Motif ID: Foxo4

Z-value: 0.887


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.521.6e-06Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_181767283 9.362 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr4_-_97778042 8.971 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_181767040 8.746 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr19_-_5796924 8.509 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr4_+_8690399 8.261 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr1_+_6487231 6.906 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr2_-_175931051 6.194 ENSMUST00000108949.2
ENSMUST00000109018.2
 Gm8898

predicted gene 8898

chr4_+_97777606 5.510 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr2_+_176521056 5.018 ENSMUST00000108997.2
ENSMUST00000178443.1
 Gm14431

predicted gene 14431

chr4_-_32950813 4.937 ENSMUST00000084750.1
ENSMUST00000084748.2
 Ankrd6

ankyrin repeat domain 6

chr17_-_51831884 4.822 ENSMUST00000124222.1
 Satb1
special AT-rich sequence binding protein 1
chr6_+_56714891 4.760 ENSMUST00000031805.8
 Avl9
AVL9 homolog (S. cerevisiase)
chr2_-_175338197 4.745 ENSMUST00000121393.2
 Gm4631
predicted gene 4631
chr2_+_175372436 4.433 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
 Gm4723


predicted gene 4723


chr14_-_98169542 4.366 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_-_175141999 4.329 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
 Gm14399


predicted gene 14399


chr2_+_175469985 4.325 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
 Gm8923



predicted gene 8923



chr2_-_175703646 4.194 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
 Gm4245


predicted gene 4245


chr17_+_80944611 4.133 ENSMUST00000025092.4
 Tmem178
transmembrane protein 178
chr2_+_178023284 4.104 ENSMUST00000108925.3
ENSMUST00000108926.2
 Etohi1

ethanol induced 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 18.1 GO:0060539 diaphragm development(GO:0060539)
1.7 8.5 GO:0035063 nuclear speck organization(GO:0035063)
2.8 8.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.7 6.9 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.6 6.9 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.3 5.5 GO:0072189 ureter development(GO:0072189)
0.3 4.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 4.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.5 4.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2 4.1 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 3.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 3.3 GO:0046888 negative regulation of hormone secretion(GO:0046888)
1.0 2.9 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.2 2.1 GO:0014029 neural crest formation(GO:0014029)
0.7 2.0 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.5 1.9 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 1.9 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 1.5 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.5 1.4 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 1.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0016607 nuclear speck(GO:0016607)
0.0 6.9 GO:0032993 protein-DNA complex(GO:0032993)
0.1 4.8 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 4.8 GO:0055037 recycling endosome(GO:0055037)
0.1 3.2 GO:0034707 chloride channel complex(GO:0034707)
0.1 2.9 GO:0016580 Sin3 complex(GO:0016580)
0.1 2.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 1.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.7 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.5 GO:0001652 granular component(GO:0001652)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 17.7 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 8.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 6.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 5.7 GO:0001047 core promoter binding(GO:0001047)
0.5 4.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 4.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 2.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 2.3 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.2 2.0 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 1.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 1.4 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 1.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.0 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.8 GO:0016936 galactoside binding(GO:0016936)
0.0 0.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 5.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 3.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 2.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 PID_FGF_PATHWAY FGF signaling pathway
0.1 1.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.5 PID_BARD1_PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.9 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.2 2.0 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.6 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation