Motif ID: Foxf2

Z-value: 1.452


Transcription factors associated with Foxf2:

Gene SymbolEntrez IDGene Name
Foxf2 ENSMUSG00000038402.2 Foxf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxf2mm10_v2_chr13_+_31625802_316258160.217.0e-02Click!


Activity profile for motif Foxf2.

activity profile for motif Foxf2


Sorted Z-values histogram for motif Foxf2

Sorted Z-values for motif Foxf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxf2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_66969616 51.165 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr6_-_148444336 40.540 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr15_+_3270767 26.004 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr16_+_91269759 24.524 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr16_-_22439719 21.771 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_22439570 21.445 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr10_+_60106452 19.080 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr8_-_84773381 18.442 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr7_+_82175156 16.646 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr1_-_87573825 13.509 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr4_+_5724304 11.804 ENSMUST00000108380.1
 Fam110b
family with sequence similarity 110, member B
chr3_+_53488677 11.661 ENSMUST00000029307.3
 Stoml3
stomatin (Epb7.2)-like 3
chr3_-_144202300 11.569 ENSMUST00000121796.1
ENSMUST00000121112.1
 Lmo4

LIM domain only 4

chr12_-_112511136 10.568 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr7_-_4844665 10.229 ENSMUST00000066041.5
ENSMUST00000172377.1
 Shisa7

shisa homolog 7 (Xenopus laevis)

chr8_+_93810832 9.900 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr19_-_17837620 9.712 ENSMUST00000025618.8
ENSMUST00000050715.8
 Pcsk5

proprotein convertase subtilisin/kexin type 5

chr17_+_70522083 9.504 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr16_-_4880284 9.466 ENSMUST00000037843.6
 Ubald1
UBA-like domain containing 1
chr10_+_79716588 9.400 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr5_+_90903864 9.253 ENSMUST00000075433.6
 Cxcl2
chemokine (C-X-C motif) ligand 2
chr4_+_101507947 8.937 ENSMUST00000149047.1
ENSMUST00000106929.3
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr17_+_70522149 8.744 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr7_+_45783686 8.568 ENSMUST00000118564.1
ENSMUST00000133428.1
 Lmtk3

lemur tyrosine kinase 3

chr7_+_45783883 8.285 ENSMUST00000072580.5
 Lmtk3
lemur tyrosine kinase 3
chr4_+_101507855 8.063 ENSMUST00000038207.5
 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr6_+_30541582 7.959 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr9_+_47530173 7.503 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1





chr8_+_58911755 6.587 ENSMUST00000062978.6
 BC030500
cDNA sequence BC030500
chr5_-_92348871 6.560 ENSMUST00000038816.6
ENSMUST00000118006.1
 Cxcl10

chemokine (C-X-C motif) ligand 10

chr7_-_90129339 6.383 ENSMUST00000181189.1
 2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr19_+_44992127 6.338 ENSMUST00000179305.1
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr11_+_118433826 6.209 ENSMUST00000106286.1
 C1qtnf1
C1q and tumor necrosis factor related protein 1
chr8_+_58912257 5.854 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr19_+_7056731 5.237 ENSMUST00000040261.5
 Macrod1
MACRO domain containing 1
chr2_-_163645125 5.147 ENSMUST00000017851.3
 Serinc3
serine incorporator 3
chr10_+_40349265 5.143 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19

chr10_-_26373956 4.837 ENSMUST00000105519.3
ENSMUST00000040219.6
 L3mbtl3

l(3)mbt-like 3 (Drosophila)

chr1_+_131970589 4.766 ENSMUST00000027695.6
 Slc45a3
solute carrier family 45, member 3
chr5_+_107437908 4.735 ENSMUST00000094541.2
 Btbd8
BTB (POZ) domain containing 8
chr5_-_103211251 4.726 ENSMUST00000060871.5
ENSMUST00000112846.1
ENSMUST00000170792.1
ENSMUST00000112847.2
 Mapk10



mitogen-activated protein kinase 10



chr9_-_48835932 4.717 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16
chr2_-_71367749 4.708 ENSMUST00000151937.1
 Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr13_+_94173992 4.603 ENSMUST00000121618.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr1_+_43445736 4.394 ENSMUST00000086421.5
ENSMUST00000114744.1
 Nck2

non-catalytic region of tyrosine kinase adaptor protein 2

chr8_-_58911627 4.177 ENSMUST00000077447.4
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr1_+_51289106 4.140 ENSMUST00000051572.6
 Sdpr
serum deprivation response
chr13_+_46669517 3.792 ENSMUST00000099547.3
 C78339
expressed sequence C78339
chr5_+_88583527 3.743 ENSMUST00000031229.6
 Rufy3
RUN and FYVE domain containing 3
chr6_-_83831736 3.712 ENSMUST00000058383.8
 Paip2b
poly(A) binding protein interacting protein 2B
chr7_-_44849075 3.695 ENSMUST00000047085.8
 Tbc1d17
TBC1 domain family, member 17
chr11_-_100397740 3.670 ENSMUST00000001592.8
ENSMUST00000107403.1
 Jup

junction plakoglobin

chr5_+_65131184 3.639 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr6_+_15185203 3.463 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr1_-_179546261 3.462 ENSMUST00000027769.5
 Tfb2m
transcription factor B2, mitochondrial
chr9_-_108649349 3.391 ENSMUST00000013338.8
 Arih2
ariadne homolog 2 (Drosophila)
chr15_+_79347534 3.220 ENSMUST00000096350.3
 Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr16_-_34263179 3.171 ENSMUST00000114949.1
ENSMUST00000114954.1
 Kalrn

kalirin, RhoGEF kinase

chr11_+_69095217 3.070 ENSMUST00000101004.2
 Per1
period circadian clock 1
chr8_-_46124146 2.995 ENSMUST00000170416.1
 Snx25
sorting nexin 25
chr2_+_28641227 2.915 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
 Tsc1


tuberous sclerosis 1


chr14_+_58072686 2.817 ENSMUST00000022545.7
 Fgf9
fibroblast growth factor 9
chr14_+_111675113 2.783 ENSMUST00000042767.7
 Slitrk5
SLIT and NTRK-like family, member 5
chr10_-_41303171 2.679 ENSMUST00000043814.3
 Fig4
FIG4 homolog (S. cerevisiae)
chr12_-_84450944 2.656 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr1_+_34005872 2.617 ENSMUST00000182296.1
 Dst
dystonin
chr12_+_69296676 2.379 ENSMUST00000021362.4
 Klhdc2
kelch domain containing 2
chr1_-_195131536 2.378 ENSMUST00000075451.6
 Cr1l
complement component (3b/4b) receptor 1-like
chr2_+_164486856 2.351 ENSMUST00000109349.2
 Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr19_-_4012656 2.349 ENSMUST00000134479.1
ENSMUST00000128787.1
ENSMUST00000133474.1
ENSMUST00000136921.1
ENSMUST00000042497.7
 Ndufv1




NADH dehydrogenase (ubiquinone) flavoprotein 1




chr15_+_79348061 2.345 ENSMUST00000163691.1
 Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr9_+_110333402 2.259 ENSMUST00000133114.1
ENSMUST00000125759.1
 Scap

SREBF chaperone

chr7_+_44849581 2.083 ENSMUST00000150335.1
ENSMUST00000107882.1
 Akt1s1

AKT1 substrate 1 (proline-rich)

chr12_+_84451485 1.974 ENSMUST00000137170.1
 Lin52
lin-52 homolog (C. elegans)
chr2_+_112284561 1.964 ENSMUST00000053666.7
 Slc12a6
solute carrier family 12, member 6
chr7_+_141476374 1.901 ENSMUST00000117634.1
 Tspan4
tetraspanin 4
chr17_+_47505211 1.828 ENSMUST00000182935.1
ENSMUST00000182506.1
 Ccnd3

cyclin D3

chr17_+_47505149 1.797 ENSMUST00000183177.1
ENSMUST00000182848.1
 Ccnd3

cyclin D3

chr16_-_34262945 1.682 ENSMUST00000114953.1
 Kalrn
kalirin, RhoGEF kinase
chr8_+_86745679 1.500 ENSMUST00000098532.2
 Gm10638
predicted gene 10638
chr2_-_148046896 1.411 ENSMUST00000172928.1
ENSMUST00000047315.3
 Foxa2

forkhead box A2

chr7_+_44849216 1.319 ENSMUST00000054343.8
 Akt1s1
AKT1 substrate 1 (proline-rich)
chr2_+_91730127 1.319 ENSMUST00000099712.3
ENSMUST00000111317.2
ENSMUST00000111316.2
ENSMUST00000045705.7
 Ambra1



autophagy/beclin 1 regulator 1



chr9_+_44072196 1.288 ENSMUST00000176671.1
 Usp2
ubiquitin specific peptidase 2
chr18_+_34758890 1.260 ENSMUST00000049281.5
 Fam53c
family with sequence similarity 53, member C
chr7_+_44848991 1.237 ENSMUST00000107885.1
 Akt1s1
AKT1 substrate 1 (proline-rich)
chr18_+_55057557 1.198 ENSMUST00000181765.1
 Gm4221
predicted gene 4221
chr11_-_120990871 1.179 ENSMUST00000154483.1
 Csnk1d
casein kinase 1, delta
chr12_-_15816762 1.169 ENSMUST00000020922.7
 Trib2
tribbles homolog 2 (Drosophila)
chr13_+_55445301 1.106 ENSMUST00000001115.8
ENSMUST00000099482.3
 Grk6

G protein-coupled receptor kinase 6

chr9_-_44802951 1.088 ENSMUST00000044694.6
 Ttc36
tetratricopeptide repeat domain 36
chr6_-_13677930 1.044 ENSMUST00000045235.5
 B630005N14Rik
RIKEN cDNA B630005N14 gene
chr2_+_176236860 1.028 ENSMUST00000166464.1
 2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr9_+_55326913 0.915 ENSMUST00000085754.3
ENSMUST00000034862.4
 AI118078

expressed sequence AI118078

chr1_+_179546303 0.885 ENSMUST00000040706.8
 Cnst
consortin, connexin sorting protein
chr12_+_98628126 0.791 ENSMUST00000048402.5
ENSMUST00000101144.3
ENSMUST00000101146.3
 Spata7


spermatogenesis associated 7


chr7_+_130692532 0.753 ENSMUST00000033141.6
 Tacc2
transforming, acidic coiled-coil containing protein 2
chr4_-_55532453 0.705 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)

chr7_-_30559828 0.607 ENSMUST00000108164.1
 Lin37
lin-37 homolog (C. elegans)
chr17_+_47505117 0.589 ENSMUST00000183044.1
ENSMUST00000037333.10
 Ccnd3

cyclin D3

chr2_-_176917518 0.569 ENSMUST00000108931.2
 Gm14296
predicted gene 14296
chr13_+_60602182 0.538 ENSMUST00000044083.7
 Dapk1
death associated protein kinase 1
chr3_-_106167564 0.532 ENSMUST00000063062.8
 Chi3l3
chitinase 3-like 3
chr5_+_118560719 0.469 ENSMUST00000100816.4
 Med13l
mediator complex subunit 13-like
chr15_-_98918131 0.364 ENSMUST00000023736.8
 Lmbr1l
limb region 1 like
chr7_+_30291941 0.326 ENSMUST00000144508.1
 Clip3
CAP-GLY domain containing linker protein 3
chr12_-_85270564 0.191 ENSMUST00000019378.6
ENSMUST00000166821.1
 Mlh3

mutL homolog 3 (E coli)

chr13_-_107890059 0.177 ENSMUST00000105097.2
 Zswim6
zinc finger SWIM-type containing 6
chr7_+_81762925 0.151 ENSMUST00000042166.4
 Fam103a1
family with sequence similarity 103, member A1
chr12_+_3807076 0.110 ENSMUST00000174817.1
 Dnmt3a
DNA methyltransferase 3A
chr12_+_3807017 0.032 ENSMUST00000020991.8
ENSMUST00000172509.1
 Dnmt3a

DNA methyltransferase 3A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 47.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
4.7 51.2 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
2.8 17.0 GO:0072318 clathrin coat disassembly(GO:0072318)
2.5 7.5 GO:0009826 unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
2.1 19.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.9 9.4 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
1.8 16.6 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.8 5.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
1.6 4.8 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
1.4 18.2 GO:0070842 aggresome assembly(GO:0070842)
1.4 13.5 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
1.3 5.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
1.3 5.1 GO:0009597 detection of virus(GO:0009597)
1.2 3.7 GO:0002159 desmosome assembly(GO:0002159)
1.2 9.7 GO:0033625 positive regulation of integrin activation(GO:0033625)
1.2 4.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.1 4.4 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
1.0 18.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.0 2.9 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.9 2.7 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.8 4.7 GO:0007258 JUN phosphorylation(GO:0007258)
0.8 6.2 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.8 11.6 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.6 3.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.6 4.9 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.6 1.1 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.5 1.4 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.4 3.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.4 9.3 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.4 4.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.3 2.4 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.3 2.7 GO:0031642 negative regulation of myelination(GO:0031642)
0.3 4.6 GO:0045792 negative regulation of cell size(GO:0045792)
0.3 0.9 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.3 3.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 2.8 GO:0060484 regulation of timing of cell differentiation(GO:0048505) lung-associated mesenchyme development(GO:0060484)
0.3 24.5 GO:0048663 neuron fate commitment(GO:0048663)
0.2 0.7 GO:0045414 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) regulation of interleukin-8 biosynthetic process(GO:0045414) positive regulation of core promoter binding(GO:1904798)
0.2 4.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 9.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 16.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 3.7 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 0.8 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.2 3.7 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 3.0 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.2 5.6 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.2 2.8 GO:0021756 striatum development(GO:0021756)
0.1 3.4 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 6.3 GO:0050919 negative chemotaxis(GO:0050919)
0.1 1.2 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.1 2.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 2.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 2.3 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1 4.7 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.1 1.3 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 0.8 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 3.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.2 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 2.3 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.0 39.7 GO:0006396 RNA processing(GO:0006396)
0.0 0.3 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.5 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776) hypermethylation of CpG island(GO:0044027)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.4 GO:0098855 HCN channel complex(GO:0098855)
1.4 51.4 GO:0055038 recycling endosome membrane(GO:0055038)
1.0 2.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.7 3.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.7 2.6 GO:0031673 H zone(GO:0031673)
0.6 9.7 GO:1990635 proximal dendrite(GO:1990635)
0.6 7.5 GO:0070852 cell body fiber(GO:0070852)
0.4 4.6 GO:0031931 TORC1 complex(GO:0031931)
0.4 3.7 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.3 3.7 GO:0071437 invadopodium(GO:0071437)
0.2 2.0 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.2 10.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 9.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 4.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 38.6 GO:0014069 postsynaptic density(GO:0014069)
0.1 6.2 GO:0005581 collagen trimer(GO:0005581)
0.1 20.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 16.6 GO:0005769 early endosome(GO:0005769)
0.1 3.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 20.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.7 GO:0005811 lipid particle(GO:0005811)
0.0 11.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.6 GO:0016605 PML body(GO:0016605)
0.0 59.7 GO:0005739 mitochondrion(GO:0005739)
0.0 0.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 4.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.8 GO:0043235 receptor complex(GO:0043235)
0.0 1.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 38.9 GO:0005654 nucleoplasm(GO:0005654)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
1.7 9.9 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.6 4.8 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
1.4 15.8 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
1.2 51.2 GO:0043015 gamma-tubulin binding(GO:0043015)
1.2 4.7 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.2 4.7 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.9 3.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.5 2.7 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.5 4.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.4 8.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 5.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 19.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 3.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 1.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 13.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 3.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 3.0 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.2 2.3 GO:0010181 FMN binding(GO:0010181)
0.2 3.1 GO:0070888 E-box binding(GO:0070888)
0.2 4.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 4.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.7 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 17.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 2.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.9 GO:0071253 connexin binding(GO:0071253)
0.1 9.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 6.2 GO:0005518 collagen binding(GO:0005518)
0.1 56.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 5.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 5.2 GO:0019213 deacetylase activity(GO:0019213)
0.1 3.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 1.3 GO:0030332 cyclin binding(GO:0030332)
0.1 2.7 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 36.9 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.3 GO:0097001 ceramide binding(GO:0097001)
0.0 2.3 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.0 1.9 GO:0003823 antigen binding(GO:0003823)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 3.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 15.2 GO:0019904 protein domain specific binding(GO:0019904)
0.0 11.0 GO:0008289 lipid binding(GO:0008289)
0.0 8.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 2.6 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 43.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.6 51.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.6 9.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.6 19.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.5 14.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.4 13.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 4.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 11.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.2 4.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 3.7 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.2 4.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 6.6 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 2.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 7.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 8.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.1 PID_CXCR4_PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 15.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.5 16.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 11.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 9.9 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.3 4.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.3 4.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 18.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 1.8 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 2.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 6.1 REACTOME_SIGNALLING_BY_NGF Genes involved in Signalling by NGF
0.2 2.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 3.1 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.7 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 9.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 4.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 9.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 4.2 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 1.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 5.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 2.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 8.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 3.5 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription