Motif ID: Ezh2_Atf2_Ikzf1

Z-value: 1.715

Transcription factors associated with Ezh2_Atf2_Ikzf1:

Gene SymbolEntrez IDGene Name
Atf2 ENSMUSG00000027104.12 Atf2
Ezh2 ENSMUSG00000029687.10 Ezh2
Ikzf1 ENSMUSG00000018654.11 Ikzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ezh2mm10_v2_chr6_-_47594967_475950470.687.6e-12Click!
Atf2mm10_v2_chr2_-_73892588_738926160.551.9e-07Click!


Activity profile for motif Ezh2_Atf2_Ikzf1.

activity profile for motif Ezh2_Atf2_Ikzf1


Sorted Z-values histogram for motif Ezh2_Atf2_Ikzf1

Sorted Z-values for motif Ezh2_Atf2_Ikzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ezh2_Atf2_Ikzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_34745952 40.883 ENSMUST00000123823.1
ENSMUST00000136907.1
ENSMUST00000126181.1
 Cald1


caldesmon 1


chr1_-_190170671 37.666 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr6_+_34746368 34.584 ENSMUST00000142716.1
 Cald1
caldesmon 1
chr14_-_98169542 28.611 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr3_-_86548268 22.852 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr1_-_190170178 20.941 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr2_+_152081529 20.278 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr9_-_91365756 18.231 ENSMUST00000034927.6
 Zic1
zinc finger protein of the cerebellum 1
chr9_-_117252450 17.999 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
 Rbms3


RNA binding motif, single stranded interacting protein


chr9_-_91365778 16.457 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr11_+_44617310 15.977 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr15_-_91191733 15.717 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr4_-_110290884 14.780 ENSMUST00000142722.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_-_59555752 14.746 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr14_+_28504736 14.542 ENSMUST00000063465.4
 Wnt5a
wingless-related MMTV integration site 5A
chr4_-_110287479 13.688 ENSMUST00000106598.1
ENSMUST00000102723.4
ENSMUST00000153906.1
 Elavl4


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)


chr6_-_23248264 13.332 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_-_78199757 12.026 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr11_-_84525514 11.774 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr17_-_35704000 11.732 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 433 entries
Log-likelihood per target Total log-likelihoodTermDescription
20.6 61.8 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.9 53.8 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.7 37.0 GO:0007628 adult walking behavior(GO:0007628)
0.4 35.4 GO:0043488 regulation of mRNA stability(GO:0043488)
0.8 31.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
9.5 28.6 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
8.8 26.3 GO:0060067 cervix development(GO:0060067)
1.1 25.9 GO:0010172 embryonic body morphogenesis(GO:0010172)
1.4 22.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.6 21.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.7 21.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.5 21.3 GO:2001222 regulation of neuron migration(GO:2001222)
3.2 19.5 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
1.6 19.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 19.3 GO:0045727 positive regulation of translation(GO:0045727)
4.8 19.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
2.1 18.7 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
1.4 17.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 16.0 GO:0001578 microtubule bundle formation(GO:0001578)
4.6 13.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 270.7 GO:0005634 nucleus(GO:0005634)
8.9 80.2 GO:0030478 actin cap(GO:0030478)
2.6 38.5 GO:0042788 polysomal ribosome(GO:0042788)
0.2 21.6 GO:0005814 centriole(GO:0005814)
0.2 20.9 GO:0032993 protein-DNA complex(GO:0032993)
0.3 18.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
1.5 16.1 GO:0032584 growth cone membrane(GO:0032584)
0.8 16.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.7 15.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 14.7 GO:0051233 spindle midzone(GO:0051233)
0.2 13.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 11.6 GO:0005657 replication fork(GO:0005657)
0.2 11.5 GO:0036064 ciliary basal body(GO:0036064)
0.1 11.5 GO:0005813 centrosome(GO:0005813)
1.0 11.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 8.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 8.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 8.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
2.0 8.0 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 7.8 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 274 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 72.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 66.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
5.2 61.8 GO:0050693 LBD domain binding(GO:0050693)
0.1 43.0 GO:0003779 actin binding(GO:0003779)
1.1 40.5 GO:0017091 AU-rich element binding(GO:0017091)
3.4 37.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.0 35.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
3.8 30.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
2.4 21.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 21.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 18.7 GO:0001047 core promoter binding(GO:0001047)
1.5 18.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.4 18.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 17.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 14.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
4.8 14.5 GO:0005110 frizzled-2 binding(GO:0005110)
0.2 14.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
1.8 14.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.6 13.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
2.2 13.0 GO:0005042 netrin receptor activity(GO:0005042)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 20.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 15.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 14.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.4 11.2 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 10.6 PID_LKB1_PATHWAY LKB1 signaling events
0.2 10.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 9.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.2 9.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 8.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 8.7 PID_PLK1_PATHWAY PLK1 signaling events
0.2 8.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 8.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 8.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 8.0 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 6.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 6.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 5.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.5 4.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 77.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.5 19.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 19.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.6 16.6 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
1.3 14.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 12.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.6 12.0 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 11.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 10.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 9.6 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 8.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 8.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 7.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 6.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.3 6.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 6.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.5 5.7 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.2 5.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 4.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 4.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions