Motif ID: Fli1

Z-value: 1.030


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_32541602-0.271.8e-02Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_175491130 45.358 ENSMUST00000027812.5
 Rgs7
regulator of G protein signaling 7
chr10_+_26229707 45.103 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr7_-_140082489 15.328 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr9_+_74848437 13.719 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
 Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr5_-_36398090 11.639 ENSMUST00000037370.7
ENSMUST00000070720.6
 Sorcs2

sortilin-related VPS10 domain containing receptor 2

chr11_-_100759942 10.215 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_-_100759740 9.892 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr17_+_79051906 9.621 ENSMUST00000040789.4
 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr8_+_23035116 7.307 ENSMUST00000117296.1
ENSMUST00000141784.2
 Ank1

ankyrin 1, erythroid

chr8_+_23035099 6.037 ENSMUST00000117662.1
 Ank1
ankyrin 1, erythroid
chr11_-_68927049 5.819 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr4_+_43406435 5.579 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chrX_-_72656135 4.848 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr8_+_106870827 4.670 ENSMUST00000176144.1
ENSMUST00000175987.1
 Has3

hyaluronan synthase 3

chr1_+_182763961 4.664 ENSMUST00000153348.1
 Susd4
sushi domain containing 4
chrX_-_136868537 4.556 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr15_-_76126538 4.212 ENSMUST00000054022.5
ENSMUST00000089654.3
 BC024139

cDNA sequence BC024139

chr16_-_42340595 4.122 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr4_-_41697040 4.081 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor

chr15_-_97020322 4.072 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 45.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.7 18.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 15.8 GO:0042391 regulation of membrane potential(GO:0042391)
0.3 13.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
3.2 9.6 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.9 6.8 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 6.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 5.1 GO:0007283 spermatogenesis(GO:0007283)
0.4 4.9 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.2 4.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.6 4.7 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.2 4.7 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.1 4.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
1.0 4.1 GO:0003360 brainstem development(GO:0003360)
0.5 4.1 GO:0016198 axon choice point recognition(GO:0016198)
0.1 4.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 4.1 GO:0030516 regulation of axon extension(GO:0030516)
0.1 3.9 GO:2001222 regulation of neuron migration(GO:2001222)
0.2 3.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 3.0 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 45.4 GO:0044292 dendrite terminus(GO:0044292)
0.0 29.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.6 12.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.7 5.8 GO:0001520 outer dense fiber(GO:0001520)
0.2 5.6 GO:0001741 XY body(GO:0001741)
0.3 4.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 4.6 GO:0045335 phagocytic vesicle(GO:0045335)
1.4 4.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 4.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 3.6 GO:0031527 filopodium membrane(GO:0031527)
0.3 3.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.2 3.0 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 2.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 2.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 2.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 2.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.2 1.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 1.4 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.1 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 45.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 20.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
2.0 15.8 GO:0032051 clathrin light chain binding(GO:0032051)
1.7 13.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.7 9.6 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.7 5.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.3 4.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 4.8 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
1.6 4.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 4.6 GO:0019003 GDP binding(GO:0019003)
0.7 4.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 4.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 3.3 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.2 3.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 2.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 2.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 2.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 1.7 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 3.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 2.5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 2.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.0 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 1.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 1.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 0.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 45.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.5 20.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 12.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 4.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 4.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 4.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 3.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 2.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 2.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.8 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 1.2 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.6 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation