Motif ID: Esr2

Z-value: 2.353


Transcription factors associated with Esr2:

Gene SymbolEntrez IDGene Name
Esr2 ENSMUSG00000021055.7 Esr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr2mm10_v2_chr12_-_76177251_76177265-0.271.9e-02Click!


Activity profile for motif Esr2.

activity profile for motif Esr2


Sorted Z-values histogram for motif Esr2

Sorted Z-values for motif Esr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 21.452 ENSMUST00000017488.4
 Vtn
vitronectin
chr4_-_136892867 17.026 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr6_+_90550789 15.530 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr2_-_25469742 14.383 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 14.348 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr18_+_20665250 12.175 ENSMUST00000075312.3
 Ttr
transthyretin
chrX_+_150547375 11.137 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr11_+_32296489 11.093 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr14_-_31168587 10.797 ENSMUST00000036618.7
 Stab1
stabilin 1
chr11_+_32283511 10.509 ENSMUST00000093209.3
 Hba-a1
hemoglobin alpha, adult chain 1
chr7_-_79386943 9.536 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr11_+_101246960 9.387 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr7_-_19698206 9.189 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr8_+_70501116 9.182 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr11_-_6065538 9.085 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr5_-_116422858 8.674 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr12_+_112620030 8.649 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chr7_-_19698383 8.576 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr17_+_35076902 8.193 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr2_+_170731807 8.142 ENSMUST00000029075.4
 Dok5
docking protein 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 907 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.1 30.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
2.5 27.2 GO:0097421 liver regeneration(GO:0097421)
0.6 21.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.5 19.2 GO:0043589 skin morphogenesis(GO:0043589)
5.9 17.8 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
2.5 17.5 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.1 16.4 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
2.3 16.1 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
5.2 15.5 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
3.8 15.3 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
1.1 14.9 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
4.7 14.1 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430)
0.6 14.1 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.5 14.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.7 13.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
2.2 13.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.3 13.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
2.6 13.0 GO:0070327 thyroid hormone transport(GO:0070327)
1.5 12.4 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
2.0 12.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 342 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 59.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 58.9 GO:0005739 mitochondrion(GO:0005739)
0.2 51.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 42.3 GO:0031012 extracellular matrix(GO:0031012)
0.8 37.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 36.4 GO:0005887 integral component of plasma membrane(GO:0005887)
4.5 27.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 26.1 GO:0005615 extracellular space(GO:0005615)
0.5 25.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 25.6 GO:0005925 focal adhesion(GO:0005925)
2.0 24.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 22.7 GO:0005768 endosome(GO:0005768)
0.4 21.8 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
5.4 21.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 21.5 GO:0072562 blood microparticle(GO:0072562)
0.3 21.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 20.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 19.3 GO:0009986 cell surface(GO:0009986)
1.3 18.8 GO:0005614 interstitial matrix(GO:0005614)
2.3 18.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 538 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 45.9 GO:0003735 structural constituent of ribosome(GO:0003735)
1.5 33.6 GO:0005044 scavenger receptor activity(GO:0005044)
2.0 30.4 GO:0046977 TAP binding(GO:0046977)
7.3 29.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 28.7 GO:0008201 heparin binding(GO:0008201)
1.4 27.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 24.5 GO:0003924 GTPase activity(GO:0003924)
0.6 22.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
5.4 21.6 GO:0031720 haptoglobin binding(GO:0031720)
2.3 20.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.7 19.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 19.7 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.8 18.4 GO:0001968 fibronectin binding(GO:0001968)
5.9 17.8 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.3 17.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 17.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
2.4 16.7 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.3 16.5 GO:0005179 hormone activity(GO:0005179)
0.3 15.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.4 15.7 GO:0005158 insulin receptor binding(GO:0005158)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 56.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.2 52.9 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.3 44.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 27.3 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.2 20.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 18.5 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.3 17.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.4 14.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.5 14.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.5 14.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.2 13.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.5 12.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.7 12.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 12.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.5 11.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.5 10.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 10.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 10.6 PID_LKB1_PATHWAY LKB1 signaling events
0.5 10.5 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.4 9.5 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 64.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.5 41.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 39.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.4 23.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
1.8 23.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 21.1 REACTOME_AMYLOIDS Genes involved in Amyloids
0.3 21.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.9 20.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.5 20.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.7 19.2 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.4 18.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 17.4 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.6 17.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.4 17.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.5 17.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
2.8 16.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 13.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.6 12.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 12.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
2.0 12.2 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport