Motif ID: Foxf1
Z-value: 0.630
Transcription factors associated with Foxf1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxf1 | ENSMUSG00000042812.4 | Foxf1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxf1 | mm10_v2_chr8_+_121084352_121084474 | -0.19 | 1.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.3 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.7 | 5.3 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.7 | 3.9 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.5 | 1.5 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 0.4 | 1.3 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 0.4 | 3.9 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.4 | 1.6 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.4 | 2.6 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.4 | 1.1 | GO:0046881 | sperm ejaculation(GO:0042713) positive regulation of follicle-stimulating hormone secretion(GO:0046881) |
| 0.4 | 1.1 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.3 | 1.7 | GO:0048133 | NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728) |
| 0.3 | 2.0 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.3 | 0.8 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
| 0.3 | 1.0 | GO:0009597 | detection of virus(GO:0009597) |
| 0.3 | 0.8 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.2 | 4.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.2 | 1.5 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.2 | 0.7 | GO:1900108 | negative regulation of nodal signaling pathway(GO:1900108) |
| 0.2 | 0.7 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.2 | 0.6 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.2 | 1.6 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.2 | 0.6 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203) |
| 0.2 | 2.0 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.2 | 2.5 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.2 | 2.5 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.2 | 0.2 | GO:0044830 | modulation by host of viral RNA genome replication(GO:0044830) |
| 0.2 | 1.0 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.2 | 1.5 | GO:0071493 | cellular response to UV-B(GO:0071493) |
| 0.2 | 1.3 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
| 0.2 | 1.8 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.2 | 1.1 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.2 | 2.2 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.2 | 0.8 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.1 | 0.4 | GO:0019389 | urate transport(GO:0015747) glucuronoside metabolic process(GO:0019389) negative regulation of intestinal absorption(GO:1904479) |
| 0.1 | 0.5 | GO:0042117 | monocyte activation(GO:0042117) |
| 0.1 | 1.0 | GO:0010572 | positive regulation of platelet activation(GO:0010572) |
| 0.1 | 1.2 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.1 | 0.5 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.1 | 0.9 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.1 | 1.2 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.1 | 3.1 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.2 | GO:0035482 | gastric motility(GO:0035482) gastric emptying(GO:0035483) musculoskeletal movement, spinal reflex action(GO:0050883) |
| 0.1 | 1.8 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
| 0.1 | 0.2 | GO:0072106 | regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) |
| 0.1 | 3.7 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.4 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.1 | 0.5 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
| 0.1 | 1.9 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.1 | 0.7 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.1 | 0.6 | GO:0045915 | positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964) |
| 0.1 | 0.8 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 0.6 | GO:0070814 | hydrogen sulfide biosynthetic process(GO:0070814) |
| 0.1 | 0.5 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 0.5 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
| 0.1 | 0.2 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.1 | 3.6 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.1 | 0.2 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) |
| 0.1 | 0.8 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.1 | 0.3 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.1 | 0.8 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.1 | 1.1 | GO:0032695 | negative regulation of interleukin-12 production(GO:0032695) |
| 0.1 | 0.3 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
| 0.1 | 1.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 0.7 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 0.5 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.1 | 0.3 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.1 | 0.4 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
| 0.1 | 1.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.3 | GO:0007603 | phototransduction, visible light(GO:0007603) |
| 0.1 | 0.6 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.1 | 0.9 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.1 | 0.2 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 0.7 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 0.1 | GO:0003180 | aortic valve development(GO:0003176) aortic valve morphogenesis(GO:0003180) |
| 0.1 | 0.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 0.2 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.0 | 0.5 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.0 | 0.1 | GO:0090004 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.0 | 0.5 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.0 | 0.2 | GO:0046391 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
| 0.0 | 0.7 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 0.4 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 3.8 | GO:0060349 | bone morphogenesis(GO:0060349) |
| 0.0 | 3.5 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.5 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.0 | 0.4 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.0 | 0.4 | GO:1902018 | regulation of mitotic spindle assembly(GO:1901673) negative regulation of cilium assembly(GO:1902018) |
| 0.0 | 0.2 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.0 | 0.1 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.0 | 0.7 | GO:0031643 | positive regulation of myelination(GO:0031643) |
| 0.0 | 0.1 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.0 | 2.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.3 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 0.5 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.0 | 0.7 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.3 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 0.2 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.3 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.0 | 0.5 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.0 | 0.1 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.0 | 0.5 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.4 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.0 | 0.7 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 1.0 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 1.0 | GO:0007628 | adult walking behavior(GO:0007628) |
| 0.0 | 0.3 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.0 | 0.5 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 0.7 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 3.8 | GO:0016042 | lipid catabolic process(GO:0016042) |
| 0.0 | 0.1 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.3 | GO:0019233 | sensory perception of pain(GO:0019233) |
| 0.0 | 0.0 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.0 | 0.8 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.0 | 0.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.7 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 0.2 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 0.0 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.0 | 0.8 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 1.0 | GO:0019882 | antigen processing and presentation(GO:0019882) |
| 0.0 | 1.0 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.0 | 1.7 | GO:0007411 | axon guidance(GO:0007411) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.4 | 3.6 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.4 | 1.1 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.4 | 1.8 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.2 | 3.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 2.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 2.2 | GO:0071437 | invadopodium(GO:0071437) |
| 0.2 | 0.8 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.1 | 0.7 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 0.8 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 1.4 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 0.5 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.1 | 0.6 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 2.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 1.6 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 0.5 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 2.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 1.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 1.6 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.8 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 1.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.5 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 4.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 3.4 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.5 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 2.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.2 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 2.3 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.0 | 4.4 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 1.5 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.8 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 1.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.4 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.7 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 1.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 5.4 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 1.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.4 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.7 | GO:0030175 | filopodium(GO:0030175) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.9 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.6 | 4.5 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.5 | 1.5 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.5 | 1.5 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.5 | 1.4 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.4 | 3.6 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.4 | 2.3 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.3 | 0.9 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.2 | 0.7 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.2 | 1.2 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.2 | 1.1 | GO:0017002 | activin-activated receptor activity(GO:0017002) |
| 0.2 | 1.5 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.2 | 1.7 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.2 | 0.8 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.2 | 0.8 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.2 | 0.5 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.1 | 1.2 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.1 | 0.4 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.1 | 1.6 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 0.4 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.1 | 1.5 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.1 | 1.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 3.8 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 0.6 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 0.4 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.1 | 2.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 1.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 1.2 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.1 | 0.8 | GO:0071253 | connexin binding(GO:0071253) |
| 0.1 | 2.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 2.3 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.1 | 0.4 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.1 | 2.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 1.0 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 0.3 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 3.1 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.1 | 0.2 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.1 | 0.3 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.1 | 0.2 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
| 0.1 | 0.8 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 1.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 0.2 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.1 | 3.7 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
| 0.1 | 1.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 1.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 1.1 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.3 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.0 | 3.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.5 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 1.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.1 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.0 | 1.3 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.5 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.8 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.2 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.0 | 0.3 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.2 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.5 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.6 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.2 | GO:0015250 | water channel activity(GO:0015250) |
| 0.0 | 0.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.9 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 1.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.4 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 1.1 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 6.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 0.1 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 0.5 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 0.2 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.8 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.7 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.5 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.4 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.3 | GO:0042165 | neurotransmitter binding(GO:0042165) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.5 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 2.0 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.1 | 1.1 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 2.3 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 4.8 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 2.4 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.8 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 1.1 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 3.0 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.3 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.1 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 0.7 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 4.0 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.5 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 3.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.6 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 1.3 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.8 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 0.5 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.0 | 1.0 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 1.1 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.3 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 3.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 4.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.3 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 0.7 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 1.8 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 3.1 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.1 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.1 | 1.5 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 1.7 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.8 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 0.5 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 1.2 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.4 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 7.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.3 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 3.0 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.5 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.2 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 1.9 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.3 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.7 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.5 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.3 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 4.5 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.6 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.2 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.3 | REACTOME_PLC_BETA_MEDIATED_EVENTS | Genes involved in PLC beta mediated events |
| 0.0 | 0.2 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.4 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
