Motif ID: Foxd2
Z-value: 0.811
Transcription factors associated with Foxd2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxd2 | ENSMUSG00000055210.3 | Foxd2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 10.6 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
| 2.6 | 18.3 | GO:0019532 | oxalate transport(GO:0019532) |
| 2.0 | 10.0 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 1.7 | 6.9 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 1.0 | 6.2 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 1.0 | 2.9 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.9 | 4.4 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.9 | 2.6 | GO:2001180 | negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180) |
| 0.8 | 2.3 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 0.6 | 14.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.6 | 4.5 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.6 | 1.9 | GO:2000224 | regulation of testosterone biosynthetic process(GO:2000224) |
| 0.6 | 5.6 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.6 | 3.3 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.5 | 4.8 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.4 | 10.0 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.4 | 2.0 | GO:0042228 | positive regulation of dendritic cell antigen processing and presentation(GO:0002606) detection of bacterium(GO:0016045) interleukin-8 biosynthetic process(GO:0042228) detection of other organism(GO:0098543) |
| 0.4 | 2.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.4 | 10.3 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.3 | 0.9 | GO:0035811 | negative regulation of urine volume(GO:0035811) |
| 0.3 | 2.5 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
| 0.2 | 2.9 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.2 | 1.2 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.2 | 1.8 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.2 | 0.8 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.2 | 7.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 6.5 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.1 | 0.4 | GO:0046032 | ADP catabolic process(GO:0046032) |
| 0.1 | 1.9 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.1 | 0.5 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.1 | 18.5 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.1 | 0.9 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.1 | 0.7 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.1 | 3.2 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.1 | 0.6 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.6 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.0 | 3.0 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.0 | 2.6 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.0 | 1.6 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.2 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.0 | 2.2 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 2.5 | GO:0006333 | chromatin assembly or disassembly(GO:0006333) |
| 0.0 | 1.4 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.1 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.0 | 5.4 | GO:0001525 | angiogenesis(GO:0001525) |
| 0.0 | 0.8 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
| 0.0 | 0.9 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 10.0 | GO:0043512 | inhibin A complex(GO:0043512) |
| 2.6 | 10.6 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 1.5 | 4.4 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.7 | 6.9 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.6 | 2.3 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.5 | 6.5 | GO:0042581 | specific granule(GO:0042581) |
| 0.3 | 5.6 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.2 | 29.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 15.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 2.6 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.2 | 1.8 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 4.8 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 2.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.9 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 20.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 3.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 12.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.7 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 2.4 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.3 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.0 | 0.5 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 9.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 7.3 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 3.5 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 2.2 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 21.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 2.1 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 1.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 2.0 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 2.0 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 10.0 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 1.7 | 18.3 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 1.5 | 10.6 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 1.1 | 37.7 | GO:0042805 | actinin binding(GO:0042805) |
| 0.6 | 2.4 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.6 | 2.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.5 | 1.9 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.4 | 4.8 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.4 | 2.0 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.3 | 4.4 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.3 | 1.4 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.2 | 4.5 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.2 | 12.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 3.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.2 | 1.8 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.2 | 3.2 | GO:0005521 | lamin binding(GO:0005521) |
| 0.2 | 6.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 0.9 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.1 | 2.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 5.6 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 0.7 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.1 | 0.6 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 0.6 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 0.9 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.4 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 0.0 | 2.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 6.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.9 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 1.2 | GO:0016860 | intramolecular oxidoreductase activity(GO:0016860) |
| 0.0 | 3.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.9 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 5.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.8 | GO:0048029 | monosaccharide binding(GO:0048029) |
| 0.0 | 3.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.0 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 15.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.9 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.3 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 5.0 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 2.2 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 0.9 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.1 | 1.9 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 3.5 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 3.2 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 2.5 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.8 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.7 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.3 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 10.0 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 2.4 | 14.3 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 1.8 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.2 | 4.3 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.2 | 18.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 0.9 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.2 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 3.5 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 0.9 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.1 | 1.9 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.4 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 2.0 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.3 | REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.0 | 4.3 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.4 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.6 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
