Motif ID: Foxd1
Z-value: 1.710
Transcription factors associated with Foxd1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxd1 | ENSMUSG00000078302.3 | Foxd1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxd1 | mm10_v2_chr13_+_98354234_98354250 | -0.22 | 5.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.8 | 107.6 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 8.6 | 43.1 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 4.8 | 33.3 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 3.6 | 10.8 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 3.1 | 9.4 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 2.6 | 7.9 | GO:0097350 | neutrophil clearance(GO:0097350) |
| 2.4 | 9.5 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) |
| 2.3 | 6.8 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 2.2 | 6.7 | GO:1902524 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 1.9 | 5.6 | GO:0015886 | heme transport(GO:0015886) |
| 1.7 | 5.1 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 1.7 | 5.1 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 1.7 | 5.0 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 1.7 | 6.7 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 1.6 | 7.8 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
| 1.6 | 4.7 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 1.5 | 13.7 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 1.5 | 7.4 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 1.5 | 4.4 | GO:0099547 | regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254) |
| 1.4 | 12.9 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 1.4 | 5.6 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 1.4 | 9.8 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 1.4 | 5.5 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 1.3 | 14.7 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 1.3 | 3.9 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 1.2 | 3.5 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 1.1 | 20.2 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 1.1 | 15.6 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 1.1 | 11.1 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 1.0 | 11.4 | GO:0071455 | cellular response to hyperoxia(GO:0071455) |
| 1.0 | 3.9 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.9 | 3.6 | GO:0035461 | vitamin transmembrane transport(GO:0035461) |
| 0.9 | 15.4 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.8 | 2.4 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.8 | 6.8 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.8 | 5.3 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.7 | 2.2 | GO:0043379 | rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 0.7 | 3.7 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.7 | 2.2 | GO:0045575 | basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575) |
| 0.7 | 13.6 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.7 | 3.6 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.7 | 7.2 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.6 | 1.9 | GO:0003032 | detection of oxygen(GO:0003032) |
| 0.6 | 1.9 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.6 | 3.0 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.6 | 5.3 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.6 | 10.9 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.6 | 5.7 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.6 | 2.8 | GO:0008355 | olfactory learning(GO:0008355) |
| 0.6 | 11.6 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.5 | 1.6 | GO:0090004 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.5 | 2.6 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.5 | 1.5 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.5 | 3.5 | GO:2000258 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.5 | 5.2 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.5 | 1.4 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.5 | 1.8 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.5 | 3.6 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.5 | 4.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.4 | 2.2 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 0.4 | 7.2 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.4 | 3.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.4 | 2.5 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.4 | 1.2 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.4 | 4.0 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.4 | 4.7 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.4 | 5.8 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.4 | 7.2 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.4 | 2.6 | GO:0035826 | rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476) |
| 0.4 | 5.9 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.4 | 1.8 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.4 | 9.8 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.3 | 5.3 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.3 | 1.5 | GO:0002667 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) negative regulation of protein kinase C signaling(GO:0090038) |
| 0.3 | 1.4 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.3 | 11.0 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
| 0.3 | 2.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.3 | 4.2 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.3 | 2.8 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.3 | 5.8 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) megakaryocyte development(GO:0035855) |
| 0.3 | 2.4 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.3 | 4.9 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.2 | 1.2 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.2 | 2.5 | GO:0043970 | histone H3-K9 acetylation(GO:0043970) |
| 0.2 | 2.4 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.2 | 1.0 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.2 | 1.3 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.2 | 0.9 | GO:0010616 | negative regulation of cardiac muscle adaptation(GO:0010616) |
| 0.2 | 8.9 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.2 | 6.0 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.2 | 2.7 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.2 | 2.5 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.2 | 3.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.2 | 0.6 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.1 | 0.7 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.1 | 2.9 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 1.4 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 1.6 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.1 | 10.5 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.1 | 6.1 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.1 | 7.3 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.1 | 0.4 | GO:0010360 | negative regulation of anion channel activity(GO:0010360) |
| 0.1 | 0.7 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.1 | 2.4 | GO:0055012 | ventricular cardiac muscle cell differentiation(GO:0055012) |
| 0.1 | 5.6 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.1 | 5.0 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.1 | 0.8 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.1 | 2.4 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.1 | 0.9 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
| 0.1 | 14.6 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.1 | 2.6 | GO:0002931 | response to ischemia(GO:0002931) |
| 0.1 | 2.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 1.0 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 0.5 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 4.2 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.1 | 2.3 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 5.2 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.1 | 0.6 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 0.0 | 2.1 | GO:0010324 | membrane invagination(GO:0010324) |
| 0.0 | 3.0 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.9 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.1 | GO:0034239 | regulation of macrophage fusion(GO:0034239) |
| 0.0 | 0.3 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 0.5 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 1.4 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.0 | 0.2 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 3.1 | GO:0016042 | lipid catabolic process(GO:0016042) |
| 0.0 | 1.4 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.6 | GO:0016925 | protein sumoylation(GO:0016925) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 10.8 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 1.2 | 9.4 | GO:0033391 | chromatoid body(GO:0033391) |
| 1.1 | 4.4 | GO:1902737 | viral replication complex(GO:0019034) dendritic filopodium(GO:1902737) |
| 1.0 | 15.6 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.9 | 2.8 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.9 | 9.5 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.7 | 2.2 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.7 | 11.1 | GO:0042555 | MCM complex(GO:0042555) |
| 0.7 | 2.1 | GO:0098835 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) |
| 0.7 | 7.2 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.6 | 1.9 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.5 | 4.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.5 | 9.5 | GO:0043657 | host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657) |
| 0.4 | 5.8 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.4 | 13.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.4 | 5.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.4 | 4.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 6.8 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.3 | 5.5 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.3 | 3.2 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.3 | 1.3 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.2 | 2.5 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.2 | 5.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 8.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.2 | 10.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.2 | 1.4 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.2 | 3.7 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.2 | 0.3 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.1 | 2.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 0.9 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.1 | 5.0 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 8.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 1.9 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 7.8 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 2.6 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 6.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 0.8 | GO:0032300 | mismatch repair complex(GO:0032300) |
| 0.1 | 42.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 5.8 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 29.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 3.6 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 1.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 5.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 15.2 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 2.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 3.6 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 3.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 2.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 2.9 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 1.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 2.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.2 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 6.8 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 0.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 97.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 7.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 5.2 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.0 | 1.8 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 45.6 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 3.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 7.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.0 | GO:0034657 | GID complex(GO:0034657) |
| 0.0 | 18.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 1.6 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.8 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.0 | 1.9 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 8.7 | GO:0005739 | mitochondrion(GO:0005739) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 107.6 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 11.1 | 33.3 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 3.7 | 14.7 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 2.9 | 8.8 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 2.7 | 10.8 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 2.2 | 13.3 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 1.9 | 5.6 | GO:0015232 | heme transporter activity(GO:0015232) |
| 1.4 | 4.1 | GO:0005118 | sevenless binding(GO:0005118) |
| 1.3 | 5.3 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 1.1 | 5.5 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 1.0 | 3.0 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
| 1.0 | 3.9 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.9 | 9.4 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.9 | 3.6 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.8 | 5.7 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.7 | 14.2 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.7 | 7.9 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.7 | 2.2 | GO:0035651 | AP-3 adaptor complex binding(GO:0035651) |
| 0.6 | 15.6 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.6 | 3.6 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.6 | 8.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.6 | 8.6 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.6 | 5.0 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.6 | 6.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.5 | 2.2 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.5 | 2.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.5 | 5.5 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.5 | 8.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.5 | 1.9 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.5 | 1.4 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.5 | 2.8 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.5 | 11.0 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.4 | 2.4 | GO:0043426 | MRF binding(GO:0043426) |
| 0.4 | 5.3 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.4 | 2.4 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.4 | 3.5 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.4 | 2.6 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.4 | 11.4 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.4 | 1.8 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.3 | 9.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.3 | 3.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.3 | 7.9 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.3 | 3.6 | GO:0090482 | vitamin transmembrane transporter activity(GO:0090482) |
| 0.3 | 2.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.3 | 10.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.3 | 9.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.3 | 0.9 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
| 0.3 | 0.9 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.3 | 11.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.2 | 3.1 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.2 | 2.6 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.2 | 1.9 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.2 | 1.6 | GO:0071253 | connexin binding(GO:0071253) |
| 0.2 | 14.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 0.8 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.2 | 5.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.2 | 0.9 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.2 | 6.8 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.2 | 3.4 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 5.2 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 11.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 5.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 2.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 1.4 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 5.1 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.1 | 9.8 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 7.7 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 4.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 1.4 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 0.6 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 5.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 2.2 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.4 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.1 | 2.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.6 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.1 | 3.9 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.1 | 3.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 32.7 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 2.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 1.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 0.7 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 2.7 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.1 | 1.2 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 1.8 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 2.4 | GO:0032934 | cholesterol binding(GO:0015485) sterol binding(GO:0032934) |
| 0.0 | 11.9 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 1.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 1.0 | GO:0000975 | regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212) |
| 0.0 | 0.2 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 2.4 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 10.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.3 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.9 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 4.1 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 1.3 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 0.2 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 2.9 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 1.5 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.5 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.2 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 111.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 1.4 | 43.7 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.7 | 17.0 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.6 | 9.6 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.6 | 13.6 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.5 | 9.5 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.3 | 13.5 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.2 | 5.1 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.2 | 7.9 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 2.8 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 10.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 7.1 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.2 | 5.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.2 | 10.4 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 2.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.2 | 12.8 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 10.1 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.1 | 13.1 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.4 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 5.8 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 3.4 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 3.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 20.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.8 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 5.5 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 5.7 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.1 | 3.1 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 2.2 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 6.7 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.1 | 2.6 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.1 | 3.7 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.1 | 1.2 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.6 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 2.9 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.6 | PID_BMP_PATHWAY | BMP receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 8.9 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 1.0 | 5.9 | REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.7 | 11.1 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.6 | 5.5 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.6 | 25.7 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.4 | 5.2 | REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 0.4 | 9.2 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.4 | 20.9 | REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.4 | 14.7 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.4 | 8.1 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.3 | 9.4 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.3 | 3.9 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.3 | 3.4 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.3 | 16.7 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 4.1 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.3 | 4.3 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 9.7 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 7.2 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.2 | 1.9 | REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING | Genes involved in PI3K events in ERBB4 signaling |
| 0.2 | 3.5 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 2.2 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 6.8 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 2.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 5.0 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 5.8 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 4.2 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.0 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.1 | 1.2 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 7.7 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 1.8 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 5.4 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 0.6 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
| 0.1 | 0.7 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 1.4 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 2.6 | REACTOME_MEIOSIS | Genes involved in Meiosis |
| 0.0 | 1.9 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.5 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.0 | 0.3 | REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 1.2 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
