Motif ID: Ets1

Z-value: 0.854


Transcription factors associated with Ets1:

Gene SymbolEntrez IDGene Name
Ets1 ENSMUSG00000032035.9 Ets1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets1mm10_v2_chr9_+_32696005_32696121-0.262.1e-02Click!


Activity profile for motif Ets1.

activity profile for motif Ets1


Sorted Z-values histogram for motif Ets1

Sorted Z-values for motif Ets1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 7.806 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr4_-_63403330 6.957 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr11_-_20112876 5.866 ENSMUST00000000137.7
 Actr2
ARP2 actin-related protein 2
chr6_-_115994953 5.153 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr7_-_127218390 5.113 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr7_-_127218303 5.059 ENSMUST00000106313.1
 Sept1
septin 1
chr11_-_76509419 4.649 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr9_+_110476985 4.143 ENSMUST00000084948.4
ENSMUST00000061155.6
ENSMUST00000140686.1
ENSMUST00000084952.5
 Kif9



kinesin family member 9



chr11_+_96464587 4.053 ENSMUST00000103154.4
ENSMUST00000100521.3
ENSMUST00000100519.4
ENSMUST00000071510.7
ENSMUST00000107662.2
 Skap1




src family associated phosphoprotein 1




chr9_-_66514567 4.012 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr10_-_6980376 3.923 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr18_+_50030977 3.334 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr1_+_107511489 3.290 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr17_+_29090969 3.247 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr11_-_105944412 3.244 ENSMUST00000019734.4
ENSMUST00000184269.1
ENSMUST00000150563.1
 Cyb561


cytochrome b-561


chr7_+_62348277 3.232 ENSMUST00000038775.4
 Ndn
necdin
chr13_-_49309217 3.232 ENSMUST00000110087.2
 Fgd3
FYVE, RhoGEF and PH domain containing 3
chr14_-_19977040 3.148 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr1_+_107511416 3.046 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr14_-_19977151 2.999 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 456 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 10.7 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.1 8.1 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 7.7 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.2 7.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.9 6.9 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
2.0 5.9 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.2 5.3 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.2 5.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.7 5.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 5.2 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
1.0 5.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
1.2 5.0 GO:0030576 Cajal body organization(GO:0030576)
0.3 4.9 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.9 4.6 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
1.5 4.5 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 4.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.9 4.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.4 3.9 GO:0042989 sequestering of actin monomers(GO:0042989)
0.3 3.8 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.2 3.8 GO:0007413 axonal fasciculation(GO:0007413)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 238 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.8 GO:0002102 podosome(GO:0002102)
0.0 12.0 GO:0016607 nuclear speck(GO:0016607)
1.1 10.3 GO:0072687 meiotic spindle(GO:0072687)
0.3 8.0 GO:0000242 pericentriolar material(GO:0000242)
0.1 7.6 GO:0001650 fibrillar center(GO:0001650)
0.2 7.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 7.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 6.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 6.3 GO:0005911 cell-cell junction(GO:0005911)
0.0 6.3 GO:0005730 nucleolus(GO:0005730)
0.7 5.9 GO:0030478 actin cap(GO:0030478)
0.3 5.5 GO:0030008 TRAPP complex(GO:0030008)
0.2 4.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.6 4.8 GO:0005818 aster(GO:0005818)
0.2 4.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.8 GO:0015030 Cajal body(GO:0015030)
0.1 4.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 4.5 GO:0005814 centriole(GO:0005814)
0.0 4.5 GO:0098794 postsynapse(GO:0098794)
0.2 4.3 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 308 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.5 9.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 8.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.2 7.7 GO:0042169 SH2 domain binding(GO:0042169)
0.2 7.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.4 6.9 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 6.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 6.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 6.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 6.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 6.3 GO:0005525 GTP binding(GO:0005525)
0.1 6.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 5.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 5.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 5.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 5.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 5.3 GO:0002039 p53 binding(GO:0002039)
0.6 5.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 5.2 GO:0019003 GDP binding(GO:0019003)
1.7 5.0 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.3 12.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.7 9.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 9.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.3 8.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 7.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 6.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 6.4 PID_CD40_PATHWAY CD40/CD40L signaling
0.2 6.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 4.3 PID_ARF_3PATHWAY Arf1 pathway
0.2 3.8 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.2 3.0 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.2 2.8 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.7 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 2.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 2.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.1 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.5 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.3 11.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 11.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 8.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 7.5 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.5 7.4 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 7.1 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.2 6.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 6.5 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.2 6.1 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.9 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.1 4.4 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.2 4.0 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 3.9 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 3.7 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 3.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.4 3.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 3.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 3.0 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.2 2.9 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC