Motif ID: Foxo3
Z-value: 0.849
Transcription factors associated with Foxo3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxo3 | ENSMUSG00000048756.5 | Foxo3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxo3 | mm10_v2_chr10_-_42276744_42276763 | 0.56 | 1.3e-07 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 19.1 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 2.4 | 7.3 | GO:1902524 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 1.4 | 4.1 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 1.3 | 24.3 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 1.2 | 5.8 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 1.1 | 3.3 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 1.0 | 3.1 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 1.0 | 7.1 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.9 | 5.4 | GO:0045919 | complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919) |
| 0.7 | 2.1 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 0.7 | 2.8 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.6 | 4.9 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.6 | 2.3 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.6 | 4.4 | GO:0072321 | chaperone-mediated protein transport(GO:0072321) |
| 0.5 | 6.4 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.5 | 3.6 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.4 | 11.4 | GO:0010574 | regulation of vascular endothelial growth factor production(GO:0010574) |
| 0.4 | 6.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.4 | 5.7 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.4 | 1.4 | GO:2000551 | positive regulation of T-helper 2 cell differentiation(GO:0045630) regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553) |
| 0.4 | 0.7 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.3 | 4.3 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.3 | 4.1 | GO:0042182 | ketone catabolic process(GO:0042182) |
| 0.3 | 1.4 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 0.3 | 1.4 | GO:1902732 | positive regulation of chondrocyte proliferation(GO:1902732) |
| 0.3 | 1.3 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.2 | 2.7 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.2 | 5.5 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.2 | 0.5 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.1 | 4.8 | GO:0009395 | phospholipid catabolic process(GO:0009395) |
| 0.1 | 0.4 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 0.1 | 1.7 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.1 | 1.4 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.1 | 0.6 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 4.6 | GO:0050729 | positive regulation of inflammatory response(GO:0050729) |
| 0.1 | 1.2 | GO:0030953 | astral microtubule organization(GO:0030953) |
| 0.1 | 0.3 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.1 | 1.2 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.1 | 11.2 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.1 | 0.4 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.1 | 0.5 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.0 | 0.8 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) |
| 0.0 | 0.7 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 2.0 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 2.5 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
| 0.0 | 0.5 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.0 | 0.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.0 | 0.2 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.0 | 0.7 | GO:0098780 | response to mitochondrial depolarisation(GO:0098780) |
| 0.0 | 0.1 | GO:0046689 | response to mercury ion(GO:0046689) |
| 0.0 | 4.4 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 2.3 | GO:0042471 | ear morphogenesis(GO:0042471) |
| 0.0 | 0.3 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.0 | 0.4 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 4.8 | GO:0001525 | angiogenesis(GO:0001525) |
| 0.0 | 1.9 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 1.2 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 1.1 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 1.7 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 0.4 | GO:0006376 | mRNA splice site selection(GO:0006376) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 13.0 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.3 | 1.3 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.3 | 0.8 | GO:0031251 | PAN complex(GO:0031251) |
| 0.2 | 1.4 | GO:0045179 | apical cortex(GO:0045179) |
| 0.2 | 2.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 2.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 2.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.2 | 6.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 1.5 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 4.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 6.6 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 1.7 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 0.7 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.1 | 4.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 5.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 0.5 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 0.2 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.0 | 6.2 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 3.1 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 3.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.1 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 1.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 2.8 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 7.6 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.2 | GO:0032300 | mismatch repair complex(GO:0032300) |
| 0.0 | 2.5 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 0.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.3 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
| 0.0 | 2.5 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 39.7 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 2.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 13.0 | GO:0031721 | haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721) |
| 2.4 | 7.1 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 1.3 | 5.4 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 1.3 | 5.1 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 1.0 | 5.7 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.8 | 3.3 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.8 | 2.3 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.7 | 4.4 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.7 | 2.1 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.6 | 1.7 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.4 | 6.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.4 | 1.4 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.3 | 2.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.3 | 4.8 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.3 | 5.8 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.3 | 1.3 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.3 | 2.8 | GO:0031957 | fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.2 | 1.9 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.2 | 5.5 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.2 | 0.6 | GO:0032564 | dATP binding(GO:0032564) |
| 0.2 | 0.9 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 0.4 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.1 | 4.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 1.4 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.1 | 5.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 31.6 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 5.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 1.4 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 0.2 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.1 | 0.5 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 5.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.8 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 3.1 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 2.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.5 | GO:0022842 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
| 0.0 | 1.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.4 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 2.5 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.1 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.0 | 4.9 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.0 | 1.2 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 0.3 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 8.0 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 2.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.5 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 5.4 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.8 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.4 | 11.7 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 10.6 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 2.7 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.1 | 3.6 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 4.4 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.1 | 1.4 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.1 | 5.7 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 3.1 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.1 | 2.3 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.5 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.1 | 1.3 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 1.8 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 3.0 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.5 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 1.1 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 1.8 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 3.8 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.5 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 2.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.3 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.4 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.3 | 3.6 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.2 | 2.3 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 2.3 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.2 | 10.5 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.1 | 1.2 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 2.5 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 2.0 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.4 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 9.5 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 1.4 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 0.5 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 6.4 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.5 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.6 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 1.3 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.5 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 0.2 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 1.3 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.1 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 1.1 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
