Motif ID: Foxo3

Z-value: 0.849


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.561.3e-07Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 108 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 24.251 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr7_-_103813913 12.987 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr16_-_22439719 11.680 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr14_-_51913393 10.578 ENSMUST00000004673.7
ENSMUST00000111632.3
 Ndrg2

N-myc downstream regulated gene 2

chr16_-_43979050 8.250 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr11_-_101785252 7.442 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr11_+_3332426 7.123 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr10_+_112271123 6.383 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr6_+_55836878 6.089 ENSMUST00000044729.6
 Ccdc129
coiled-coil domain containing 129
chr5_+_66968559 5.807 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr3_-_145649970 5.801 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr5_+_66968416 5.786 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr7_+_141476374 5.013 ENSMUST00000117634.1
 Tspan4
tetraspanin 4
chr4_-_116405986 4.867 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chr2_-_120245157 4.827 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr5_+_65131184 4.683 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr17_+_43389436 4.659 ENSMUST00000113599.1
 Gpr116
G protein-coupled receptor 116
chr10_+_40349265 4.600 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19

chr14_-_121698417 4.427 ENSMUST00000040700.7
 Dock9
dedicator of cytokinesis 9
chr7_+_82175156 4.290 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 24.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
2.7 19.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.4 11.4 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.1 11.2 GO:0031032 actomyosin structure organization(GO:0031032)
2.4 7.3 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
1.0 7.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.4 6.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.5 6.4 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
1.2 5.8 GO:0060591 chondroblast differentiation(GO:0060591)
0.4 5.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 5.5 GO:0018345 protein palmitoylation(GO:0018345)
0.9 5.4 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.6 4.9 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.1 4.8 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 4.8 GO:0001525 angiogenesis(GO:0001525)
0.1 4.6 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.6 4.4 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 4.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.3 4.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.4 4.1 GO:0071492 cellular response to UV-A(GO:0071492)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 39.7 GO:0005654 nucleoplasm(GO:0005654)
3.2 13.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 7.6 GO:0005769 early endosome(GO:0005769)
0.1 6.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 6.4 GO:0030673 axolemma(GO:0030673)
0.0 6.2 GO:0005903 brush border(GO:0005903)
0.1 5.4 GO:0072562 blood microparticle(GO:0072562)
0.1 4.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.6 GO:0005604 basement membrane(GO:0005604)
0.0 3.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.8 GO:0005901 caveola(GO:0005901)
0.2 2.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.5 GO:0030139 endocytic vesicle(GO:0030139)
0.0 2.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 2.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 2.3 GO:0005922 connexon complex(GO:0005922)
0.0 2.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.5 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
3.2 13.0 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 8.0 GO:0003712 transcription cofactor activity(GO:0003712)
2.4 7.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.4 6.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 5.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.0 5.7 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 5.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 5.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.3 5.4 GO:0001851 complement component C3b binding(GO:0001851)
0.1 5.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.3 5.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 5.0 GO:0003823 antigen binding(GO:0003823)
0.0 4.9 GO:0019902 phosphatase binding(GO:0019902)
0.3 4.8 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 4.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.7 4.4 GO:0097001 ceramide binding(GO:0097001)
0.8 3.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 3.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 10.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.4 5.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 5.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 3.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.1 PID_SHP2_PATHWAY SHP2 signaling
0.0 3.0 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.8 PID_P73PATHWAY p73 transcription factor network
0.1 1.4 PID_IGF1_PATHWAY IGF1 pathway
0.1 1.3 PID_MYC_PATHWAY C-MYC pathway
0.0 1.1 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID_IFNG_PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.1 9.5 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 6.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
1.1 5.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.3 3.6 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 2.5 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 2.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 2.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 2.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.4 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.3 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.2 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 1.1 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 0.5 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells