Motif ID: Foxc2
Z-value: 0.535
Transcription factors associated with Foxc2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxc2 | ENSMUSG00000046714.6 | Foxc2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxc2 | mm10_v2_chr8_+_121116163_121116177 | 0.11 | 3.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 8.6 | GO:1901894 | regulation of calcium-transporting ATPase activity(GO:1901894) |
| 1.9 | 5.7 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.7 | 3.7 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.6 | 1.9 | GO:1902524 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.6 | 1.9 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 0.5 | 9.1 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.5 | 1.8 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.4 | 3.1 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366) |
| 0.4 | 3.7 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.4 | 4.0 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.4 | 1.1 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 0.3 | 1.0 | GO:0090004 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.3 | 1.6 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.3 | 2.3 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.3 | 1.9 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.3 | 1.9 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 0.3 | 4.8 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.3 | 3.3 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.3 | 2.6 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.2 | 1.4 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.2 | 1.7 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.2 | 3.1 | GO:0002043 | blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043) |
| 0.1 | 1.9 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.1 | 5.2 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.4 | GO:0015886 | heme transport(GO:0015886) |
| 0.1 | 0.5 | GO:0008295 | spermidine biosynthetic process(GO:0008295) |
| 0.1 | 1.0 | GO:0060613 | fat pad development(GO:0060613) |
| 0.1 | 0.6 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.1 | 0.5 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.1 | 0.4 | GO:1903898 | positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898) |
| 0.1 | 1.7 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.1 | 2.0 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 1.5 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.1 | 0.4 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 0.5 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 0.7 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 0.3 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 0.1 | 0.7 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 0.4 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 0.2 | GO:0038145 | macrophage colony-stimulating factor signaling pathway(GO:0038145) |
| 0.1 | 0.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 0.5 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.6 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.4 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 0.3 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.0 | 0.3 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.0 | 0.6 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 0.2 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 1.2 | GO:2001240 | negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240) |
| 0.0 | 0.1 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.0 | 2.5 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.0 | 0.5 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 1.0 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.7 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 0.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.0 | 0.1 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.0 | 0.4 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.0 | 0.2 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.0 | 0.1 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.0 | 0.3 | GO:0098780 | response to mitochondrial depolarisation(GO:0098780) |
| 0.0 | 0.2 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.0 | 0.5 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.0 | 0.9 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.5 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.0 | 0.2 | GO:0001553 | luteinization(GO:0001553) |
| 0.0 | 0.5 | GO:0036465 | synaptic vesicle recycling(GO:0036465) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.3 | 1.5 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.1 | 1.5 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.1 | 1.9 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 0.5 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 4.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 0.5 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.1 | 0.2 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.1 | 1.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.6 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 0.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 3.2 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 3.3 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 0.5 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.5 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 2.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 2.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 1.1 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 1.6 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 1.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 6.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 3.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.6 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.8 | 3.3 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.6 | 1.9 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.6 | 2.3 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.5 | 1.4 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.5 | 1.8 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.4 | 1.2 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.3 | 2.0 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.2 | 5.7 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 0.4 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 1.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 1.0 | GO:0071253 | connexin binding(GO:0071253) |
| 0.1 | 2.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.4 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.1 | 1.2 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.1 | 3.5 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 1.6 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 0.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.3 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.1 | 0.7 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 3.1 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 1.7 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.4 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.1 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.0 | 0.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 2.3 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 1.7 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 3.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 1.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 7.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.3 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.0 | 0.4 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.0 | 0.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.5 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.4 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.0 | GO:0008201 | heparin binding(GO:0008201) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.7 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 5.3 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.1 | 3.7 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.1 | 1.7 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 3.3 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.3 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 4.0 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.1 | 1.9 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 1.7 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.7 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.9 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 0.5 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.5 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.5 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.1 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.5 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.2 | 4.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 1.7 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 1.9 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 4.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.8 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.3 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 0.7 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.2 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 1.4 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.5 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.5 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 2.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.5 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.7 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 1.9 | REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 0.2 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.3 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.5 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.3 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.2 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
