Motif ID: Fos

Z-value: 0.910


Transcription factors associated with Fos:

Gene SymbolEntrez IDGene Name
Fos ENSMUSG00000021250.7 Fos

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosmm10_v2_chr12_+_85473883_85473896-0.324.4e-03Click!


Activity profile for motif Fos.

activity profile for motif Fos


Sorted Z-values histogram for motif Fos

Sorted Z-values for motif Fos



Network of associatons between targets according to the STRING database.



First level regulatory network of Fos

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_82910863 17.671 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr2_+_13573927 16.247 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr11_-_84067063 13.443 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr11_-_84068766 11.701 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr13_+_15463837 11.514 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr8_+_94984399 11.376 ENSMUST00000093271.6
 Gpr56
G protein-coupled receptor 56
chr11_-_84069179 10.937 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chr8_-_61591130 10.518 ENSMUST00000135439.1
ENSMUST00000121200.1
 Palld

palladin, cytoskeletal associated protein

chr17_+_35049966 10.022 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr7_+_27486910 9.677 ENSMUST00000008528.7
 Sertad1
SERTA domain containing 1
chr2_-_18048784 9.275 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr1_+_107511489 8.661 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 8.614 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr17_+_43952999 8.095 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chrX_-_143827391 8.014 ENSMUST00000087316.5
 Capn6
calpain 6
chrX_-_23266751 8.012 ENSMUST00000115316.2
 Klhl13
kelch-like 13
chr6_+_7555053 7.948 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr2_+_20737306 7.682 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr13_-_21780616 7.436 ENSMUST00000080511.2
 Hist1h1b
histone cluster 1, H1b
chr13_-_23991158 7.413 ENSMUST00000021770.7
 Scgn
secretagogin, EF-hand calcium binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 36.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.6 20.6 GO:0009409 response to cold(GO:0009409)
0.1 19.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
3.2 16.2 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.8 15.0 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
3.8 11.5 GO:0060364 frontal suture morphogenesis(GO:0060364)
1.1 10.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 9.8 GO:0003334 keratinocyte development(GO:0003334)
0.2 8.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 8.0 GO:0001578 microtubule bundle formation(GO:0001578)
2.6 7.9 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.6 7.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 7.4 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
1.8 7.3 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.6 6.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.3 6.8 GO:0043486 histone exchange(GO:0043486)
0.1 6.8 GO:0006334 nucleosome assembly(GO:0006334)
2.2 6.5 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 6.3 GO:0000910 cytokinesis(GO:0000910)
2.0 6.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.4 GO:0044295 axonal growth cone(GO:0044295)
0.1 17.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
4.1 16.2 GO:0045098 type III intermediate filament(GO:0045098)
0.3 11.2 GO:0016592 mediator complex(GO:0016592)
0.3 11.0 GO:0034707 chloride channel complex(GO:0034707)
0.8 10.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 8.5 GO:0005925 focal adhesion(GO:0005925)
0.4 8.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.7 7.3 GO:0005915 zonula adherens(GO:0005915)
0.1 5.9 GO:0005876 spindle microtubule(GO:0005876)
0.1 5.8 GO:0000786 nucleosome(GO:0000786)
1.9 5.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 5.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.5 GO:0031225 anchored component of membrane(GO:0031225)
0.3 4.8 GO:0031105 septin complex(GO:0031105)
0.0 4.8 GO:0030496 midbody(GO:0030496)
0.1 4.6 GO:0030315 T-tubule(GO:0030315)
1.5 4.4 GO:1990047 spindle matrix(GO:1990047)
1.0 4.0 GO:0008623 CHRAC(GO:0008623)
0.3 3.9 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 36.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 19.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 19.6 GO:0033613 activating transcription factor binding(GO:0033613)
4.7 18.9 GO:1990254 keratin filament binding(GO:1990254)
0.9 17.1 GO:0035497 cAMP response element binding(GO:0035497)
2.5 15.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 14.5 GO:0019208 phosphatase regulator activity(GO:0019208)
0.7 14.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 13.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.8 10.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 10.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.5 8.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 8.3 GO:0001671 ATPase activator activity(GO:0001671)
0.1 8.2 GO:0005254 chloride channel activity(GO:0005254)
0.0 7.8 GO:0003779 actin binding(GO:0003779)
0.0 7.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.8 7.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 7.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.4 7.2 GO:0017166 vinculin binding(GO:0017166)
0.4 6.8 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 24.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 21.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 13.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.4 12.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 11.5 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.3 10.3 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 9.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 8.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.3 7.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 6.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 5.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 4.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 4.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 4.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 4.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.2 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 3.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 3.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 2.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 31.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.7 16.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 14.8 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 8.7 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 7.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 7.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 6.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.4 6.5 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 6.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.3 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 5.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.7 5.0 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 4.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 4.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 3.9 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.1 3.6 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.2 3.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 3.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 2.9 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 2.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis