Motif ID: Figla

Z-value: 0.825


Transcription factors associated with Figla:

Gene SymbolEntrez IDGene Name
Figla ENSMUSG00000030001.3 Figla



Activity profile for motif Figla.

activity profile for motif Figla


Sorted Z-values histogram for motif Figla

Sorted Z-values for motif Figla



Network of associatons between targets according to the STRING database.



First level regulatory network of Figla

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 16.436 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr2_+_164769892 15.340 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr15_-_78773452 14.457 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_+_99864476 13.682 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chr1_-_119053339 11.389 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr1_+_74791516 10.749 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr5_+_123749696 10.264 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr13_-_100786402 8.784 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr12_+_109459843 7.973 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr8_+_127064107 7.903 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr15_+_25622525 7.692 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr6_+_47244359 7.572 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr2_-_62483637 7.072 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chrX_-_23266751 7.063 ENSMUST00000115316.2
 Klhl13
kelch-like 13
chr17_-_35700520 6.952 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr9_+_91368970 6.713 ENSMUST00000172646.1
 Zic4
zinc finger protein of the cerebellum 4
chr7_-_127218390 6.695 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr2_+_168081004 6.159 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr4_+_11156411 6.076 ENSMUST00000029865.3
 Trp53inp1
transformation related protein 53 inducible nuclear protein 1
chr7_-_144939823 5.811 ENSMUST00000093962.4
 Ccnd1
cyclin D1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 15.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
1.3 14.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
3.1 12.5 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
2.8 11.1 GO:0060032 notochord regression(GO:0060032)
1.0 10.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 10.7 GO:0048706 embryonic skeletal system development(GO:0048706)
1.8 9.2 GO:0035063 nuclear speck organization(GO:0035063)
2.9 8.8 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.9 8.5 GO:0030035 microspike assembly(GO:0030035)
0.4 8.0 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
1.3 7.9 GO:0003383 apical constriction(GO:0003383)
0.1 7.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
1.5 7.6 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.5 7.2 GO:0048194 Golgi vesicle budding(GO:0048194)
1.0 7.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.1 7.1 GO:0000910 cytokinesis(GO:0000910)
0.6 7.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
2.0 6.1 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.8 5.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.8 5.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 17.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 14.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
1.4 12.5 GO:0072687 meiotic spindle(GO:0072687)
0.1 12.0 GO:0030496 midbody(GO:0030496)
0.9 11.1 GO:0097542 ciliary tip(GO:0097542)
0.3 10.7 GO:0030673 axolemma(GO:0030673)
3.4 10.3 GO:1990423 RZZ complex(GO:1990423)
2.2 8.8 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 8.1 GO:0031225 anchored component of membrane(GO:0031225)
1.0 7.9 GO:0033269 internode region of axon(GO:0033269)
0.1 6.1 GO:0005776 autophagosome(GO:0005776)
0.1 5.9 GO:0016459 myosin complex(GO:0016459)
0.1 5.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 5.7 GO:0016605 PML body(GO:0016605)
0.0 5.7 GO:0016607 nuclear speck(GO:0016607)
0.0 5.5 GO:0031012 extracellular matrix(GO:0031012)
0.1 4.9 GO:0031985 Golgi cisterna(GO:0031985)
1.2 4.7 GO:0008537 proteasome activator complex(GO:0008537)
0.1 4.7 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 4.5 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 15.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
4.8 14.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 10.7 GO:0005109 frizzled binding(GO:0005109)
0.3 10.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 10.0 GO:0005525 GTP binding(GO:0005525)
2.2 8.8 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 7.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 7.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 7.7 GO:0030507 spectrin binding(GO:0030507)
0.3 7.3 GO:0070064 proline-rich region binding(GO:0070064)
0.2 7.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.8 7.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 6.8 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 6.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 6.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 6.3 GO:0002020 protease binding(GO:0002020)
0.1 6.1 GO:0016209 antioxidant activity(GO:0016209)
0.9 5.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 4.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.5 4.7 GO:0061133 endopeptidase activator activity(GO:0061133)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 11.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.7 10.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 9.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 8.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 8.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 7.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 7.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 5.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 5.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 4.5 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.5 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 2.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.3 2.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.7 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.7 PID_FGF_PATHWAY FGF signaling pathway
0.0 2.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 26.3 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.5 14.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.6 12.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 10.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 10.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 9.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 8.7 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 8.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 8.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 7.1 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 7.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 6.0 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.1 4.9 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 4.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 4.5 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.1 3.5 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.1 3.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.2 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.3 3.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.1 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins