Motif ID: Foxn1
Z-value: 0.396
Transcription factors associated with Foxn1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxn1 | ENSMUSG00000002057.4 | Foxn1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.2 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.5 | 2.1 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.5 | 1.5 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) |
| 0.4 | 1.3 | GO:1900275 | negative regulation of phospholipase C activity(GO:1900275) |
| 0.4 | 4.9 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.2 | 0.7 | GO:1901608 | dense core granule localization(GO:0032253) cellular response to isoquinoline alkaloid(GO:0071317) regulation of vesicle transport along microtubule(GO:1901608) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811) |
| 0.2 | 0.9 | GO:0071034 | CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) |
| 0.2 | 0.6 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.2 | 1.9 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.2 | 1.2 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 0.2 | 0.8 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.1 | 0.4 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
| 0.1 | 0.7 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.1 | 0.4 | GO:0070973 | COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.1 | 1.3 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 0.4 | GO:0001828 | inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828) |
| 0.1 | 0.5 | GO:0021564 | glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564) |
| 0.1 | 0.9 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.1 | 2.0 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 1.1 | GO:1904668 | mitotic spindle midzone assembly(GO:0051256) positive regulation of ubiquitin protein ligase activity(GO:1904668) |
| 0.1 | 0.5 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.1 | 0.8 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 0.3 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 0.1 | 0.4 | GO:0061511 | centriole elongation(GO:0061511) |
| 0.1 | 0.2 | GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) |
| 0.1 | 0.6 | GO:2000301 | myeloid progenitor cell differentiation(GO:0002318) negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.1 | 2.0 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 0.2 | GO:0010796 | regulation of multivesicular body size(GO:0010796) multivesicular body assembly(GO:0036258) |
| 0.1 | 0.8 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 0.1 | 0.2 | GO:0036216 | response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) |
| 0.1 | 0.5 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.1 | 0.2 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.0 | 1.4 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 1.1 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.0 | 0.1 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.0 | 0.6 | GO:1902170 | cellular response to reactive nitrogen species(GO:1902170) |
| 0.0 | 0.3 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.0 | 0.6 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.2 | GO:0098734 | protein depalmitoylation(GO:0002084) positive regulation of pinocytosis(GO:0048549) macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 0.4 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.0 | 0.3 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.0 | 1.0 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.0 | 0.4 | GO:0021756 | striatum development(GO:0021756) |
| 0.0 | 1.0 | GO:0050688 | regulation of defense response to virus(GO:0050688) |
| 0.0 | 0.7 | GO:0061512 | protein localization to cilium(GO:0061512) |
| 0.0 | 0.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.7 | GO:0033120 | positive regulation of RNA splicing(GO:0033120) |
| 0.0 | 0.2 | GO:0044804 | nucleophagy(GO:0044804) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.2 | 1.2 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.2 | 1.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.2 | 1.3 | GO:0033648 | host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648) |
| 0.1 | 0.6 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.1 | 1.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 2.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 0.9 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.1 | 1.8 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 0.3 | GO:0031523 | Myb complex(GO:0031523) |
| 0.0 | 1.9 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.2 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 5.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.7 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.3 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 1.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.2 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.0 | 0.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 1.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.2 | 1.5 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.1 | 0.7 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.1 | 0.9 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.1 | 0.4 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.1 | 1.4 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 2.1 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 0.6 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.1 | 0.2 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
| 0.1 | 0.3 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.1 | 0.9 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 1.1 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.5 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.8 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.1 | GO:0004335 | galactokinase activity(GO:0004335) |
| 0.0 | 0.9 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 0.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857) |
| 0.0 | 1.0 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 1.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 4.5 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.2 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.0 | 0.4 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.2 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.2 | GO:0031489 | myosin V binding(GO:0031489) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.6 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 1.1 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.6 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.2 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.4 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.9 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.4 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.0 | PID_P53_REGULATION_PATHWAY | p53 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 5.4 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.1 | 0.9 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 1.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 2.1 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 0.4 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.3 | REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 0.5 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.5 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.4 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.2 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
