Motif ID: Ets2

Z-value: 1.206


Transcription factors associated with Ets2:

Gene SymbolEntrez IDGene Name
Ets2 ENSMUSG00000022895.8 Ets2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets2mm10_v2_chr16_+_95702044_957020940.755.0e-15Click!


Activity profile for motif Ets2.

activity profile for motif Ets2


Sorted Z-values histogram for motif Ets2

Sorted Z-values for motif Ets2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 25.447 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr6_+_5725812 22.064 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr15_-_66969616 17.129 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr5_-_44799643 14.992 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr9_-_29411736 13.321 ENSMUST00000115236.1
 Ntm
neurotrimin
chr1_-_56969864 12.814 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 12.636 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr11_-_55419898 12.549 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr11_-_67922136 12.015 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr10_+_85386813 11.670 ENSMUST00000105307.1
ENSMUST00000020231.3
 Btbd11

BTB (POZ) domain containing 11

chr17_+_3397189 10.335 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr17_-_68004075 9.510 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr15_-_37458523 8.938 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr7_-_4546567 8.623 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr7_+_30413744 8.381 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr4_+_128058962 8.294 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr2_-_5714490 8.038 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr19_-_57360668 7.737 ENSMUST00000181921.1
 B230217O12Rik
RIKEN cDNA B230217O12 gene
chr4_+_103313806 7.671 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr17_+_55445550 6.979 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 47.5 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 28.4 GO:0007266 Rho protein signal transduction(GO:0007266)
1.6 25.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.6 17.1 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
1.5 13.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.4 12.5 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.2 11.7 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 9.6 GO:0016579 protein deubiquitination(GO:0016579)
2.4 9.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 9.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.2 8.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 8.5 GO:0010669 epithelial structure maintenance(GO:0010669)
0.7 8.4 GO:0002283 neutrophil activation involved in immune response(GO:0002283)
1.1 8.0 GO:0060267 positive regulation of respiratory burst(GO:0060267)
1.5 7.7 GO:0010637 diet induced thermogenesis(GO:0002024) negative regulation of mitochondrial fusion(GO:0010637)
0.8 7.2 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.5 7.0 GO:0036296 cellular response to increased oxygen levels(GO:0036295) response to increased oxygen levels(GO:0036296)
0.4 7.0 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 6.8 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
1.1 6.6 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
15.8 47.5 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.5 17.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.5 13.6 GO:0031430 M band(GO:0031430)
0.1 13.3 GO:0031225 anchored component of membrane(GO:0031225)
3.1 12.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.0 11.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 11.5 GO:0000139 Golgi membrane(GO:0000139)
0.2 11.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 11.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 10.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 10.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 9.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 8.7 GO:0031410 cytoplasmic vesicle(GO:0031410)
2.2 8.6 GO:1990769 proximal neuron projection(GO:1990769)
0.9 7.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.9 6.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 6.4 GO:0005604 basement membrane(GO:0005604)
1.3 6.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.0 6.2 GO:0000235 astral microtubule(GO:0000235)
0.3 5.8 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 47.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 36.3 GO:0005096 GTPase activator activity(GO:0005096)
0.4 27.8 GO:0030276 clathrin binding(GO:0030276)
0.2 16.9 GO:0008565 protein transporter activity(GO:0008565)
0.2 14.7 GO:0005518 collagen binding(GO:0005518)
0.4 14.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 14.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.3 14.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 13.6 GO:0030507 spectrin binding(GO:0030507)
0.0 13.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 12.2 GO:0008013 beta-catenin binding(GO:0008013)
0.1 9.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.7 8.7 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 8.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 7.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 7.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
1.4 7.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.8 6.9 GO:0030274 LIM domain binding(GO:0030274)
2.1 6.4 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 6.4 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 21.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 15.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 13.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 12.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.3 8.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 7.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 6.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 5.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 4.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 4.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 4.3 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 3.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.5 PID_ARF_3PATHWAY Arf1 pathway
0.1 3.5 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.2 PID_BCR_5PATHWAY BCR signaling pathway
0.1 3.2 PID_INSULIN_PATHWAY Insulin Pathway
0.1 2.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 66.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 15.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 14.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.8 13.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4 10.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 10.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 8.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.7 8.8 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 8.4 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.2 6.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 6.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 5.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 5.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 5.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.4 5.3 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 4.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.4 4.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 4.3 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.7 4.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 4.0 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters