Motif ID: Foxo4
Z-value: 0.887
Transcription factors associated with Foxo4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxo4 | ENSMUSG00000042903.7 | Foxo4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxo4 | mm10_v2_chrX_+_101254528_101254574 | 0.52 | 1.6e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 8.3 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 1.7 | 8.5 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 1.6 | 18.1 | GO:0060539 | diaphragm development(GO:0060539) |
| 1.5 | 4.4 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 1.0 | 2.9 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.7 | 6.9 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.7 | 2.0 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.6 | 6.9 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.5 | 1.9 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.5 | 1.4 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.3 | 5.5 | GO:0072189 | ureter development(GO:0072189) |
| 0.3 | 4.9 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.3 | 4.8 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.2 | 4.1 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
| 0.2 | 2.1 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.2 | 0.5 | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) rRNA export from nucleus(GO:0006407) |
| 0.1 | 1.4 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 3.7 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 0.3 | GO:0039533 | regulation of MDA-5 signaling pathway(GO:0039533) |
| 0.1 | 0.8 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.1 | 0.3 | GO:1903750 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135) regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.1 | 1.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 1.5 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) |
| 0.1 | 0.4 | GO:0070458 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
| 0.0 | 3.3 | GO:0046888 | negative regulation of hormone secretion(GO:0046888) |
| 0.0 | 0.5 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 1.9 | GO:0030279 | negative regulation of ossification(GO:0030279) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 2.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 2.9 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 0.5 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 3.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 4.8 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 6.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.7 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 0.4 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 4.8 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.2 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 2.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 7.5 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.4 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.4 | 6.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.2 | 8.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.2 | 1.4 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.2 | 2.0 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 2.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 18.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 1.9 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 0.8 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 0.4 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.1 | 2.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 1.0 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 0.5 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.7 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 4.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 5.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.1 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 1.2 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 1.4 | GO:0004702 | receptor signaling protein serine/threonine kinase activity(GO:0004702) |
| 0.0 | 17.7 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.4 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.0 | 2.3 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.3 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 5.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 1.9 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 4.8 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.1 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.9 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 2.0 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 1.8 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.4 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.1 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 2.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.5 | PID_BARD1_PATHWAY | BARD1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.0 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 4.8 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 0.6 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 1.9 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.8 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.4 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 2.9 | REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
