Motif ID: Foxi1_Foxo1

Z-value: 2.992

Transcription factors associated with Foxi1_Foxo1:

Gene SymbolEntrez IDGene Name
Foxi1 ENSMUSG00000047861.2 Foxi1
Foxo1 ENSMUSG00000044167.5 Foxo1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo1mm10_v2_chr3_+_52268337_522683880.037.7e-01Click!


Activity profile for motif Foxi1_Foxo1.

activity profile for motif Foxi1_Foxo1


Sorted Z-values histogram for motif Foxi1_Foxo1

Sorted Z-values for motif Foxi1_Foxo1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxi1_Foxo1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 121.656 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_-_52104891 75.790 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr8_+_34807287 67.639 ENSMUST00000033930.4
 Dusp4
dual specificity phosphatase 4
chr2_+_181767283 64.707 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr2_+_181767040 64.542 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr17_-_70851710 47.706 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_37773555 47.172 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr15_+_25752860 45.742 ENSMUST00000022882.5
ENSMUST00000135173.1
 Myo10

myosin X

chr14_+_73237891 44.065 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr10_-_92165159 43.660 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr3_-_27153861 41.477 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr7_-_115824699 40.941 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr1_+_6487231 40.164 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr3_-_27153844 39.689 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr11_-_101551837 37.177 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr18_+_5593566 36.479 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr4_-_97584605 36.052 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 35.911 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_-_69206146 35.319 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr15_-_84855093 35.167 ENSMUST00000016768.5
 Phf21b
PHD finger protein 21B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 491 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.5 134.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
11.7 129.2 GO:0060539 diaphragm development(GO:0060539)
20.3 121.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
7.5 120.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
5.8 87.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
7.3 80.7 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
5.3 69.1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
7.5 67.4 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
2.6 57.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
5.2 56.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
5.0 54.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.0 51.0 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
1.8 49.4 GO:0006270 DNA replication initiation(GO:0006270)
2.7 48.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
9.6 48.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.5 46.3 GO:0042462 eye photoreceptor cell development(GO:0042462)
3.8 45.7 GO:0060013 righting reflex(GO:0060013)
1.2 45.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
7.5 44.7 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
2.4 40.2 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 206 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 373.7 GO:0005654 nucleoplasm(GO:0005654)
0.1 297.2 GO:0005634 nucleus(GO:0005634)
0.4 134.1 GO:0016607 nuclear speck(GO:0016607)
25.6 128.2 GO:0097149 centralspindlin complex(GO:0097149)
9.0 80.8 GO:0030478 actin cap(GO:0030478)
0.5 76.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.4 59.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.8 58.7 GO:0005902 microvillus(GO:0005902)
9.7 58.3 GO:0031262 Ndc80 complex(GO:0031262)
0.9 56.4 GO:0016459 myosin complex(GO:0016459)
0.5 52.0 GO:0032993 protein-DNA complex(GO:0032993)
16.9 50.8 GO:0070557 PCNA-p21 complex(GO:0070557)
0.4 48.1 GO:0000776 kinetochore(GO:0000776)
4.4 47.9 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.8 47.3 GO:0051233 spindle midzone(GO:0051233)
1.3 47.0 GO:0035371 microtubule plus-end(GO:0035371)
6.3 37.9 GO:0070531 BRCA1-A complex(GO:0070531)
0.4 35.4 GO:0005814 centriole(GO:0005814)
3.1 30.7 GO:0001939 female pronucleus(GO:0001939)
0.7 29.6 GO:0005876 spindle microtubule(GO:0005876)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 334 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 277.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 122.5 GO:0017048 Rho GTPase binding(GO:0017048)
0.8 86.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
5.7 85.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.8 71.8 GO:0003774 motor activity(GO:0003774)
0.0 70.3 GO:0003676 nucleic acid binding(GO:0003676)
21.7 65.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.9 59.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
8.2 57.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 51.2 GO:0003714 transcription corepressor activity(GO:0003714)
16.9 50.8 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
2.8 48.1 GO:0051010 microtubule plus-end binding(GO:0051010)
2.5 47.7 GO:0070410 co-SMAD binding(GO:0070410)
1.4 46.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.2 44.0 GO:0030215 semaphorin receptor binding(GO:0030215)
2.4 43.5 GO:0045295 gamma-catenin binding(GO:0045295)
5.1 40.9 GO:0050693 LBD domain binding(GO:0050693)
0.7 40.8 GO:0003684 damaged DNA binding(GO:0003684)
0.4 36.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.7 35.7 GO:0001047 core promoter binding(GO:0001047)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 164.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
2.5 129.8 PID_PLK1_PATHWAY PLK1 signaling events
2.4 117.4 PID_AURORA_B_PATHWAY Aurora B signaling
1.5 73.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
1.4 71.0 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
1.6 54.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
3.8 53.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.7 52.8 PID_MYC_PATHWAY C-MYC pathway
5.6 50.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.7 47.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.9 37.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
1.1 37.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.7 26.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
1.2 23.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 23.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5 22.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.3 22.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.8 21.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
4.1 20.4 PID_ALK1_PATHWAY ALK1 signaling events
0.6 20.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 196.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.6 125.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
2.3 97.5 REACTOME_G1_PHASE Genes involved in G1 Phase
5.1 86.3 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
2.3 86.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
3.1 82.6 REACTOME_KINESINS Genes involved in Kinesins
4.3 63.9 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
1.7 53.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.9 51.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
2.6 49.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
2.3 49.0 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
5.2 47.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
1.1 40.4 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
1.1 32.3 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.6 31.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
1.8 29.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.9 29.0 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
1.2 29.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
1.7 28.5 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
1.4 24.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation