Motif ID: Fosb

Z-value: 0.413


Transcription factors associated with Fosb:

Gene SymbolEntrez IDGene Name
Fosb ENSMUSG00000003545.2 Fosb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosbmm10_v2_chr7_-_19310035_19310050-0.066.2e-01Click!


Activity profile for motif Fosb.

activity profile for motif Fosb


Sorted Z-values histogram for motif Fosb

Sorted Z-values for motif Fosb



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosb

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_113663670 4.361 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr6_+_17463927 3.505 ENSMUST00000115442.1
Met
met proto-oncogene
chr16_+_78930940 3.222 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
Chodl


chondrolectin


chr8_+_36489191 2.969 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr2_+_118663235 2.703 ENSMUST00000099557.3
Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr10_-_64090241 2.536 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090265 2.462 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr9_+_104566677 2.227 ENSMUST00000157006.1
Cpne4
copine IV
chr14_+_27622433 1.769 ENSMUST00000090302.5
Erc2
ELKS/RAB6-interacting/CAST family member 2
chr16_+_17561885 1.759 ENSMUST00000171002.1
ENSMUST00000023441.4
P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr3_+_123267445 1.735 ENSMUST00000047923.7
Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr9_+_114978507 1.644 ENSMUST00000183104.1
Osbpl10
oxysterol binding protein-like 10
chr2_-_45110241 1.625 ENSMUST00000177302.1
Zeb2
zinc finger E-box binding homeobox 2
chr3_+_55461758 1.604 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr2_-_151632471 1.575 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
Snph






syntaphilin






chr8_-_8639363 1.469 ENSMUST00000152698.1
Efnb2
ephrin B2
chr7_+_30413744 1.469 ENSMUST00000032800.9
Tyrobp
TYRO protein tyrosine kinase binding protein
chr14_+_79426454 1.287 ENSMUST00000061222.7
Kbtbd7
kelch repeat and BTB (POZ) domain containing 7
chr17_+_35841668 1.227 ENSMUST00000174124.1
Mdc1
mediator of DNA damage checkpoint 1
chr15_-_102257306 1.227 ENSMUST00000135466.1
Rarg
retinoic acid receptor, gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.0 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.5 3.5 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 3.0 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 2.7 GO:0007613 memory(GO:0007613)
0.6 2.3 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 1.8 GO:0033198 response to ATP(GO:0033198)
0.1 1.7 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 1.6 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 1.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 1.6 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.2 1.5 GO:2001204 regulation of osteoclast development(GO:2001204)
0.2 1.5 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 1.2 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 1.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.2 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.3 1.0 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 1.0 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 1.0 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 0.9 GO:0007296 vitellogenesis(GO:0007296)
0.2 0.8 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 4.5 GO:0042734 presynaptic membrane(GO:0042734)
0.1 3.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.7 GO:0001650 fibrillar center(GO:0001650)
0.1 1.8 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 1.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 1.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 1.2 GO:0071439 clathrin complex(GO:0071439)
0.1 1.2 GO:0042581 specific granule(GO:0042581)
0.1 1.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.9 GO:0045298 tubulin complex(GO:0045298)
0.2 0.8 GO:0097447 dendritic tree(GO:0097447)
0.0 0.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 0.7 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.7 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.9 3.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.5 3.0 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 2.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.3 1.8 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 1.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.7 GO:0000149 SNARE binding(GO:0000149)
0.1 1.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.6 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 3.7 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.1 PID_ATM_PATHWAY ATM pathway
0.0 1.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 2.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 2.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.1 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.7 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.9 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.8 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix