Motif ID: Foxm1

Z-value: 0.796


Transcription factors associated with Foxm1:

Gene SymbolEntrez IDGene Name
Foxm1 ENSMUSG00000001517.8 Foxm1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxm1mm10_v2_chr6_+_128362919_128363058-0.132.6e-01Click!


Activity profile for motif Foxm1.

activity profile for motif Foxm1


Sorted Z-values histogram for motif Foxm1

Sorted Z-values for motif Foxm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxm1

PNG image of the network

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Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_65845833 8.764 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_+_65845767 8.072 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr18_+_67133713 6.266 ENSMUST00000076605.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr15_+_98167806 6.238 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr19_+_25672408 5.729 ENSMUST00000053068.5
 Dmrt2
doublesex and mab-3 related transcription factor 2
chrX_-_141725181 5.103 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chrX_+_164373363 4.798 ENSMUST00000033751.7
 Figf
c-fos induced growth factor
chr12_-_40037387 4.358 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr8_+_58912257 4.261 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr1_-_79440039 4.056 ENSMUST00000049972.4
 Scg2
secretogranin II
chr18_+_36952621 3.692 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr4_-_36136463 3.536 ENSMUST00000098151.2
 Lingo2
leucine rich repeat and Ig domain containing 2
chr18_-_62741387 3.289 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr6_-_59024340 3.257 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr7_-_19921139 3.218 ENSMUST00000043517.7
 Pvr
poliovirus receptor
chr9_-_100571049 3.155 ENSMUST00000093792.2
 Slc35g2
solute carrier family 35, member G2
chr3_+_134828993 3.043 ENSMUST00000029822.4
 Tacr3
tachykinin receptor 3
chr2_+_136052180 3.035 ENSMUST00000144403.1
 Lamp5
lysosomal-associated membrane protein family, member 5
chr1_-_138842429 2.946 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr4_-_15149755 2.914 ENSMUST00000108273.1
 Necab1
N-terminal EF-hand calcium binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.0 6.3 GO:0009405 pathogenesis(GO:0009405)
1.4 5.7 GO:0061055 myotome development(GO:0061055)
0.1 4.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.8 4.1 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.4 3.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 3.9 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.3 3.7 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.4 3.6 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.0 3.6 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 3.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.7 3.3 GO:0060467 negative regulation of fertilization(GO:0060467)
1.1 3.2 GO:0002423 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.6 2.9 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 2.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 2.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.3 1.9 GO:0000733 DNA strand renaturation(GO:0000733)
0.2 1.8 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.8 GO:1902652 cholesterol metabolic process(GO:0008203) secondary alcohol metabolic process(GO:1902652)
0.0 1.6 GO:0042551 neuron maturation(GO:0042551)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.1 GO:0031225 anchored component of membrane(GO:0031225)
0.2 4.1 GO:0031045 dense core granule(GO:0031045)
0.3 3.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 3.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.5 3.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 3.0 GO:0032590 dendrite membrane(GO:0032590)
0.1 2.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 1.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 1.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 0.9 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.9 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 6.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 5.7 GO:0005525 GTP binding(GO:0005525)
0.1 5.1 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 4.9 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.2 4.1 GO:0042056 chemoattractant activity(GO:0042056)
0.2 3.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 3.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 3.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 3.2 GO:0001618 virus receptor activity(GO:0001618)
0.2 3.0 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.3 2.3 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.2 GO:0043274 phospholipase binding(GO:0043274)
0.3 1.9 GO:0009378 four-way junction helicase activity(GO:0009378)
0.4 1.8 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 1.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.5 GO:0005178 integrin binding(GO:0005178)
0.2 1.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 1.4 GO:0002020 protease binding(GO:0002020)
0.4 1.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 6.1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.4 4.8 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 3.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 2.4 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 2.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 0.7 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.2 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 7.0 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 5.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 4.8 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 3.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 3.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 1.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.2 1.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.3 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.2 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.2 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 1.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.0 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 0.8 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.8 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis