Motif ID: Evx2

Z-value: 0.991


Transcription factors associated with Evx2:

Gene SymbolEntrez IDGene Name
Evx2 ENSMUSG00000001815.9 Evx2



Activity profile for motif Evx2.

activity profile for motif Evx2


Sorted Z-values histogram for motif Evx2

Sorted Z-values for motif Evx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Evx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_109978004 16.214 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chrX_-_60893430 15.384 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_-_98030727 11.332 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr13_+_51645232 10.110 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr2_+_119047116 9.819 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr2_+_119047129 9.481 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr7_+_51879041 8.961 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr2_-_168767136 8.340 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chrX_+_58030999 8.137 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr14_+_62292475 7.512 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chr18_-_88927447 6.702 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chr2_+_154548888 6.386 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chrX_+_58030622 6.324 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr9_-_66514567 5.675 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr15_+_34453285 5.193 ENSMUST00000060894.7
 BC030476
cDNA sequence BC030476
chr4_-_132075250 4.934 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chr11_+_60537978 4.736 ENSMUST00000044250.3
 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr4_-_42661893 4.413 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr2_-_132247747 4.358 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
 Tmem230


transmembrane protein 230


chr2_-_168767029 4.201 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr10_-_8886033 3.455 ENSMUST00000015449.5
 Sash1
SAM and SH3 domain containing 1
chr10_+_80264942 3.447 ENSMUST00000105362.1
ENSMUST00000105361.3
 Dazap1

DAZ associated protein 1

chr4_+_140701466 3.178 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr12_+_52699297 3.120 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr4_-_129227883 3.070 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr14_+_73173825 2.992 ENSMUST00000166875.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr17_+_17402672 2.803 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr4_-_132345686 2.469 ENSMUST00000030726.6
 Rcc1
regulator of chromosome condensation 1
chr16_-_45724600 2.462 ENSMUST00000096057.4
 Tagln3
transgelin 3
chr5_-_84417359 2.365 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr4_-_132345715 2.255 ENSMUST00000084250.4
 Rcc1
regulator of chromosome condensation 1
chr19_+_5088534 2.039 ENSMUST00000025811.4
 Yif1a
Yip1 interacting factor homolog A (S. cerevisiae)
chr11_-_61267177 2.007 ENSMUST00000066277.3
ENSMUST00000074127.7
ENSMUST00000108715.2
 Aldh3a2


aldehyde dehydrogenase family 3, subfamily A2


chr17_+_36837123 1.891 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
 Trim26





tripartite motif-containing 26





chrX_-_111536325 1.756 ENSMUST00000156639.1
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr9_-_85749308 1.738 ENSMUST00000039213.8
 Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr7_-_126800354 1.690 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr17_-_36032682 1.506 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr1_-_24612700 1.492 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr4_+_100478806 1.479 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
 Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr6_+_72097561 1.468 ENSMUST00000069994.4
ENSMUST00000114112.1
 St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr2_+_91256813 1.463 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
 Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr7_+_27927592 1.453 ENSMUST00000181644.1
 Gm26891
predicted gene, 26891
chr14_+_48446128 1.420 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr2_+_91257323 1.310 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr11_+_116843278 1.112 ENSMUST00000106370.3
 Mettl23
methyltransferase like 23
chr7_-_143460989 1.096 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr14_-_59365410 1.085 ENSMUST00000161031.1
ENSMUST00000160425.1
 Phf11d

PHD finger protein 11D

chr6_-_69284319 1.078 ENSMUST00000103349.1
 Igkv4-69
immunoglobulin kappa variable 4-69
chr3_+_94837702 1.051 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
 Pogz


pogo transposable element with ZNF domain


chr2_-_150255591 1.014 ENSMUST00000063463.5
 Gm21994
predicted gene 21994
chr11_+_75532099 1.006 ENSMUST00000169547.2
 Slc43a2
solute carrier family 43, member 2
chr13_+_38204928 0.992 ENSMUST00000091641.5
ENSMUST00000178564.1
 Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)

chr12_-_98577940 0.928 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr19_+_47067721 0.921 ENSMUST00000026027.5
 Taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr5_-_106926245 0.822 ENSMUST00000117588.1
 Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr6_-_69400097 0.743 ENSMUST00000177795.1
 Igkv4-62
immunoglobulin kappa variable 4-62
chrM_+_10167 0.711 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr8_+_14888022 0.692 ENSMUST00000123990.1
ENSMUST00000027554.7
 Cln8

ceroid-lipofuscinosis, neuronal 8

chrM_+_7759 0.467 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr7_+_29816061 0.453 ENSMUST00000032796.6
ENSMUST00000178162.1
 Zfp790

zinc finger protein 790

chr6_-_124779686 0.416 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr8_-_31168699 0.370 ENSMUST00000033983.4
 Mak16
MAK16 homolog (S. cerevisiae)
chr18_+_9958147 0.362 ENSMUST00000025137.7
 Thoc1
THO complex 1
chr11_+_116657106 0.194 ENSMUST00000116318.2
 Gm11744
predicted gene 11744
chr10_+_70175011 0.176 ENSMUST00000156001.1
ENSMUST00000135607.1
 Ccdc6

coiled-coil domain containing 6

chr17_-_47834682 0.169 ENSMUST00000066368.6
 Mdfi
MyoD family inhibitor
chr3_-_130709419 0.152 ENSMUST00000043937.7
 Ostc
oligosaccharyltransferase complex subunit
chr15_-_58034289 0.105 ENSMUST00000100655.3
 9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr11_+_35121126 0.065 ENSMUST00000069837.3
 Slit3
slit homolog 3 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 14.5 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.2 4.7 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
1.2 3.5 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
1.0 16.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.8 3.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.7 15.4 GO:0007530 sex determination(GO:0007530)
0.7 12.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.5 3.2 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.5 1.5 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.4 7.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 2.0 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.2 2.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 0.7 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.2 11.3 GO:1901998 toxin transport(GO:1901998)
0.2 10.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.2 1.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 1.1 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 3.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.8 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 2.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 1.9 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 0.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 4.7 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 6.7 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 2.8 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.8 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 9.0 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.7 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 4.4 GO:0048489 synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480)
0.0 1.5 GO:0016574 histone ubiquitination(GO:0016574)
0.0 2.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.7 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209) negative regulation of sequestering of calcium ion(GO:0051283)
0.0 1.0 GO:0015807 L-amino acid transport(GO:0015807)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 5.7 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.0 0.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.1 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0 0.2 GO:0060707 trophoblast giant cell differentiation(GO:0060707)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 2.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 3.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.2 1.5 GO:0033503 HULC complex(GO:0033503)
0.2 15.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 3.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 6.7 GO:0001772 immunological synapse(GO:0001772)
0.1 1.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 14.2 GO:0000792 heterochromatin(GO:0000792)
0.1 4.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 13.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 3.4 GO:0005844 polysome(GO:0005844)
0.0 0.4 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 3.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 4.4 GO:0055037 recycling endosome(GO:0055037)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)
0.0 2.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 4.7 GO:0016607 nuclear speck(GO:0016607)
0.0 30.9 GO:0005654 nucleoplasm(GO:0005654)
0.0 0.7 GO:0070469 respiratory chain(GO:0070469)
0.0 2.5 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.2 4.7 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
1.1 7.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.8 4.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.5 2.0 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.4 1.7 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.4 15.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 2.4 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.3 1.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 3.1 GO:0043495 protein anchor(GO:0043495)
0.2 2.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 1.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 3.4 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 3.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 6.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.5 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 12.1 GO:0008017 microtubule binding(GO:0008017)
0.0 14.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 28.8 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 7.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.0 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 2.5 GO:0051015 actin filament binding(GO:0051015)
0.0 0.8 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 9.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 12.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 4.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.6 PID_BCR_5PATHWAY BCR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 19.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 6.7 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 5.6 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.8 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 2.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 3.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane