Motif ID: Esrrg

Z-value: 0.364


Transcription factors associated with Esrrg:

Gene SymbolEntrez IDGene Name
Esrrg ENSMUSG00000026610.7 Esrrg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrrgmm10_v2_chr1_+_187997835_187997882-0.437.8e-05Click!


Activity profile for motif Esrrg.

activity profile for motif Esrrg


Sorted Z-values histogram for motif Esrrg

Sorted Z-values for motif Esrrg



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrg

PNG image of the network

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Top targets:


Showing 1 to 20 of 178 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_68869563 3.413 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr9_-_107668967 2.458 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr1_+_104768510 2.193 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr10_+_79716588 2.157 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr7_-_93081027 1.974 ENSMUST00000098303.1
 Gm9934
predicted gene 9934
chr7_-_105482197 1.767 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr9_+_37401993 1.761 ENSMUST00000115046.1
ENSMUST00000102895.4
 Robo4

roundabout homolog 4 (Drosophila)

chr19_+_6400523 1.461 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr3_+_90514435 1.423 ENSMUST00000048138.6
ENSMUST00000181271.1
 S100a13

S100 calcium binding protein A13

chr3_-_90514250 1.358 ENSMUST00000107340.1
ENSMUST00000060738.8
 S100a1

S100 calcium binding protein A1

chr9_+_37401897 1.310 ENSMUST00000115048.1
 Robo4
roundabout homolog 4 (Drosophila)
chr5_-_137613759 1.310 ENSMUST00000155251.1
ENSMUST00000124693.1
 Pcolce

procollagen C-endopeptidase enhancer protein

chr19_+_6399857 1.198 ENSMUST00000146601.1
ENSMUST00000150713.1
 Rasgrp2

RAS, guanyl releasing protein 2

chr16_-_95459245 1.165 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
 Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr19_+_6400611 1.122 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr8_-_46294592 1.061 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr1_+_75546522 1.011 ENSMUST00000138814.1
 Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr19_+_6399746 0.995 ENSMUST00000113468.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr19_-_43674844 0.976 ENSMUST00000046038.7
 Slc25a28
solute carrier family 25, member 28
chr8_-_105295934 0.962 ENSMUST00000057855.3
 Exoc3l
exocyst complex component 3-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 3.4 GO:2000146 negative regulation of cell motility(GO:2000146)
0.5 2.5 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.4 2.2 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.0 2.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.5 1.4 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.2 1.4 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 1.3 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.2 1.2 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.1 1.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 1.1 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 1.0 GO:0051601 exocyst localization(GO:0051601)
0.3 0.9 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.9 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.3 0.8 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0 0.8 GO:0051453 regulation of intracellular pH(GO:0051453)
0.2 0.7 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.1 0.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 0.7 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.7 2.2 GO:0098855 HCN channel complex(GO:0098855)
0.0 2.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:0031430 M band(GO:0031430)
0.0 1.4 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 1.2 GO:0030315 T-tubule(GO:0030315)
0.1 1.1 GO:0046930 pore complex(GO:0046930)
0.1 1.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.0 GO:0000145 exocyst(GO:0000145)
0.2 0.9 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 0.8 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.7 GO:0005902 microvillus(GO:0005902)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.5 GO:0071439 clathrin complex(GO:0071439)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.8 2.5 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.5 2.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 1.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 1.4 GO:0044548 S100 protein binding(GO:0044548)
0.0 1.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.0 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.3 0.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.9 GO:0030332 cyclin binding(GO:0030332)
0.2 0.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.8 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.7 GO:0015288 porin activity(GO:0015288)
0.0 0.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.6 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 2.7 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 2.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.0 0.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 0.6 REACTOME_SHC_MEDIATED_SIGNALLING Genes involved in SHC-mediated signalling
0.0 0.6 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 0.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis