Motif ID: Esrrb_Esrra

Z-value: 1.322

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrrbmm10_v2_chr12_+_86421628_86421662-0.171.3e-01Click!
Esrramm10_v2_chr19_-_6921753_6921803-0.123.1e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 24.485 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr11_+_7063423 22.003 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr19_-_57314896 17.518 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr3_-_54915867 14.812 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr2_+_121357714 14.524 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr4_+_13751297 14.508 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr5_-_110343009 13.774 ENSMUST00000058016.9
ENSMUST00000112478.3
 P2rx2

purinergic receptor P2X, ligand-gated ion channel, 2

chr8_+_124793013 13.641 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr8_+_124793061 13.604 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr15_-_79804717 12.030 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr5_+_63649335 11.894 ENSMUST00000159584.1
 3110047P20Rik
RIKEN cDNA 3110047P20 gene
chrX_-_72656135 11.771 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr2_+_121358591 11.770 ENSMUST00000000317.6
ENSMUST00000129130.1
 Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr7_-_74554474 11.671 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr19_+_6399857 11.231 ENSMUST00000146601.1
ENSMUST00000150713.1
 Rasgrp2

RAS, guanyl releasing protein 2

chr6_+_38663061 11.063 ENSMUST00000114874.3
 Clec2l
C-type lectin domain family 2, member L
chr19_+_6400523 10.792 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr11_+_42419729 10.742 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr7_-_141429351 9.982 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chr8_-_13494479 9.936 ENSMUST00000033828.5
 Gas6
growth arrest specific 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 261 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 27.2 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.5 26.7 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 23.2 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
1.6 22.0 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.5 19.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.5 19.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
6.2 18.6 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.3 18.1 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
1.9 17.2 GO:0071420 cellular response to histamine(GO:0071420)
0.7 16.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 16.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 15.3 GO:0032091 negative regulation of protein binding(GO:0032091)
1.5 13.8 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
1.2 13.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.6 12.6 GO:0019388 galactose catabolic process(GO:0019388)
0.6 11.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 11.8 GO:0014003 oligodendrocyte development(GO:0014003)
3.7 11.2 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
3.3 9.9 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.6 9.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 57.2 GO:0030054 cell junction(GO:0030054)
0.3 35.9 GO:0043204 perikaryon(GO:0043204)
1.9 28.9 GO:1902711 GABA-A receptor complex(GO:1902711)
1.4 22.0 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
1.1 20.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.4 19.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 19.0 GO:0009925 basal plasma membrane(GO:0009925)
1.4 14.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.9 14.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 13.8 GO:0000118 histone deacetylase complex(GO:0000118)
1.6 12.9 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
1.1 12.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.3 11.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 11.1 GO:0016363 nuclear matrix(GO:0016363)
0.2 10.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 10.3 GO:0005604 basement membrane(GO:0005604)
0.1 10.0 GO:0043209 myelin sheath(GO:0043209)
0.2 9.9 GO:0030018 Z disc(GO:0030018)
1.0 9.5 GO:0032426 stereocilium tip(GO:0032426)
0.1 9.5 GO:0019898 extrinsic component of membrane(GO:0019898)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 38.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
7.4 29.8 GO:0004111 creatine kinase activity(GO:0004111)
3.7 22.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.9 20.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
2.8 19.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.1 18.2 GO:0004890 GABA-A receptor activity(GO:0004890)
1.1 16.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 15.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 15.5 GO:0030246 carbohydrate binding(GO:0030246)
0.6 14.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
2.3 13.8 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) mercury ion binding(GO:0045340)
3.2 12.9 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
2.6 12.9 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.4 12.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.8 12.6 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.5 12.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
3.0 12.0 GO:0001847 opsonin receptor activity(GO:0001847)
0.1 11.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 11.5 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.5 11.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 32.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 22.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.3 22.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 12.3 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 11.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 10.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.2 9.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 7.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 7.0 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.4 5.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 4.3 PID_ARF_3PATHWAY Arf1 pathway
0.3 3.2 PID_ALK2_PATHWAY ALK2 signaling events
0.1 3.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.0 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 1.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.8 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 1.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.8 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 43.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
1.2 41.5 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
1.8 28.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.5 24.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
1.8 22.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
1.2 21.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
2.5 19.8 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.6 17.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 16.3 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.4 15.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 15.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.2 15.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.6 12.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 12.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 11.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
1.4 11.0 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.4 9.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 9.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.6 7.8 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.3 7.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation