Motif ID: Foxf1

Z-value: 0.630


Transcription factors associated with Foxf1:

Gene SymbolEntrez IDGene Name
Foxf1 ENSMUSG00000042812.4 Foxf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxf1mm10_v2_chr8_+_121084352_121084474-0.191.0e-01Click!


Activity profile for motif Foxf1.

activity profile for motif Foxf1


Sorted Z-values histogram for motif Foxf1

Sorted Z-values for motif Foxf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 3.937 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_+_4375462 3.738 ENSMUST00000061925.4
 Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr1_+_66386968 3.554 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr1_-_158814469 3.389 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr4_-_110290884 3.366 ENSMUST00000142722.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_81200697 2.937 ENSMUST00000067602.3
ENSMUST00000037785.7
 Ncam2

neural cell adhesion molecule 2

chr2_+_68117713 2.894 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr2_-_79908428 2.884 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr6_-_143947092 2.794 ENSMUST00000144289.1
ENSMUST00000111748.1
 Sox5

SRY-box containing gene 5

chr13_-_41273977 2.583 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr6_-_143947061 2.552 ENSMUST00000124233.1
 Sox5
SRY-box containing gene 5
chr6_+_147032528 2.520 ENSMUST00000036194.4
 Rep15
RAB15 effector protein
chr4_-_36056726 2.409 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chrX_+_119927196 2.342 ENSMUST00000040961.2
ENSMUST00000113366.1
 Pabpc5

poly(A) binding protein, cytoplasmic 5

chr6_-_59024470 2.333 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr14_-_93888732 2.323 ENSMUST00000068992.2
 Pcdh9
protocadherin 9
chr9_-_100506844 2.269 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr10_-_29535857 2.223 ENSMUST00000092623.3
 Rspo3
R-spondin 3 homolog (Xenopus laevis)
chr18_+_67133713 1.991 ENSMUST00000076605.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr19_+_23723279 1.971 ENSMUST00000067077.1
 Gm9938
predicted gene 9938

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 4.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.7 3.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 3.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 3.8 GO:0060349 bone morphogenesis(GO:0060349)
0.0 3.8 GO:0016042 lipid catabolic process(GO:0016042)
0.1 3.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 3.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 3.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 3.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.4 2.6 GO:0046549 retinal cone cell development(GO:0046549)
0.2 2.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 2.5 GO:0033572 transferrin transport(GO:0033572)
0.0 2.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.8 2.3 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.2 2.2 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.3 2.0 GO:0009405 pathogenesis(GO:0009405)
0.2 2.0 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 1.9 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 1.8 GO:2001214 positive regulation of vasculogenesis(GO:2001214)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0014069 postsynaptic density(GO:0014069)
0.0 4.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.4 3.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 3.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 3.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 2.3 GO:0044291 cell-cell contact zone(GO:0044291)
0.2 2.2 GO:0071437 invadopodium(GO:0071437)
0.4 1.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.6 GO:0097440 apical dendrite(GO:0097440)
0.0 1.6 GO:0001772 immunological synapse(GO:0001772)
0.5 1.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 1.5 GO:0005901 caveola(GO:0005901)
0.1 1.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.4 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.6 4.5 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
1.0 3.9 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 3.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.8 GO:0017091 AU-rich element binding(GO:0017091)
0.1 3.7 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.4 3.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 3.1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 2.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 2.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 2.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 2.1 GO:0031489 myosin V binding(GO:0031489)
0.1 1.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 1.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 1.6 GO:0043495 protein anchor(GO:0043495)
0.1 1.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 1.5 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.5 1.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 1.5 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 4.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.8 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.2 1.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 1.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 4.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 3.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 3.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.5 2.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 1.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.1 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.8 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor