.5 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 4.5 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
1.5 4.4 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.3 4.2 GO:0004089 carbonate dehydratase activity(GO:0004089)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 7.2 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.2 6.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 6.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 5.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 5.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 5.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 4.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 4.5 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.2 3.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 3.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 3.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 3.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 3.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 2.8 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 2.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 2.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 2.4 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 6.3 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.2 6.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 5.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.2 5.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 5.6 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 5.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 5.1 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.6 5.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 5.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 4.7 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 4.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 4.5 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 4.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.3 3.8 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 3.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 3.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
1.0 3.1 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.2 3.0 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 3.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases