Motif ID: Etv1_Etv5_Gabpa

Z-value: 1.563

Transcription factors associated with Etv1_Etv5_Gabpa:

Gene SymbolEntrez IDGene Name
Etv1 ENSMUSG00000004151.10 Etv1
Etv5 ENSMUSG00000013089.9 Etv5
Gabpa ENSMUSG00000008976.10 Gabpa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv5mm10_v2_chr16_-_22439719_22439733-0.693.8e-12Click!
Etv1mm10_v2_chr12_+_38783455_387834820.225.5e-02Click!
Gabpamm10_v2_chr16_+_84835070_84835124-0.019.0e-01Click!


Activity profile for motif Etv1_Etv5_Gabpa.

activity profile for motif Etv1_Etv5_Gabpa


Sorted Z-values histogram for motif Etv1_Etv5_Gabpa

Sorted Z-values for motif Etv1_Etv5_Gabpa



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv1_Etv5_Gabpa

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_127042420 20.239 ENSMUST00000032915.6
 Kif22
kinesin family member 22
chr2_+_105682463 16.103 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr2_+_152847961 15.427 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr2_+_5845243 15.248 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr2_+_118814237 14.854 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr2_+_152847993 14.539 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr19_+_6084983 14.385 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr4_-_43499608 14.105 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr2_+_118814195 13.769 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr1_+_187215501 12.966 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
 Gpatch2



G patch domain containing 2



chr16_+_48994185 12.821 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr2_+_118813995 12.621 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr17_-_33890584 12.567 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr9_-_96889381 12.389 ENSMUST00000112951.2
ENSMUST00000126411.1
ENSMUST00000078478.1
ENSMUST00000119141.1
ENSMUST00000120101.1
 Acpl2




acid phosphatase-like 2




chr16_-_22161450 12.142 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chrX_+_100625737 11.313 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr2_+_73312601 11.102 ENSMUST00000090811.4
ENSMUST00000112050.1
 Scrn3

secernin 3

chr9_-_105395237 10.998 ENSMUST00000140851.1
 Nek11
NIMA (never in mitosis gene a)-related expressed kinase 11
chr14_+_31495065 10.490 ENSMUST00000022446.5
 Eaf1
ELL associated factor 1
chr17_-_33890539 10.472 ENSMUST00000173386.1
 Kifc1
kinesin family member C1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 741 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 53.9 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
2.9 51.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 50.4 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
6.9 27.8 GO:0019323 pentose catabolic process(GO:0019323)
0.4 27.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.2 26.6 GO:0007080 mitotic metaphase plate congression(GO:0007080)
1.0 25.8 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
7.7 23.0 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.3 22.8 GO:0006413 translational initiation(GO:0006413)
0.2 20.9 GO:0007059 chromosome segregation(GO:0007059)
0.7 20.7 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.5 18.8 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
1.0 18.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.5 17.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
1.3 16.7 GO:0007076 mitotic chromosome condensation(GO:0007076)
3.2 16.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.2 16.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.2 15.9 GO:0007050 cell cycle arrest(GO:0007050)
1.0 15.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
4.8 14.4 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 319 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 53.0 GO:0005634 nucleus(GO:0005634)
1.0 51.6 GO:0005871 kinesin complex(GO:0005871)
1.3 44.5 GO:0035371 microtubule plus-end(GO:0035371)
2.1 39.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 34.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
4.2 33.2 GO:0005818 aster(GO:0005818)
1.0 22.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 22.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.8 20.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
3.2 19.1 GO:0031262 Ndc80 complex(GO:0031262)
0.3 19.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 18.5 GO:0016607 nuclear speck(GO:0016607)
1.1 16.9 GO:0017119 Golgi transport complex(GO:0017119)
0.1 16.2 GO:0016604 nuclear body(GO:0016604)
1.0 15.8 GO:0030008 TRAPP complex(GO:0030008)
3.1 15.7 GO:0048476 Holliday junction resolvase complex(GO:0048476)
1.6 15.6 GO:0031595 nuclear proteasome complex(GO:0031595)
1.3 15.1 GO:0005687 U4 snRNP(GO:0005687)
0.3 13.8 GO:0045171 intercellular bridge(GO:0045171)
0.2 13.7 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 427 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 51.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 41.0 GO:0003777 microtubule motor activity(GO:0003777)
3.4 30.2 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.3 29.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.9 25.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.4 24.7 GO:0003743 translation initiation factor activity(GO:0003743)
7.7 23.1 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
1.6 22.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 21.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.4 20.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.3 20.3 GO:0003680 AT DNA binding(GO:0003680)
0.4 18.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 17.2 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
2.1 16.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
1.2 16.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 14.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.3 14.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 13.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.8 12.9 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.4 12.5 GO:0051059 NF-kappaB binding(GO:0051059)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 54.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.7 33.6 PID_ATR_PATHWAY ATR signaling pathway
0.7 28.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 20.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 19.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.3 18.5 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.6 18.1 PID_MYC_PATHWAY C-MYC pathway
0.3 12.9 PID_PLK1_PATHWAY PLK1 signaling events
0.2 11.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 11.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 11.2 PID_CDC42_PATHWAY CDC42 signaling events
0.3 10.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 9.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 8.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 8.6 PID_MTOR_4PATHWAY mTOR signaling pathway
0.3 8.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 8.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 8.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.3 8.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 6.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 60.1 REACTOME_KINESINS Genes involved in Kinesins
0.5 49.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.2 47.3 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.8 41.4 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 36.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 33.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.6 31.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 28.7 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
1.6 19.8 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.7 19.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
1.3 17.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.7 17.0 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.7 16.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.1 14.7 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.6 14.7 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.5 14.0 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.2 11.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.5 11.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 10.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.5 10.0 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation