Motif ID: Foxk1_Foxj1

Z-value: 0.937

Transcription factors associated with Foxk1_Foxj1:

Gene SymbolEntrez IDGene Name
Foxj1 ENSMUSG00000034227.7 Foxj1
Foxk1 ENSMUSG00000056493.8 Foxk1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxk1mm10_v2_chr5_+_142401484_142401532-0.394.8e-04Click!
Foxj1mm10_v2_chr11_-_116335384_1163353990.361.3e-03Click!


Activity profile for motif Foxk1_Foxj1.

activity profile for motif Foxk1_Foxj1


Sorted Z-values histogram for motif Foxk1_Foxj1

Sorted Z-values for motif Foxk1_Foxj1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxk1_Foxj1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_117178726 16.876 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr10_-_130280218 12.310 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr13_-_103920295 11.645 ENSMUST00000169083.1
 Erbb2ip
Erbb2 interacting protein
chr10_-_92165159 11.345 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr1_-_97977233 11.265 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr3_+_159495408 9.597 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr3_-_100969644 8.920 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chr11_+_119022962 8.548 ENSMUST00000026662.7
 Cbx2
chromobox 2
chr14_-_62456286 8.425 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr5_+_30666886 8.105 ENSMUST00000144742.1
 Cenpa
centromere protein A
chr1_+_136467958 7.478 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr4_-_43499608 7.240 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr19_+_37376359 6.508 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr10_-_92164666 6.347 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr15_+_57912199 6.260 ENSMUST00000022992.6
 Tbc1d31
TBC1 domain family, member 31
chr10_+_127705170 6.232 ENSMUST00000079590.5
 Myo1a
myosin IA
chr9_-_100506844 6.228 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr16_-_36784784 6.109 ENSMUST00000165531.1
 Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr14_+_46832127 6.064 ENSMUST00000068532.8
 Cgrrf1
cell growth regulator with ring finger domain 1
chr19_+_53329413 6.036 ENSMUST00000025998.7
 Mxi1
Max interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 16.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 13.2 GO:0006182 cGMP biosynthetic process(GO:0006182)
1.4 12.9 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.9 12.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.7 11.9 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.9 11.3 GO:0009404 toxin metabolic process(GO:0009404)
2.2 11.2 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.3 9.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.4 8.9 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.8 8.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.3 7.6 GO:0030033 microvillus assembly(GO:0030033)
1.9 7.5 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.7 6.5 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 6.3 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
2.1 6.2 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 5.6 GO:0006284 base-excision repair(GO:0006284)
0.1 5.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.3 4.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.8 4.6 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.5 4.6 GO:0050957 equilibrioception(GO:0050957)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 29.1 GO:0005871 kinesin complex(GO:0005871)
0.1 14.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.7 13.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 11.4 GO:0030667 secretory granule membrane(GO:0030667)
0.1 10.1 GO:0005902 microvillus(GO:0005902)
2.5 9.9 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.5 8.5 GO:0035102 PRC1 complex(GO:0035102)
0.1 8.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.6 7.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 7.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.4 GO:0005681 spliceosomal complex(GO:0005681)
0.5 6.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 4.7 GO:0097546 ciliary base(GO:0097546)
0.4 4.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 4.1 GO:0031965 nuclear membrane(GO:0031965)
1.3 4.0 GO:0071914 prominosome(GO:0071914)
0.0 3.9 GO:0043296 apical junction complex(GO:0043296)
0.1 3.7 GO:0016459 myosin complex(GO:0016459)
0.0 3.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.3 GO:0051015 actin filament binding(GO:0051015)
1.0 16.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 15.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 13.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.7 13.2 GO:0004383 guanylate cyclase activity(GO:0004383)
3.8 11.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
3.7 11.2 GO:0042936 dipeptide transporter activity(GO:0042936)
0.1 10.6 GO:0004386 helicase activity(GO:0004386)
0.1 9.8 GO:0035064 methylated histone binding(GO:0035064)
0.2 8.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 7.3 GO:0005521 lamin binding(GO:0005521)
1.0 6.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 5.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.1 5.4 GO:0000405 bubble DNA binding(GO:0000405)
0.8 5.0 GO:0030284 estrogen receptor activity(GO:0030284)
1.6 4.9 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 4.9 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 4.4 GO:0005096 GTPase activator activity(GO:0005096)
0.2 4.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.6 4.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 25.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 12.9 PID_MYC_PATHWAY C-MYC pathway
0.2 12.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 6.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 5.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.9 PID_ATR_PATHWAY ATR signaling pathway
0.2 2.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.9 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 1.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.2 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 23.4 REACTOME_KINESINS Genes involved in Kinesins
0.3 17.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 13.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.5 8.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.3 4.9 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 2.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 2.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 2.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.1 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.0 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 1.9 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.2 1.8 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.7 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.7 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.7 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein