Motif ID: Fos
Z-value: 0.910
Transcription factors associated with Fos:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Fos | ENSMUSG00000021250.7 | Fos |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Fos | mm10_v2_chr12_+_85473883_85473896 | -0.32 | 4.4e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 11.5 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
| 3.2 | 16.2 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 2.6 | 7.9 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 2.2 | 6.5 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 2.0 | 6.1 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 1.8 | 7.3 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 1.7 | 5.2 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 1.4 | 5.7 | GO:0035937 | estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864) |
| 1.2 | 3.7 | GO:0034140 | negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) |
| 1.1 | 5.7 | GO:0021764 | amygdala development(GO:0021764) |
| 1.1 | 10.7 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 1.1 | 36.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 1.0 | 3.1 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) |
| 0.9 | 3.4 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
| 0.8 | 2.5 | GO:0071873 | response to norepinephrine(GO:0071873) |
| 0.8 | 2.5 | GO:0097278 | transforming growth factor beta activation(GO:0036363) complement-dependent cytotoxicity(GO:0097278) |
| 0.8 | 3.2 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.8 | 15.0 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.7 | 2.8 | GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) |
| 0.7 | 2.0 | GO:0035523 | protein K29-linked deubiquitination(GO:0035523) |
| 0.7 | 4.0 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.6 | 1.9 | GO:0042097 | tricuspid valve formation(GO:0003195) interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.6 | 1.9 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.6 | 7.4 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.6 | 6.8 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.6 | 3.1 | GO:1990839 | response to endothelin(GO:1990839) |
| 0.6 | 1.2 | GO:0021506 | anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995) |
| 0.6 | 4.1 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.6 | 20.6 | GO:0009409 | response to cold(GO:0009409) |
| 0.6 | 2.8 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
| 0.5 | 4.9 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.5 | 9.8 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.5 | 2.0 | GO:0002572 | pro-T cell differentiation(GO:0002572) |
| 0.5 | 1.5 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) negative regulation of determination of dorsal identity(GO:2000016) |
| 0.5 | 2.5 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
| 0.5 | 4.7 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.4 | 3.5 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.4 | 1.7 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.4 | 5.3 | GO:0002467 | germinal center formation(GO:0002467) |
| 0.4 | 2.1 | GO:0032375 | negative regulation of sterol transport(GO:0032372) negative regulation of cholesterol transport(GO:0032375) |
| 0.3 | 1.7 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.3 | 1.0 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
| 0.3 | 1.9 | GO:0048840 | otolith development(GO:0048840) |
| 0.3 | 7.4 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.3 | 2.7 | GO:0019240 | citrulline biosynthetic process(GO:0019240) |
| 0.3 | 2.7 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.3 | 6.8 | GO:0043486 | histone exchange(GO:0043486) |
| 0.3 | 4.7 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.3 | 1.7 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
| 0.3 | 1.4 | GO:0032329 | serine transport(GO:0032329) |
| 0.3 | 3.6 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.3 | 2.2 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.3 | 1.0 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.3 | 3.0 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.2 | 3.2 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.2 | 0.7 | GO:0036233 | glycine import(GO:0036233) |
| 0.2 | 0.7 | GO:0007621 | negative regulation of female receptivity(GO:0007621) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of cellular pH reduction(GO:0032847) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
| 0.2 | 0.7 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.2 | 2.2 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.2 | 0.8 | GO:0001787 | natural killer cell proliferation(GO:0001787) |
| 0.2 | 5.6 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
| 0.2 | 8.9 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.2 | 2.6 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.2 | 1.1 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.2 | 1.1 | GO:0042256 | mature ribosome assembly(GO:0042256) |
| 0.2 | 1.2 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.2 | 4.6 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.2 | 2.0 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.2 | 2.7 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.2 | 3.4 | GO:0050892 | intestinal absorption(GO:0050892) |
| 0.2 | 2.3 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.2 | 0.6 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.2 | 1.4 | GO:0098937 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
| 0.2 | 3.6 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.2 | 3.9 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 4.4 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.1 | 1.7 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.1 | 0.5 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.1 | 0.9 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.1 | 1.7 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.1 | 0.9 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146) |
| 0.1 | 0.7 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.1 | 2.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 5.7 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.1 | 0.9 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.1 | 19.5 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.1 | 1.2 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.1 | 1.7 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 2.0 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 0.2 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 3.6 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.1 | 2.3 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.1 | 0.6 | GO:0048570 | notochord morphogenesis(GO:0048570) |
| 0.1 | 4.2 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.1 | 0.5 | GO:0030316 | osteoclast differentiation(GO:0030316) |
| 0.1 | 1.5 | GO:0021924 | olfactory bulb interneuron development(GO:0021891) cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930) |
| 0.1 | 0.4 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 0.6 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.1 | 6.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 8.0 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 5.1 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.1 | 5.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 2.7 | GO:0044380 | protein localization to cytoskeleton(GO:0044380) |
| 0.1 | 2.4 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
| 0.1 | 0.5 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.1 | 2.0 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.1 | 2.3 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 1.3 | GO:0045760 | positive regulation of action potential(GO:0045760) |
| 0.1 | 1.6 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.1 | 1.6 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 2.6 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.1 | 2.6 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.1 | 6.3 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.1 | 0.9 | GO:0007099 | centriole replication(GO:0007099) |
| 0.1 | 2.9 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.0 | 0.9 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.0 | 0.9 | GO:0072337 | modified amino acid transport(GO:0072337) |
| 0.0 | 1.3 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 4.3 | GO:0030833 | regulation of actin filament polymerization(GO:0030833) |
| 0.0 | 1.5 | GO:0042775 | mitochondrial ATP synthesis coupled electron transport(GO:0042775) |
| 0.0 | 0.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 4.0 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 0.1 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.0 | 0.5 | GO:0010762 | regulation of fibroblast migration(GO:0010762) |
| 0.0 | 1.9 | GO:0000082 | G1/S transition of mitotic cell cycle(GO:0000082) |
| 0.0 | 2.3 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731) |
| 0.0 | 0.2 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.8 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 0.4 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 3.2 | GO:0045444 | fat cell differentiation(GO:0045444) |
| 0.0 | 0.5 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 0.1 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.0 | 0.9 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 2.2 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.7 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 1.0 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.8 | GO:0046888 | negative regulation of hormone secretion(GO:0046888) |
| 0.0 | 0.4 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.0 | 0.1 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.0 | 0.2 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 16.2 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 1.9 | 5.7 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 1.5 | 4.4 | GO:1990047 | spindle matrix(GO:1990047) |
| 1.0 | 4.0 | GO:0008623 | CHRAC(GO:0008623) |
| 0.8 | 10.7 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.7 | 2.8 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) |
| 0.7 | 7.3 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.6 | 1.9 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.6 | 2.5 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.5 | 0.5 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.5 | 1.6 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.5 | 1.5 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.5 | 2.5 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.5 | 3.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.5 | 2.5 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.5 | 0.9 | GO:0044753 | amphisome(GO:0044753) |
| 0.4 | 8.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.3 | 4.8 | GO:0031105 | septin complex(GO:0031105) |
| 0.3 | 18.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.3 | 0.9 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.3 | 11.2 | GO:0016592 | mediator complex(GO:0016592) |
| 0.3 | 11.0 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.3 | 3.9 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.3 | 3.0 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.2 | 3.2 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.2 | 2.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 2.0 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.2 | 3.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 2.1 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 0.9 | GO:0098536 | deuterosome(GO:0098536) |
| 0.2 | 0.6 | GO:1990590 | ATF1-ATF4 transcription factor complex(GO:1990590) |
| 0.1 | 1.2 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 2.9 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.6 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 17.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 2.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 5.9 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 1.2 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 0.8 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.1 | 1.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 5.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 0.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 0.2 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.1 | 0.2 | GO:0098842 | postsynaptic early endosome(GO:0098842) |
| 0.1 | 0.6 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 1.9 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 5.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 0.6 | GO:0098533 | ATPase dependent transmembrane transport complex(GO:0098533) |
| 0.1 | 2.0 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 1.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 3.0 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 2.8 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 4.6 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 8.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 0.6 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 5.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 4.8 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 2.3 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 1.5 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.6 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 2.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 2.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 1.8 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.0 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 0.6 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 2.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.8 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.1 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 0.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.1 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 2.4 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 2.1 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.8 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 18.9 | GO:1990254 | keratin filament binding(GO:1990254) |
| 2.5 | 15.0 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 2.4 | 36.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 1.8 | 10.7 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 1.4 | 5.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 1.4 | 5.7 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 1.0 | 3.1 | GO:0004936 | alpha-adrenergic receptor activity(GO:0004936) |
| 1.0 | 3.0 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 1.0 | 2.9 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.9 | 17.1 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.8 | 7.4 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.8 | 3.1 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.7 | 3.6 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.7 | 14.1 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.7 | 4.1 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.7 | 2.7 | GO:0034618 | arginine binding(GO:0034618) |
| 0.7 | 2.0 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.6 | 1.7 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153) |
| 0.6 | 1.7 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.6 | 2.8 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.5 | 8.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.4 | 19.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 7.2 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.4 | 2.5 | GO:0002135 | CTP binding(GO:0002135) |
| 0.4 | 1.6 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.4 | 4.6 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.4 | 6.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.4 | 2.3 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.4 | 2.8 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.3 | 2.4 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.3 | 6.5 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.3 | 5.2 | GO:0055103 | ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.3 | 1.2 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.3 | 3.2 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.3 | 0.8 | GO:0034211 | GTP-dependent protein kinase activity(GO:0034211) |
| 0.3 | 2.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.2 | 1.0 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.2 | 10.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.2 | 1.9 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.2 | 6.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.2 | 0.9 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.2 | 1.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 3.8 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.2 | 8.3 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 19.6 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.2 | 1.4 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.2 | 3.6 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.2 | 4.6 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.2 | 1.5 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.2 | 2.0 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.2 | 1.8 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.2 | 4.3 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.2 | 0.7 | GO:0031893 | vasopressin receptor binding(GO:0031893) |
| 0.2 | 2.4 | GO:0048038 | quinone binding(GO:0048038) |
| 0.2 | 14.5 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.2 | 3.0 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.2 | 0.6 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.1 | 2.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 8.2 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.1 | 0.5 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.1 | 1.6 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.2 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 1.7 | GO:0015108 | chloride transmembrane transporter activity(GO:0015108) |
| 0.1 | 1.2 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 2.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 1.4 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 2.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 0.5 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 2.8 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 0.5 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.1 | 1.1 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 1.9 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 0.7 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 2.7 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 2.8 | GO:0008200 | ion channel inhibitor activity(GO:0008200) |
| 0.1 | 7.4 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.1 | 6.5 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 0.6 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 0.5 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.0 | 0.9 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 2.1 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 13.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 3.0 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.2 | GO:0051021 | GDP-dissociation inhibitor binding(GO:0051021) |
| 0.0 | 1.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.6 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 3.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 1.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 2.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 2.4 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.0 | 1.1 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.0 | 0.1 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.0 | 0.2 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.0 | 6.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 7.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.1 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.0 | 0.4 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.1 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 1.7 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 7.6 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 0.7 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.0 | 0.1 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 0.7 | GO:0030414 | peptidase inhibitor activity(GO:0030414) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 24.1 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.4 | 12.8 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.4 | 13.1 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.4 | 2.8 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 7.4 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.3 | 10.3 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 2.2 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 2.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.2 | 11.5 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.2 | 0.6 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 21.6 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.2 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 4.4 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.1 | 4.9 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 2.2 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.1 | 4.2 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 8.7 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 4.4 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 5.0 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.5 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.1 | 0.6 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 2.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.5 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.1 | 2.0 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 1.2 | ST_B_CELL_ANTIGEN_RECEPTOR | B Cell Antigen Receptor |
| 0.1 | 3.1 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.1 | 9.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 0.2 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 2.3 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 1.5 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.1 | 4.3 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.1 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.9 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.1 | 3.1 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 2.5 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 1.8 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 1.7 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.8 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.5 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.6 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.8 | PID_P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 31.8 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.7 | 5.0 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.7 | 16.2 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.5 | 7.4 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.4 | 6.5 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.4 | 6.8 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.3 | 4.1 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.3 | 2.5 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.2 | 3.5 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.2 | 3.1 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.2 | 2.1 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 1.9 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.2 | 5.3 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 2.9 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 4.5 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 2.4 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 2.7 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 8.7 | REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 1.2 | REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.1 | 1.1 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 5.2 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.7 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 2.4 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.1 | 2.2 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 14.8 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 3.6 | REACTOME_IRON_UPTAKE_AND_TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 0.5 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.1 | 0.7 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 0.7 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 1.6 | REACTOME_CELL_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.0 | 7.7 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 6.0 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.8 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 1.5 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.6 | REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
| 0.0 | 1.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 3.9 | REACTOME_HEMOSTASIS | Genes involved in Hemostasis |
