Motif ID: Fli1
Z-value: 1.030
Transcription factors associated with Fli1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Fli1 | ENSMUSG00000016087.7 | Fli1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Fli1 | mm10_v2_chr9_-_32541589_32541602 | -0.27 | 1.8e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 9.6 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 1.6 | 4.7 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 1.2 | 4.7 | GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) |
| 1.0 | 4.1 | GO:0003360 | brainstem development(GO:0003360) |
| 0.9 | 2.6 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
| 0.9 | 6.8 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.7 | 18.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.5 | 4.1 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.4 | 1.3 | GO:0002586 | positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499) |
| 0.4 | 4.9 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.4 | 1.1 | GO:0034287 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) |
| 0.4 | 45.4 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.3 | 13.3 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
| 0.2 | 3.3 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.2 | 1.2 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 0.2 | 2.5 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.2 | 0.9 | GO:0032901 | positive regulation of neurotrophin production(GO:0032901) |
| 0.2 | 0.8 | GO:0015786 | UDP-glucose transport(GO:0015786) |
| 0.2 | 1.6 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.2 | 4.8 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.2 | 0.7 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.2 | 1.2 | GO:0032261 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) |
| 0.2 | 0.6 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 0.1 | 0.6 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.1 | 1.0 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
| 0.1 | 1.7 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.1 | 4.1 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.1 | 0.5 | GO:0035087 | siRNA loading onto RISC involved in RNA interference(GO:0035087) |
| 0.1 | 0.7 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.1 | 3.0 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.1 | 0.9 | GO:0009644 | response to high light intensity(GO:0009644) |
| 0.1 | 1.1 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.1 | 0.7 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.1 | 0.4 | GO:0002667 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) |
| 0.1 | 2.7 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.1 | 0.8 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.1 | 0.3 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.1 | 0.8 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.1 | 6.1 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 1.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 0.2 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.1 | 3.9 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.1 | 0.2 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 2.5 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 1.3 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 0.4 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 2.2 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.1 | 4.6 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.1 | 0.3 | GO:1904690 | adenosine to inosine editing(GO:0006382) regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690) |
| 0.1 | 0.3 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 15.8 | GO:0042391 | regulation of membrane potential(GO:0042391) |
| 0.0 | 4.1 | GO:0030516 | regulation of axon extension(GO:0030516) |
| 0.0 | 1.1 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 0.0 | 1.5 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 0.2 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.0 | 0.1 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.0 | 0.4 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.0 | 0.1 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.0 | 2.4 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.0 | 1.2 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 0.1 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 0.2 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
| 0.0 | 1.6 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.6 | GO:0043388 | positive regulation of DNA binding(GO:0043388) |
| 0.0 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 0.1 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.0 | 5.1 | GO:0007283 | spermatogenesis(GO:0007283) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 45.4 | GO:0044292 | dendrite terminus(GO:0044292) |
| 1.4 | 4.1 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.7 | 5.8 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.6 | 12.8 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.3 | 4.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.3 | 3.3 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.2 | 5.6 | GO:0001741 | XY body(GO:0001741) |
| 0.2 | 1.6 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.2 | 2.6 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.2 | 3.0 | GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178) |
| 0.2 | 3.6 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 1.1 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 4.6 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.1 | 2.6 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 0.2 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.1 | 2.5 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 0.5 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.1 | 0.3 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.1 | 1.1 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.0 | 4.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 29.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 1.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.2 | GO:0000235 | astral microtubule(GO:0000235) |
| 0.0 | 1.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 2.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.1 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 1.0 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.8 | GO:0043195 | terminal bouton(GO:0043195) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 45.1 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 2.0 | 15.8 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 1.7 | 13.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 1.6 | 4.7 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.7 | 9.6 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.7 | 5.6 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.7 | 4.1 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 0.5 | 2.6 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.3 | 3.3 | GO:0016886 | ligase activity, forming phosphoric ester bonds(GO:0016886) |
| 0.3 | 1.3 | GO:0070891 | peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891) |
| 0.3 | 4.8 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.2 | 20.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.2 | 3.0 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.2 | 1.7 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.2 | 1.2 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.2 | 1.1 | GO:0004340 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) |
| 0.2 | 1.2 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.2 | 0.6 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
| 0.1 | 0.8 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.1 | 0.9 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 0.1 | 1.6 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 0.1 | 4.1 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 0.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 0.2 | GO:0019002 | GMP binding(GO:0019002) |
| 0.1 | 4.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 2.7 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 0.3 | GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422) |
| 0.1 | 1.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.2 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.1 | 0.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 4.8 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.0 | 2.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.5 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) siRNA binding(GO:0035197) |
| 0.0 | 0.8 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.0 | 2.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 1.2 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.3 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.0 | 0.4 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 1.1 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.8 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.8 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 1.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.1 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.0 | 1.1 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.6 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.5 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 0.7 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 3.4 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.1 | 1.3 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 1.8 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 2.5 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 3.4 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.7 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 2.0 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.3 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.7 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.8 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.4 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.1 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 12.8 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 45.4 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.3 | 4.7 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.3 | 4.8 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 2.5 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 3.0 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 4.8 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 0.7 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.2 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 1.2 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 2.5 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 1.3 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 1.3 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.7 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.6 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.8 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.4 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 0.4 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 1.8 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.6 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.2 | REACTOME_RAF_MAP_KINASE_CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.0 | 0.1 | REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.0 | 0.8 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
