Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3

Z-value: 0.661

Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3:

Gene SymbolEntrez IDGene Name
Elk1 ENSMUSG00000009406.7 Elk1
Elk3 ENSMUSG00000008398.8 Elk3
Elk4 ENSMUSG00000026436.9 Elk4
Erf ENSMUSG00000040857.9 Erf
Etv3 ENSMUSG00000003382.12 Etv3
Fev ENSMUSG00000055197.4 Fev

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elk4mm10_v2_chr1_+_132008285_1320083160.584.2e-08Click!
Elk3mm10_v2_chr10_-_93310963_93310989-0.252.8e-02Click!
Erfmm10_v2_chr7_-_25250720_252507610.181.1e-01Click!
Etv3mm10_v2_chr3_+_87525572_875256430.151.9e-01Click!
Elk1mm10_v2_chrX_-_20950597_209506130.152.1e-01Click!


Activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3.

activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3


Sorted Z-values histogram for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3

Sorted Z-values for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_48816936 4.979 ENSMUST00000140800.1
 Trim41
tripartite motif-containing 41
chr11_+_54522872 4.578 ENSMUST00000108895.1
ENSMUST00000101206.3
 Rapgef6

Rap guanine nucleotide exchange factor (GEF) 6

chr12_-_64965496 4.573 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr2_+_163602331 4.085 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr16_-_87432597 3.981 ENSMUST00000039449.7
 Ltn1
listerin E3 ubiquitin protein ligase 1
chr11_-_104550392 3.955 ENSMUST00000106962.2
 Cdc27
cell division cycle 27
chr5_-_3803081 3.907 ENSMUST00000043551.6
 Ankib1
ankyrin repeat and IBR domain containing 1
chr11_-_48817332 3.878 ENSMUST00000047145.7
 Trim41
tripartite motif-containing 41
chrX_-_12762069 3.655 ENSMUST00000096495.4
ENSMUST00000076016.5
 Med14

mediator complex subunit 14

chr14_+_75284343 3.633 ENSMUST00000022577.5
 Zc3h13
zinc finger CCCH type containing 13
chr19_-_28011138 3.605 ENSMUST00000174850.1
 Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr11_-_42182924 3.591 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr18_-_84589491 3.522 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr9_-_29411736 3.337 ENSMUST00000115236.1
 Ntm
neurotrimin
chr6_+_8259288 3.329 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr16_-_3872378 3.211 ENSMUST00000090522.4
 Zfp597
zinc finger protein 597
chr6_-_29609811 3.207 ENSMUST00000012679.8
 Tnpo3
transportin 3
chr9_+_65908967 3.180 ENSMUST00000034949.3
ENSMUST00000154589.1
 Csnk1g1

casein kinase 1, gamma 1

chr14_-_49066368 3.160 ENSMUST00000161504.1
 Exoc5
exocyst complex component 5
chr9_-_110476637 3.153 ENSMUST00000111934.1
ENSMUST00000068025.6
 Klhl18

kelch-like 18


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 415 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.8 7.6 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.3 7.2 GO:0030033 microvillus assembly(GO:0030033)
0.1 6.9 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.4 5.7 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.6 5.6 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
1.6 4.8 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.5 4.6 GO:0071420 cellular response to histamine(GO:0071420)
0.9 4.5 GO:0021764 amygdala development(GO:0021764)
1.5 4.4 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.6 4.4 GO:0030242 pexophagy(GO:0030242)
0.0 4.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.5 4.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 4.1 GO:0002076 osteoblast development(GO:0002076)
1.3 3.9 GO:0019085 early viral transcription(GO:0019085)
1.0 3.9 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
0.1 3.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 3.7 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.9 3.6 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.2 3.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.1 GO:0005815 microtubule organizing center(GO:0005815)
0.0 9.0 GO:0016604 nuclear body(GO:0016604)
0.2 8.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 8.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
1.3 7.6 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.3 6.4 GO:0000145 exocyst(GO:0000145)
0.1 6.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 5.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.7 5.7 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
1.1 5.6 GO:1990745 EARP complex(GO:1990745)
0.1 5.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 4.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 4.6 GO:0031965 nuclear membrane(GO:0031965)
0.0 4.6 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.5 4.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 3.9 GO:0071439 clathrin complex(GO:0071439)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.2 3.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 3.7 GO:0030877 beta-catenin destruction complex(GO:0030877)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 268 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.0 GO:0008270 zinc ion binding(GO:0008270)
0.0 21.7 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 10.5 GO:0000149 SNARE binding(GO:0000149)
0.4 8.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.4 7.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 7.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 6.5 GO:0030276 clathrin binding(GO:0030276)
0.3 5.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 5.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 5.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.2 5.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 4.9 GO:0051219 phosphoprotein binding(GO:0051219)
0.8 4.6 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 4.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.7 4.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 4.1 GO:0019903 protein phosphatase binding(GO:0019903)
0.1 4.0 GO:0051018 protein kinase A binding(GO:0051018)
0.8 3.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 3.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 3.9 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 6.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 6.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 5.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 4.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 3.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 3.0 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.7 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 2.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.3 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 2.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 2.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.2 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.1 2.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.6 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 8.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.4 7.5 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.3 7.1 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 6.1 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.3 5.6 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 5.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 5.2 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.3 4.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 4.4 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.3 4.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 3.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 3.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 3.5 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.3 3.4 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 3.0 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 2.9 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 2.5 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.2 2.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP