Motif ID: Fos

Z-value: 0.910


Transcription factors associated with Fos:

Gene SymbolEntrez IDGene Name
Fos ENSMUSG00000021250.7 Fos

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosmm10_v2_chr12_+_85473883_85473896-0.324.4e-03Click!


Activity profile for motif Fos.

activity profile for motif Fos


Sorted Z-values histogram for motif Fos

Sorted Z-values for motif Fos



Network of associatons between targets according to the STRING database.



First level regulatory network of Fos

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_82910863 17.671 ENSMUST00000171238.1
Zfp516
zinc finger protein 516
chr2_+_13573927 16.247 ENSMUST00000141365.1
ENSMUST00000028062.2
Vim

vimentin

chr11_-_84067063 13.443 ENSMUST00000108101.1
Dusp14
dual specificity phosphatase 14
chr11_-_84068766 11.701 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr13_+_15463837 11.514 ENSMUST00000110510.3
Gli3
GLI-Kruppel family member GLI3
chr8_+_94984399 11.376 ENSMUST00000093271.6
Gpr56
G protein-coupled receptor 56
chr11_-_84069179 10.937 ENSMUST00000138208.1
Dusp14
dual specificity phosphatase 14
chr8_-_61591130 10.518 ENSMUST00000135439.1
ENSMUST00000121200.1
Palld

palladin, cytoskeletal associated protein

chr17_+_35049966 10.022 ENSMUST00000007257.9
Clic1
chloride intracellular channel 1
chr7_+_27486910 9.677 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr2_-_18048784 9.275 ENSMUST00000142856.1
Skida1
SKI/DACH domain containing 1
chr1_+_107511489 8.661 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 8.614 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr17_+_43952999 8.095 ENSMUST00000177857.1
Rcan2
regulator of calcineurin 2
chrX_-_143827391 8.014 ENSMUST00000087316.5
Capn6
calpain 6
chrX_-_23266751 8.012 ENSMUST00000115316.2
Klhl13
kelch-like 13
chr6_+_7555053 7.948 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr2_+_20737306 7.682 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr13_-_21780616 7.436 ENSMUST00000080511.2
Hist1h1b
histone cluster 1, H1b
chr13_-_23991158 7.413 ENSMUST00000021770.7
Scgn
secretagogin, EF-hand calcium binding protein
chr17_-_35697971 7.389 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr18_+_35118880 7.314 ENSMUST00000042345.6
Ctnna1
catenin (cadherin associated protein), alpha 1
chr7_+_19083842 7.049 ENSMUST00000032568.7
ENSMUST00000122999.1
ENSMUST00000108473.3
ENSMUST00000108474.1
Dmpk



dystrophia myotonica-protein kinase



chr17_+_43953191 6.929 ENSMUST00000044792.4
Rcan2
regulator of calcineurin 2
chr9_-_72111172 6.787 ENSMUST00000183992.1
Tcf12
transcription factor 12
chr9_-_72111651 6.675 ENSMUST00000185117.1
Tcf12
transcription factor 12
chr15_-_90679307 6.290 ENSMUST00000014777.8
ENSMUST00000064391.5
Cpne8

copine VIII

chr10_+_88091070 6.114 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr10_+_26772477 6.010 ENSMUST00000039557.7
Arhgap18
Rho GTPase activating protein 18
chr3_+_95232287 5.907 ENSMUST00000107200.1
ENSMUST00000107199.1
Cdc42se1

CDC42 small effector 1

chr1_+_109993982 5.745 ENSMUST00000027542.6
Cdh7
cadherin 7, type 2
chr10_-_42583628 5.658 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr7_-_126799163 5.606 ENSMUST00000032934.5
Aldoa
aldolase A, fructose-bisphosphate
chr7_+_139834148 5.283 ENSMUST00000026548.7
Gpr123
G protein-coupled receptor 123
chr7_+_67647405 5.147 ENSMUST00000032774.8
ENSMUST00000107471.1
Ttc23

tetratricopeptide repeat domain 23

chr7_-_126799134 5.066 ENSMUST00000087566.4
Aldoa
aldolase A, fructose-bisphosphate
chr7_-_102250086 5.048 ENSMUST00000106923.1
ENSMUST00000098230.4
Rhog

ras homolog gene family, member G

chr19_+_5050807 4.948 ENSMUST00000025818.6
Rin1
Ras and Rab interactor 1
chrX_+_164269371 4.565 ENSMUST00000145412.1
ENSMUST00000033749.7
Pir

pirin

chr2_+_30078584 4.312 ENSMUST00000045246.7
Pkn3
protein kinase N3
chr19_-_58455903 4.307 ENSMUST00000131877.1
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr2_-_166581969 4.238 ENSMUST00000109246.1
Prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr7_+_127800844 4.128 ENSMUST00000106271.1
ENSMUST00000138432.1
Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chr12_-_54999102 4.049 ENSMUST00000173529.1
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr14_-_12345847 4.029 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr16_-_44558864 3.930 ENSMUST00000023370.4
Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr11_+_117232254 3.909 ENSMUST00000106354.2
Sept9
septin 9
chr12_+_16810940 3.898 ENSMUST00000020908.7
E2f6
E2F transcription factor 6
chr18_+_61639542 3.858 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr7_-_109781538 3.839 ENSMUST00000033331.6
Nrip3
nuclear receptor interacting protein 3
chr14_+_79515618 3.836 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr2_+_52038005 3.796 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr9_-_71896047 3.687 ENSMUST00000184448.1
Tcf12
transcription factor 12
chr10_+_128790903 3.628 ENSMUST00000026411.6
Mmp19
matrix metallopeptidase 19
chr14_-_62454793 3.623 ENSMUST00000128573.1
Gucy1b2
guanylate cyclase 1, soluble, beta 2
chrX_+_96455359 3.623 ENSMUST00000033553.7
Heph
hephaestin
chr1_+_156035392 3.604 ENSMUST00000111757.3
Tor1aip2
torsin A interacting protein 2
chr4_-_91376490 3.595 ENSMUST00000107124.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_-_71632897 3.550 ENSMUST00000065509.4
Kdm3a
lysine (K)-specific demethylase 3A
chr6_+_42349826 3.541 ENSMUST00000070635.6
Zyx
zyxin
chr3_+_95929246 3.525 ENSMUST00000165307.1
ENSMUST00000015893.6
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr13_-_98891036 3.496 ENSMUST00000109399.2
Tnpo1
transportin 1
chr4_-_43558386 3.464 ENSMUST00000130353.1
Tln1
talin 1
chr19_+_46305682 3.451 ENSMUST00000111881.2
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr16_-_44558879 3.440 ENSMUST00000114634.1
Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr6_+_42350000 3.432 ENSMUST00000164375.1
Zyx
zyxin
chr11_+_94327984 3.331 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40

ankyrin repeat domain 40

chr13_-_98890974 3.274 ENSMUST00000179301.1
ENSMUST00000179271.1
Tnpo1

transportin 1

chr3_+_95929325 3.251 ENSMUST00000171368.1
ENSMUST00000168106.1
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr6_+_53573364 3.233 ENSMUST00000047450.7
Creb5
cAMP responsive element binding protein 5
chr1_-_12991109 3.221 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1

solute carrier organic anion transporter family, member 5A1

chr4_-_91376433 3.193 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr1_+_134560157 3.190 ENSMUST00000047714.7
Kdm5b
lysine (K)-specific demethylase 5B
chr2_+_143915273 3.167 ENSMUST00000103172.3
Dstn
destrin
chr14_+_66635251 3.117 ENSMUST00000159365.1
ENSMUST00000054661.1
ENSMUST00000159068.1
Adra1a


adrenergic receptor, alpha 1a


chr3_+_89421619 3.068 ENSMUST00000094378.3
ENSMUST00000137793.1
Shc1

src homology 2 domain-containing transforming protein C1

chr15_-_91049823 3.034 ENSMUST00000088614.5
ENSMUST00000100304.4
ENSMUST00000067205.8
ENSMUST00000109288.2
ENSMUST00000109287.2
Kif21a




kinesin family member 21A




chr16_+_78930940 3.022 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
Chodl


chondrolectin


chr6_-_71632651 2.980 ENSMUST00000167220.1
Kdm3a
lysine (K)-specific demethylase 3A
chr17_+_75178797 2.979 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr11_+_94328242 2.952 ENSMUST00000021227.5
Ankrd40
ankyrin repeat domain 40
chr1_-_156034800 2.920 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr11_-_70015346 2.904 ENSMUST00000018718.7
ENSMUST00000102574.3
Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr6_+_4755327 2.875 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr4_-_141723401 2.837 ENSMUST00000177592.1
ENSMUST00000102484.4
Rsc1a1
Ddi2
regulatory solute carrier protein, family 1, member 1
DNA-damage inducible protein 2
chr3_+_116878227 2.829 ENSMUST00000040260.6
Frrs1
ferric-chelate reductase 1
chr5_-_148552783 2.796 ENSMUST00000079324.7
ENSMUST00000164904.1
Ubl3

ubiquitin-like 3

chr17_+_75178911 2.748 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr13_-_90905321 2.726 ENSMUST00000109541.3
Atp6ap1l
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr2_+_84734050 2.703 ENSMUST00000090729.2
Ypel4
yippee-like 4 (Drosophila)
chr4_-_140774196 2.698 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr15_-_76014318 2.669 ENSMUST00000060807.5
Fam83h
family with sequence similarity 83, member H
chr15_+_59648350 2.660 ENSMUST00000067543.6
Trib1
tribbles homolog 1 (Drosophila)
chr3_-_10208569 2.659 ENSMUST00000029041.4
Fabp4
fatty acid binding protein 4, adipocyte
chrX_+_7762652 2.623 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
Tfe3



transcription factor E3



chr9_-_119977250 2.623 ENSMUST00000035101.7
Csrnp1
cysteine-serine-rich nuclear protein 1
chr15_-_99705490 2.593 ENSMUST00000163472.2
Gm17349
predicted gene, 17349
chr15_+_59648644 2.524 ENSMUST00000118228.1
Trib1
tribbles homolog 1 (Drosophila)
chr5_-_62766153 2.515 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_-_85173692 2.509 ENSMUST00000005406.10
App
amyloid beta (A4) precursor protein
chr1_+_134560190 2.493 ENSMUST00000112198.1
ENSMUST00000112197.1
Kdm5b

lysine (K)-specific demethylase 5B

chr10_+_128909866 2.486 ENSMUST00000026407.7
Cd63
CD63 antigen
chr1_-_163725123 2.425 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr10_-_19015347 2.406 ENSMUST00000019997.4
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr7_+_128523576 2.312 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr19_+_36409719 2.289 ENSMUST00000062389.5
Pcgf5
polycomb group ring finger 5
chr19_+_8989277 2.262 ENSMUST00000092955.3
ENSMUST00000092956.2
Ahnak

AHNAK nucleoprotein (desmoyokin)

chr11_+_80383279 2.250 ENSMUST00000165565.1
ENSMUST00000017567.7
Zfp207

zinc finger protein 207

chr19_+_33822908 2.188 ENSMUST00000042061.6
Gm5519
predicted pseudogene 5519
chr7_-_126369543 2.169 ENSMUST00000032997.6
Lat
linker for activation of T cells
chr3_+_88621436 2.153 ENSMUST00000170653.2
ENSMUST00000177303.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr16_+_35770382 2.146 ENSMUST00000023555.4
Hspbap1
Hspb associated protein 1
chr7_-_133782721 2.141 ENSMUST00000063669.1
Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr4_+_133130505 2.094 ENSMUST00000084241.5
ENSMUST00000138831.1
Wasf2

WAS protein family, member 2

chr12_+_76370266 2.041 ENSMUST00000042779.3
Zbtb1
zinc finger and BTB domain containing 1
chr14_-_34310503 2.037 ENSMUST00000111917.1
Fam35a
family with sequence similarity 35, member A
chr7_+_126766397 2.021 ENSMUST00000032944.7
Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
chr1_+_130717320 2.019 ENSMUST00000049813.4
Yod1
YOD1 OTU deubiquitinating enzyme 1 homologue (S. cerevisiae)
chr1_-_51915968 2.015 ENSMUST00000046390.7
Myo1b
myosin IB
chr16_+_20651652 1.942 ENSMUST00000007212.8
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr2_-_38644087 1.941 ENSMUST00000028083.5
Psmb7
proteasome (prosome, macropain) subunit, beta type 7
chr4_-_140665891 1.929 ENSMUST00000069623.5
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr8_+_122282117 1.925 ENSMUST00000054052.8
Zfpm1
zinc finger protein, multitype 1
chr19_-_60581013 1.922 ENSMUST00000111460.3
ENSMUST00000081790.7
ENSMUST00000166712.1
Cacul1


CDK2 associated, cullin domain 1


chr5_+_30013141 1.868 ENSMUST00000026845.7
Il6
interleukin 6
chr6_-_113934679 1.854 ENSMUST00000101044.2
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_160906372 1.844 ENSMUST00000161609.1
Rc3h1
RING CCCH (C3H) domains 1
chr1_-_156034826 1.813 ENSMUST00000141878.1
ENSMUST00000123705.1
Tor1aip1

torsin A interacting protein 1

chr17_-_45573253 1.809 ENSMUST00000165127.1
ENSMUST00000166469.1
ENSMUST00000024739.7
Hsp90ab1


heat shock protein 90 alpha (cytosolic), class B member 1


chr2_-_26092149 1.735 ENSMUST00000114159.2
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr13_+_75839868 1.723 ENSMUST00000022082.7
Glrx
glutaredoxin
chr11_+_101082565 1.719 ENSMUST00000001806.3
ENSMUST00000107308.3
Coasy

Coenzyme A synthase

chr11_-_69880971 1.696 ENSMUST00000050555.3
Kctd11
potassium channel tetramerisation domain containing 11
chr11_-_102365111 1.692 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr2_-_20943413 1.689 ENSMUST00000140230.1
Arhgap21
Rho GTPase activating protein 21
chr16_+_27388869 1.665 ENSMUST00000100026.3
ENSMUST00000039443.7
ENSMUST00000096127.4
Ccdc50


coiled-coil domain containing 50


chr2_+_69670100 1.660 ENSMUST00000100050.3
Klhl41
kelch-like 41
chr10_+_18845071 1.659 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr17_-_34628005 1.650 ENSMUST00000166040.2
Ppt2
palmitoyl-protein thioesterase 2
chr2_-_102451792 1.641 ENSMUST00000099678.3
Fjx1
four jointed box 1 (Drosophila)
chr10_+_80264942 1.640 ENSMUST00000105362.1
ENSMUST00000105361.3
Dazap1

DAZ associated protein 1

chr4_-_126256226 1.578 ENSMUST00000122129.1
ENSMUST00000061143.8
ENSMUST00000106132.2
Map7d1


MAP7 domain containing 1


chr10_+_128933782 1.564 ENSMUST00000099112.2
Itga7
integrin alpha 7
chr3_-_95739544 1.562 ENSMUST00000153026.1
ENSMUST00000123143.1
ENSMUST00000137912.1
ENSMUST00000029753.6
ENSMUST00000131376.1
ENSMUST00000117507.2
ENSMUST00000128885.1
ENSMUST00000147217.1
Ecm1







extracellular matrix protein 1







chr12_+_31265279 1.533 ENSMUST00000002979.8
ENSMUST00000170495.1
Lamb1

laminin B1

chrX_+_74424534 1.520 ENSMUST00000135165.1
ENSMUST00000114128.1
ENSMUST00000114133.2
ENSMUST00000004330.3
Ikbkg



inhibitor of kappaB kinase gamma



chr1_-_171240055 1.519 ENSMUST00000131286.1
Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr10_+_127290774 1.510 ENSMUST00000026475.8
ENSMUST00000139091.1
Ddit3

DNA-damage inducible transcript 3

chr7_-_44816586 1.501 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr10_+_57486354 1.500 ENSMUST00000079833.4
Hsf2
heat shock factor 2
chrX_+_74424632 1.495 ENSMUST00000114129.2
ENSMUST00000132749.1
Ikbkg

inhibitor of kappaB kinase gamma

chr11_+_80428598 1.486 ENSMUST00000173938.1
ENSMUST00000017572.7
Psmd11

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

chr11_+_20543307 1.449 ENSMUST00000093292.4
Sertad2
SERTA domain containing 2
chr1_-_155527083 1.447 ENSMUST00000097531.2
Gm5532
predicted gene 5532
chr13_-_8871696 1.435 ENSMUST00000054251.6
ENSMUST00000176813.1
Wdr37

WD repeat domain 37

chr17_+_28951950 1.401 ENSMUST00000153462.1
Kctd20
potassium channel tetramerisation domain containing 20
chr17_+_45555693 1.396 ENSMUST00000024742.7
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
chr1_-_58973421 1.378 ENSMUST00000173590.1
ENSMUST00000027186.5
Trak2

trafficking protein, kinesin binding 2

chr17_+_78508063 1.365 ENSMUST00000024880.9
Vit
vitrin
chr7_-_142372210 1.337 ENSMUST00000084412.5
Ifitm10
interferon induced transmembrane protein 10
chr13_-_58215615 1.326 ENSMUST00000058735.5
ENSMUST00000076454.6
Ubqln1

ubiquilin 1

chr14_+_25459206 1.295 ENSMUST00000162645.1
Zmiz1
zinc finger, MIZ-type containing 1
chr12_+_31265234 1.283 ENSMUST00000169088.1
Lamb1
laminin B1
chr16_+_20548577 1.271 ENSMUST00000003319.5
Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr19_+_8850785 1.270 ENSMUST00000096257.2
Lrrn4cl
LRRN4 C-terminal like
chr5_+_42067960 1.267 ENSMUST00000087332.4
Gm16223
predicted gene 16223
chr8_+_105373265 1.260 ENSMUST00000160650.1
Plekhg4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr11_-_100135928 1.251 ENSMUST00000107411.2
Krt15
keratin 15
chr6_+_92940572 1.236 ENSMUST00000181145.1
ENSMUST00000181840.1
9530026P05Rik

RIKEN cDNA 9530026P05 gene

chr12_-_85288419 1.231 ENSMUST00000121930.1
Acyp1
acylphosphatase 1, erythrocyte (common) type
chr5_+_34999046 1.210 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr8_-_69974367 1.208 ENSMUST00000116463.2
Gatad2a
GATA zinc finger domain containing 2A
chr8_+_107293500 1.206 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
Nfat5


nuclear factor of activated T cells 5


chr11_-_33843526 1.194 ENSMUST00000065970.5
ENSMUST00000109340.2
Kcnip1

Kv channel-interacting protein 1

chr2_-_17731035 1.187 ENSMUST00000028080.5
Nebl
nebulette
chr12_-_84194007 1.166 ENSMUST00000110294.1
Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chr11_+_80383309 1.133 ENSMUST00000108216.1
Zfp207
zinc finger protein 207
chrX_+_13280970 1.077 ENSMUST00000000804.6
Ddx3x
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
chr7_-_126584220 1.046 ENSMUST00000128970.1
ENSMUST00000116269.2
Cln3

ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)

chr10_+_111473186 1.024 ENSMUST00000065917.8
Nap1l1
nucleosome assembly protein 1-like 1
chr10_+_94550852 0.996 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3

transmembrane and coiled coil domains 3

chr5_-_134946917 0.984 ENSMUST00000051401.2
Cldn4
claudin 4
chr7_-_144751968 0.979 ENSMUST00000155175.1
Ano1
anoctamin 1, calcium activated chloride channel
chr11_+_80383397 0.969 ENSMUST00000053740.8
Zfp207
zinc finger protein 207
chr18_+_42275353 0.965 ENSMUST00000046972.7
ENSMUST00000091920.5
Rbm27

RNA binding motif protein 27

chr5_+_34999070 0.963 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chrX_-_101222426 0.956 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr3_+_116594959 0.949 ENSMUST00000029571.8
Sass6
spindle assembly 6 homolog (C. elegans)
chr7_-_114276107 0.938 ENSMUST00000033008.9
Psma1
proteasome (prosome, macropain) subunit, alpha type 1
chr13_-_55528511 0.935 ENSMUST00000047877.4
Dok3
docking protein 3
chr2_+_167777467 0.931 ENSMUST00000139927.1
ENSMUST00000127441.1
Gm14321

predicted gene 14321

chr11_-_50210765 0.931 ENSMUST00000143379.1
ENSMUST00000015981.5
ENSMUST00000102774.4
Sqstm1


sequestosome 1


chr2_+_119174483 0.891 ENSMUST00000069711.2
Gm14137
predicted gene 14137
chr11_+_87582201 0.882 ENSMUST00000133202.1
Sept4
septin 4
chr11_-_33843405 0.871 ENSMUST00000101368.2
Kcnip1
Kv channel-interacting protein 1
chrX_+_73675500 0.868 ENSMUST00000171398.1
Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chrY_-_1286563 0.861 ENSMUST00000091190.5
Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr1_+_55052770 0.850 ENSMUST00000027125.5
ENSMUST00000087617.4
Coq10b

coenzyme Q10 homolog B (S. cerevisiae)

chrX_-_74023745 0.838 ENSMUST00000114353.3
ENSMUST00000101458.2
Irak1

interleukin-1 receptor-associated kinase 1

chr7_-_4778141 0.833 ENSMUST00000094892.5
Il11
interleukin 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.5 GO:0060364 frontal suture morphogenesis(GO:0060364)
3.2 16.2 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
2.6 7.9 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
2.2 6.5 GO:0007290 spermatid nucleus elongation(GO:0007290)
2.0 6.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
1.8 7.3 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.7 5.2 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
1.4 5.7 GO:0035937 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
1.2 3.7 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
1.1 5.7 GO:0021764 amygdala development(GO:0021764)
1.1 10.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.1 36.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.0 3.1 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.9 3.4 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.8 2.5 GO:0071873 response to norepinephrine(GO:0071873)
0.8 2.5 GO:0097278 transforming growth factor beta activation(GO:0036363) complement-dependent cytotoxicity(GO:0097278)
0.8 3.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.8 15.0 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.7 2.8 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.7 2.0 GO:0035523 protein K29-linked deubiquitination(GO:0035523)
0.7 4.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 1.9 GO:0042097 tricuspid valve formation(GO:0003195) interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.6 1.9 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.6 7.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.6 6.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.6 3.1 GO:1990839 response to endothelin(GO:1990839)
0.6 1.2 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.6 4.1 GO:0035754 B cell chemotaxis(GO:0035754)
0.6 20.6 GO:0009409 response to cold(GO:0009409)
0.6 2.8 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.5 4.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.5 9.8 GO:0003334 keratinocyte development(GO:0003334)
0.5 2.0 GO:0002572 pro-T cell differentiation(GO:0002572)
0.5 1.5 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792) negative regulation of determination of dorsal identity(GO:2000016)
0.5 2.5 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.5 4.7 GO:0071763 nuclear membrane organization(GO:0071763)
0.4 3.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.4 1.7 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.4 5.3 GO:0002467 germinal center formation(GO:0002467)
0.4 2.1 GO:0032375 negative regulation of sterol transport(GO:0032372) negative regulation of cholesterol transport(GO:0032375)
0.3 1.7 GO:0051684 maintenance of Golgi location(GO:0051684)
0.3 1.0 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.3 1.9 GO:0048840 otolith development(GO:0048840)
0.3 7.4 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.3 2.7 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.3 2.7 GO:0071285 cellular response to lithium ion(GO:0071285)
0.3 6.8 GO:0043486 histone exchange(GO:0043486)
0.3 4.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.3 1.7 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.3 1.4 GO:0032329 serine transport(GO:0032329)
0.3 3.6 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.3 2.2 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.3 1.0 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.3 3.0 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.2 3.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 0.7 GO:0036233 glycine import(GO:0036233)
0.2 0.7 GO:0007621 negative regulation of female receptivity(GO:0007621) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of cellular pH reduction(GO:0032847) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.2 0.7 GO:0046133 pyrimidine ribonucleoside catabolic process(GO:0046133)
0.2 2.2 GO:0006968 cellular defense response(GO:0006968)
0.2 0.8 GO:0001787 natural killer cell proliferation(GO:0001787)
0.2 5.6 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.2 8.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 2.6 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.2 1.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 1.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.2 1.2 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2 4.6 GO:0030224 monocyte differentiation(GO:0030224)
0.2 2.0 GO:0015701 bicarbonate transport(GO:0015701)
0.2 2.7 GO:0030574 collagen catabolic process(GO:0030574)
0.2 3.4 GO:0050892 intestinal absorption(GO:0050892)
0.2 2.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 0.6 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.2 1.4 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.2 3.6 GO:0006825 copper ion transport(GO:0006825)
0.2 3.9 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 4.4 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 1.7 GO:0097186 amelogenesis(GO:0097186)
0.1 0.5 GO:0016240 autophagosome docking(GO:0016240)
0.1 0.9 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 1.7 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 0.9 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
0.1 0.7 GO:0072675 osteoclast fusion(GO:0072675)
0.1 2.1 GO:0043248 proteasome assembly(GO:0043248)
0.1 5.7 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.1 0.9 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 19.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 1.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 1.7 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 2.0 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.2 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 3.6 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 2.3 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.6 GO:0048570 notochord morphogenesis(GO:0048570)
0.1 4.2 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 0.5 GO:0030316 osteoclast differentiation(GO:0030316)
0.1 1.5 GO:0021924 olfactory bulb interneuron development(GO:0021891) cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)
0.1 0.4 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.6 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 6.8 GO:0006334 nucleosome assembly(GO:0006334)
0.1 8.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 5.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 5.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.7 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.1 2.4 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 0.5 GO:0046541 saliva secretion(GO:0046541)
0.1 2.0 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 2.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 1.3 GO:0045760 positive regulation of action potential(GO:0045760)
0.1 1.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.6 GO:0010842 retina layer formation(GO:0010842)
0.1 2.6 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 2.6 GO:0060325 face morphogenesis(GO:0060325)
0.1 6.3 GO:0000910 cytokinesis(GO:0000910)
0.1 0.9 GO:0007099 centriole replication(GO:0007099)
0.1 2.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.9 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.9 GO:0072337 modified amino acid transport(GO:0072337)
0.0 1.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 4.3 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 1.5 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.0 0.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 4.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.5 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.0 1.9 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)
0.0 2.3 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.8 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 3.2 GO:0045444 fat cell differentiation(GO:0045444)
0.0 0.5 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 2.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.8 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.0 0.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 16.2 GO:0045098 type III intermediate filament(GO:0045098)
1.9 5.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.5 4.4 GO:1990047 spindle matrix(GO:1990047)
1.0 4.0 GO:0008623 CHRAC(GO:0008623)
0.8 10.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.7 2.8 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.7 7.3 GO:0005915 zonula adherens(GO:0005915)
0.6 1.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.6 2.5 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.5 0.5 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.5 1.6 GO:0005927 muscle tendon junction(GO:0005927)
0.5 1.5 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.5 2.5 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.5 3.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.5 2.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.5 0.9 GO:0044753 amphisome(GO:0044753)
0.4 8.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 4.8 GO:0031105 septin complex(GO:0031105)
0.3 18.4 GO:0044295 axonal growth cone(GO:0044295)
0.3 0.9 GO:0031595 nuclear proteasome complex(GO:0031595)
0.3 11.2 GO:0016592 mediator complex(GO:0016592)
0.3 11.0 GO:0034707 chloride channel complex(GO:0034707)
0.3 3.9 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 3.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 3.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.2 2.7 GO:0045095 keratin filament(GO:0045095)
0.2 2.0 GO:0070545 PeBoW complex(GO:0070545)
0.2 3.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 2.1 GO:0031209 SCAR complex(GO:0031209)
0.2 0.9 GO:0098536 deuterosome(GO:0098536)
0.2 0.6 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 1.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 2.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 17.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 2.3 GO:0005839 proteasome core complex(GO:0005839)
0.1 5.9 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.8 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 5.8 GO:0000786 nucleosome(GO:0000786)
0.1 0.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 0.2 GO:0097513 myosin II filament(GO:0097513)
0.1 0.2 GO:0098842 postsynaptic early endosome(GO:0098842)
0.1 0.6 GO:0042587 glycogen granule(GO:0042587)
0.1 1.9 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 5.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 0.6 GO:0098533 ATPase dependent transmembrane transport complex(GO:0098533)
0.1 2.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 3.0 GO:0005871 kinesin complex(GO:0005871)
0.1 2.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 4.6 GO:0030315 T-tubule(GO:0030315)
0.1 8.5 GO:0005925 focal adhesion(GO:0005925)
0.1 0.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 5.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 4.8 GO:0030496 midbody(GO:0030496)
0.0 2.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 2.0 GO:0005811 lipid particle(GO:0005811)
0.0 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.8 GO:0005844 polysome(GO:0005844)
0.0 1.0 GO:0000502 proteasome complex(GO:0000502)
0.0 0.6 GO:0014704 intercalated disc(GO:0014704)
0.0 2.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 3.1 GO:0010008 endosome membrane(GO:0010008)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 2.4 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.1 GO:0043235 receptor complex(GO:0043235)
0.0 0.8 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 18.9 GO:1990254 keratin filament binding(GO:1990254)
2.5 15.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
2.4 36.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.8 10.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.4 5.7 GO:0050436 microfibril binding(GO:0050436)
1.4 5.7 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
1.0 3.1 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
1.0 3.0 GO:1990450 linear polyubiquitin binding(GO:1990450)
1.0 2.9 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.9 17.1 GO:0035497 cAMP response element binding(GO:0035497)
0.8 7.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.8 3.1 GO:0048408 epidermal growth factor binding(GO:0048408)
0.7 3.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.7 14.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.7 4.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.7 2.7 GO:0034618 arginine binding(GO:0034618)
0.7 2.0 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.6 1.7 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153)
0.6 1.7 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.6 2.8 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.5 8.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.4 19.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 7.2 GO:0017166 vinculin binding(GO:0017166)
0.4 2.5 GO:0002135 CTP binding(GO:0002135)
0.4 1.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.4 4.6 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.4 6.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 2.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.4 2.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.3 2.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 6.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 5.2 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.3 1.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.3 3.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.3 0.8 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.3 2.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 1.0 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.2 10.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 1.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 6.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 0.9 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 1.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 3.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 8.3 GO:0001671 ATPase activator activity(GO:0001671)
0.2 19.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 1.4 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.2 3.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 4.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 1.5 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.2 2.0 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 1.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 4.3 GO:0004697 protein kinase C activity(GO:0004697)
0.2 0.7 GO:0031893 vasopressin receptor binding(GO:0031893)
0.2 2.4 GO:0048038 quinone binding(GO:0048038)
0.2 14.5 GO:0019208 phosphatase regulator activity(GO:0019208)
0.2 3.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 0.6 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 2.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 8.2 GO:0005254 chloride channel activity(GO:0005254)
0.1 0.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 1.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.7 GO:0015108 chloride transmembrane transporter activity(GO:0015108)
0.1 1.2 GO:0031996 thioesterase binding(GO:0031996)
0.1 2.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.5 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 2.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.9 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 0.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 2.7 GO:0005504 fatty acid binding(GO:0005504)
0.1 2.8 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.1 7.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 6.5 GO:0005178 integrin binding(GO:0005178)
0.1 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.5 GO:0019956 chemokine binding(GO:0019956)
0.0 0.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 2.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 13.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.2 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021)
0.0 1.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.6 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 3.0 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.4 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 1.1 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.1 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.2 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 6.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 7.8 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.4 GO:0017022 myosin binding(GO:0017022)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.7 GO:0008201 heparin binding(GO:0008201)
0.0 7.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.7 GO:0030414 peptidase inhibitor activity(GO:0030414)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 24.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 12.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.4 13.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.4 2.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 7.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 10.3 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.2 2.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 2.5 PID_ARF6_PATHWAY Arf6 signaling events
0.2 11.5 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 0.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 21.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 4.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 4.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.2 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 4.2 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 8.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 5.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.5 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 0.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 2.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 2.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.2 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.1 3.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 9.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 0.2 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 4.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 3.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.8 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.8 PID_P73PATHWAY p73 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 31.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.7 5.0 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.7 16.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 7.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 6.5 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.4 6.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.3 4.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.3 2.5 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.2 3.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 3.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 2.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 1.9 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.2 5.3 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 2.9 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 4.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 2.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 2.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 8.7 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS Genes involved in Activation of NF-kappaB in B Cells
0.1 1.2 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 1.1 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 5.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.7 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 2.4 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 2.2 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 14.8 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 3.6 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 0.5 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.1 0.7 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 0.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.6 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 7.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 6.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.0 1.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 3.9 REACTOME_HEMOSTASIS Genes involved in Hemostasis