Motif ID: Fosl2_Bach2

Z-value: 0.791

Transcription factors associated with Fosl2_Bach2:

Gene SymbolEntrez IDGene Name
Bach2 ENSMUSG00000040270.10 Bach2
Fosl2 ENSMUSG00000029135.9 Fosl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl2mm10_v2_chr5_+_32136458_321365050.741.1e-14Click!
Bach2mm10_v2_chr4_+_32238950_322389640.207.5e-02Click!


Activity profile for motif Fosl2_Bach2.

activity profile for motif Fosl2_Bach2


Sorted Z-values histogram for motif Fosl2_Bach2

Sorted Z-values for motif Fosl2_Bach2



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosl2_Bach2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_17463927 17.245 ENSMUST00000115442.1
 Met
met proto-oncogene
chr1_-_33907721 17.057 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr14_+_65968483 11.972 ENSMUST00000022616.6
 Clu
clusterin
chr7_-_105482197 8.205 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chrY_-_1286563 7.759 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr16_-_22439719 7.672 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr6_-_124769548 7.487 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr9_+_60712989 7.299 ENSMUST00000038407.5
 Larp6
La ribonucleoprotein domain family, member 6
chr14_+_101840602 7.291 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr14_+_101840501 6.935 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr10_-_64090241 6.876 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_-_88503331 6.754 ENSMUST00000029699.6
 Lmna
lamin A
chr9_-_20728219 6.720 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr18_+_32938955 6.452 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr2_+_156475803 6.422 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr17_-_24644933 6.416 ENSMUST00000019684.5
 Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr2_+_156475844 6.234 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr3_-_88503187 6.188 ENSMUST00000120377.1
 Lmna
lamin A
chr10_-_64090265 6.143 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr6_+_17463749 5.983 ENSMUST00000115443.1
 Met
met proto-oncogene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 28.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 17.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.4 13.0 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
2.6 12.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 12.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
2.0 12.0 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
2.6 10.6 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.7 8.7 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
1.5 7.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.5 7.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.1 7.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
1.2 7.3 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
1.2 7.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 6.4 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.2 5.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.8 5.7 GO:0015862 uridine transport(GO:0015862)
0.3 5.7 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 5.4 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.2 5.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.3 4.8 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 28.8 GO:0009925 basal plasma membrane(GO:0009925)
0.1 22.0 GO:0016324 apical plasma membrane(GO:0016324)
0.2 13.3 GO:0042734 presynaptic membrane(GO:0042734)
1.8 12.9 GO:0005638 lamin filament(GO:0005638)
0.1 12.4 GO:0001650 fibrillar center(GO:0001650)
1.7 12.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
1.0 11.4 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 9.0 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.2 8.9 GO:0005581 collagen trimer(GO:0005581)
0.1 8.4 GO:0005604 basement membrane(GO:0005604)
0.8 7.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 7.5 GO:0031985 Golgi cisterna(GO:0031985)
0.0 7.5 GO:0014069 postsynaptic density(GO:0014069)
0.3 6.9 GO:0032279 asymmetric synapse(GO:0032279)
0.2 6.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 6.4 GO:0032420 stereocilium(GO:0032420)
0.0 5.5 GO:0055037 recycling endosome(GO:0055037)
0.0 5.3 GO:0009897 external side of plasma membrane(GO:0009897)
1.7 5.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.2 4.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.1 28.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 18.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.5 18.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.5 17.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 14.2 GO:0042805 actinin binding(GO:0042805)
0.4 12.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.0 11.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 10.0 GO:0070412 R-SMAD binding(GO:0070412)
0.4 9.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.8 7.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 7.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 7.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.3 7.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 6.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.6 6.0 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 5.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 5.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.5 GO:0030165 PDZ domain binding(GO:0030165)
0.1 5.3 GO:0001786 phosphatidylserine binding(GO:0001786)
1.3 5.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 35.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 12.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.4 12.0 PID_ARF_3PATHWAY Arf1 pathway
0.1 8.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 7.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 7.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 7.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 7.4 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 7.2 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 6.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 5.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 4.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.1 PID_INSULIN_PATHWAY Insulin Pathway
0.1 3.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 3.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 3.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.7 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 2.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 25.8 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 13.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.6 11.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 10.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 7.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 7.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 7.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 7.0 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 5.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 5.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 4.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 4.4 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.2 4.3 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.3 4.1 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 4.1 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.3 4.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 3.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 3.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 3.4 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage