Motif ID: Foxb1

Z-value: 0.864


Transcription factors associated with Foxb1:

Gene SymbolEntrez IDGene Name
Foxb1 ENSMUSG00000059246.4 Foxb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxb1mm10_v2_chr9_-_69760924_697609400.271.9e-02Click!


Activity profile for motif Foxb1.

activity profile for motif Foxb1


Sorted Z-values histogram for motif Foxb1

Sorted Z-values for motif Foxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 96 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 10.392 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr6_-_56362356 10.332 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr6_+_14901344 10.065 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr1_-_158814469 7.497 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr18_-_47333311 7.217 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr3_+_55782500 7.035 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr3_-_123672321 6.827 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr6_+_8948608 6.787 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr10_+_37139558 6.460 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chrX_+_106920618 5.994 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr2_+_181767283 5.650 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr2_+_181767040 5.600 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr3_+_76075583 5.282 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr3_-_95904683 5.005 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr17_-_70851710 4.806 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr6_+_14901440 4.766 ENSMUST00000128567.1
 Foxp2
forkhead box P2
chr3_-_123690806 4.392 ENSMUST00000154668.1
 Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr17_+_93199348 4.342 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr7_+_67655414 4.179 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr8_+_58912257 3.612 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 11.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.9 11.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
1.0 11.2 GO:0060539 diaphragm development(GO:0060539)
0.6 10.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.7 7.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.5 7.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 7.3 GO:0060349 bone morphogenesis(GO:0060349)
0.3 7.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 6.2 GO:0043010 camera-type eye development(GO:0043010)
0.3 6.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.6 5.0 GO:0015670 carbon dioxide transport(GO:0015670)
0.5 4.8 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 4.7 GO:0007129 synapsis(GO:0007129)
1.4 4.3 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.0 3.2 GO:0007098 centrosome cycle(GO:0007098)
0.7 2.9 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 2.8 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.7 2.7 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.4 2.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.3 2.7 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0005929 cilium(GO:0005929)
0.4 7.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 5.4 GO:0097440 apical dendrite(GO:0097440)
0.0 5.1 GO:0005819 spindle(GO:0005819)
0.0 4.8 GO:0016607 nuclear speck(GO:0016607)
1.6 4.7 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 4.0 GO:0043195 terminal bouton(GO:0043195)
0.0 3.8 GO:0030315 T-tubule(GO:0030315)
0.6 2.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.4 2.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 2.7 GO:0030478 actin cap(GO:0030478)
0.0 2.6 GO:0005811 lipid particle(GO:0005811)
0.0 2.6 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.0 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 1.8 GO:0070852 cell body fiber(GO:0070852)
0.0 1.8 GO:0000790 nuclear chromatin(GO:0000790)
0.1 1.6 GO:0070822 Sin3-type complex(GO:0070822)
0.1 1.1 GO:0042405 nuclear inclusion body(GO:0042405)
0.2 0.9 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.8 11.2 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
1.5 10.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 8.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 8.6 GO:0030507 spectrin binding(GO:0030507)
0.1 7.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 7.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 7.0 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.9 6.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.4 5.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 4.8 GO:0070410 co-SMAD binding(GO:0070410)
0.1 4.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 4.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.6 2.9 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.5 2.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 2.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 2.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 2.7 GO:0045182 translation regulator activity(GO:0045182)
0.2 2.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.6 GO:0005521 lamin binding(GO:0005521)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 6.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 6.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 4.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 4.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 4.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 0.8 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.5 7.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 7.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 7.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.7 6.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 4.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 4.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 4.3 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.7 2.9 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 2.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 2.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha