Motif ID: Etv6

Z-value: 0.915


Transcription factors associated with Etv6:

Gene SymbolEntrez IDGene Name
Etv6 ENSMUSG00000030199.10 Etv6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv6mm10_v2_chr6_+_134035691_134035717-0.243.6e-02Click!


Activity profile for motif Etv6.

activity profile for motif Etv6


Sorted Z-values histogram for motif Etv6

Sorted Z-values for motif Etv6



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_168230597 2.992 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr5_-_31220491 2.611 ENSMUST00000031032.7
 Ppm1g
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
chr2_+_180257373 2.327 ENSMUST00000059080.6
 Rps21
ribosomal protein S21
chr7_-_4546567 2.292 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr15_+_58933774 2.086 ENSMUST00000022980.3
 Ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr3_-_94886945 2.013 ENSMUST00000005923.6
 Psmb4
proteasome (prosome, macropain) subunit, beta type 4
chr1_+_58586381 2.003 ENSMUST00000027193.8
 Ndufb3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3
chr5_-_116024452 1.989 ENSMUST00000031486.7
 Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr17_+_35135695 1.943 ENSMUST00000174478.1
ENSMUST00000174281.2
ENSMUST00000173550.1
 Bag6


BCL2-associated athanogene 6


chr4_+_155943824 1.904 ENSMUST00000103175.1
ENSMUST00000166489.1
ENSMUST00000024056.3
ENSMUST00000136492.1
ENSMUST00000105583.2
ENSMUST00000152536.1
 Ube2j2





ubiquitin-conjugating enzyme E2J 2





chr14_-_31001588 1.893 ENSMUST00000162092.1
ENSMUST00000160342.1
 Spcs1

signal peptidase complex subunit 1 homolog (S. cerevisiae)

chr1_+_33669816 1.877 ENSMUST00000051203.5
 1700001G17Rik
RIKEN cDNA 1700001G17 gene
chr9_+_48450327 1.854 ENSMUST00000165252.1
 Gm5616
predicted gene 5616
chr9_-_79759849 1.836 ENSMUST00000034881.6
 Cox7a2
cytochrome c oxidase subunit VIIa 2
chr15_+_78877172 1.836 ENSMUST00000041587.7
 Gga1
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr8_-_70510322 1.827 ENSMUST00000140679.1
ENSMUST00000129909.1
ENSMUST00000081940.4
 Uba52


ubiquitin A-52 residue ribosomal protein fusion product 1


chr5_-_115348953 1.823 ENSMUST00000040154.8
 Cox6a1
cytochrome c oxidase subunit VIa polypeptide 1
chr4_-_98383232 1.807 ENSMUST00000143116.1
ENSMUST00000030292.5
ENSMUST00000102793.4
 Tm2d1


TM2 domain containing 1


chr5_-_116024475 1.805 ENSMUST00000111999.1
 Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr15_-_34443508 1.780 ENSMUST00000079735.5
 Rpl30
ribosomal protein L30

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.6 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.9 6.9 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 6.3 GO:0006412 translation(GO:0006412)
0.4 4.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.3 4.6 GO:0006465 signal peptide processing(GO:0006465)
0.0 4.1 GO:0008643 carbohydrate transport(GO:0008643)
0.6 3.8 GO:0035878 nail development(GO:0035878)
0.5 3.6 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 3.6 GO:0032543 mitochondrial translation(GO:0032543)
0.4 3.5 GO:0071569 protein ufmylation(GO:0071569)
0.2 3.5 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.2 3.1 GO:0000338 protein deneddylation(GO:0000338)
0.7 3.0 GO:0018307 tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307)
0.0 3.0 GO:0050714 positive regulation of protein secretion(GO:0050714)
0.1 2.9 GO:0048268 clathrin coat assembly(GO:0048268)
1.3 2.7 GO:2000157 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.1 2.7 GO:0016601 Rac protein signal transduction(GO:0016601)
0.2 2.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 2.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 2.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.0 6.9 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 5.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 5.6 GO:0000139 Golgi membrane(GO:0000139)
0.2 5.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.6 4.6 GO:0005787 signal peptidase complex(GO:0005787)
0.6 4.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 4.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 3.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 3.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 3.5 GO:0005839 proteasome core complex(GO:0005839)
0.0 3.4 GO:0032587 ruffle membrane(GO:0032587)
1.0 2.9 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.2 2.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 2.5 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.3 2.4 GO:0000243 commitment complex(GO:0000243)
0.2 2.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 2.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.6 2.3 GO:1990769 proximal neuron projection(GO:1990769)
0.2 2.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 8.8 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.5 6.9 GO:0015643 toxic substance binding(GO:0015643)
0.0 6.0 GO:0008022 protein C-terminus binding(GO:0008022)
0.7 5.5 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 5.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 4.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 4.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 4.2 GO:0017124 SH3 domain binding(GO:0017124)
1.0 4.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.4 3.8 GO:1990446 U1 snRNP binding(GO:1990446)
0.4 3.8 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 3.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 3.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 3.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.6 3.0 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.2 2.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 2.9 GO:0031386 protein tag(GO:0031386)
0.7 2.7 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.1 2.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 PID_LKB1_PATHWAY LKB1 signaling events
0.2 4.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.7 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 3.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 2.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 1.9 PID_MYC_PATHWAY C-MYC pathway
0.1 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 1.0 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.0 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.8 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 8.5 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.1 8.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 7.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 6.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.4 4.8 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.3 4.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 4.3 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.1 4.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.3 3.8 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 3.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 3.3 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.0 3.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 2.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 2.4 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 2.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 2.3 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 2.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection