Motif ID: Foxa2_Foxa1
Z-value: 1.687
Transcription factors associated with Foxa2_Foxa1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxa1 | ENSMUSG00000035451.6 | Foxa1 |
| Foxa2 | ENSMUSG00000037025.5 | Foxa2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxa1 | mm10_v2_chr12_-_57546121_57546141 | 0.31 | 6.8e-03 | Click! |
| Foxa2 | mm10_v2_chr2_-_148045891_148045948 | 0.21 | 7.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.6 | 49.9 | GO:0060023 | soft palate development(GO:0060023) |
| 5.0 | 15.0 | GO:1900108 | negative regulation of nodal signaling pathway(GO:1900108) |
| 4.8 | 33.3 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366) |
| 4.7 | 51.9 | GO:0060539 | diaphragm development(GO:0060539) |
| 3.9 | 35.0 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 3.5 | 6.9 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 3.1 | 12.5 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 3.0 | 17.8 | GO:0003383 | apical constriction(GO:0003383) |
| 2.9 | 8.6 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 2.8 | 8.4 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
| 2.7 | 24.0 | GO:0071493 | cellular response to UV-B(GO:0071493) |
| 2.6 | 10.3 | GO:1901894 | regulation of calcium-transporting ATPase activity(GO:1901894) |
| 2.5 | 10.1 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
| 2.4 | 7.1 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) skeletal muscle fiber differentiation(GO:0098528) |
| 2.2 | 48.9 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 2.2 | 6.6 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 2.1 | 4.2 | GO:0002572 | pro-T cell differentiation(GO:0002572) |
| 2.0 | 9.9 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 1.9 | 11.5 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 1.9 | 28.7 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 1.8 | 10.6 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 1.7 | 5.1 | GO:0021759 | globus pallidus development(GO:0021759) |
| 1.6 | 24.7 | GO:0072189 | ureter development(GO:0072189) |
| 1.6 | 16.0 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 1.6 | 18.9 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 1.6 | 12.6 | GO:0015074 | DNA integration(GO:0015074) |
| 1.4 | 16.9 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 1.4 | 4.2 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 1.4 | 63.8 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 1.4 | 6.9 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
| 1.3 | 10.7 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 1.3 | 13.4 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 1.3 | 2.6 | GO:0002069 | columnar/cuboidal epithelial cell maturation(GO:0002069) |
| 1.2 | 12.0 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
| 1.1 | 5.7 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 1.1 | 12.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 1.1 | 3.4 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 1.1 | 10.0 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 1.0 | 2.0 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 1.0 | 3.0 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 1.0 | 1.0 | GO:0060681 | branch elongation involved in ureteric bud branching(GO:0060681) |
| 1.0 | 6.9 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 1.0 | 4.0 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 0.9 | 23.4 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.9 | 4.6 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.9 | 3.7 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.9 | 10.0 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.9 | 2.6 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.8 | 5.0 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.8 | 44.2 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.7 | 6.0 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.7 | 26.9 | GO:0007129 | synapsis(GO:0007129) |
| 0.7 | 4.1 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.6 | 2.5 | GO:0060686 | regulation of prostatic bud formation(GO:0060685) negative regulation of prostatic bud formation(GO:0060686) |
| 0.6 | 3.8 | GO:0021830 | interneuron migration from the subpallium to the cortex(GO:0021830) neurotransmitter receptor metabolic process(GO:0045213) |
| 0.6 | 3.1 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.6 | 1.2 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.6 | 1.8 | GO:0016332 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) |
| 0.6 | 5.5 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.6 | 4.2 | GO:0021937 | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) |
| 0.5 | 14.0 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.5 | 1.6 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
| 0.5 | 17.0 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.5 | 2.0 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.5 | 7.7 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.5 | 5.8 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.5 | 1.9 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
| 0.5 | 2.3 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.5 | 3.7 | GO:0021559 | trigeminal nerve development(GO:0021559) |
| 0.5 | 6.4 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
| 0.4 | 2.6 | GO:1901072 | glucosamine-containing compound catabolic process(GO:1901072) |
| 0.4 | 3.3 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) anterior/posterior axon guidance(GO:0033564) |
| 0.4 | 3.6 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.4 | 5.1 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.4 | 4.3 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.4 | 5.2 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.3 | 2.0 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.3 | 4.4 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.3 | 5.1 | GO:0060746 | parental behavior(GO:0060746) |
| 0.3 | 4.3 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.3 | 1.5 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.3 | 1.8 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.3 | 6.2 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.3 | 2.0 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.3 | 1.3 | GO:0021798 | forebrain dorsal/ventral pattern formation(GO:0021798) |
| 0.2 | 1.2 | GO:0035701 | hematopoietic stem cell migration(GO:0035701) |
| 0.2 | 8.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 2.3 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.2 | 8.5 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
| 0.2 | 7.6 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 0.2 | 0.4 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
| 0.2 | 1.8 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.2 | 0.3 | GO:0071707 | immunoglobulin heavy chain V-D-J recombination(GO:0071707) |
| 0.2 | 2.0 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.2 | 2.6 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.2 | 1.1 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.2 | 1.5 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.2 | 2.4 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 1.0 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.1 | 7.5 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.1 | 0.7 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 3.6 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 0.3 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.1 | 3.1 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.1 | 3.7 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.1 | 2.1 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.1 | 1.1 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 3.0 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.1 | 0.4 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 0.1 | 5.8 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.1 | 6.4 | GO:0050868 | negative regulation of T cell activation(GO:0050868) |
| 0.1 | 4.4 | GO:0002011 | morphogenesis of an epithelial sheet(GO:0002011) |
| 0.1 | 2.2 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.1 | 9.4 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.1 | 2.3 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 1.3 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.1 | 0.7 | GO:0017144 | drug metabolic process(GO:0017144) |
| 0.1 | 0.2 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.1 | 2.1 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.1 | 0.1 | GO:0007521 | muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596) |
| 0.1 | 1.3 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.1 | 1.5 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 1.3 | GO:1903846 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.0 | 0.9 | GO:0010996 | response to auditory stimulus(GO:0010996) |
| 0.0 | 0.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 1.1 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.0 | 1.3 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 1.3 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 2.5 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 1.2 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.2 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 0.4 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731) |
| 0.0 | 0.2 | GO:0044458 | motile cilium assembly(GO:0044458) left/right pattern formation(GO:0060972) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 24.3 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 8.0 | 24.0 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 4.9 | 44.2 | GO:0030478 | actin cap(GO:0030478) |
| 2.3 | 55.2 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 2.2 | 13.4 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 2.2 | 17.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 2.1 | 8.3 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 2.0 | 10.1 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 1.8 | 19.3 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 1.4 | 9.9 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.9 | 2.6 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.7 | 4.6 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.6 | 3.1 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.6 | 3.0 | GO:1990357 | terminal web(GO:1990357) |
| 0.5 | 10.3 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.5 | 4.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.4 | 2.6 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.4 | 1.8 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.3 | 1.7 | GO:0001652 | granular component(GO:0001652) |
| 0.3 | 2.0 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.3 | 4.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.3 | 6.0 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.3 | 4.1 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.3 | 18.9 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.2 | 8.5 | GO:0030904 | retromer complex(GO:0030904) |
| 0.2 | 12.3 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.2 | 1.8 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.1 | 2.1 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 1.3 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.1 | 10.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 44.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 2.6 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 2.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 1.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 1.9 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 3.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 2.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 1.1 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 3.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 12.3 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.1 | 2.1 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 7.5 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 2.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 7.5 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 1.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 45.1 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 0.2 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.0 | 8.5 | GO:0005819 | spindle(GO:0005819) |
| 0.0 | 0.4 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.0 | 2.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 9.8 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.9 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 2.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 2.0 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 3.7 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.1 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 3.7 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 2.3 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.4 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.4 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.0 | 39.3 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 0.5 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 0.9 | GO:0043235 | receptor complex(GO:0043235) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.0 | 24.0 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 6.7 | 46.9 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 6.3 | 18.9 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 5.0 | 15.0 | GO:0016015 | morphogen activity(GO:0016015) |
| 4.3 | 17.3 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 2.2 | 13.4 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 1.4 | 4.3 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 1.4 | 8.6 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 1.3 | 4.0 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 1.2 | 5.0 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
| 1.1 | 1.1 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 1.1 | 8.4 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 1.0 | 3.0 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 1.0 | 21.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.8 | 4.2 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.7 | 6.0 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.7 | 24.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.7 | 8.8 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.7 | 2.2 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.7 | 14.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.7 | 16.0 | GO:0005521 | lamin binding(GO:0005521) |
| 0.7 | 6.9 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.7 | 129.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.7 | 4.6 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.6 | 11.9 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.5 | 1.6 | GO:0071723 | lipopeptide binding(GO:0071723) |
| 0.5 | 2.5 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.5 | 1.9 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.4 | 1.7 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.4 | 2.1 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.4 | 4.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.4 | 12.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.4 | 17.8 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.4 | 43.5 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.4 | 4.3 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.3 | 2.6 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.3 | 5.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.3 | 0.9 | GO:0005118 | sevenless binding(GO:0005118) |
| 0.3 | 3.7 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.3 | 1.3 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.2 | 0.7 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 2.0 | GO:0071253 | connexin binding(GO:0071253) |
| 0.2 | 3.4 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.2 | 4.2 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.2 | 8.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 2.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 1.1 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.2 | 2.6 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.2 | 16.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 2.5 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.2 | 10.4 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 4.1 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 1.5 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.1 | 1.3 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.1 | 3.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 1.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 2.3 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 8.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 3.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 0.7 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 30.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 2.0 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 1.9 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.1 | 27.1 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 0.8 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 2.6 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 2.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 2.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 1.5 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 0.4 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 1.0 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 31.2 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 3.8 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 7.4 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.1 | 4.3 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.1 | 1.5 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 5.3 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 31.5 | GO:0019904 | protein domain specific binding(GO:0019904) |
| 0.0 | 5.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.5 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 1.7 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 2.9 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.7 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.9 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.0 | 0.2 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 18.5 | GO:0005215 | transporter activity(GO:0005215) |
| 0.0 | 0.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 1.4 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.0 | 2.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 4.4 | GO:0030234 | enzyme regulator activity(GO:0030234) |
| 0.0 | 0.9 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 0.3 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 24.0 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 2.5 | 34.4 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.1 | 35.0 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.9 | 45.7 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.8 | 8.4 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.6 | 6.9 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.3 | 15.0 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.3 | 12.4 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.3 | 31.0 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 1.6 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.3 | 20.0 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.3 | 5.5 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.3 | 10.0 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.3 | 7.7 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 7.4 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.3 | 3.6 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.3 | 3.8 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.2 | 2.9 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.2 | 6.9 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.2 | 12.5 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 5.1 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.5 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 15.1 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.3 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 2.5 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 1.9 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 9.1 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.6 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.1 | 5.5 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 2.3 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 1.7 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.2 | PID_TXA2PATHWAY | Thromboxane A2 receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 45.3 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 1.9 | 32.5 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 1.3 | 34.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 1.2 | 43.8 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.0 | 13.4 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.9 | 28.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.8 | 22.2 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.7 | 21.6 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.7 | 12.3 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.7 | 14.5 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.6 | 3.8 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.6 | 14.0 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.5 | 4.4 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.4 | 4.3 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.4 | 11.3 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.4 | 18.1 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 2.3 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.3 | 3.3 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.3 | 6.4 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.2 | 3.0 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.2 | 2.3 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.2 | 5.6 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 5.7 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 4.0 | REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.1 | 2.6 | REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 5.0 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 3.2 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 1.0 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.1 | 1.9 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 6.5 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 3.6 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.1 | 2.1 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.6 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 6.2 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 2.6 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 4.1 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.3 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.3 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 1.7 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.5 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
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